CN109172047A - Heart valve prosthesis function test system - Google Patents
Heart valve prosthesis function test system Download PDFInfo
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- CN109172047A CN109172047A CN201811087517.3A CN201811087517A CN109172047A CN 109172047 A CN109172047 A CN 109172047A CN 201811087517 A CN201811087517 A CN 201811087517A CN 109172047 A CN109172047 A CN 109172047A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2472—Devices for testing
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- Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
- External Artificial Organs (AREA)
Abstract
The present invention provides a kind of heart valve prosthesis function test system, including a human body simulation mechanism for testing, a mechanism for monitoring and a control mechanism, the human body simulation mechanism for testing includes a heart simulation pump and a blood circulation analog loopback, the control mechanism connects the mechanism for monitoring and the heart simulation pump, the mechanism for monitoring are also connected with the heart simulation pump and the blood circulation analog loopback.A kind of heart valve prosthesis function test system of the invention, analog real human body physiological environment improve the science and accuracy of test, and rich precision out is high, can meet the valve testing requirements under different test environment.
Description
Technical field
The present invention relates to test heart valve prosthesis hydrodynamic performance technical field more particularly to a kind of artificial heart valves
Film function test system.
Background technique
Valvulopathy is a kind of common heart disease, with the extension of human longevity and the astogeny of population, this kind of disease
The disease incidence of disease is higher and higher.Valvulopathy be it is irreversible, only can gradually aggravate, Prosthetic valve replacement operation be to control
Treat the effective ways of severe valvulopathy.The patient for needing to carry out valve surgery every year accounts for adult heart up to more than 30 ten thousand
Operation first.Either mechanical prosthetic valve or bioprosthetic valves requires to carry out stringent testing in vitro, animal examination before clinical application
It tests and clinical test.Testing in vitro is the important content of heart valve prosthesis performance evaluation, it is therefore an objective to obtain the performance ginseng of valve
Number, evaluates the quality good or not of valve, provides foundation for the performance optimization of valve.Wherein, the external functional test of heart valve prosthesis
It is the important means for evaluating valve hydrodynamic performance.
Current existing, the heart valve prosthesis functional test equipment of China's independent development continues to use traditional simple design
Method only considers that principle does not account for human body cardiovascular structures when simulating psychological environment, and device fluctuation of service, performance can not
It leans on, state modulator is inaccurate, and complicated for operation.Import equipment, it is expensive although performance is stablized, cause valve to grind
It sends out at high cost, is unfavorable for the development and popularization and application of valve.
Summary of the invention
In view of the deficiency of the prior art, the present invention provides a kind of heart valve prosthesis function test system, can mould
Quasi- real human body physiological environment improves the science and accuracy of test, and rich precision out is high, can meet different test environment
Under valve testing requirement.
To achieve the goals above, the present invention provides a kind of heart valve prosthesis function test system, including a human mould
Quasi- mechanism for testing, a mechanism for monitoring and a control mechanism, the human body simulation mechanism for testing include a heart simulation pump and a blood
Liquid circulating analog circuit, the control mechanism connects the mechanism for monitoring and the heart simulation pump, the mechanism for monitoring also connect
Connect the heart simulation pump and the blood circulation analog loopback;
The blood circulation analog loopback include a ventricular chamber, a branching block, an aortic stents, a valve erecting bed,
One aorta lumen, one first diversion pipe, one second diversion pipe, an orifice valve, an atrial chamber, a unidirectional mechanical valve and one are complied with
Chamber;The ventricular chamber side connects the heart simulation pump, and the branching block is fixed on the top of the ventricular chamber and described point
The top surface of the bottom surface and the ventricular chamber of flowing block forms a first passage of the conducting ventricular chamber and the branching block;The master
Arterial bracket and the atrial chamber are individually fixed in the two sides of the branching block top surface, between the atrial chamber and the branching block
A second channel of the conducting atrial chamber and the branching block is formed, the unidirectional mechanical valve is installed on the second channel
On;The valve erecting bed is fixed on the top of the aortic stents, and the aorta lumen is fixed on the valve erecting bed
Top, the aorta lumen pass through between the valve erecting bed and aortic stents and the branching block formed conducting described in
One third channel of aorta lumen and the branching block, the valve erecting bed include a valve mounting rack, the valve installation
Frame is detachably secured on the third channel;The lower part of the aorta lumen passes through first diversion pipe and the atrium
Chamber conducting, the orifice valve are installed on first diversion pipe;The top of the aorta lumen passes through second diversion pipe
It is connected to the compliance chamber.
Preferably, the heart simulation pump pushes away cylinder, a piston and one including a shell, an AC servo motor, a lead screw
Cylinder body, the cylinder body and the AC servo motor are fixed in the shell, and the lead screw pushes away cylinder and AC servo electricity
Machine transmission connection, the piston are fixed on the lead screw and push away the one end of cylinder far from the AC servo motor and can be along the lead screw
Cylinder transmission direction is pushed away reciprocally to cooperate with the inboard wall of cylinder block piston;The cylinder body far from the AC servo motor one
End is connected with the ventricular chamber.
Preferably, it is horizontal direction that the lead screw, which pushes away cylinder transmission direction, and the cylinder body pushes away cylinder with the lead screw and coaxially lays.
Preferably, the mechanism for monitoring includes a temperature control equipment, flow meters, at least a flow sensor, a letter
Number amplifier, a first pressure sensor, a second pressure sensor and multiple displacement sensors;The temperature control equipment connects
Connect the blood circulation analog loopback;The flowmeter connects the flow sensor, and the flow sensor is installed on described
In the third channel between aortic stents and the branching block;The signal amplifier connects the first pressure sensing
Device and the second pressure sensor, the first pressure sensor are installed on the branching block, the second pressure sensor
It is installed on the aorta lumen;The flowmeter connects the control mechanism with the signal amplifier;Institute's displacement sensors
The lead screw is installed on to push away on cylinder and connect the control mechanism.
Preferably, the control mechanism include an alternating-current servo controller, a data collecting card and a host computer, it is described on
Position machine connects the data collecting card, and the data collecting card connects the alternating-current servo controller, the flowmeter, the letter
Number amplifier and institute's displacement sensors, the alternating-current servo controller connect the AC servo motor.
Preferably, the branching block forms a splitter cavity in the horizontal direction, and the both ends of the splitter cavity are respectively formed one and open
Mouthful, the opening is respectively arranged with an end cover.
Preferably, the branching block that is axially set in of the aortic stents and the atrial chamber along the splitter cavity
Top two sides and the two sides for being symmetrically laid in the first passage.
Preferably, a discharge outlet is formed on the bottom of the ventricular chamber, and the discharge outlet is provided with a draining end cap.
Preferably, the atrial chamber uses transparent material.
The present invention due to use above technical scheme, make it have it is following the utility model has the advantages that
The use of human body simulation mechanism for testing can be achieved to comprehensively consider cardiac structure, blood circulation environment, damping, compliance
Situations such as human physiological environment's simulation, analog real human body physiological environment improves the science and accuracy of test.It is logical
The cooperation of human body simulation test mechanism, mechanism for monitoring and control mechanism is crossed, it can be achieved that the heart valve prosthesis function of automation is surveyed
Examination.Orifice valve is used to adjust the size of resistance in blood circulation simulation process, the fidelity of human body environment is improved, to improve survey
The precision of test result.Compliance chamber is used for by changing ullage volume of air in compliance chamber, the compliance of regulating system, simulation
True physiological environment improves the precision of test result.Valve mounting rack is detachably secured on third channel, passes through replacement
The valve mounting rack of different model can meet the measurement of the heart valve prosthesis to be measured of different size.Atrial chamber uses transparent material
Material, can be convenient the open and-shut mode and motion conditions for intuitively observing heart valve prosthesis to be measured.
Detailed description of the invention
Fig. 1 is the schematic diagram of the heart valve prosthesis function test system of the embodiment of the present invention;
Fig. 2 is the structural schematic diagram of the heart valve prosthesis function test system of the embodiment of the present invention;
Fig. 3 is the structural schematic diagram of the blood circulation analog loopback of the embodiment of the present invention;
Fig. 4 is the structural schematic diagram of the heart simulation pump of the embodiment of the present invention.
Specific embodiment
Below according to attached FIG. 1 to FIG. 4, presently preferred embodiments of the present invention is provided, and is described in detail, is enabled more preferable geographical
Solve function of the invention, feature.
Please refer to Fig. 1 and Fig. 2, a kind of heart valve prosthesis function test system of the embodiment of the present invention, including a human body
Simulation test mechanism 1, a mechanism for monitoring 2 and a control mechanism 3, human body simulation mechanism for testing 1 include 11 He of a heart simulation pump
One blood circulation analog loopback 12, control mechanism 3 connects mechanism for monitoring 2 and heart simulation pump 11, mechanism for monitoring 2 are also connected with heart
Simulation pump 11 and blood circulation analog loopback 12.
The use of human body simulation mechanism for testing 1 can be achieved to comprehensively consider cardiac structure, blood circulation environment, damp, comply with
Property situations such as human physiological environment's simulation, analog real human body physiological environment improves the science and accuracy of test.
By the cooperation of human body simulation mechanism for testing 1, mechanism for monitoring 2 and control mechanism 3, it can be achieved that the heart valve prosthesis function automated
It can test.
In the present embodiment, heart simulation pump 11 has the function of position-force control, wins precision height, can meet different tests
Valve testing requirement under environment.
Fig. 2 and Fig. 3 are please referred to, blood circulation analog loopback 12 includes a ventricular chamber 1201,1202, one active of a branching block
Pulsation frame 1203, a valve erecting bed 1204, an aorta lumen 1205, one first diversion pipe 1206, one second diversion pipe 1207,
One orifice valve 1208, an atrial chamber 1209, a unidirectional mechanical valve 1210 and a compliance chamber 1211;1201 side of ventricular chamber connects the heart
Dirty simulation pump 11, branching block 1202 are fixed on the bottom surface at the top of ventricular chamber 1201 and branching block 1202 and the top of ventricular chamber 1201
Face forms a first passage of conducting ventricular chamber 1201 and branching block 1202;Aortic stents 1203 and atrial chamber 1209 are solid respectively
Due to the two sides of 1202 top surface of branching block, conducting atrial chamber 1209 and branching block are formed between atrial chamber 1209 and branching block 1202
1202 second channel, unidirectional mechanical valve 1210 are installed on second channel;Valve erecting bed 1204 is fixed on active pulsation
The top of frame 1203, aorta lumen 1205 are fixed on the top of valve erecting bed 1204, and aorta lumen 1205 is installed by valve
The one the of conducting aorta lumen 1205 and branching block 1202 is formed between platform 1204 and aortic stents 1203 and branching block 1202
Triple channel, valve erecting bed 1204 include a valve mounting rack 12041, and valve mounting rack 12041 is detachably secured to third
On channel;The lower part of aorta lumen 1205 is connected by the first diversion pipe 1206 with atrial chamber 1209, and orifice valve 1208 is installed on
On first diversion pipe 1206;The top of aorta lumen 1205 is connected to by the second diversion pipe 1207 with compliance chamber 1211.
Orifice valve 1208 is used to adjust the size of resistance in blood circulation simulation process, improves the fidelity of human body environment,
To improve the precision of test result.Compliance chamber 1211 is used to adjust by changing ullage volume of air in compliance chamber 1211
The compliance of section system simulates true physiological environment, improves the precision of test result.In the present embodiment, compliance chamber 1211 is solid
Due on heart simulation pump 11.Valve mounting rack 12041 is detachably secured on third channel, passes through replacement different model
Valve mounting rack 12041 can meet the measurement of the heart valve prosthesis to be measured 4 of different size.
In the present embodiment, branching block 1202 forms a splitter cavity in the horizontal direction, and the both ends of splitter cavity are respectively formed one and open
Mouthful, opening is respectively arranged with an end cover 1212.
Aortic stents 1203 and atrial chamber 1209 along the top two sides for being axially set in branching block 1202 of splitter cavity simultaneously
Symmetrically it is laid in the two sides of first passage.
One discharge outlet is formed on the bottom of ventricular chamber 1201, and discharge outlet is provided with a draining end cap 1213.Atrial chamber 1209 is adopted
With transparent material, in the present embodiment, transparent material is made every effort to overcome using transparent Asia, be can be convenient and is intuitively observed artificial heart valve to be measured
The open and-shut mode and motion conditions of film 4.
Fig. 2 and Fig. 4 are please referred to, heart simulation pump 11 pushes away cylinder including a shell 111, an AC servo motor 112, a lead screw
113, a piston 114 and a cylinder body 115, cylinder body 115 and AC servo motor 112 are fixed in shell 111, and lead screw pushes away cylinder 113
It is sequentially connected with AC servo motor 112, piston 114 is fixed on lead screw and pushes away the one end of cylinder 113 far from AC servo motor 112 simultaneously
113 transmission direction of cylinder can be pushed away along lead screw reciprocally to cooperate with 115 inner wall piston 114 of cylinder body;Cylinder body 115 is far from AC servo
One end of motor 112 and ventricular chamber 1201 are connected.
Wherein, it is horizontal direction that lead screw, which pushes away 113 transmission direction of cylinder, and cylinder body 115 pushes away the coaxial laying of cylinder 113 with lead screw.
In the present embodiment, mechanism for monitoring 2 includes a temperature control equipment 21, flow meters 22, at least a flow sensor
23, a signal amplifier 24, a first pressure sensor 25, a second pressure sensor 26 and multiple displacement sensors 27;Temperature
It spends control device 21 and connects blood circulation analog loopback 12;Flowmeter 22 connects flow sensor 23, and flow sensor 23 is installed
In third channel between aortic stents 1203 and branching block 1202;Signal amplifier 24 connects first pressure sensor 25
With second pressure sensor 26, first pressure sensor 25 is installed on branching block 1202, and second pressure sensor 26 is installed on master
Lumen of artery 1205;24 connection control mechanism 3 of flowmeter 22 and signal amplifier;Displacement sensor 27 is installed on lead screw and pushes away cylinder 113
Upper and connection control mechanism 3.
In addition, control mechanism 3 includes an alternating-current servo controller 31, a data collecting card 32 and a host computer 33, it is upper
Machine 33 connects data collecting card 32, and data collecting card 32 connects alternating-current servo controller 31, flowmeter 22,24 and of signal amplifier
Displacement sensor 27, alternating-current servo controller 31 connect AC servo motor 112.In the present embodiment, data collecting card 32 includes
One I/O module and a data acquisition module, host computer 33 send instructions to the I/O module of data collecting card 32 by usb bus,
Then the pulse delivery outlet of I/O module sends pulse data to alternating-current servo controller 31, so that it is past to control heart simulation pump 11
Multiple movement.Meanwhile the frequency and quantity that pulse exports can be set by host computer 33, accurately control fighting for heart simulation pump 11
Dynamic frequency, output.
Fig. 2~Fig. 4 is please referred to, a kind of operating method of heart valve prosthesis function test system of the embodiment of the present invention is such as
Under:
Firstly, heart valve prosthesis 4 to be measured is fixed on valve mounting rack 12041, then by atrial chamber 1209
The liquid injection port injection blood simulated solution 5 opened up is held, due to being connected state in blood circulation analog loopback 12, so blood
Simulated solution 5 can be full of the chamber of entire blood circulation analog loopback 12.Then end cap seal liquid injection port is used.Then pass through temperature control
Device 21 processed simulates the temperature environment for being similar to human body, and blood simulated solution 5 need to maintain 37 DEG C.
Then, power supply (not shown) is opened, using medical three-way valve, to first pressure sensor 25 and second
Pressure sensor 26 communicates with atmosphere before testing and carries out pressure calibration.After base measuring pressure, can be made by crossover tee valve
One pressure sensor 25 and second pressure sensor 26 are communicated with blood circulation analog loopback 12.Start heart by host computer 33
Simulation pump 11, and lead screw is observed by displacement sensor 27 and whether pushes away cylinder 113 in default origin position, it then begins to test,
Under the action of heart simulation pump 11, power is directly acted on blood simulated solution 5 by piston 114.Piston 114 travels forward, and simulates the heart
When dirty diastolic action, load is transmitted to heart valve prosthesis 4 to be measured by blood simulated solution 5, so that heart valve prosthesis to be measured 4 is beaten
It opens, unidirectional mechanical valve 1210 is closed, and blood simulated solution 5 is pumped out from ventricular chamber 1201, is surveyed heart valve prosthesis 4 to be measured and enters master
Lumen of artery 1205 flows into atrial chamber 1209 by the first diversion pipe 1206, orifice valve 1208;When piston 114 moves backward, mould
When pseudocardia contractive action, 1201 pressure of ventricular chamber reduces, and heart valve prosthesis 4 to be measured is closed, and unidirectional mechanical valve 1210 is opened,
Blood simulated solution 5 flows back into ventricular chamber 1201 from atrial chamber 1209.The draining of openable 1201 lower end of ventricular chamber after test
Blood simulated solution 5 is discharged in end cap 1213.
Flow sensor 23, flowmeter 21, first pressure sensor 25 and second pressure sensor 26 can real-time monitoring wait for
Survey the hydrodynamic performance of heart valve prosthesis 4;The data collecting module collected of data collecting card 32 through signal amplifier 24 at
The signal of the voltage signal and flowmeter 22 managed, and can be shown on host computer 33 with curve, data mode, by meter
The measurable aortic pressure of processing, ventricular pressure, average pressure gradient, blood is calculated to pass through valve flow and regurgitation volume, effectively open
Data needed for open area etc..
A kind of heart valve prosthesis function test system of the embodiment of the present invention, test result is accurate, optimizes simulation
Cardiovascular structures, have reappeared the physiological environment of valve from principle and form, it is possible to reduce test error improves test result
Precision.
The present invention has been described in detail with reference to the accompanying drawings, those skilled in the art can be according to upper
It states and bright many variations example is made to the present invention.Thus, certain details in embodiment should not constitute limitation of the invention, this
Invention will be using the range that the appended claims define as protection scope of the present invention.
Claims (9)
1. a kind of heart valve prosthesis function test system, which is characterized in that including a human body simulation mechanism for testing, a monitoring machine
Structure and a control mechanism, the human body simulation mechanism for testing includes a heart simulation pump and a blood circulation analog loopback, described
Control mechanism connects the mechanism for monitoring and the heart simulation pump, the mechanism for monitoring are also connected with the heart simulation pump and institute
State blood circulation analog loopback;
The blood circulation analog loopback includes a ventricular chamber, a branching block, an aortic stents, a valve erecting bed, a master
Lumen of artery, one first diversion pipe, one second diversion pipe, an orifice valve, an atrial chamber, a unidirectional mechanical valve and a compliance chamber;Institute
It states ventricular chamber side and connects the heart simulation pump, the branching block is fixed on the top of the ventricular chamber and the branching block
Bottom surface and the top surface of the ventricular chamber form a first passage of the conducting ventricular chamber and the branching block;The active pulsation
Frame and the atrial chamber are individually fixed in the two sides of the branching block top surface, are formed and are led between the atrial chamber and the branching block
Lead to a second channel of the atrial chamber and the branching block, the unidirectional mechanical valve is installed on the second channel;It is described
Valve erecting bed is fixed on the top of the aortic stents, and the aorta lumen is fixed on the top of the valve erecting bed,
The aorta is connected by being formed between the valve erecting bed and aortic stents and the branching block in the aorta lumen
One third channel of chamber and the branching block, the valve erecting bed include a valve mounting rack, and the valve mounting rack is removable
It is fixed on unloading on the third channel;It is led by first diversion pipe with the atrial chamber lower part of the aorta lumen
Logical, the orifice valve is installed on first diversion pipe;The top of the aorta lumen passes through second diversion pipe and institute
State compliance chamber connection.
2. heart valve prosthesis function test system according to claim 1, which is characterized in that the heart simulation pump packet
It includes a shell, an AC servo motor, a lead screw and pushes away cylinder, a piston and a cylinder body, the cylinder body and the AC servo motor
It is fixed in the shell, the lead screw pushes away cylinder and the AC servo motor is sequentially connected, and the piston is fixed on the silk
Thick stick push away the one end of cylinder far from the AC servo motor and can be pushed away along the lead screw cylinder transmission direction reciprocally with the cylinder
Internal wall piston cooperation;The one end of the cylinder body far from the AC servo motor is connected with the ventricular chamber.
3. heart valve prosthesis function test system according to claim 2, which is characterized in that the lead screw pushes away cylinder transmission
Direction is horizontal direction, and the cylinder body pushes away cylinder with the lead screw and coaxially lays.
4. heart valve prosthesis function test system according to claim 2 or 3, which is characterized in that the mechanism for monitoring
Including a temperature control equipment, flow meters, at least a flow sensor, a signal amplifier, a first pressure sensor, one
Second pressure sensor and multiple displacement sensors;The temperature control equipment connects the blood circulation analog loopback;It is described
Flowmeter connects the flow sensor, and the flow sensor is installed between the aortic stents and the branching block
In the third channel;The signal amplifier connects the first pressure sensor and the second pressure sensor, described
First pressure sensor is installed on the branching block, and the second pressure sensor is installed on the aorta lumen;The flow
Meter connects the control mechanism with the signal amplifier;Institute's displacement sensors are installed on the lead screw and push away on cylinder and connect institute
State control mechanism.
5. heart valve prosthesis function test system according to claim 4, which is characterized in that the control mechanism includes
One alternating-current servo controller, a data collecting card and a host computer, the host computer connect the data collecting card, the data
Capture card connects the alternating-current servo controller, the flowmeter, the signal amplifier and institute's displacement sensors, the friendship
It flows servo controller and connects the AC servo motor.
6. heart valve prosthesis function test system according to claim 5, which is characterized in that the branching block is along horizontal
Direction forms a splitter cavity, and the both ends of the splitter cavity are respectively formed an opening, and the opening is respectively arranged with an end cover.
7. heart valve prosthesis function test system according to claim 6, which is characterized in that the aortic stents and
The atrial chamber along the splitter cavity the top two sides for being axially set in the branching block and symmetrically be laid in it is described first logical
The two sides in road.
8. heart valve prosthesis function test system according to claim 7, which is characterized in that the bottom of the ventricular chamber
A discharge outlet is formed, the discharge outlet is provided with a draining end cap.
9. heart valve prosthesis function test system according to claim 8, which is characterized in that the atrial chamber is using saturating
Bright material.
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CN111789700A (en) * | 2020-06-30 | 2020-10-20 | 成都赛拉诺医疗科技有限公司 | Valve function testing device |
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