CN108181223A - A kind of measuring device and measuring method for porous biomaterial permeability - Google Patents
A kind of measuring device and measuring method for porous biomaterial permeability Download PDFInfo
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- CN108181223A CN108181223A CN201711432377.4A CN201711432377A CN108181223A CN 108181223 A CN108181223 A CN 108181223A CN 201711432377 A CN201711432377 A CN 201711432377A CN 108181223 A CN108181223 A CN 108181223A
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- pressure
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- porous material
- porous
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- 239000012620 biological material Substances 0.000 title claims abstract description 14
- 230000035699 permeability Effects 0.000 title claims abstract description 12
- 238000000034 method Methods 0.000 title abstract description 14
- 230000035515 penetration Effects 0.000 claims abstract description 16
- 239000011148 porous material Substances 0.000 claims abstract description 15
- 239000000463 material Substances 0.000 claims abstract description 10
- 238000001514 detection method Methods 0.000 claims abstract description 6
- 238000012360 testing method Methods 0.000 claims abstract description 5
- 239000007788 liquid Substances 0.000 claims description 7
- 230000036760 body temperature Effects 0.000 claims description 2
- 238000004891 communication Methods 0.000 claims description 2
- 239000002504 physiological saline solution Substances 0.000 claims description 2
- 230000008595 infiltration Effects 0.000 claims 1
- 238000001764 infiltration Methods 0.000 claims 1
- 238000005259 measurement Methods 0.000 abstract description 10
- 230000010261 cell growth Effects 0.000 abstract description 3
- 238000012546 transfer Methods 0.000 abstract description 3
- 210000004027 cell Anatomy 0.000 description 5
- 230000000694 effects Effects 0.000 description 3
- 230000009123 feedback regulation Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 230000002706 hydrostatic effect Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 210000000963 osteoblast Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000011425 standardization method Methods 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/08—Investigating permeability, pore-volume, or surface area of porous materials
- G01N15/082—Investigating permeability by forcing a fluid through a sample
- G01N15/0826—Investigating permeability by forcing a fluid through a sample and measuring fluid flow rate, i.e. permeation rate or pressure change
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
-
- G01N15/01—
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- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Fluid Mechanics (AREA)
- Investigation Of Foundation Soil And Reinforcement Of Foundation Soil By Compacting Or Drainage (AREA)
Abstract
The Penetration ration of porous material is equally closely related with the mechanical environment residing for seed cell and mass transfer situation, significantly affects cell growth efficiency.Lack the measuring method of perfect measuring apparatus and standard about the measurement of material Penetration ration at present, often there are large errors for measurement result.The present invention proposes a kind of measuring device and its measuring method for porous biomaterial permeability, flow cavity, pressure propeller, differential pressure pickup and PC control end including placing porous material.Pressure propeller and differential pressure pickup realize feedback control by PC control end, provide constant flow and constant pressure two kinds of test patterns, and the standardization detection to realize porous biomaterial proposes new departure.
Description
Technical field
It is specifically a kind of to have the present invention relates to a kind of measuring device and its measuring method of porous biomaterial permeability
The measuring device for porous biomaterial permeability and its accurate measuring method of feedback regulation.
Background technology
The Effects on Microstructure of porous biomaterial implant outer mass exchange efficiency and the microenvironment suffered by cell
An important factor for feature is seed cell growth, has a very important significance the tissue reconstruction after implantation.Multiporous biological material
The aperture size and porosity of material can influence the proliferation and activity of seed cell, and the aperture size of bigger is conducive to cambium
Interior growth, and high porosity also for cell provide bigger amplification and migration space, the two is considered as timbering material
Important feature parameter.However recent studies have indicated that, the Penetration ration of porous material equally with the mechanical environment residing for seed cell
It is closely related with mass transfer situation, significantly affect cell growth efficiency.
Penetration ration is also referred to as permeability, refers to the degree that material allows fluid under certain pressure difference, is that measurement is more
The parameter of hole medium mass-transfer efficiency.The porous material of high permeability can enhance proliferation, metabolic activity and the alkalinity of osteoblast
Phosphatase activity promotes cell to be grown in inner void.It drips however, being used mostly about the measurement of material Penetration ration at present
Method is realized using instruments such as the flask of laboratory routine, graduated cylinders.Due to lacking perfect measuring apparatus and unified measurement mark
Standard, often there are large errors for measurement result.The present invention proposes a kind of accurate side for porous biomaterial permeability survey
Method and device, to realize that its standardization detection proposes new departure.
Invention content
Lack unified and standardization method and perfect in order to which the existing Penetration ration for porous biomaterial is overcome to measure
Device, a kind of measuring method and device of the porous biomaterial Penetration ration with feedback regulation are proposed, based on Darcy's law
Calculation formula, it can be achieved that two kinds of measurement patterns of Penetration ration constant flow and constant pressure, to realize that its standardization detection proposes new side
Case.
The technical solution that the present invention takes is：A kind of measuring device of porous biomaterial permeability, feature are mainly wrapped
It includes：101 place the flow cavity of porous material, 102 pressure propellers, 103 differential pressure pickups and 104 PC control ends.Pressure
The output terminal of propeller is connected through leading one end of pipeline flow chamber, and porous material to be tested is placed at position among flow cavity,
Both ends are connected respectively with differential pressure pickup, and pressure propeller and differential pressure pickup realize feedback control by PC control end
System, provides constant flow and constant pressure two kinds of test patterns.Device controls propeller to pressurize by microcontroller, and microcontroller passes through
Self-programming realizes the communication with PC control end, while realizes the signal acquisition of differential pressure pickup；And further pass through journey
Sequence realizes the feedback control to propeller signal by hydraulic pressure signal, to realize the autonomous control of pressure and flow, the perseverance of realization
Constant flow loads and constant pressure forces two kinds of measurement patterns of load.According to classical Darcy's law, the calculating formula of Penetration ration is as follows：
Wherein, B is porous material Penetration ration, and Q is the flow velocity of liquid, and η is the viscous of physiological saline at a temperature of 37 DEG C (body temperature)
Coefficient is spent, δ is the length of porous material to be measured, and A is the sectional area of porous material to be measured, and P is detection material both ends pressure difference.
In calculating, each physical quantity Q, η, δ, A, P unit takes international unit, respectively m3、Pa·s、m、s、m2, Pa, Pa, be calculated
The unit of permeability is m2。
Description of the drawings
Fig. 1 is the measuring device schematic diagram of porous biomaterial permeability of the present invention.
Specific embodiment
1st, material preparation：Before test, treated first, in accordance with flow cavity internal diameter and the length dimension preparation for placing porous material
It measures and monitor the growth of standing timber material, is fixed in flow cavity after the completion.
2nd, prepare before measuring：Leakage fluid dram (flow cavity bottom end) is first turned on, injection liquid crude exhaust body makes liquid full of dress
It puts, is closed exhaust outlet, continue to inject liquid later, detection material is made to be completely soaked in liquid.Gushed out by liquid flowing and taken out of
Bubble, can be discharged in small exhaust outlet, ensure the seal of whole device.
3rd, the measuring method of both of which：1) for the measuring method of constant flow pattern：In control terminal setting propeller
Fltting speed, and measure import and the pressure differential exported using two hydralic pressure gauges；The load mode to maintain stable flow,
Pressure is shown as dynamic change, Darcy's law is utilized to can measure the Penetration ration under constant flow after stabilization.2) for constant pressure mould
The measuring method of formula：Since pressure propeller and differential pressure pickup pass through PC control end feedback control, load mode reality
Continual and steady hydraulic pressure in now measuring, and the regime flow under the pressure is calculated by the fltting speed of propeller, final utilize reaches
Western law can measure the Penetration ration under constant flow.The measurement pattern of constant flow and constant pressure can facilitate realization in different flow and pressure
The standardization of Penetration ration measures under the conditions of power.Due to the measuring method using the teady state pressure value under the conditions of constant flow and
Steady-state flow magnitude under the conditions of constant pressure, therefore measurement result is compared compared with conventional method with higher accuracy.
4th, control method：Realizing in the control of propeller and hydrostatic sensor, hydrostatic sensor with RS423/485-
USB converter is connected with PC, realizes that high frequency acquires hydraulic pressure signal by programming；Propulsion device is by motor, tooth sector, note
Emitter fixes propulsion device and control is formed with microcontroller, and microcontroller is connected, and lead to by TTL-RS232 converters with PC
It crosses programming and carries out Solid rocket engine；Host computer realizes the pressure signal acquisition of sensor and the signal control of propeller, and leads to
Cross the feedback control that pressure is realized in programming.
Claims (4)
1. a kind of measuring device of porous biomaterial permeability, feature mainly include：Place the flow cavity of porous material, pressure
Power propeller, differential pressure pickup and PC control end.The output terminal of pressure propeller is connected through leading one end of pipeline flow chamber
Connect, porous material to be tested is placed at position among flow cavity, and both ends are connected respectively with differential pressure pickup, pressure propeller and
Differential pressure pickup realizes feedback control by PC control end.
2. device controls propeller to pressurize by microcontroller, microcontroller is realized and PC control end by self-programming
Communication, while realize the signal acquisition of differential pressure pickup；And it is further realized by program and propeller is believed by hydraulic pressure signal
Number feedback control, to realize the autonomous control of pressure and flow, it is possible to provide constant flow rate load and constant pressure forces load two kinds survey
Amount pattern.
3. the calculating of Penetration ration is according to classical Darcy's law, as follows：
Wherein, B is porous material Penetration ration, and Q is the flow velocity of liquid, and η is the viscosity system of physiological saline at a temperature of 37 DEG C (body temperature)
Number, δ are the length of porous material to be measured, and A is the sectional area of porous material to be measured, and P is detection material both ends pressure difference.It is calculating
In, each physical quantity Q, η, δ, A, P unit takes international unit, respectively m3、Pa·s、m、s、m2, Pa, Pa, infiltration is calculated
The unit of rate is m2。
4. for constant flow test pattern：Control terminal setting propeller fltting speed, and using two hydralic pressure gauges measure into
Mouth and the pressure differential exported；For the load mode to maintain stable flow, pressure is shown as dynamic change, can measure constant flow
Under Penetration ration.For constant pressure test pattern：Propeller works after sensor pressure values reach preset value, is reduced in hydraulic pressure
Propeller stops after preset value；The load mode is to maintain stable hydraulic pressure, to obtain the correlation of long period stable state
Data, while can be calculated to comparison among groups, flow by the range of propeller.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711432377.4A CN108181223A (en) | 2017-12-26 | 2017-12-26 | A kind of measuring device and measuring method for porous biomaterial permeability |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711432377.4A CN108181223A (en) | 2017-12-26 | 2017-12-26 | A kind of measuring device and measuring method for porous biomaterial permeability |
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| Publication Number | Publication Date |
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| CN108181223A true CN108181223A (en) | 2018-06-19 |
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|---|---|---|---|
| CN201711432377.4A Pending CN108181223A (en) | 2017-12-26 | 2017-12-26 | A kind of measuring device and measuring method for porous biomaterial permeability |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113588515A (en) * | 2021-07-28 | 2021-11-02 | 清华大学 | Water permeability coefficient detection device and method |
| CN114166719A (en) * | 2021-11-27 | 2022-03-11 | 北京擎科生物科技有限公司 | Method and device for screening nucleic acid synthetic vector |
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| CN113588515A (en) * | 2021-07-28 | 2021-11-02 | 清华大学 | Water permeability coefficient detection device and method |
| CN114166719A (en) * | 2021-11-27 | 2022-03-11 | 北京擎科生物科技有限公司 | Method and device for screening nucleic acid synthetic vector |
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Application publication date: 20180619 |