CN102160777B - Body fluid bioinformation fiber dynamic testing system - Google Patents
Body fluid bioinformation fiber dynamic testing system Download PDFInfo
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- CN102160777B CN102160777B CN 201110057068 CN201110057068A CN102160777B CN 102160777 B CN102160777 B CN 102160777B CN 201110057068 CN201110057068 CN 201110057068 CN 201110057068 A CN201110057068 A CN 201110057068A CN 102160777 B CN102160777 B CN 102160777B
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Abstract
The invention discloses a body fluid bioinformation fiber dynamic testing system, including an optical fiber sensing probe used for collecting spectrum information of body fluid, an optical transmitter connected to a launching fiber and providing required light source, a spectrum analyzer connected to a receiving fiber to receive optical signals and making spectrum analysis of the signals and processing, and a signal processing unit connected to the spectrum analyzer to receive spectrum signals and deliver signal processing results. In the invention, optical fiber is employed to obtain the spectrum information of human body fluid and to compare with standard spectrum information parameters stored in advance, so as to obtain a body fluid component which is different from that in the standard body fluid. The invention can be applied to clinical treatment for testing human body fluid including blood, so as to obtain comparatively comprehensive information of the body fluid of patients. The invention is suitable for the parameter testing of blood in capillaries, thereby helps to learn the process of the pathological changes, and facilitates early prevention and treatment of diseases like diabetes and the like. The invention that helps to learn the pathophysiological condition of a human body dynamically and in real time has important guiding significance for clinical treatment.
Description
Technical field
The present invention relates to a kind of medical apparatus and instruments, particularly a kind of for the medical apparatus and instruments that human body fluid information is carried out dynamic monitoring.
Background technology
The variation of human body fluid (comprising blood) composition can reflect the many diseases of human body; Such as for diabetic, kinetic parameters such as the blood flow rate of vessel inner blood, blood stickiness all are different from ordinary person with the blood physiology information parameter relevant with diabetes.In diabetes early discovery pathological changes, can control pathological changes, delay the development of diabetes, be beneficial to later stage patient's treatment.Blood capillary is the structural units of basic unit in the blood of human body circulation, account for 90% of the interior blood vessel of body, little blood flow is the dynamic process of circulation constantly, variation, early stage in diabetes, little blood flow disorder, microcirculation blood physicochemical property change, and when causing carbohydrate metabolism disturbance, endothelial cell damage, erythrocyte aggregation strengthen, make that whole blood viscosity increases, microcirculation disturbance, histanoxia, above hemorheology is the key factor that finally causes the microangiopathies development unusually.And the acquisition of above blood capillary parameter, for the microangiopathies of finding diabetics early, prevent and delay its generation and the development particularly important.Yet the microangiopathies process need has dynamic detection method, can judge accurately comprehensively that microangiopathies takes place, development; The sampling of single time can not be reacted the information of dynamic change comprehensively, and in the prior art, because microvascular own complex changeable characteristics: multiple compositions such as erythrocyte, leukocyte, platelet, serum albumin are arranged in the blood, comprise multiple information such as blood flow rate, mode, blood stickiness, the single blood drawing detects inaccurate, because existing research, analytical method and the technical limitations that directly detects blood information in real time, still do not have at present accurately in body real-time analysis method, can't be familiar with whole blood capillary rheology information, pathological and physiological condition in real time.There is no the method for simple possible for the acquisition of the above parameter of blood capillary.
For another example, (Advanced Glycosylafion end Product's advanced diabetes glycosylation dead end product AGEs) raises, and causes the change of multiple proteins gene expression dose, also is one of basic performance of diabetes; Whether blood capillary causes pathological changes because AGEs exists in early days in diabetes, all is in early days to the foundation of its detection and control in diabetes.
And in the prior art, all adopt vein haemospasia to detect blood sample for diabetes, the various detection that needs to understand blood information, vein haemospasia and quick finger tip tip blood detect information such as blood glucose, and defective is to need the repeated puncture blood sampling, and the patient is agonized with loaded down with trivial details.The more important thing is that these methods can only reflect the blood glucose of several points in a day, not only can only reflect transient information, exist one-sidedness, inaccuracy, and pinpoint the problems during blood capillary generation pathological changes in early days, the best period that delays control and delay.Moment blood glucose value moved, all multifactor influences such as diet, medicine, anxious state of mind, can't reflect patient's comprehensively " blood glucose spectrum ", also be difficult to the asymptomatic hyperglycemia of discovery and hypoglycemia.If can carry out painless and continual lasting blood sugar test to the patient, just can point out patient's blood glucose " overall picture ", this has more importantly meaning to instructing treatment of diabetes.
In clinical, the detection of hormone in vivo level also is the test item of using always, but, many hormones all are pulsatile secretion in the body, and the basal secretion state is arranged, and also can raise because of factors such as anxiety, irriates, thereby cause the fluctuation of its concentration in peripheral hemogram, simple disposable blood-sample withdrawal can not antimer in the real level of various hormones, even the assay that may make the mistake brings wrong information for clinical diagnosis and treatment.Also have a lot and blood body fluid components diseases associated in addition, can't realize that all real-time and dynamic detects, can only carry out gradation by artificial collected specimens and detect, exist one-sidedness and discontinuity, thereby can't draw the generation mechanism of disease.
Therefore, need a kind of device that can realize the dynamic real-time detection to human body fluid, human body fluid (comprising blood) is detected, can dynamically obtain patient's the comparatively comprehensive information of body fluid continuously; Detection applicable to blood capillary inner blood parameter, understand the process that it produces pathological changes, thereby be beneficial to early prevention and treat for example diabetes and other diseases, understand the pathological and physiological condition of human body in real time, also can be used for the various projects that need detection of dynamic, such as information such as molecule, albumen in blood fat, blood glucose, hormonal readiness, the blood, aligning is made a definite diagnosis disconnected disease, guiding clinical treatment has the meaning of outbalance.
Summary of the invention
In view of this, the purpose of this invention is to provide a kind of body fluid bio information optical fiber dynamic detection system, be applied to clinically, human body fluid (comprising blood) is detected, the body fluid that can obtain the patient is information comparatively comprehensively; Be applicable to the detection of blood capillary inner blood parameter, understand the process that it produces pathological changes, thereby be beneficial to early prevention and treat for example diabetes and other diseases, understand the pathological and physiological condition of human body in real time, guiding clinical treatment is had the meaning of outbalance.
Body fluid bio information optical fiber dynamic detection system of the present invention comprises:
Optical fiber sensing probe is used for the collection of body fluids spectral information, comprises the flexible tubular shell of front end sealing and is arranged at flexible tubular shell interior reception optical fiber and launching fiber, and described reception optical fiber and launching fiber extend flexible tubular shell tail end; Described launching fiber emergent light end with receive between the optical fiber input light end relative and be provided with flow channels, the corresponding lateral direction penetrating mouth that is provided with flow channels of described flexible tubular shell;
Optical transmitter is connected in launching fiber and required light source is provided;
Spectroanalysis instrument is connected in and receives optical fiber and receiving optical signals and carry out spectrum analysis and handle;
Signal processing unit is connected in spectroanalysis instrument and is used for receiving spectrum signal and output signal result.
Further, being provided with between launching fiber emergent light end and the reception optical fiber input light end makes the launching fiber emergent light focus on the battery of lens that receives optical fiber input light end, described battery of lens comprises exit lens and incident lens, and described flow channels is between exit lens and incident lens;
Further, described reception optical fiber and launching fiber all are connected in spectroanalysis instrument and optical transmitter by adapter;
Further, also comprise the indwelling body, the external flexible tubular shell that is placed in of described indwelling, the lateral direction penetrating mouth of described flexible tubular shell extends the indwelling body;
Further, described indwelling body is the venous indwelling needle construction, the poroid passage of the common composition of the lateral direction penetrating mouth of described flow channels and flexible tubular shell;
Further, the lateral direction penetrating mouth of described flow channels and flexible tubular shell is formed opening shape passage jointly;
Further, also comprise puncture needle, be placed in puncture needle in the described flexible tubular shell, described puncture needle pin wall is provided with the needle body through hole relative with the lateral direction penetrating mouth of flexible tubular shell, and described needle body through hole is the reticulated cell structure;
Further, described signal processing unit is the computer that stores the standard spectrum data, described standard spectrum data by the standard figures scope of collection human body fluid signal correspondence.
The invention has the beneficial effects as follows: body fluid bio information optical fiber dynamic detection system of the present invention, adopt the optical fiber sensing probe structure, can be by keeping somewhere in human body or external collection and the detection of carrying out blood capillary inner blood parameter or other body fluid parameter than the thin skin skin, obtain spectral information, and compare with the standard spectrum information parameter that stores in advance, thereby draw the body fluid components of the standard of differing from; Be applied to clinically, human body fluid (comprising blood) is detected, the body fluid that can obtain the patient is information comparatively comprehensively; Be applicable to the detection of blood capillary inner blood parameter, understand the process that it produces pathological changes, thereby be beneficial to early prevention and treat for example diabetes and other diseases, understand the pathological and physiological condition of human body in real time, guiding clinical treatment is had the meaning of outbalance.
Description of drawings
Below in conjunction with drawings and Examples the present invention is further described.
Fig. 1 is the structural representation of first kind of embodiment of optical fiber sensing probe of the present invention;
Fig. 2 is the structural representation of second kind of embodiment of optical fiber sensing probe of the present invention;
Fig. 3 is the structural representation of the third embodiment of optical fiber sensing probe of the present invention;
Fig. 4 is system construction drawing of the present invention.
The specific embodiment
Fig. 1 is the structural representation of first kind of embodiment of optical fiber sensing probe of the present invention, and Fig. 4 is system construction drawing of the present invention, and as shown in the figure: the body fluid bio information optical fiber dynamic detection system of present embodiment comprises:
Optical fiber sensing probe is used for the collection of body fluids spectral information, comprises the flexible tubular shell 3 and the reception optical fiber 1 and the launching fiber 2 that are arranged in the flexible tubular shell 3 of front end sealing, and described reception optical fiber 1 and launching fiber 2 extend flexible tubular shell 3 tail ends; Described launching fiber 2 emergent light ends with receive between the optical fiber 1 incident illumination end relative and be provided with flow channels 4, described flexible tubular shell 3 and the flow channels 4 corresponding lateral direction penetrating mouths that are provided with;
Optical transmitter 11 is connected in launching fiber 2 and required light source is provided;
Spectroanalysis instrument 9 is connected in and receives optical fiber 1 and receiving optical signals and carry out spectrum analysis and handle;
Signal processing unit 10 is connected in spectroanalysis instrument 9 and is used for receiving spectrum signal and output signal result.
In the present embodiment, being provided with between launching fiber 2 emergent light ends and the reception optical fiber 1 incident illumination end makes the launching fiber emergent light focus on the battery of lens that receives optical fiber input light end, described battery of lens comprises exit lens 6 and incident lens 5, and described flow channels 4 is between exit lens 6 and incident lens 5; This structure makes the light of launching fiber 2 outgoing all receiving optical fiber 1 focusing, makes testing result accurate, improves accuracy of detection.
In the present embodiment, described reception optical fiber 1 and launching fiber 2 all are connected in spectroanalysis instrument 9 and optical transmitter 11 by adapter 12; Use simply, flexibly, conveniently, can dismantle at any time or connect.
In the present embodiment, comprise also and keep somewhere body 8 that described indwelling body 8 is coated at flexible tubular shell 3, the lateral direction penetrating mouth of described flexible tubular shell 3 extends keeps somewhere body 8; Keep somewhere body 8 and can keep somewhere in patient's body, be convenient to Real-time and Dynamic Detection.
When the present invention used: sensor probe is kept somewhere in body by keeping somewhere body 8, was example with the blood vessel, flexible tubular shell 3 intravasations, and blood flows by flow channels 4; The emergent light of launching fiber 2 enters reception optical fiber 1 after being absorbed part light through blood, produce absorption spectrum and deliver to spectroanalysis instrument 9 and signal processing unit 10 is analyzed, obtain Real-time and Dynamic spectrum, compare with the standard spectrum that stores in advance, reach a conclusion.
In the present embodiment, described indwelling body 8 is the venous indwelling needle construction, the poroid passage of the common composition of the lateral direction penetrating mouth of described flow channels 4 and flexible tubular shell; Passage is poroid passage, is beneficial to guarantee that the flexible tubular shell stretches into the intensity of blood vessel or body part, guarantees the accuracy of testing result, is beneficial to indexs such as gathering flow velocity simultaneously.
In the present embodiment, described signal processing unit 10 is for storing the computer of standard spectrum data, described standard spectrum data by the standard figures scope of collection human body fluid signal correspondence; The standard figures of body fluid comprises two kinds of the standard figures of morbid state or the standard figureses of normal condition, is beneficial to contrast.
Fig. 2 is the structural representation of second kind of embodiment of optical fiber sensing probe of the present invention, and as shown in the figure, the difference of present embodiment and first kind of embodiment only is: the lateral direction penetrating mouth of described flow channels 4a and flexible tubular shell is formed opening shape passage jointly.Present embodiment in use, with opening shape channel card on than the thin skin skin, the emergent light of launching fiber enters reception optical fiber after seeing through body fluid and the blood capillary in skin and the skin and being absorbed part light, produce absorption spectrum and deliver to spectroanalysis instrument and signal processing unit is analyzed, obtain Real-time and Dynamic spectrum, compare with the standard spectrum that stores in advance, reach a conclusion.
Fig. 3 is the structural representation of the third embodiment of optical fiber sensing probe of the present invention, as shown in the figure, the difference of present embodiment and first kind of embodiment only is: the optical fiber sensing probe of present embodiment also comprises puncture needle 7, be placed in puncture needle 7 in the described flexible tubular shell 3, described puncture needle 7 pin walls are provided with the needle body through hole relative with the lateral direction penetrating mouth of flexible tubular shell 3, and described needle body through hole is the reticulated cell structure; Present embodiment in use, the direct puncture of puncture needle is entered human body, body fluid (comprising blood) was positioned at after by the reticulated cell structure and was passed to, the emergent light of launching fiber sees through and enters reception optical fiber after body fluid is absorbed part light, produce absorption spectrum and deliver to spectroanalysis instrument and signal processing unit is analyzed, obtain Real-time and Dynamic spectrum, compare with the standard spectrum that stores in advance, reach a conclusion.The reticulated cell structure is beneficial to flatness and the integrity that guarantees the puncture needle needle body, is beneficial to puncture.
Explanation is at last, above embodiment is only unrestricted in order to technical scheme of the present invention to be described, although with reference to preferred embodiment the present invention is had been described in detail, those of ordinary skill in the art is to be understood that, can make amendment or be equal to replacement technical scheme of the present invention, and not breaking away from aim and the scope of technical solution of the present invention, it all should be encompassed in the middle of the claim scope of the present invention.
Claims (6)
1. body fluid bio information optical fiber dynamic detection system is characterized in that: comprising:
Optical fiber sensing probe is used for the collection of body fluids spectral information, comprises the flexible tubular shell of front end sealing and is arranged at flexible tubular shell interior reception optical fiber and launching fiber, and described reception optical fiber and launching fiber extend flexible tubular shell tail end; Described launching fiber emergent light end with receive between the optical fiber input light end relative and be provided with flow channels, the corresponding lateral direction penetrating mouth that is provided with flow channels of described flexible tubular shell;
Optical transmitter is connected in launching fiber and required light source is provided;
Spectroanalysis instrument is connected in and receives optical fiber and receiving optical signals and carry out spectrum analysis and handle;
Signal processing unit is connected in spectroanalysis instrument and is used for receiving spectrum signal and output signal result;
Also comprise the indwelling body, the external flexible tubular shell that is placed in of described indwelling, the lateral direction penetrating mouth of described flexible tubular shell extends the indwelling body.
2. body fluid bio information optical fiber dynamic detection system is characterized in that: comprising:
Optical fiber sensing probe is used for the collection of body fluids spectral information, comprises the flexible tubular shell of front end sealing and is arranged at flexible tubular shell interior reception optical fiber and launching fiber, and described reception optical fiber and launching fiber extend flexible tubular shell tail end; Described launching fiber emergent light end with receive between the optical fiber input light end relative and be provided with flow channels, the corresponding lateral direction penetrating mouth that is provided with flow channels of described flexible tubular shell;
Optical transmitter is connected in launching fiber and required light source is provided;
Spectroanalysis instrument is connected in and receives optical fiber and receiving optical signals and carry out spectrum analysis and handle;
Signal processing unit is connected in spectroanalysis instrument and is used for receiving spectrum signal and output signal result;
Also comprise puncture needle, be placed in puncture needle in the described flexible tubular shell, described puncture needle pin wall is provided with the needle body through hole relative with the lateral direction penetrating mouth of flexible tubular shell, and described needle body through hole is the reticulated cell structure.
3. body fluid bio information optical fiber dynamic detection system according to claim 1 and 2, it is characterized in that: launching fiber emergent light end and receive to be provided with between the optical fiber input light end and make the launching fiber emergent light focus on the battery of lens that receives optical fiber input light end, described battery of lens comprises exit lens and incident lens, and described flow channels is between exit lens and incident lens.
4. body fluid bio information optical fiber dynamic detection system according to claim 3, it is characterized in that: described reception optical fiber and launching fiber all are connected in spectroanalysis instrument and optical transmitter by adapter.
5. body fluid bio information optical fiber dynamic detection system according to claim 1, it is characterized in that: described indwelling body is the venous indwelling needle construction, the lateral direction penetrating mouth of described flow channels and flexible tubular shell is common forms poroid passage.
6. body fluid bio information optical fiber dynamic detection system according to claim 1 and 2, it is characterized in that: described signal processing unit is the computer that stores the standard spectrum data, described standard spectrum data by the standard figures scope of collection human body fluid signal correspondence.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201110057068 CN102160777B (en) | 2011-03-10 | 2011-03-10 | Body fluid bioinformation fiber dynamic testing system |
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| CN 201110057068 CN102160777B (en) | 2011-03-10 | 2011-03-10 | Body fluid bioinformation fiber dynamic testing system |
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| CN102160777A CN102160777A (en) | 2011-08-24 |
| CN102160777B true CN102160777B (en) | 2013-07-03 |
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| CN104619241A (en) * | 2012-08-30 | 2015-05-13 | 西门子公司 | Device and method for in vivo determination of at least one blood value within an object to be examined |
| CN102954955A (en) * | 2012-10-16 | 2013-03-06 | 上海镭立激光科技有限公司 | Method for immediately monitoring urine by laser |
| CN106963459B (en) * | 2017-04-28 | 2019-05-24 | 山东大学 | A kind of bone marrow aspiration endoscopic imaging system and method |
| CN108775981B (en) * | 2018-06-12 | 2024-08-02 | 南昌大学 | High-precision differential diaphragm optical fiber pressure sensing system |
| CN109381246B (en) * | 2018-10-19 | 2019-09-24 | 四川大学华西医院 | Multi-functional intelligent medical device that punctures |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1777394A (en) * | 2003-04-24 | 2006-05-24 | 皇家飞利浦电子股份有限公司 | Catheter head |
| CN101232843A (en) * | 2005-09-13 | 2008-07-30 | 爱德华兹生命科学公司 | Continuous spectroscopic measurement of total hemoglobin |
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| US7496392B2 (en) * | 2003-11-26 | 2009-02-24 | Becton, Dickinson And Company | Fiber optic device for sensing analytes |
| WO2006079043A2 (en) * | 2005-01-21 | 2006-07-27 | Medrad, Inc. | Pulse oximetry grip sensor and method of making same |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1777394A (en) * | 2003-04-24 | 2006-05-24 | 皇家飞利浦电子股份有限公司 | Catheter head |
| CN101232843A (en) * | 2005-09-13 | 2008-07-30 | 爱德华兹生命科学公司 | Continuous spectroscopic measurement of total hemoglobin |
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