CN1192351A - Instrument for quick measuring blood viscosity - Google Patents
Instrument for quick measuring blood viscosity Download PDFInfo
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- CN1192351A CN1192351A CN98100797A CN98100797A CN1192351A CN 1192351 A CN1192351 A CN 1192351A CN 98100797 A CN98100797 A CN 98100797A CN 98100797 A CN98100797 A CN 98100797A CN 1192351 A CN1192351 A CN 1192351A
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- blood
- microcomputer
- piston
- syringe needle
- viscosity
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- 239000008280 blood Substances 0.000 title claims abstract description 84
- 210000004369 blood Anatomy 0.000 title claims abstract description 84
- 210000003462 vein Anatomy 0.000 claims abstract description 7
- 239000000284 extract Substances 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 claims description 14
- 230000008569 process Effects 0.000 claims description 13
- 230000017531 blood circulation Effects 0.000 claims description 12
- 239000012530 fluid Substances 0.000 claims description 10
- 230000009467 reduction Effects 0.000 claims description 6
- 230000003321 amplification Effects 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 2
- 230000036772 blood pressure Effects 0.000 abstract description 2
- 238000005259 measurement Methods 0.000 description 7
- 238000005070 sampling Methods 0.000 description 4
- 208000006011 Stroke Diseases 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 208000024172 Cardiovascular disease Diseases 0.000 description 2
- 239000003146 anticoagulant agent Substances 0.000 description 2
- 229940127219 anticoagulant drug Drugs 0.000 description 2
- 230000008081 blood perfusion Effects 0.000 description 2
- 208000026106 cerebrovascular disease Diseases 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 230000002526 effect on cardiovascular system Effects 0.000 description 2
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- 208000033386 Buerger disease Diseases 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 208000002330 Congenital Heart Defects Diseases 0.000 description 1
- 201000006306 Cor pulmonale Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 208000004186 Pulmonary Heart Disease Diseases 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 206010043540 Thromboangiitis obliterans Diseases 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
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- 239000003814 drug Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
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- 201000011461 pre-eclampsia Diseases 0.000 description 1
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- 238000013519 translation Methods 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
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Abstract
A blood viscosity quick measuring apparatus is composed of needle, conduct, barometric pump micro pressure senser and microcomputer. Under the control of microcomputer, the barometric pump extracts a little amount of blood from the vein of human body through the needle and conduct; the micropressure sensor measures the blood pressure at the two ends of the needle, which passes through preamplifier and A/D converter and enters the micro computer; and then with the support of software, the microcomputer computes the pressure difference across the needle and flow of blood, so that the apparent blood viscosity can be calculated.
Description
The present invention relates to a kind of instrument of under physiological status, measuring the apparent blood viscosity of human body fast in real time.
Mobile blood is human life activity's symbol.Human body has only the blood flow state that keeps good, just can keep normal physiological function of organism and defense function, and human internal organ organizing ability obtains normal blood perfusion, thereby guarantees oxygen and the normal supply of nutrient substance and the timely discharging of metabolite.Normal blood flow state also depends on the rheological equationm of state of blood itself or the viscosity of blood except closely related with the function of heart and blood vessel.If the viscosity of blood flow occurs unusual, then can directly have influence on the blood perfusion of organs and tissues, make organs and tissues hypoxic-ischemic, Metabolic disorder, obstacle appears in function, thereby causes a series of serious consequences.Modern medicine is verified, hypertension, apoplexy, myocardial infarction, thromboangiitis obliterans, high altitude heart disease, pulmonary heart disease, preeclampsia, congenital heart disease and a series of hematopathy, especially high cardiovascular and cerebrovascular disease of fatality rate and disability rate and malignant tumor etc., its generation and development all are accompanied by the unusual of hemorheology character.Therefore, accurately measure the viscosity of blood, the particularly accurate blood viscosity of measuring under the different shear rates, the diagnosis and the treatment that not only can be some disease provide foundation, also have great significance for the generation of some disease of pathogeny, prediction and prevention (particularly cardiovascular and cerebrovascular disease) of some disease of research.
The instrument that is used to measure human blood viscosity in the prior art has polytype, as rotating cylinder viscometer, capillary viscosimeter, falling sphere viscometer, translation and crossing current viscometer etc.Though the blood viscometer structure of above-mentioned these types is different, measuring principle also is not quite similar, and but has a common characteristic, promptly all be to collect blood of human body external and add anticoagulant to measure as a kind of simple industrial fluids later.Such measuring method is measuring period long (generally needing 1-2 days) not only, and be subjected to inevitably taking a blood sample and measuring process in the influence of various extraneous factors, the length of for example adding of Cai Xue speed, anticoagulant, blood sample waiting time and the height of storage temperature, and measure temperature controlling etc.Because the influence of these factors not only can make the accuracy rate of blood viscosity measurement result reduce greatly, and can make measurement result not possess horizontal comparability.
Purpose of the present invention promptly is to obtain a kind of instrument of measuring human body bloodviscosity under the different shear rates under physiological status fast in real time, reducing the influence that extraneous factor is measured human blood viscosity to greatest extent, thereby improve the accuracy that blood viscosity measures and make measurement result have horizontal comparability.
To achieve these goals, the present invention utilizes syringe needle, conduit, pulsometer, micro-pressure sensor and microcomputer to form an instrument for quick measuring blood viscosity.Pulsometer extracts small amounts of blood by syringe needle and conduit from human vein under control of microcomputer, utilize micro-pressure sensor to measure the blood sample pressure at syringe needle two ends in blood drawing and row's blood process subsequently.The output of micro-pressure sensor is read in microcomputer after preposition amplification and A/D conversion, microcomputer calculates the blood sample pressure differential and the blood flow at syringe needle two ends in blood drawing and the row's blood process under the support of software, utilize the calibrating parameters (length and internal diameter) of syringe needle to calculate the apparent blood viscosity under each shear rate and be depicted as the blood viscosity curve by non-Newtonian fluid model viscosity formula again.Be described in further detail below in conjunction with the technical characterictic of specific embodiment instrument for quick measuring blood viscosity of the present invention.
Accompanying drawing 1 is the sketch map of instrument for quick measuring blood viscosity of the present invention.
With reference to the accompanying drawings 1, instrument for quick measuring blood viscosity of the present invention mainly is made up of syringe needle, conduit, pulsometer, micro-pressure sensor and microcomputer.
Syringe needle 1 is to cooperate pulsometer and conduit to extract the utensil of blood from human vein, is again the blood viscosity measuring cell simultaneously.During blood drawing, the front end level of syringe needle is inserted in the human vein blood vessel, and its rear end then is communicated with pulsometer by conduit 2 and electromagnetic valve 3.As measuring cell, the length L of syringe needle and internal diameter R can adopt conventional method to be demarcated.Result of calculation shows that L and R are respectively about 40mm He about 0.15mm can satisfy laminar flow condition and run-up condition.
Microcomputer in this measuring instrument can adopt IBM PC and compatible family microcomputer, and the A/D change-over panel can adopt with the bus compatible HT-1232A/D change-over panel of IBM PC XT/AT and directly insert in the microcomputer expansion slot.This A/D change-over panel has 32 tunnel single-ended analog input channels, and this measuring instrument uses two paths wherein, connects micro-pressure sensor 4 and micro-pressure sensor 5 respectively and adopts the software gating.Because the flow velocity of blood is very little in the measuring process, every interval is the ability once sampling about 1 second, so transfer of data can adopt inquiry mode.
Pulsometer can have multiple pattern, for example can constitute a kind of piston-type pressure pump by piston and piston cylinder and leading screw, motor and piston stroke switch.Microcomputer rotates forward or backwards by I/O card control motor, and motor shaft can make piston 7 move back and forth in piston cylinder 8 to change the air pressure in the piston cylinder by leading screw 6 after slowing down.The piston stroke switch can adopt photoswitch, the photoelectric yield of photoswitch 9 and photoswitch 10 is by I/O card input microcomputer, the bottom of piston 7 has the dark slide 11 of working in coordination with photoswitch 9 and photoswitch 10, and the top of piston cylinder 8 is communicated with conduit 2 and atmosphere respectively by electromagnetic valve 3 and electromagnetic valve 12.
The process of utilizing this measuring instrument to measure the human body blood viscosity mainly comprises with individual step:
1, resets: close electromagnetic valve 3, open electromagnetic valve 12, make piston 7 move to the top of piston cylinder 8, and then close electromagnetic valve 12.
2, cause negative pressure: make piston 7 to the motion of piston cylinder 8 bottoms, make and cause certain negative pressure P in the piston cylinder 8
0(by micro-pressure sensor 5 monitoring and with microcomputer in set negative pressure value and compare), this moment, the volume of piston cylinder was V
0
3, blood drawing: syringe needle 1 level is inserted in the human vein, opened electromagnetic valve 4.Under the effect of negative pressure, blood will be in the slow inflow catheter of syringe needle.In this process, utilize micro-pressure sensor 4 to sample, sampled result deposits microcomputer in.Theoretically, sampled value should increase gradually, and we define a value, when the difference that continuous 3 sampled values occur is worth less than this, stops sampling.The fluctuation that human vein is pressed is very little, particularly can think certain value under the hemostatic situation.At the end of blood drawing process, when micro-pressure sensor 4 detected force value no longer change, can think that the pressure in venous pressure and the piston cylinder has reached balance, the micro-pressure sensor measured value of this moment promptly equals venous pressure.
4, cause malleation: close electromagnetic valve 4, open electromagnetic valve 12 and make piston 7 move to the bottom of piston cylinder 8, close electromagnetic valve 12 then and make piston 7, in piston cylinder 8, to cause certain malleation P to piston cylinder 8 tip motions
0' (by micro-pressure sensor 5 monitoring and with microcomputer in set the malleation value and compare), this moment, the volume of piston cylinder was V
0'.
5, row's blood: extract syringe needle 1 and open electromagnetic valve 5, under the effect of malleation, the blood that is stored in the conduit 2 will be discharged by syringe needle 1.In the process of row's blood, utilize micro-pressure sensor 4 to sample, sampled result deposits microcomputer in.In row's blood process, the pressure of syringe needle 1 front end is atmospheric pressure.
The key of utilizing this measuring instrument to measure human blood viscosity is to detect by the syringe needle blood drawing and arranges the blood sample pressure at syringe needle two ends in the blood process and calculate blood sample pressure reduction and corresponding blood flow, and the calculating of blood sample pressure reduction and corresponding blood flow is to utilize blood sample force samples value to finish under the support of software by microcomputer.Under the situation of blood drawing, blood sample pressure reduction is the poor of sampled value and venous pressure, and corresponding blood flow then can and utilize P by the isotherm compression equation of gaseous state
0, V
0Calculate with sampling time interval.Under the situation of row's blood, blood sample pressure reduction is the poor of sampled value and atmospheric pressure, and corresponding blood flow then can and utilize P by the isotherm compression equation of gaseous state
0', V
0' and sampling time interval calculating.Calculate after the blood sample pressure reduction and corresponding blood flow at syringe needle two ends, microcomputer can calculate the apparent blood viscosity under the different shear rates and be depicted as the blood viscosity curve by the viscosity formula of non-Newtonian fluid model.Blood of human body is a kind of non-Newtonian fluid, many studies show that, and it can be used as power law Model Fluid, Cusson law model fluid or Blngham plastic fluid and handles.
The present invention can measure the blood viscosity of human body under the different shear rates fast in real time under physiological status, can get rid of the influence that extraneous factor is measured human blood viscosity to greatest extent, thereby can significantly improve the accuracy of blood viscosity measurement and make measurement result have horizontal comparability.Therefore, the present invention is particularly suitable for the multimeter as the human body blood viscosity.
Claims (2)
1, a kind of instrument for quick measuring blood viscosity of under physiological status, measuring people's body surface sight blood viscosity under the different shear rates fast in real time, it is characterized in that by syringe needle, conduit, pulsometer, micro-pressure sensor and microcomputer are formed, pulsometer extracts small amounts of blood by syringe needle and conduit from human vein under control of microcomputer, in blood drawing and row's blood process subsequently, utilize micro-pressure sensor to measure the blood sample pressure at syringe needle two ends, the output of micro-pressure sensor is read in microcomputer after preposition amplification and A/D conversion, microcomputer calculates the blood sample pressure reduction and the blood flow at syringe needle two ends in blood drawing and the row's blood process under the support of software, the calibrating parameters that utilizes syringe needle again calculates the apparent blood viscosity under each shear rate and is depicted as the blood viscosity curve by the viscosity formula of non-Newtonian fluid model.
2, instrument for quick measuring blood viscosity according to claim 1 is characterized in that described pulsometer is the piston-type pressure pump that is made of piston, piston cylinder and leading screw, motor and piston stroke switch; Microcomputer rotates forward or backwards by I/O card control motor, and motor shaft can make piston move back and forth in piston cylinder by leading screw; The piston stroke switch is a photoswitch, and its photoelectric yield is by I/O card input microcomputer, and the lower end of piston has the dark slide of working in coordination with photoswitch; Piston cylinder is communicated with conduit and atmosphere respectively by electromagnetic valve.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98100797A CN1192351A (en) | 1998-03-26 | 1998-03-26 | Instrument for quick measuring blood viscosity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98100797A CN1192351A (en) | 1998-03-26 | 1998-03-26 | Instrument for quick measuring blood viscosity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1192351A true CN1192351A (en) | 1998-09-09 |
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ID=5216253
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98100797A Pending CN1192351A (en) | 1998-03-26 | 1998-03-26 | Instrument for quick measuring blood viscosity |
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| CN (1) | CN1192351A (en) |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102048546A (en) * | 2010-12-30 | 2011-05-11 | 中国人民解放军第三军医大学第一附属医院 | System for monitoring, collecting and detecting biological information of human blood in real time |
| CN102138800A (en) * | 2010-12-30 | 2011-08-03 | 中国人民解放军第三军医大学第一附属医院 | Piston type portable detection system for blood of human body |
| CN1920526B (en) * | 2005-08-22 | 2012-01-11 | 北京普利生仪器有限公司 | Method and equipment for measuring fluid viscosity of capillary pipeline |
| CN101874201B (en) * | 2007-11-28 | 2012-08-15 | 柯尼卡美能达精密光学株式会社 | Blood fluidity measurement apparatus and blood fluidity measurement method |
| CN106405134A (en) * | 2016-08-26 | 2017-02-15 | 卢明杰 | Concealed blood collection device used in blood cell analyzer |
| CN112584759A (en) * | 2018-06-06 | 2021-03-30 | 开迪恩有限公司 | Determining device and method for determining the viscosity of a fluid |
| CN113288073A (en) * | 2021-05-10 | 2021-08-24 | 华中科技大学同济医学院附属协和医院 | Method, system, device and storage medium for measuring vaginal bleeding amount of pregnant woman |
| US12144976B2 (en) | 2018-06-21 | 2024-11-19 | Kardion Gmbh | Method and device for detecting a wear condition of a ventricular assist device and for operating same, and ventricular assist device |
| US12194287B2 (en) | 2018-05-30 | 2025-01-14 | Kardion Gmbh | Method of manufacturing electrical conductor tracks in a region of an intravascular blood pump |
| US12201821B2 (en) | 2018-06-06 | 2025-01-21 | Kardion Gmbh | Method for determining a flow rate of a fluid flowing through an implanted vascular support system, and implantable vascular support system |
| US12222267B2 (en) | 2018-06-06 | 2025-02-11 | Kardion Gmbh | Analysis device and method for analyzing a viscosity of a fluid |
| US12257424B2 (en) | 2018-06-06 | 2025-03-25 | Kardion Gmbh | Implantable ventricular assist system and method for operating same |
| US12310708B2 (en) | 2018-06-06 | 2025-05-27 | Kardion Gmbh | Systems and methods for determining a flow speed of a fluid flowing through a cardiac assist device |
| US12311160B2 (en) | 2018-06-06 | 2025-05-27 | Kardion Gmbh | Method and system for determining the speed of sound in a fluid in the region of a cardiac support system |
| US12324906B2 (en) | 2018-06-06 | 2025-06-10 | Kardion Gmbh | Systems and methods for determining a total blood volume flow in a cardiac support system and vascular support system |
-
1998
- 1998-03-26 CN CN98100797A patent/CN1192351A/en active Pending
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1920526B (en) * | 2005-08-22 | 2012-01-11 | 北京普利生仪器有限公司 | Method and equipment for measuring fluid viscosity of capillary pipeline |
| CN101874201B (en) * | 2007-11-28 | 2012-08-15 | 柯尼卡美能达精密光学株式会社 | Blood fluidity measurement apparatus and blood fluidity measurement method |
| CN102048546A (en) * | 2010-12-30 | 2011-05-11 | 中国人民解放军第三军医大学第一附属医院 | System for monitoring, collecting and detecting biological information of human blood in real time |
| CN102138800A (en) * | 2010-12-30 | 2011-08-03 | 中国人民解放军第三军医大学第一附属医院 | Piston type portable detection system for blood of human body |
| CN102138800B (en) * | 2010-12-30 | 2012-09-05 | 中国人民解放军第三军医大学第一附属医院 | Piston type portable detection system for blood of human body |
| CN106405134A (en) * | 2016-08-26 | 2017-02-15 | 卢明杰 | Concealed blood collection device used in blood cell analyzer |
| CN106405134B (en) * | 2016-08-26 | 2018-01-26 | 山丹县天马科技有限责任公司 | A blood cell analyzer |
| US12194287B2 (en) | 2018-05-30 | 2025-01-14 | Kardion Gmbh | Method of manufacturing electrical conductor tracks in a region of an intravascular blood pump |
| CN112584759B (en) * | 2018-06-06 | 2024-03-29 | 开迪恩有限公司 | Device and method for determining the viscosity of a fluid |
| US12178554B2 (en) | 2018-06-06 | 2024-12-31 | Kardion Gmbh | Systems and methods for determining a viscosity of a fluid |
| CN112584759A (en) * | 2018-06-06 | 2021-03-30 | 开迪恩有限公司 | Determining device and method for determining the viscosity of a fluid |
| US12201821B2 (en) | 2018-06-06 | 2025-01-21 | Kardion Gmbh | Method for determining a flow rate of a fluid flowing through an implanted vascular support system, and implantable vascular support system |
| US12222267B2 (en) | 2018-06-06 | 2025-02-11 | Kardion Gmbh | Analysis device and method for analyzing a viscosity of a fluid |
| US12257424B2 (en) | 2018-06-06 | 2025-03-25 | Kardion Gmbh | Implantable ventricular assist system and method for operating same |
| US12310708B2 (en) | 2018-06-06 | 2025-05-27 | Kardion Gmbh | Systems and methods for determining a flow speed of a fluid flowing through a cardiac assist device |
| US12311160B2 (en) | 2018-06-06 | 2025-05-27 | Kardion Gmbh | Method and system for determining the speed of sound in a fluid in the region of a cardiac support system |
| US12324906B2 (en) | 2018-06-06 | 2025-06-10 | Kardion Gmbh | Systems and methods for determining a total blood volume flow in a cardiac support system and vascular support system |
| US12144976B2 (en) | 2018-06-21 | 2024-11-19 | Kardion Gmbh | Method and device for detecting a wear condition of a ventricular assist device and for operating same, and ventricular assist device |
| CN113288073A (en) * | 2021-05-10 | 2021-08-24 | 华中科技大学同济医学院附属协和医院 | Method, system, device and storage medium for measuring vaginal bleeding amount of pregnant woman |
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