CN102048546B - System for monitoring, collecting and detecting biological information of human blood in real time - Google Patents
System for monitoring, collecting and detecting biological information of human blood in real time Download PDFInfo
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- CN102048546B CN102048546B CN2010106162196A CN201010616219A CN102048546B CN 102048546 B CN102048546 B CN 102048546B CN 2010106162196 A CN2010106162196 A CN 2010106162196A CN 201010616219 A CN201010616219 A CN 201010616219A CN 102048546 B CN102048546 B CN 102048546B
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Abstract
The invention discloses a system for monitoring, collecting and detecting the biological information of human blood in real time, which comprises a sensor group, a central processor, a blood-specimen collecting system, a blood-specimen detecting system and a vein indwelling body, wherein the indwelling body which can be indwelled in a vein is adopted, the time interval of blood-specimen collection is set by the central processor, and a blood specimen is collected and transported to the blood-specimen detecting system by the blood-specimen collecting system. When applied to clinics, the system can be used for perform painless, controllable and uninterrupted monitoring, blood-specimen collection and blood-specimen detection for the human blood to obtain the more comprehensive information about the blood of patients and integrally and dynamically know the pathophysiologic states of human bodies in real time. The invention solves the technical difficult problems that the blood coagulation and the deposition of protein and other substances in the blood influence subsequent continuous monitoring and cause wounds to the patients and the like; and the system uses capillaries for collecting blood, has an extremely-small blood collecting quantity, can not damage the safety range of human health and has more important significance for guiding clinical treatment.
Description
Technical field
The present invention relates to a kind of medical apparatus and instruments, particularly a kind of medical apparatus and instruments that blood of human body is monitored, gathered and detects of being used for.
Background technology
Blood of human body is except that containing cell component; In the blood plasma of liquid state; Contain protein, nonprotein nitrogenous compound, lipid, sugar, other Organic substances (comprising vitamin, enzyme, blood coagulation and anticoagulin etc.) are gone back organic/inorganic substance; To adapt to the needs of body, from blood of human body, can learn a large amount of human body condition informations.
In the prior art, in the time of need monitoring and detect blood, clinical vein haemospasias and the finger tip tip blood fast of adopting detect blood sample more, take a blood sample through repeated puncture and realize increasing the purpose that detects patient's misery, and medical personnel's workload is increased.The more important thing is; Single time sampling at interval; Can only reflect the blood information (being the moment blood information) of set time point, exist certain one-sidedness and inaccuracy, even frequent again finger tip or venous blood are measured the 24 hours successive blood sample information that also can't provide.Moment the blood sample value of information also moved, the influence of many factors such as diet, medicine, anxious state of mind, can't reflect patient's comprehensively " blood sample information spectrum ", it is unusual also to be difficult to the asymptomatic blood information of discovery, for example, comparatively commonly hyperglycemia and hypoglycemia.In clinical, the detection of hormone in vivo level also is the test item of using always, still; Many hormones all are pulsatile secretion in the body, and the basal secretion state is arranged, and also can raise because of factors such as anxiety, irriates; Thereby cause the fluctuation of its concentration in peripheral hemogram; Simple disposable blood-sample withdrawal can not antimer in the real level of various hormones, even the assay that possibly make the mistake brings wrong information for clinical diagnosis and treatment.Have again to be exactly, in the critical emergency case of majority, be the pathological information of understanding the patient and guiding treatment, evaluate its prognosis; Need also repeatedly that blood drawing detects, but take a blood sample repeatedly can damaged tissue and blood vessel for a lot of severe crisis patients, to the patient of part dysfunction of blood coagulation even cause the point of puncture haemophilia; When the unexpected variation of the state of an illness increases the weight of; Even because of patient's hypovolemia, blood vessel subside can not be successful blood sample collection, and the blood drawing amount of every day may cause the patient to occur anemia in a short time.
Therefore; Need a kind of device that can realize dynamic real-time monitoring and detection to blood of human body; Blood of human body is carried out painless and controlled continual monitoring, blood specimen collection and blood examination; The blood that can obtain the patient is information comparatively comprehensively, thereby understand the pathological and physiological condition of human body in real time from integral body, guiding clinical treatment is had the meaning of outbalance.
Summary of the invention
In view of this; The purpose of this invention is to provide that a kind of blood of human body bio information is monitored in real time, collection and detection system; Be applied to clinically, can carry out painless and controlled continual monitoring, blood specimen collection and blood examination blood of human body, thus the comparatively comprehensive information of the blood that obtains the patient; Understand the pathological and physiological condition of human body in real time from integral body, guiding clinical treatment is had the meaning of outbalance.
Blood of human body bio information of the present invention is monitored in real time, collection and detection system, comprises sensor groups, central processing unit, blood specimen collection system, blood examination system and venous indwelling body;
Said sensor groups is arranged at the indwelling body and is used to gather blood of human body hydrodynamics and gas content parameter and is delivered to the central processing unit storage;
Said blood examination system is used to receive the blood sample of blood specimen collection system and carries out check and analysis and analytical data is reached central processing unit storing;
The blood specimen collection system comprises blood sampling capillary tube, capillary drive device and aspirator; Be provided with the capillary channel that front opening and front opening place are provided with diaphragm type one-way valve in the said indwelling body; Said blood sampling capillary tube is to have flexible elastomer and penetrate capillary channel and can reciprocatingly slide with it to cooperate; Capillary channel was provided with the gas passage, and said gas passage one end opening of crossing is communicated with atmosphere, and other end opening is communicated in capillary channel near the capillary channel front end; Said capillary drive device comprises drive motors and pinion and rack, and the rotor of drive motors cooperates with the gear drive of pinion and rack, and the tooth bar of pinion and rack is fixedly set in the blood sampling capillary tube; The order output terminal of said central processing unit is connected in the control circuit of drive motors; Said aspirator comprises cylinder body, be arranged at cylinder body and its piston of cooperating and be used for driven plunger pistons reciprocating drive motors of reciprocatingly sliding; Said cylinder body setting is communicated in blood sampling inlet capillaceous and the leakage fluid dram that is communicated in the blood examination system; Said inlet is provided with the feed liquor check valve, and leakage fluid dram is provided with the discharge opeing check valve.
Further, also comprise housing, said indwelling body is positioned at the detachable housing that is connected in of outside, and said capillary drive device, aspirator, central processing unit and blood examination system all are arranged in the housing, and said blood sampling capillary extending goes out housing;
Further, said gas passage excessively is made up of the cannelure of capillary channel inner surface setting;
Further; Said indwelling body is the venous indwelling needle construction; Said capillary channel, the logarithmic output signal of crossing gas passage and sensor groups all are arranged at the trocar sheath tube wall of venous detaining needle according to line, and said sensor groups is arranged at the trocar sheath tube wall leading section of venous detaining needle;
Further, also comprise the man-machine dialog interface that is connected in central processing unit, the key and the screen of said man-machine dialog interface are arranged at housing;
Further, said central processing unit is provided with the lead-out terminal that information is exported to outer computer;
Further, said blood sampling capillary tube passes through soft pipe connection in the inlet of cylinder body;
Further, the coaxial screw mandrel that fixedly installs of said piston, the rotor of piston actuated motor is through gear engagement mechanism transmission setting and screw mandrel nut engaged; Said inner surface of cylinder block is provided with axial slide, and the structure of the convexity that is embedded in axial slide is set on the piston.
The invention has the beneficial effects as follows: blood of human body bio information of the present invention is monitored in real time, collection and detection system; Comprise sensor groups, central processing unit, blood specimen collection system, blood examination system and venous indwelling body, employing can be kept somewhere in venous and kept somewhere body, and passes through the blanking time that central processing unit is set blood-sample withdrawal; By blood specimen collection system acquisition blood sample and be delivered to the blood examination system; The blood specimen collection system is applied to clinically, can carry out painless and controlled continual monitoring, blood specimen collection and blood examination to blood of human body; Thereby the comparatively comprehensive information of the blood that obtains the patient is from the pathological and physiological condition of whole Real-time and Dynamic understanding human body; The present invention avoided electrodeposition substance influence such as albumen in blood coagulation, the blood follow-up continue to monitor, the patient caused technical barrier such as wound, and blood sampling volume is few, each blood sampling volume is about 0.05ml; The blood specimen collection above 300 times can be provided every day; Detailed testing result is provided, all only needs 15 milliliters of blood, the routine that the is less than general common patient blood sampling volume of being in hospital is few; Can not damage the safety range of health, guiding clinical treatment had the meaning of outbalance.
Description of drawings
Below in conjunction with accompanying drawing and embodiment the present invention is further described.
Fig. 1 is a structural representation of the present invention;
Fig. 2 is Figure 1A place enlarged drawing;
Fig. 3 is Figure 1B place enlarged drawing;
Fig. 4 for Fig. 1 along the C-C place cutaway view.
The specific embodiment
Fig. 1 is a structural representation of the present invention; Fig. 2 is Figure 1A place enlarged drawing; Fig. 3 is Figure 1B place enlarged drawing; Fig. 4 for Fig. 1 along the C-C place cutaway view, as shown in the figure: the blood of human body bio information of present embodiment is monitored in real time, collection and detection system, comprises sensor groups 27, central processing unit 17, blood specimen collection system, blood examination system and venous indwelling body 1;
Said sensor groups 27 is arranged at indwelling body 1 and is used to gather blood of human body hydrodynamics and gas content parameter and is delivered to central processing unit 17 storages; Data after the storage provide diagnosis basis through the output back for the medical worker; Said sensor groups 27 can comprise pressure transducer, flow sensor, temperature sensor, each item gas sensor etc., can adopt different sensor according to patient's situation;
Said blood examination system is used to receive the blood sample of blood specimen collection system and carries out check and analysis and analytical data is reached central processing unit 17 storing; Data after the storage provide diagnosis basis through the output back for the medical worker; Blood detection system 10 can adopt the fully automatic blood detector structure of prior art; This detector comprises full-automatic sample introduction needle, hematocrit, diluter, vortex mixer, proportioning device and vacuum pump; To accomplish absorption, dilution, transmission, the mixing of sample; And sample moved into the detection zone of various parameters, in addition, cleaning detector pipeline and the function of getting rid of waste liquid are set also; As shown in the figure, waste liquid drains into non-also holding vessel 12; During use; Set the interval that detects in advance through central processing unit 17; Blood sampling is after the unified detection of follow-up blood detector integrated chip realizes collection, the detection of multiple bio signal, such as biochemical indicators such as blood glucose, blood fat; Also can detect in cytokine, the blood numerical value such as hormonal readiness, and the input central processing unit stores.
The blood specimen collection system comprises blood sampling capillary tube 2, capillary drive device and aspirator; Be provided with the capillary channel 3 that front opening and front opening place are provided with diaphragm type one-way valve 19 in the said indwelling body 1; Said blood sampling capillary tube 2 cooperates for having flexible elastomer and penetrating capillary channel 3 and can reciprocatingly slide with it; Adopt no gap or little gap to be slidingly matched between blood sampling capillary tube 2 and the capillary channel 3, blood flows out from the gap when avoiding taking a blood sample; Capillary channel 3 was provided with gas passage 4, and said gas passage one end opening of crossing is communicated with atmosphere, and other end opening is communicated in capillary channel 3 near capillary channel 3 front ends; Sealing when the capillary tube that can guarantee to take a blood sample stretches out capillary channel and gets into vein between the two; Return remove above on the capillary channel cross the gas access portal time, guarantee with air admission capillary channel 3 the blood emptying that the capillary tube 3 of being beneficial to take a blood sample is interior; For blood sampling is next time got ready, and keep the cleaning of blood sampling capillary tube 2; Said capillary drive device comprises drive motors 7 and pinion and rack, and the rotor of drive motors 7 cooperates with 6 transmissions of the gear of pinion and rack, and the tooth bar 5 of pinion and rack is fixedly set in blood sampling capillary tube 2; Said aspirator comprises cylinder body 21, piston 24 and is used for driven plunger 24 pistons reciprocating drive motors 13; Said piston 24 reciprocatingly slides with cylinder body 21 and cooperates; The said piston 24 coaxial screw mandrels 9 that fixedly install, the rotor transmission setting of piston actuated motor 13 and screw mandrel 9 nut engaged 31, as shown in the figure; Cooperate through gear engagement mechanism 11 transmissions, be used for driven plunger 24 and move back and forth; The single-degree-of-freedom that reciprocatingly slides vertically between cylinder body 21 and the piston 24 cooperates, and can adopt the structure that axial slide 21a is set in the cylinder body 21, and the structure of the protruding 24a that is embedded in axial slide 21a is set on the piston 24, to guarantee the driving of nut 31; Said cylinder body 21 is provided with inlet 23 that is communicated in blood sampling capillary tube 2 and the leakage fluid dram 26 that is communicated in the blood examination system, and said inlet 23 is provided with feed liquor check valve 22, and leakage fluid dram 26 is provided with discharge opeing check valve 25; As shown in the figure, said blood sampling capillary tube 2 is communicated in the inlet 23 of cylinder body 21 through flexible pipe 8, is beneficial to the smooth and easy action that guarantees blood sampling capillary tube 2.
The order output terminal of said central processing unit 17 is connected in the control circuit 18 of drive motors 7 and the control circuit 14 of piston actuated motor 13; Central processing unit 17 is accomplished automatic blood collection procedure according to the running of the time of setting and periodic Control drive motors 7 and piston actuated motor 13; Dotted line is data signal and command signal transmission principle among the figure.
The present invention in use; Venous indwelling body 1 is implanted vein, and blood sampling capillary tube 2 inserts capillary channel 3, utilizes drive motors 7 driven wheel tooth bar mechanisms to make blood sampling capillary tube 2 back down diaphragm type one-way valve 19 and gets into vein; Piston actuated motor 13 driven plunger 24 move back and forth simultaneously; Accomplish swabbing action, blood is sucked blood sampling capillary tube 2, when the blood sampling volume of setting reaches requirement; 7 reverse rotations of central processing unit 17 control drive motors make blood sampling capillary tube 2 front ends bounce back to capillary channel 3 and be higher than the opening that gas passage 4 is positioned at capillary channel 3; Piston 24 continues to move back and forth, and the blood in blood sampling capillary tube 2 all gets into blood examination system 10,10 pairs of blood samples of blood examination system detect and obtain a result after the result is imported central processing unit 17 store and export; Meanwhile, sensor groups 27 is gathered intravenous blood flow kinetic parameter, such as blood pressure, flow velocity etc.; Also have gas content such as; The content of oxygen, carbon dioxide etc. is delivered to central processing unit with collection result and stores and export, and reaches the purpose of automatic monitoring, collection and detection.
In the present embodiment; Also comprise housing 30, said indwelling body 1 is positioned at the housing 30 outside detachable housings 30 that are connected in, during life-time service; It is fixing it to be connected the back; Connection can be adopted clamping, the grafting of prior art or be threaded or the like, and is as shown in the figure, adopts the mode of pegging graft to connect in the present embodiment; Said capillary drive device, aspirator, central processing unit 17 and blood examination system 10 all are arranged in the housing 30, and said blood sampling capillary tube 2 extends housing 30; This is simple and compact for structure, easy to use, can adopt slack comparatively easily and fixed structure, is convenient to the patient and uses voluntarily; Housing can be made into smaller volume, can be that the patient wears with oneself by the medical professional, and the patient detects and write down the blood sample data under the daily life situation; The central processing unit corresponding software of can packing into, the patient also can import " incident " labelling voluntarily, comprises situation such as dining, motion, medication, is beneficial to diagnoses and treatment.
In the present embodiment; Said indwelling body 1 is the venous indwelling needle construction; Said capillary channel 3, the logarithmic output signal of crossing gas passage 4 and sensor groups 27 all are arranged at the trocar sheath tube wall of venous detaining needle according to line 28; Said sensor groups 27 is arranged at the trocar sheath tube wall leading section of venous detaining needle, and logarithmic output signal is connected in central processing unit 17 according to line through interface 29; When carrying out blood testing, treatment measure such as can also infuse makes the present invention realize functional diversities.
In the present embodiment, said gas passage 3 excessively is made up of the cannelure of capillary channel 4 inner surface settings, during use, forms gas passage 3 between the cannelure of blood sampling capillary tube 2 outer surfaces and mistake gas passage 3; Process simple and convenient, in the time of can guaranteeing to take a blood sample capillary tube 2 blood samplings with capillary channel 4 between sealing, blood sampling is accomplished blood sampling capillary tube retraction back and is guaranteed air admission, is beneficial to the abundant sucking-off of blood in the capillary tube of taking a blood sample and drains into blood examination system 10.
In the present embodiment, also comprise the man-machine dialog interface 16 that is connected in central processing unit 17; Can the data of gathering in real time be delivered to this interface, be convenient to real-time monitoring.
In the present embodiment, said central processing unit 17 is provided with the lead-out terminal 32 that information is exported to outer computer, after blood specimen collection and the record end, can be with the data information transfer that stores to computer, and show or print, for treatment provides effective geographical opinion foundation; Pass through date processing; The medical professional can be known the blood sample situation of change in the patient 1～3 day; Comprise that the highest and minimum blood sample value of acquisition time, blood sample surpass or be lower than time of setting the blood sample value and blood sample value of proportion, blood sample excursion and any definite time or the like; Can also draw out accurate every day of blood sample change curve; Be marked with motion, diet at curve, sleep, take medicine, the sign of incident such as emotion changes, promptly draw out complete, detailed, comprehensive blood examination collection of illustrative plates.Through the blood sample collection of illustrative plates, the doctor can find the problem that many conventional blood sample monitoring methods can not be found, really is familiar with the pathophysiological process of human body, thereby for clinical timely diagnosis and rational therapy important clue is provided.
Explanation is at last; Above embodiment is only unrestricted in order to technical scheme of the present invention to be described; Although with reference to preferred embodiment the present invention is specified, those of ordinary skill in the art should be appreciated that and can make amendment or be equal to replacement technical scheme of the present invention; And not breaking away from the aim and the scope of technical scheme of the present invention, it all should be encompassed in the middle of the claim scope of the present invention.
Claims (8)
- A blood of human body bio information monitor in real time, collection and detection system, it is characterized in that: comprise sensor groups, central processing unit, blood specimen collection system, blood examination system and venous indwelling body;Said sensor groups is arranged at the venous indwelling body and is used to gather blood of human body hydrodynamics and gas content parameter and is delivered to the central processing unit storage;Said blood examination system is used to receive the blood sample of blood specimen collection system and carries out check and analysis and analytical data is reached central processing unit storing;The blood specimen collection system comprises blood sampling capillary tube, capillary drive device and aspirator; Be provided with the capillary channel that front opening and front opening place are provided with diaphragm type one-way valve in the said venous indwelling body; Said blood sampling capillary tube cooperates for having flexible elastomer and penetrating capillary channel and can reciprocatingly slide with it; Capillary channel was provided with the gas passage, and said gas passage one end opening of crossing is communicated with atmosphere, and other end opening is communicated in capillary channel near the capillary channel front end; Said capillary drive device comprises drive motors and pinion and rack, and the rotor of drive motors cooperates with the gear drive of pinion and rack, and the tooth bar of pinion and rack is fixedly set in the blood sampling capillary tube; The order output terminal of said central processing unit is connected in the control circuit of drive motors; Said aspirator comprises cylinder body, be arranged at cylinder body and its piston of cooperating and be used for driven plunger pistons reciprocating drive motors of reciprocatingly sliding; Said cylinder body setting is communicated in blood sampling inlet capillaceous and the leakage fluid dram that is communicated in the blood examination system; Said inlet is provided with the feed liquor check valve, and leakage fluid dram is provided with the discharge opeing check valve.
- 2. blood of human body bio information according to claim 1 is monitored in real time, collection and detection system; It is characterized in that: also comprise housing; Said venous indwelling body is positioned at the detachable housing that is connected in of outside; Said capillary drive device, aspirator, central processing unit and blood examination system all are arranged in the housing, and said blood sampling capillary extending goes out housing.
- 3. blood of human body bio information according to claim 2 is monitored in real time, collection and detection system, it is characterized in that: the said gas passage of crossing is made up of the cannelure of capillary channel inner surface setting.
- 4. blood of human body bio information according to claim 3 is monitored in real time, collection and detection system; It is characterized in that: said venous indwelling body is the venous indwelling needle construction; Said capillary channel, the logarithmic output signal of crossing gas passage and sensor groups all are arranged at the trocar sheath tube wall of venous detaining needle according to line, and said sensor groups is arranged at the trocar sheath tube wall leading section of venous detaining needle.
- 5. blood of human body bio information according to claim 4 is monitored in real time, collection and detection system, and it is characterized in that: also comprise the man-machine dialog interface that is connected in central processing unit, the key and the screen of said man-machine dialog interface are arranged at housing.
- 6. blood of human body bio information according to claim 5 is monitored in real time, collection and detection system, and it is characterized in that: said central processing unit is provided with the lead-out terminal that information is exported to outer computer.
- 7. blood of human body bio information according to claim 6 is monitored in real time, collection and detection system, it is characterized in that: said blood sampling capillary tube through soft pipe connection in the inlet of cylinder body.
- 8. blood of human body bio information according to claim 7 is monitored in real time, collection and detection system, it is characterized in that: the coaxial screw mandrel that fixedly installs of said piston, and the rotor of piston actuated motor is through gear engagement mechanism transmission setting and screw mandrel nut engaged; Said inner surface of cylinder block is provided with axial slide, and the structure of the convexity that is embedded in axial slide is set on the piston.
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| CN2010106162196A CN102048546B (en) | 2010-12-30 | 2010-12-30 | System for monitoring, collecting and detecting biological information of human blood in real time |
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| CN2010106162196A CN102048546B (en) | 2010-12-30 | 2010-12-30 | System for monitoring, collecting and detecting biological information of human blood in real time |
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| CN102048546B true CN102048546B (en) | 2012-08-22 |
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Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102697511A (en) * | 2012-05-24 | 2012-10-03 | 胡明建 | Intelligent needle system for internal detection |
| ITUB20154038A1 (en) * | 2015-09-30 | 2017-03-30 | Rocco Iannini | BIOMEDICAL CONTAINER TO COLLECT AND TEST BLOOD WHOLE OR HEMOCOMPONENT |
| CN106236114A (en) * | 2016-08-24 | 2016-12-21 | 川北医学院附属医院 | Arterial blood drawing pin |
| CN106390234A (en) * | 2016-12-02 | 2017-02-15 | 苏州科技城医院 | Indwelling needle |
| CN107802271B (en) * | 2017-10-30 | 2020-05-15 | 中国人民解放军第三军医大学第一附属医院 | Indwelling needle for blood collection and method of use |
| CN109507428B (en) * | 2018-11-27 | 2022-11-22 | 南京市中医院 | Intelligent blood sugar monitoring analyzer |
| CN110192871B (en) * | 2019-03-20 | 2023-10-03 | 南昌大学第二附属医院 | Portable dynamic venous hemostix |
| CN109938754B (en) * | 2019-03-29 | 2021-11-09 | 西安医学院 | Venipuncture blood sampling device |
| CN111759427B (en) * | 2020-07-28 | 2023-05-09 | 南阳市中心医院 | Pericardium puncture liquid pumping device for department of cardiology |
| CN113456072A (en) * | 2021-06-25 | 2021-10-01 | 常州市金坛第一人民医院 | Modular blood collection, detection and transfer system for hospital |
| CN113317788B (en) * | 2021-07-07 | 2023-07-07 | 中国人民解放军总医院第四医学中心 | Arterial detection blood sampling inspection integrated machine |
| CN115132304B (en) * | 2022-08-30 | 2022-11-11 | 蓝海睿创科技(山东)有限责任公司 | Blood sample track tracing management system |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1192351A (en) * | 1998-03-26 | 1998-09-09 | 王明时 | Instrument for quick measuring blood viscosity |
| DE19846466A1 (en) * | 1998-10-08 | 2000-04-27 | Ghs Gesundheits Service Ag | Analysis method for the simultaneous determination of parameters from different media |
| US20030212379A1 (en) * | 2002-02-26 | 2003-11-13 | Bylund Adam David | Systems and methods for remotely controlling medication infusion and analyte monitoring |
| US8774886B2 (en) * | 2006-10-04 | 2014-07-08 | Dexcom, Inc. | Analyte sensor |
| US20080021294A1 (en) * | 2006-07-14 | 2008-01-24 | Levin Paul D | Disposable blood glucose sensor with internal pump |
| CN201353361Y (en) * | 2009-02-23 | 2009-12-02 | 刘春香 | Disposable multifunctional vein remaining needle |
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