CN102894981A - Continuous high-precision detecting instrument for blood glucose concentration of human body based on trace blood sampling - Google Patents
Continuous high-precision detecting instrument for blood glucose concentration of human body based on trace blood sampling Download PDFInfo
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- CN102894981A CN102894981A CN2012103644849A CN201210364484A CN102894981A CN 102894981 A CN102894981 A CN 102894981A CN 2012103644849 A CN2012103644849 A CN 2012103644849A CN 201210364484 A CN201210364484 A CN 201210364484A CN 102894981 A CN102894981 A CN 102894981A
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Abstract
The invention discloses a continuous high-precision detecting instrument for blood glucose concentration of a human body based on trace blood sampling. The detecting instrument comprises a continuous blood sampling pipeline, a sample inlet pipeline, a detecting pipeline, a first cleaning pipeline and a second cleaning pipeline, wherein the continuous blood sampling pipeline is used for implementing trace blood sampling; the sample inlet pipeline is connected with the output end of the continuous blood sampling pipeline and used for mixing blood and anticoagulant and delivering the mixed liquid to the detecting pipeline to realize continuous measurement of the blood glucose concentration; the detecting pipeline is connected with the output end of the sample inlet pipeline and used for detecting the blood; the first cleaning pipeline is respectively connected with the sample inlet pipeline and the detecting pipeline and used for cleaning the sample inlet pipeline and the detecting pipeline; and the second cleaning pipeline is connected with the continuous blood sampling pipeline and used for cleaning the continuous blood sampling pipeline. The detecting instrument does not cause fluctuation of the blood glucose concentration due to trace continuous blood sampling. The detecting instrument realizes integrated operation of uninterrupted and non-interference blood sampling in the glucose detecting process, uninterrupted and non-interference blood sampling in the cleaning process of the sample inlet and detecting pipelines, buffer solution reference measurement, blood glucose concentration measurement, cleaning of the sample inlet and detecting pipelines and the like.
Description
Technical field
The present invention relates to glucose concentration continuous monitoring device in a kind of blood of human body.The continuous precise detecting instrument based on the human blood glucose concentration of trace blood that particularly relates to a kind of continuous phlebotomizing pipeline, sample introduction pipeline, signal piping and detergent line that includes micro blood.
Background technology
Along with the raising of people's living standard, the variation of dietary structure and the change of life style, the increase of aged tendency of population and fat incidence rate, the sickness rate of diabetes is year by year ascendant trend.The continuous blood sugar monitoring more and more is familiar with by people the significance of diabetes diagnosis and treatment.If can carry out painless and continual continuous blood sugar monitoring to the patient, the data that provide more close blood glucose drift to change, the blood glucose " overall picture " that just can reflect the patient, measure those uncared-for blood glucose information, disclose hiding blood sugar condition, find the peak value etc. of repeatedly hypoglycemic episodes, dawn phenomenon and the hyperglycemia of those no conscious symptons, glucose-lowering treatment scheme more reasonable for drafting, individuation, valuable clinical foundation is provided, thereby instructs better the treatment of diabetes.
Present blood sugar monitoring adopts quick finger tip to take a blood sample to detect blood glucose.Because the restriction of detection method, blood sugar monitoring can only be finished at isolated time point, its result reflection be the moment blood glucose in certain several moment in one day, moment blood glucose value moved, the impact of the factors such as diet, medicine, anxious state of mind, exist certain one-sidedness and inaccuracy.In order more fully to reflect the variation of human blood glucose concentration, just must realize the continuous detecting of blood sugar concentration.Noinvasive and Wicresoft's detection technique are so that the continuous detecting of blood sugar concentration becomes possibility.The Woundless blood sugar detection technique does not need to extract the substance in vivos such as blood, does not need sensor is implanted subcutaneous, relies on light and the interaction of human body specific part tissue to detect the variation of the interior blood sugar concentration of patient body, is optimal blood sugar for human body detection method.Wicresoft's blood sugar concentration detection technique is by sensor being implanted subcutaneous or measured concentration of glucose in the tissue liquid by the method for tissue fluid transdermal extraction, and the relation according to concentration of glucose in the tissue fluid and the concentration of glucose in blood obtains the concentration of glucose in blood again.Wicresoft's blood sugar test technology can realize dynamic, the continuous monitoring of human blood glucose concentration on the basis of reducing to greatest extent wound, know-why is relatively simple, has the characteristics such as realizability is strong, easy to use, measuring speed is fast.
The new theory, the new method that propose in noinvasive and the Wicresoft's blood glucose measurement scientific research, must study by experiment proved, and in experimental verification, only known the actual value of human blood glucose concentration, could estimate and characterize the new theory, the new method that propose.
Summary of the invention
Technical problem to be solved by this invention is, a kind of a kind of certainty of measurement height, good stability of providing is provided, the scientific research that can be embodied as noinvasive and Wicresoft's blood glucose measurement provides the reference value of human blood glucose concentration, and in ICU and the operation critical patient blood sugar concentration in real time, the continuous precise detecting instrument based on the human blood glucose concentration of trace blood of continuous monitoring.
The technical solution adopted in the present invention is: a kind of continuous precise detecting instrument of the human blood glucose concentration based on trace blood comprises: the continuous phlebotomizing pipeline of realizing trace blood; Link to each other with the outfan of continuous phlebotomizing pipeline, realize that blood mixes with anticoagulant, and mixed liquid is sent into the sample introduction pipeline that signal piping is realized the continuous measurement of blood glucose concentration; The signal piping that links to each other blood is detected with the outfan of sample introduction pipeline; Connect respectively sample introduction pipeline and signal piping, realize the first detergent line that sample introduction pipeline and signal piping are cleaned; And link to each other with the continuous phlebotomizing pipeline, realize the second detergent line that the continuous phlebotomizing pipeline is cleaned.
Described continuous phlebotomizing pipeline comprises: the venous detaining needle, miniature three-way valve, miniature peristaltic pump and the first miniature check valve that are used for imbedding human body, wherein, the c valve position of described miniature three-way valve connects venous detaining needle by catheter, the a valve position of miniature three-way valve is by an end of catheter connection miniature peristaltic pump, and the other end of miniature peristaltic pump connects an end of the first miniature check valve.
Described sample introduction pipeline comprises: the anticoagulant container, the first Miniature injection pump, the second miniature check valve, little six-way valve and little injection annulus, wherein, described anticoagulant container connects the input of the first Miniature injection pump by catheter, the outfan of described the first Miniature injection pump connects the second miniature check valve by catheter, the other end of described the second miniature check valve connects respectively the first miniature check valve in the continuous phlebotomizing pipeline away from that end of miniature peristaltic pump, and a valve position that connects little six-way valve, the b valve position of described little six-way valve is connected by little injection annulus with the e valve position
The f valve position of described little six-way valve connects the second waste liquid bottle by catheter.
Described signal piping comprises: degasser, little sample cell and glucose sensor, wherein, one end of described degasser connects the c valve position of little six-way valve in the sample introduction pipeline by catheter, the other end of degasser connects little sample cell by catheter, and described glucose sensor is arranged in little sample cell.
Described little sample cell also connects the first waste liquid bottle.
Described the first detergent line comprises: the first buffer container and the second Miniature injection pump, wherein, described buffer container connects the input of the second Miniature injection pump by catheter, and the outfan of described the second Miniature injection pump connects the d valve position of little six-way valve in the sample introduction pipeline by catheter.
Described the second detergent line includes the second buffer container, and described the second buffer container connects the b valve position of miniature three-way valve in the continuous phlebotomizing pipeline by catheter.
The continuous precise detecting instrument of the human blood glucose concentration based on trace blood of the present invention has following features:
1. continuously blood sampling of the trace of the present invention's proposition, blood sampling volume can not destroy the interior environment of blood circulation of human body in μ L magnitude, can not cause the fluctuation of getting blood place blood glucose concentration because of taking a blood sample continuously.
2. the present invention proposes a kind of micro-creep formula human body micro blood dynamically, the continuous sampling method, the external nothing that has designed a kind of micro blood that injects based on bypass duct transmission method and the microfluid system of flowing that condense.
3. the present invention proposes the micro blood continuous drawing is detected the method and system of separating in real time with the concentration of glucose in blood, realized uninterrupted, the noiseless blood sampling in the glucose detection process.
4. the present invention proposes the micro blood continuous drawing is detected the method and system of separating in real time with the concentration of glucose in blood, realized uninterrupted, the noiseless blood sampling in sample introduction and the signal piping cleaning process.
5. the present invention proposes the sample injection method based on the micro liquid of microfluid loop, realized the integrated operation of the processes such as buffer reference measure, blood glucose concentration measurement, sample introduction and signal piping cleaning.
Description of drawings
Fig. 1 is overall structure sketch map of the present invention.
Among the figure
1: venous detaining needle 2: the miniature three-way valve
3: 4: the first miniature check valves of miniature peristaltic pump
5: 6: the first Miniature injection pumps of anticoagulant container
Miniature check valve 8 in 7: the second: little six-way valve
9: little injection annulus 10: degasser
11: sample cell 12: glucose sensor
14: the first buffer container of 13: the second waste liquid bottles
16: the second buffer container of 15: the second Miniature injection pumps
17: the first waste liquid bottles
The specific embodiment
Make a detailed description below in conjunction with embodiment and the accompanying drawing continuous precise detecting instrument to the human blood glucose concentration based on trace blood of the present invention.
For science frontier innovation this application demand to scientific instrument, the present invention proposes to study a kind of continuous precise detecting instrument of the human blood glucose concentration based on trace blood.
Continuous precise detecting instrument based on the human blood glucose concentration of trace blood, except the scientific research for noinvasive and Wicresoft's blood glucose measurement provides the reference value of human blood glucose concentration, also has an important clinical practice, be exactly to be ICU(Intensive Care Unit, the serious symptom intensive care unit) and in the operation critical patient provide blood sugar concentration in real time, continuous monitoring, and this also is puzzlement clinician's global problem always, up to now clinically also without any available accurate monitoring instrument.
The continuous precise detecting instrument of the human blood glucose concentration based on trace blood of the present invention, proposed a kind of micro-creep formula human body micro blood dynamically, the continuous sampling method, the external nothing that has designed a kind of micro blood that injects based on bypass duct transmission method and the microfluid system of flowing that condense; Employing detects the method and system of separating in real time with the micro blood continuous drawing with the concentration of glucose in blood, has realized uninterrupted, the noiseless blood sampling in the glucose detection process; Also adopt the micro blood continuous drawing is cleaned the method and system of separating in real time with sample introduction with signal piping, realized uninterrupted, the noiseless blood sampling in sample introduction and the signal piping cleaning process; Propose the sample injection method based on the micro liquid of microfluid loop, realized the integrated operation of the processes such as buffer reference measure, blood glucose concentration measurement, sample introduction and signal piping cleaning.
As shown in Figure 1, the continuous precise detecting instrument of the human blood glucose concentration based on trace blood of the present invention comprises: the continuous phlebotomizing pipeline of realizing trace blood; Link to each other with the outfan of continuous phlebotomizing pipeline, realize that blood mixes with anticoagulant, and mixed liquid sent into the sample introduction pipeline that signal piping is realized the continuous measurement of blood glucose concentration, the signal piping that links to each other blood is detected with the outfan of sample introduction pipeline, connect respectively sample introduction pipeline and signal piping, the first detergent line that realization is cleaned sample introduction pipeline and signal piping, and link to each other with the continuous phlebotomizing pipeline, realize the second detergent line that the continuous phlebotomizing pipeline is cleaned.
Described continuous phlebotomizing pipeline comprises: the venous detaining needle 1, miniature three-way valve 2, miniature peristaltic pump 3 and the first miniature check valve 4 that are used for imbedding human body, wherein, the c valve position of described miniature three-way valve 2 connects venous detaining needle 1 by catheter, the a valve position of miniature three-way valve 2 is by an end of catheter connection miniature peristaltic pump 3, and the other end of miniature peristaltic pump 3 connects an end of the first miniature check valve 4.
Described sample introduction pipeline comprises: anticoagulant container 5, the first Miniature injection pump 6, the second miniature check valve 7, little six-way valve 8 and little injection annulus 9, wherein, described anticoagulant container 5 connects the input of the first Miniature injection pump 6 by catheter, the outfan of described the first Miniature injection pump 6 connects the second miniature check valve 7 by catheter, the other end of described the second miniature check valve 7 connects respectively the first miniature check valve 4 in the continuous phlebotomizing pipeline away from that end of miniature peristaltic pump 3, and a valve position that connects little six-way valve 8.The b valve position of described little six-way valve 8 is connected by little injection annulus 9 with the e valve position.The f valve position of described little six-way valve 8 connects the second waste liquid bottle 13 by catheter.
Described signal piping comprises: degasser 10, little sample cell 11 and glucose sensor 12, wherein, one end of described degasser 10 connects the c valve position of little six-way valve 8 in the sample introduction pipeline by catheter, the other end of degasser 10 connects little sample cell 11 by catheter, described glucose sensor 12 is arranged in little sample cell 11, Fibre Optical Sensor can be adopted, also the enzyme electrode sensor can be adopted.Described little sample cell 11 also connects the first waste liquid bottle 17.
Described the first detergent line comprises: the first buffer container 14 and the second Miniature injection pump 15, wherein, described buffer container 14 connects the input of the second Miniature injection pump 15 by catheter, and the outfan of described the second Miniature injection pump 15 connects the d valve position of little six-way valve 8 in the sample introduction pipeline by catheter.
Described the second detergent line includes the second buffer container 16, and described the second buffer container 16 connects the b valve position of miniature three-way valve 2 in the continuous phlebotomizing pipeline by catheter.
The operation principle of the continuous precise detecting instrument of the human blood glucose concentration based on trace blood of the present invention is: the continuous phlebotomizing pipeline passes through venous detaining needle, the miniature three-way valve, miniature peristaltic pump, realize at the uniform velocity, continuously, the uninterrupted blood drawing sampling in trace ground, in the external mobile transmission course of micro blood, for blood drawing speed and microfluid line size, according to clinical medical result of calculation, utilize the first Miniature injection pump that anticoagulant is slowly injected blood by bypass line, prevent external the solidifying when mobile of micro blood, utilize miniature check valve to guarantee that blood and anticoagulant are without refluence.The second Miniature injection pump enters signal piping for promoting buffer by little injection annulus, realize reference measure and pipe blow-through, and the micro blood that promotes in little injection annulus by buffer enters signal piping, and realizing that glucose molecule detects provides unified driving force.By the design of miniature six-way valve and little injection annulus, so that the four processes such as the sample introduction of micro blood, reference measure, glucose molecule detection and cleaning become possibility based on a time-division processing of overlapping microfluid system.Blood and buffer carry out degasification to reduce measurement error by degasser before entering little sample cell, improve accuracy of detection.Detergent line is divided into cleaning two parts of the cleaning of extracting pipeline and sample introduction, signal piping, switch by the miniature three-way valve, utilizing miniature peristaltic pump extraction buffer to enter the blood drawing pipeline cleans it, by miniature six-way valve and little injection annulus, realization utilizes Miniature injection pump that buffer is injected sample introduction and signal piping to its process of cleaning, the carrying out synchronously of blood continuous drawing.
The continuous precise detecting instrument measuring process of the human blood glucose concentration based on trace blood of the present invention is as follows:
Initialize:
1) pipeline cleaning.Open the miniature three-way valve, make its a, the conducting of b valve position.Open miniature six-way valve, make its a and f, b and c, d and the conducting of e valve position.Open miniature peristaltic pump, extract the first buffer, make its miniature three-way valve a that flows through, b valve position, miniature peristaltic pump, the first miniature check valve, miniature six-way valve a and f valve position, waste liquid flows into the first waste liquid bottle, realizes the cleaning of blood drawing pipeline.Open the second syringe pump, make the buffer in the second buffer container pass through successively miniature six-way valve d and e valve position, little injection annulus, b and c valve position, then flow through degasser and little sample cell enter the first waste liquid bottle, realize the cleaning of sample introduction and signal piping.Close miniature peristaltic pump and the second Miniature injection pump after cleaning a period of time.
2) micro-continuous phlebotomizing.The miniature three-way valve is switched to a, the conducting of b valve position, miniature six-way valve a and the conducting of f valve position.With venous detaining needle (disposable) end and miniature three-way valve interface UNICOM, an end inserts the human vein blood vessel.Open miniature peristaltic pump and the first Miniature injection pump, micro blood and anticoagulant mixed liquor slowly flow into the second waste liquid bottle.
Measure:
3) obtain the witness mark value.Open the second Miniature injection pump, miniature six-way valve a and f valve position, b and c valve position, d and the conducting of e valve position make buffer through little injection annulus flow through degasser and little sample cell, measure by glucose sensor, obtain the witness mark value.
4) little injection annulus is got the blood sampling.Close the second Miniature injection pump, switch miniature six-way valve and make a and b valve position, c and d valve position, e and the conducting of f valve position.Blood flow enters little injection annulus through miniature six-way valve a, b valve position, the amount of blood is no more than the cumulative volume of little injection annulus, switch miniature six-way valve after a period of time and make its a and f valve position, b and c valve position, d and the conducting of e valve position, the blood of continuous drawing continues to flow directly into the second waste liquid bottle.
5) concentration of glucose in the measurement micro blood.Open the second Miniature injection pump, buffer enters little injection annulus and promotes blood flow through degasser and little sample cell, by the glucose molecule concentration in the glucose sensor measurement blood.
6) clean the measurement pipeline.After measuring the concentration of glucose in blood, continue to open for second syringe pump a period of time, by buffer little injection annulus and signal piping are cleaned.
Finish:
7) close the first Miniature injection pump and the second Miniature injection pump.
8) switch the miniature three-way valve and make a, the conducting of b valve position, extract venous detaining needle.The buffer of the first buffer container flow through miniature three-way valve, miniature peristaltic pump, the first miniature check valve, miniature six-way valve a and f valve position enter the second waste liquid bottle, and the continuous phlebotomizing pipeline is cleaned.Close peristaltic pump, miniature three-way valve and miniature six-way valve after cleaning a period of time.
The present invention is open and that disclose, and all combinations can produce by using for reference this paper disclosure, although combination of the present invention is described by detailed implementation process, but those skilled in the art obviously can be spliced device as herein described within not breaking away from content of the present invention, spirit and scope or change, or increase and decrease some parts, more particularly, the replacement that all are similar and change apparent to those skilled in the artly, they are deemed to be included among spirit of the present invention, scope and the content.
Claims (8)
1. the continuous precise detecting instrument based on the human blood glucose concentration of trace blood is characterized in that, comprising: the continuous phlebotomizing pipeline of realizing trace blood; Link to each other with the outfan of continuous phlebotomizing pipeline, realize that blood mixes with anticoagulant, and mixed liquid is sent into the sample introduction pipeline that signal piping is realized the continuous measurement of blood glucose concentration; The signal piping that links to each other blood is detected with the outfan of sample introduction pipeline; Connect respectively sample introduction pipeline and signal piping, realize the first detergent line that sample introduction pipeline and signal piping are cleaned; And link to each other with the continuous phlebotomizing pipeline, realize the second detergent line that the continuous phlebotomizing pipeline is cleaned.
2. the continuous precise detecting instrument of the human blood glucose concentration based on trace blood according to claim 1, it is characterized in that, described continuous phlebotomizing pipeline comprises: the venous detaining needle (1) that is used for imbedding human body, miniature three-way valve (2), miniature peristaltic pump (3) and the first miniature check valve (4), wherein, the c valve position of described miniature three-way valve (2) connects venous detaining needle (1) by catheter, the a valve position of miniature three-way valve (2) connects an end of miniature peristaltic pump (3) by catheter, and the other end of miniature peristaltic pump (3) connects an end of the first miniature check valve (4).
3. the continuous precise detecting instrument of the human blood glucose concentration based on trace blood according to claim 1, it is characterized in that, described sample introduction pipeline comprises: anticoagulant container (5), the first Miniature injection pump (6), the second miniature check valve (7), little six-way valve (8) and little injection annulus (9), wherein, described anticoagulant container (5) connects the input of the first Miniature injection pump (6) by catheter, the outfan of described the first Miniature injection pump (6) connects the second miniature check valve (7) by catheter, the other end of described the second miniature check valve (7) connects respectively the first miniature check valve (4) in the continuous phlebotomizing pipeline away from that end of miniature peristaltic pump (3), and a valve position that connects little six-way valve (8), the b valve position of described little six-way valve (8) is connected by little injection annulus (9) with the e valve position.
4. the continuous precise detecting instrument of the human blood glucose concentration based on trace blood according to claim 3 is characterized in that the f valve position of described little six-way valve (8) connects the second waste liquid bottle (13) by catheter.
5. the continuous precise detecting instrument of the human blood glucose concentration based on trace blood according to claim 1, it is characterized in that, described signal piping comprises: degasser (10), little sample cell (11) and glucose sensor (12), wherein, one end of described degasser (10) connects the c valve position of little six-way valve (8) in the sample introduction pipeline by catheter, the other end of degasser (10) connects little sample cell (11) by catheter, and described glucose sensor (12) is arranged in little sample cell (11).
6. the continuous precise detecting instrument of the human blood glucose concentration based on trace blood according to claim 5 is characterized in that described little sample cell (11) also connects the first waste liquid bottle (17).
7. the continuous precise detecting instrument of the human blood glucose concentration based on trace blood according to claim 1, it is characterized in that, described the first detergent line comprises: the first buffer container (14) and the second Miniature injection pump (15), wherein, described buffer container (14) connects the input of the second Miniature injection pump (15) by catheter, and the outfan of described the second Miniature injection pump (15) connects the d valve position of little six-way valve (8) in the sample introduction pipeline by catheter.
8. the continuous precise detecting instrument of the human blood glucose concentration based on trace blood according to claim 1, it is characterized in that, described the second detergent line includes the second buffer container (16), and described the second buffer container (16) connects the b valve position of miniature three-way valve (2) in the continuous phlebotomizing pipeline by catheter.
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| CN112618819A (en) * | 2021-01-07 | 2021-04-09 | 上海药明康德新药开发有限公司 | Novel automatic blood sampling instrument and blood sampling method design |
| CN112642018A (en) * | 2020-12-18 | 2021-04-13 | 河南科技大学第一附属医院 | Blood glucose detection device matched with venous indwelling needle and detection method thereof |
| CN113116348A (en) * | 2021-03-02 | 2021-07-16 | 天津大学 | Continuous arterial blood detection device |
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