WO2023007813A1

WO2023007813A1 - Measurement probe, adaptor, and measurement system

Info

Publication number: WO2023007813A1
Application number: PCT/JP2022/010592
Authority: WO
Inventors: 賢志澤田
Original assignee: テルモ株式会社
Priority date: 2021-07-30
Filing date: 2022-03-10
Publication date: 2023-02-02

Abstract

Disclosed is a measurement probe, etc. that enables continuous monitoring of the state of a patient via a connector.　A measurement probe (18) comprises: a first connection part that has a first duct which is attachable and detachable to and from a connector (163) disposed midway along a medical duct (161) and which communicates with the medical duct (161) when attached to the connector (163); a second connection part (182) that has a second duct to and from which a syringe (168) is attachable and detachable and which communicates with the first duct; a valve body that keeps the second duct fluid-tight when the syringe (168) is not attached to the second connection part (182); and a sensor that measures the state of fluid which flows through the medical duct (161).

Description

Measuring probes, adapters and measuring systems

The present invention relates to measurement probes, adapters and measurement systems.

Various medical tubes are used to connect the inside and outside of the patient's body, such as bladder indwelling catheters, intravascular indwelling catheters, and drainage tubes. A connector may be connected in the middle of these medical tubes (Patent Document 1).

WO2010/073643

By using the connector of Patent Document 1, medical personnel can quickly perform tasks such as collecting body fluids from patients. However, the connector of Patent Literature 1 cannot continuously monitor components of a patient's bodily fluids.

In one aspect, the object is to provide a measurement probe or the like that can continuously monitor the patient's condition via a connector.

The measuring probe is attachable to and detachable from a connector arranged in the middle of a medical pipeline, and when attached to the connector, has a first pipeline that communicates with the medical pipeline; is detachable and has a second conduit that communicates with the first conduit, and when the syringe is not attached to the second connection, the second conduit is liquid-tight and a sensor for measuring the condition of the fluid flowing through the medical pipeline.

In one aspect, it is possible to provide a measurement probe or the like that can continuously monitor the patient's condition via a connector.

It is an explanatory view explaining composition of a measurement system. 1 is an exploded view of a measuring probe; FIG. FIG. 4 is a cross-sectional view of the measuring probe; FIG. 3 is a view in the direction of arrow IV in FIG. 2; 3 is a view in the direction of arrow V in FIG. 2; FIG. FIG. 5 is a cross-sectional view taken along line VI-VI in FIG. 4; It is an explanatory view explaining composition of a measuring device. 4 is a flowchart for explaining the flow of processing of a program; FIG. 10 is a front view of an adapter of modification 1-1; FIG. 10 is a view in the direction of arrow X in FIG. 9; FIG. 10 is a view in the direction of arrow XI in FIG. 9; FIG. 11 is a cross-sectional view taken along line XII-XII in FIG. 10; FIG. 11 is a perspective view of a measurement probe of modification 1-2; FIG. 11 is an enlarged view of the tip of the sensor probe of modification 1-3; FIG. 10 is an enlarged cross-sectional view of the tip portion of the sensor probe of modification 1-4; FIG. 11 is an enlarged cross-sectional view of the tip portion of the sensor probe of modification 1-5; FIG. 10 is a front view of the measurement probe of Embodiment 2; FIG. 18 is a view in the direction of arrow XVIII in FIG. 17; FIG. 18 is a view in the direction of arrow XIX in FIG. 17; FIG. 19 is a cross-sectional view taken along line XX-XX in FIG. 18; FIG. 11 is a front view of a measurement probe according to Embodiment 3; 21. It is a XXII arrow directional view in FIG. FIG. 22 is a cross-sectional view taken along line XXIII-XXIII in FIG. 21; FIG. 11 is a front view of a measurement probe according to Embodiment 4; 24. It is a XXV arrow directional view in FIG. FIG. 11 is an explanatory diagram for explaining how to use the measurement probe of Embodiment 4; FIG. 27 is a cross-sectional view taken along line XXVII in FIG. 26; FIG. 11 is an explanatory diagram for explaining the configuration of a measuring device according to Embodiment 5; 10 is a time chart for explaining the operation of the measuring device according to Embodiment 5; FIG. 12 is a time chart for explaining the operation of the measuring device of Embodiment 6; FIG. FIG. 20 is a perspective view of a tip portion of a sensor probe of modification 6-1; It is an example of a screen of modification 6-2. FIG. 11 is an explanatory diagram for explaining the configuration of a measuring device according to Embodiment 7; 13 is a time chart for explaining the operation of the measuring device of Embodiment 7; FIG. 11 is an explanatory diagram for explaining the configuration of a measuring device according to an eighth embodiment; FIG. 20 is a functional block diagram of a measurement system according to Embodiment 9;

[Embodiment 1]
FIG. 1 is an explanatory diagram for explaining the configuration of the measurement system 10. As shown in FIG. A catheter 161 is placed in a patient's blood vessel 169 . In the embodiment, the case where the blood vessel 169 is a patient's arm vein and the catheter 161 is a peripheral vein indwelling catheter will be described as an example.

An infusion bag 162 is connected to the catheter 161 via a drip tube and clamp (not shown). A connector 163 is connected to the middle of the catheter 161 . Catheter 161, infusion bag 162 and connector 163 of the present embodiment have been conventionally used in the medical field. Note that the catheter 161 is an example of a medical conduit according to the present embodiment, which connects instruments inside and outside the patient's body. The infusion bag 162 is an example of the extracorporeal device of this embodiment. An infusion is an example of a fluid administered to a patient via a medical line.

In the following description, the infusion administration route configured by the catheter 161, the infusion bag 162 and the connector 163 may be referred to as an infusion line. A three-way stopcock, an infusion pump, or the like may be connected to the infusion line. A method using a conventional infusion line is outlined.

The catheter 161 is left in the blood vessel 169 continuously for several days. An infusion such as physiological saline, Ringer's solution, drugs, or blood for transfusion in the infusion bag 162 is continuously administered to the blood vessel 169 via the catheter 161 . When collecting a patient's blood for testing, a user such as a doctor or nurse attaches a blood collection syringe to connector 163 and performs aspiration. Since there is no need to pierce the blood vessel 169 with a new needle each time blood is collected, the burden on the patient and the user can be reduced. That is, the connector 163 is used for collecting samples such as blood.

The user can also attach a syringe containing medicine to the connector 163 and inject it into the patient via the catheter 161 . The user can administer the drug to the patient more quickly than when mixing the drug with the infusion in the infusion bag 162 . Thus, connector 163 is also used for rapid administration of drugs.

In the present embodiment, a measuring probe 18 is attached to connector 163 instead of a blood sampling syringe. In this embodiment, a configuration in which the connector 163 and the measurement probe 18 are fixed by two binding bands 199 will be described as an example. The measurement probe 18 has an optical fiber 41 and a second connection portion 182 . Details of the configuration of the measurement probe 18 will be described later.

The optical fiber 41 is connected to the measuring device 30 and continuously measures the patient's blood condition. In the example shown in FIG. 1, the oxygen partial pressure (pO2) in the patient's blood is displayed on the display unit 35 in real time. When blood sampling is required, the user attaches the syringe 168 to the second connector 182 and performs aspiration. When rapid administration of the drug is required, the user attaches the syringe 168 to the second connector 182 and injects the drug.

FIG. 2 is an exploded view of the measurement probe 18. FIG. The measuring probe 18 comprises an adapter 185, a sensor probe 40 and a plug 196. FIG. Sensor probe 40 comprises optical fiber 41 , emitter 24 , optical fiber connector 411 and fiber plug 42 . The light emitter 24 is arranged at one end of the optical fiber connector 411 . The optical fiber connector 411 is arranged at the other end of the optical fiber 41 . The fiber plug 42 is a rubber plug having a through hole and is inserted through the optical fiber 41 .

The plug 196 has a second connection portion 182 . Plug 196 is, for example, a body fluid guide tube for a commercially available closed infusion system. Details of the light emitter 24 and details of the shape of the adapter 185 will be described later.

FIG. 3 is a cross-sectional view of the measurement probe 18. FIG. An optical fiber 41 is inserted through a first conduit 191 provided in the adapter 185 . The optical fiber 41 is liquid-tightly secured to the adapter 185 by a fiber plug 42 .

The plug 196 is fixed to the measurement probe 18. A through hole provided in the plug 196 communicates with the first conduit 191 via a second conduit 192 provided in the adapter 185 . A through-hole provided in the plug 196 is liquid-tightly sealed by a valve body 197 arranged inside the second connecting portion 182 . Valve body 197 is, for example, a rubber stopper having a slit. Alternatively, the plug 196 may be fixed in advance to the 185 in a liquid-tight manner by adhesive or physical fitting.

FIG. 4 is a view in the direction of arrow IV in FIG. 5 is a view in the direction of arrow V in FIG. 2. FIG. FIG. 6 is a cross-sectional view taken along line VI-VI in FIG. The configuration of the adapter 185 will be described using FIGS. 4 to 6. FIG.

The adapter 185 includes a plate-like portion 183 , a first connection portion 181 and a plug mounting portion 186 . The first connecting portion 181 protrudes from one surface of the plate-like portion 183 . The plug attachment portion 186 protrudes from the side surface of the first connection portion 181 . The first connecting portion 181 has the same shape as the tip of a syringe for collecting blood, and can be attached to and detached from the connector 163 .

A first pipeline 191 is provided inside the first connecting portion 181 . The first pipeline 191 branches into a second pipeline 192 and a sensor pipeline 194 inside the adapter 185 . The second conduit 192 opens at the end face of the plug attachment portion 186 . The opening of the second pipeline 192 is provided with a stepped portion that is thicker on the opening side.

The sensor conduit 194 opens on the surface of the plate-like portion 183 . The sensor conduit 194 has a smaller diameter than the first conduit 191 near the branch. The opening of the sensor pipe line 194 is provided with a stepped portion having a larger diameter on the opening side. A side wall of the stepped portion is tapered to be thicker on the opening side. The first conduit 191, the sensor conduit 194 and the fiber plug 42 are examples of the sensor mounting portion of the present embodiment.

As shown in FIG. 4, the plate-like portion 183 is provided with four band holes 189 . The band hole 189 is a square hole through which the binding band 199 described using FIG. 1 can be inserted. As shown in FIG. 5, two band attachment portions 188 protrude from the plate-like portion 183 with the first connection portion 181 interposed therebetween. Each band attachment portion 188 is provided with a band hole 189 . The band hole 189 is also a square hole through which the binding band 199 can be inserted. The band hole 189 is an example of the connector fixing portion of this embodiment, which is used when fixing the measurement probe 18 to the connector 163 .

The luminous body 24 is, for example, translucent resin in which phosphor is kneaded, and is applied to the end surface of the optical fiber 41 . A phosphor is an example of a fluorescent dye in this embodiment. In the present embodiment, an example will be described in which a fluorescent material is used in which the fluorescence generated when exposed to excitation light changes in response to oxygen in blood. Fluorescence is an example of radiation emitted by light emitter 24 . Oxygen partial pressure and oxygen concentration in blood can be measured in real time by analyzing the characteristics of the fluorescence emitted by the phosphor. The light-emitting body 24 may be applied, or may be molded as a separate body and then attached.

　The outline of the measurement method using a fluorescent material will be explained. When irradiated with excitation light, the phosphor enters a high-energy excited state. Fluorescence is emitted from the phosphor in the excited state, and the phosphor returns to the ground state. The properties of the fluorescence, such as the intensity, phase angle and decay time of the emitted fluorescence, change based on the concentration of the quencher with which the fluorophore contacts. Therefore, the concentration of the quencher can be measured by analyzing the properties of the emitted light.

As described above, in this embodiment, a phosphor whose fluorescence characteristics change when it comes into contact with oxygen is used. That is, the quencher in this embodiment is oxygen. By analyzing the fluorescence properties in real time, it is possible to measure the oxygen partial pressure and oxygen concentration in the blood in real time. Phosphors that use oxygen as a quencher include pyrylene derivatives, pyrene derivatives, porphyrin metal complexes, and the like.

The emitted light emitted by phosphors also includes phosphorescence. That is, measurements may be made by analyzing the properties of phosphorescence. Both fluorescence and phosphorescence properties may be analyzed simultaneously.

A phosphor that emits fluorescence in response to carbon dioxide in blood may be used. By analyzing the properties of fluorescence, it is possible to measure carbon dioxide partial pressure and carbon dioxide concentration in blood in real time. Phosphors that change the properties of their emitted fluorescence with the proton index of blood may be used. By analyzing the properties of fluorescence, it is possible to measure the hydrogen ion index, or pH (potential of Hydrogen), of blood in real time.

The phosphor may react with ions such as potassium ions, sodium ions, or chloride ions to emit fluorescence. A fluorophore that responds similarly to multiple quenchers may be used. For example, a diffusion permeation film placed on the surface of the emitter 24 can select the quencher, ie the component to be measured, that contacts the phosphor.

The fluorescent properties of the phosphor also change depending on temperature and pressure. By analyzing the fluorescence properties, blood temperature can be measured in real time. The phosphor also changes its luminescence state depending on the pressure of the blood in contact with it. By analyzing the properties of fluorescence, the pressure of body fluids can be measured in situ in real time. That is, by analyzing the characteristics of the radiated light emitted by the light emitter 24, it is possible to simultaneously measure a plurality of items such as blood components, blood temperature, blood specific gravity, and blood flow rate.

Alternatively, a sensor that grasps the properties of body fluid by measuring absorbance without using a fluorescent substance may be used. For example, creatinine amount, urea nitrogen amount, lactic acid amount, glucose amount, HbA1c value, CRP (C-reactive protein) amount, uric acid amount, hemoglobin amount, free hemoglobin amount, hematocrit value, albumin amount, globmin amount, or bilirubin amount, For example, absorbance in a specific wavelength range may be measured according to any parameter that indicates the state of blood.

The side surface of the optical fiber 41 is desirably covered with a coating (not shown). The coating is desirably a light shield that prevents external light from entering from the side surface of the optical fiber 41 . It is possible to provide the sensor probe 40 that prevents the influence of noise due to ambient light.

FIG. 7 is an explanatory diagram illustrating the configuration of the measuring device 30. FIG. In addition to the display unit 35 and the input connector 371, the measurement device 30 includes a control unit 31, a main storage device 32, an auxiliary storage device 33, a communication unit 34, an input unit 36, a light source 51, an optical analyzer 52, a light guide path 55, It has a beam splitter 56 and a bus. The control unit 31 is an arithmetic control device that executes the program of this embodiment. One or a plurality of CPUs (Central Processing Units), GPUs (Graphics Processing Units), multi-core CPUs, or the like is used for the control unit 31 . The control unit 31 is connected to each hardware unit constituting the measuring device 30 via a bus.

The main storage device 32 is a storage device such as SRAM (Static Random Access Memory), DRAM (Dynamic Random Access Memory), flash memory, or the like. The main storage device 32 temporarily stores information necessary during the process performed by the control unit 31 and the program being executed by the control unit 31 .

The auxiliary storage device 33 is a storage device such as SRAM, flash memory, hard disk, or magnetic tape. The auxiliary storage device 33 stores programs to be executed by the control unit 31 and various data necessary for executing the programs. The communication unit 34 is an interface that performs communication between the measuring device 30 and a network or other equipment.

The display unit 35 is, for example, a liquid crystal display panel or an organic EL (electro-luminescence) panel. The display unit 35 is attached to the housing of the measuring device 30 as shown in FIG. The display unit 35 may be a separate display device from the measuring device 30 . For example, a screen of another device such as a biological information monitor may also serve as the display unit 35 .

The input unit 36 is a button or the like provided on the housing of the measuring device 30 . The display unit 35 and the input unit 36 may be an integrated panel. The input connector 371 is an optical connector to which the optical fiber 41 is connected. The measurement device 30 may have multiple input connectors 371 .

The light source 51 is, for example, an LED (light emitting diode) or a laser diode. The light source 51 irradiates the light emitter 24 with excitation light to excite the phosphor contained in the light emitter 24 . The light emitted by the light source 51 hardly contains the wavelength of fluorescence emitted by the phosphor. Alternatively, an excitation light filter may be installed to narrow down the light emitted from the light source 51 to a desired wavelength range.

The optical analyzer 52 analyzes the received light after converting it into an electrical signal using, for example, a photodiode. A light guide path 55 connects between the light source 51 and the beam splitter 56, between the light analyzer 52 and the beam splitter 56, and between the beam splitter 56 and the input connector 371, respectively.

Even if an optical filter that transmits only the wavelength band necessary to excite the phosphor is provided in the middle of the light guide path 55 arranged between the light source 51 and the beam splitter 56 or at the end of the light guide path 55. good. Even when the light source 51 with a wide wavelength range is used, the wavelength range of the excitation light with which the light-emitting body 24 is irradiated can be precisely selected. Since noise due to wavelengths other than the excitation light does not occur, the measurement device 30 with high measurement accuracy can be provided.

An optical lens may be arranged in the middle of the light guide path 55 or at the end of the light guide path 55 . By effectively using the excitation light and the fluorescence, it is possible to provide the measurement device 30 with high measurement sensitivity. The optical lens may be made of glass, quartz, plastic, or an elastic material such as silicon rubber.

The measurement device 30 may have a second light source that supplies reference light to the optical analyzer 52 in addition to the light source 51 that emits excitation light. It is possible to provide the measurement device 30 that performs analysis using reference light. The reference light emitted from the second light source directly enters the light analyzer 52 . The second light source and the optical analyzer 52 are connected, for example, by a dedicated light guide path. Between the second light source and the light analyzer 52 may be a cavity configured such that the light emitted from the second light source is incident on the light analyzer 52 .

Using FIG. 1, an outline of how to use the measurement system 10 will be described. An infusion line is connected to the patient's vein. The user inserts the optical fiber 41 into the adapter 185 to a position where it does not protrude from the first connecting portion 181 . The user loosely inserts the fiber plug 42 into the adapter 185 and presses the optical fiber 41 and fiber plug 42 with a finger.

The user disinfects the connector 163 by wiping it with alcohol for disinfection or the like. The user inserts the first connection portion 181 into the connector 163 . A plug provided on the connector 163 is opened. While holding down adapter 185 and fiber plug 42 , the user inserts optical fiber 41 until light emitter 24 enters blood vessel 169 . After that, the user firmly pushes the fiber plug 42 into the adapter 185 to fix the optical fiber 41 and the adapter 185 in a liquid-tight manner.

The user uses two binding bands 199 to fix the connector 163 and the adapter 185 . The user connects the fiber optic connector 411 to the input connector 371 . In addition, it is not limited to this, and a known jig that is fixed by just fitting may be used, or the connection part may be configured with a male-female screw shape like a luer lock syringe and fixed without a binding band. . The user may fix the connector 163 to the catheter 161, the drip stand, the bed rail, the patient's arm, or the like using medical tape or the like.

The user operates the measuring device 30 to operate the light source 51 . The excitation light emitted from the light source 51 is applied to the light emitter 24 via the light guide path 55 , the beam splitter 56 and the optical fiber 41 . When the luminous body 24 comes into contact with blood, fluorescence corresponding to oxygen in the blood is emitted. That is, the light emitter 24 functions as a sensor capable of detecting oxygen partial pressure and oxygen concentration in blood.

Fluorescence enters the beam splitter 56 via the optical fiber 41 , the input connector 371 and the light guide path 55 . That is, the optical fiber 41 has a function of propagating the light emitted from the light source 51 to the light emitter 24 and the light emitted from the light emitter 24 . The optical fiber 41 is an example of the light guide of this embodiment, which guides the fluorescence emitted from the light emitter 24 . The input connector 371 is an example of the light-receiving part of the present embodiment that receives fluorescence light guided to the optical fiber 41 .

Fluorescence enters the beam splitter 56 from the input connector 371 via the light guide path 55 . A beam splitter 56 causes the fluorescent light to enter an optical waveguide 55 leading to an optical analyzer 52 . The optical analyzer 52 analyzes the characteristics of the incident fluorescence and outputs the oxygen partial pressure or oxygen concentration in the blood to the bus in real time. The control unit 31 displays the oxygen partial pressure in blood output from the optical analyzer 52 on the display unit 35 .

When blood collection is necessary, the user wipes and disinfects the second connection part 182 and the valve body 197 with alcohol for disinfection or the like. The user operates a clamp (not shown) to stop administration of the infusion. The user then attaches the syringe 168 to the second connector 182 . The slit of the valve body 197 is opened. The user pulls the plunger of the second connection portion 182 to perform suction. Note that the user may replace the syringe 168 after confirming that blood has been sucked into the syringe 168 . By doing so, it is possible to collect blood that is not mixed with the components of the infusion solution.

The user removes the syringe 168 from the second connection section 182 . The valve body 197 closes. The user then opens the clamp and resumes administering the infusion.

Before inserting the adapter 185 into the connector 163, the user may wind a tourniquet on the peripheral side of the position where the catheter 161 is inserted to stop venous blood flow. By doing so, the amount of bleeding from the gap between the sensor conduit 194 and the optical fiber 41 when the optical fiber 41 is inserted into the blood vessel 169 is reduced.

The user removes the optical fiber connector 411 from the input connector 371 when the measurement by the measuring device 30 is no longer required. After that, the user fixes the optical fiber 41 to the drip stand using, for example, medical tape. By doing so, the user can easily restart the measurement according to the patient's condition.

The user may remove the measurement probe 18 from the connector 163 if the possibility of restarting the measurement is low. The plug provided on the connector 163 is closed, and the infusion line returns to the state before the measurement probe 18 was used.

FIG. 8 is a flowchart explaining the flow of program processing. The control unit 31 starts the program of FIG. 8 when the user gives an instruction to operate the light source 51 .

The control unit 31 turns on the light source 51 (step S501). The excitation light is applied to the light emitter 24 via the beam splitter 56 and the optical fiber 41 . Fluorescence emitted from the phosphor of the light emitter 24 enters the optical analyzer 52 via the optical fiber 41 and the beam splitter 56 .

The optical analyzer 52 outputs oxygen partial pressure data in blood based on the fluorescence. The control unit 31 acquires oxygen partial pressure data in blood from the optical analyzer 52 (step S502). By step S502, the control unit 31 realizes the function of the data acquisition unit that acquires data from the sensor held in the sensor holding unit.

The control unit 31 displays the oxygen partial pressure in the blood on the display unit 35 as illustrated in FIG. 1 (step S503). The control unit 31 determines whether or not to end the process (step S504). For example, when an operation to turn off the light source 51 is received, or when the optical fiber 41 is removed from the input connector 371, the control unit 31 determines to end the process.

If it is determined not to end the process (NO in step S504), the control unit 31 returns to step S502. If it is determined to end the process (YES in step S504), the control unit 31 turns off the light source 51 (step S505). The control unit 31 terminates the process.

According to the present embodiment, it is possible to provide the measurement system 10 that can measure the patient's condition in real time using the connector 163 provided on the existing infusion line. For example, when the condition of a patient who was determined not to require real-time measurement at the beginning of treatment changes, the user can immediately start measurement using the infusion line that has already been placed in the patient.

Note that the user may fix the optical fiber 41 in a state in which the light emitter 24 does not protrude from the catheter 161 into the blood vessel 169 . By doing so, the user can measure the status of the infusion being administered to the patient in real time.

The control unit 31 may notify the user, for example, when the oxygen partial pressure in the blood becomes equal to or less than the threshold. For example, the control unit 31 notifies the user through display on the display unit 35 or audio output from the measuring device 30 . The control unit 31 may transmit the notification to a nurse station or the like via a network such as HIS (Hospital Information System) or EMR (Electronic Medical Record).

The control unit 31 may, for example, calculate an index representing the patient's condition based on the partial pressure of oxygen in blood and display it on the display unit 35 . The index representing the patient's condition may be calculated by combining information obtained from other equipment such as a vital information monitor and the partial pressure of oxygen in the blood.

The optical analyzer 52 may output data indicating characteristics of fluorescence such as the intensity, phase angle and decay time of the received fluorescence to the bus. In such a case, the control unit 31 calculates the oxygen partial pressure in the blood, the oxygen concentration in the blood, or the like.

An optical analysis block composed of the light source 51 , the optical analyzer 52 , the light guide path 55 , the beam splitter 56 and the input connector 371 may be separate from the measuring device 30 .

When the optical analysis block is separate, the measurement device 30 of the present embodiment may be configured by combining a general-purpose information processing device such as a personal computer, tablet, or smartphone with the optical analysis block. In such a case, the optical analysis block and the information processing device are connected by wire or wirelessly.

The display of the display unit 35 shown in FIG. 1 is an example. For example, if the light emitter 24 has a phosphor that reacts with potassium ions, the measuring device 30 displays the potassium ion concentration or the amount of potassium ions in blood on the display unit 35 in real time.

The measuring probe 18 is preferably a single-use product that is supplied to the user in a sterile condition. The adapter 185, the second connection section 182 and the sensor probe 40 that constitute the measurement probe 18 may be individually sterilized and supplied to the user.

A peripheral vein indwelling catheter is an example of the catheter 161 of the present embodiment. Catheter 161 may be any medical tube such as a central venous catheter or feeding tube.

[Modification 1-1]
This modification relates to an adapter 185 integrated with a plug 196. FIG. Descriptions of parts common to the first embodiment are omitted.

FIG. 9 is a front view of the adapter 185 of modification 1-1. 10 is a view in the direction of arrow X in FIG. 9. FIG. 11 is a view in the direction of arrow XI in FIG. 9. FIG. 12 is a cross-sectional view taken along line XII-XII in FIG. 10. FIG.

The adapter 185 includes a plate-like portion 183 and a first connecting portion 181 protruding from one surface of the plate-like portion 183 . A second connection portion 182 protrudes from the side surface of the first connection portion 181 . The adapter 185 of this embodiment is integrally formed by resin injection molding or the like.

As shown in FIG. 12 , the adapter 185 has two independent pipelines, a first pipeline 191 and a sensor pipeline 194 . The sensor pipe line 194 penetrates between the tip surface of the first connection portion 181 and the plate-like portion 183 . The opening on the plate-like portion 183 side is provided with a stepped portion having a larger diameter on the opening side. A side wall of the stepped portion is tapered to be thicker on the opening side.

The first pipe line 191 extends from the tip surface of the first connection portion 181 substantially parallel to the sensor pipe line 194 and bends toward the end surface of the second connection portion 182 along the way. The first pipeline 191 is connected to a second pipeline 192 having a diameter larger than that of the first connecting portion 181 . The second pipe line 192 opens to the end surface of the second connecting portion 182 . A valve body 197 is arranged in the second connecting portion 182 . The sensor conduit 194 is an example of the sensor mounting portion of this modification.

According to this modified example, a lightweight and low-cost measuring probe 18 can be provided. Since the blood does not pass through the gap between the first connecting portion 181 and the optical fiber 41 when collecting blood from the second connecting portion 182, it is possible to provide the measuring probe 18 in which blood cells and the like are less likely to break.

[Modification 1-2]
This modification relates to a measuring probe 18 in which an adapter 185, a plug 196 and a sensor probe 40 are integrated. Descriptions of parts common to the first embodiment are omitted.

FIG. 13 is a perspective view of the measurement probe 18 of modification 1-2. The adapter 185 includes a plate-like portion 183 and a first connecting portion 181 protruding from one surface of the plate-like portion 183 . A second connection portion 182 and two band attachment portions 188 protrude from the side surface of the first connection portion 181 . A valve body 197 having a slit is arranged in the second connecting portion 182 . The band attachment portion 188 has a band hole 189 .

The optical fiber 41 is fixed to the adapter 185. The light emitter 24 fixed to the tip of the optical fiber 41 is arranged near the tip of the first connection portion 181 .

The measurement probe 18 of this modified example is suitable for real-time measurement of the state of fluid flowing through the catheter 161 . For example, by inserting the measurement probe 18 of this modified example into a connector 163 provided in the middle of a medical tube for discharging bodily fluids, the user can measure the condition of discharged bodily fluids in real time. Medical tubes for draining bodily fluids are, for example, indwelling bladder catheters, urinary catheters, thoracic drainage tubes, peritoneal drainage tubes, or cerebral drainage tubes.

[Modification 1-3]
FIG. 14 is an enlarged view of the tip of the sensor probe 40 of Modification 1-3. In this modified example, a sheet-shaped light emitter 24 is fixed to the end surface of the optical fiber 41 via an adhesive layer 249 .

The luminous body 24 is, for example, a translucent resin plate into which a phosphor is kneaded. The light emitter 24 may be a translucent plate coated with phosphor. By using an adhesive with a short curing time for the adhesive layer 249, it is possible to provide the sensor probe 40 that can be manufactured in a short period of time.

[Modification 1-4]
FIG. 15 is an enlarged cross-sectional view of the tip portion of the sensor probe 40 of Modification 1-4. In this modified example, the end of the optical fiber 41 is covered with the light emitter 24 .

For example, the optical fiber 41 of this modification can be manufactured by immersing the tip of the optical fiber 41 in an uncured transparent resin in which a phosphor is kneaded, pulling it out, and then curing it. A mold may be used to mold the transparent resin into which the phosphor is kneaded at the tip of the optical fiber 41 .

[Modification 1-5]
FIG. 16 is an enlarged cross-sectional view of the tip portion of the sensor probe 40 of Modification 1-5. In this modification, a plate-like light emitter 24 is fixed substantially perpendicular to the end face of the optical fiber 41 .

Between the end of the optical fiber 41 and the light emitter 24, a light guide section 248 using, for example, translucent resin is arranged. The optical fiber 41, the light guide portion 248, and the light emitter 24 are bonded and fixed with an adhesive (not shown). The light guide portion 248 may also serve as an adhesive for adhesively fixing the optical fiber 41 and the light emitter 24 .

[Embodiment 2]
The present embodiment relates to a measurement probe 18 in which the blood sampling conduit is not bent. Descriptions of parts common to the first embodiment are omitted.

FIG. 17 is a front view of the measurement probe 18 of Embodiment 2. FIG. 18 is a view in the direction of arrow XVIII in FIG. 17. FIG. 19 is a view in the direction of arrow XIX in FIG. 17. FIG. 20 is a cross-sectional view taken along line XX-XX in FIG. 18. FIG.

The measurement probe 18 includes an adapter 185, a plug 196, and a sensor probe 40. The adapter 185 includes a plate-like portion 183 and a first connecting portion 181 protruding from one surface of the plate-like portion 183 . As shown in FIG. 18, the plate-like portion 183 is provided with four band holes 189 . As shown in FIG. 19, two band attachment portions 188 protrude from the plate-like portion 183 with the first connection portion 181 interposed therebetween. Each band attachment portion 188 is provided with a band hole 189 .

As shown in FIG. 20 , the adapter 185 has two independent pipelines, a first pipeline 191 and a sensor pipeline 194 . The first conduit 191 penetrates between the tip surface of the first connecting portion 181 and the plate-like portion 183 . The opening on the plate-like portion 183 side is provided with a stepped portion having a larger diameter on the opening side, and a plug 196 is attached thereto. As shown in FIG. 18, first conduit 191 has a semi-circular cross-section.

The sensor pipe line 194 extends from the tip end surface of the first connection portion 181 substantially parallel to the first pipe line 191 and bends in the middle to open on the side surface of the first connection portion 181 . An optical fiber 41 is inserted into the sensor conduit 194 and fixed in a liquid-tight manner. The light emitter 24 fixed to the tip of the optical fiber 41 is arranged near the end surface of the first connection portion 181 .

The measurement probe 18 of the present embodiment is suitable for real-time measurement of the state of the infusion flowing through the catheter 161, like the measurement probe 18 of Modification 1-2.

According to this embodiment, since the first conduit 191 is not bent, it is possible to provide the measurement probe 18 in which solid components such as blood cells are less likely to break when a sample of fluid flowing through the catheter 161 is collected.

[Embodiment 3]
This embodiment relates to a luer lock type measuring probe 18 . The description of the parts common to the second embodiment is omitted.

FIG. 21 is a front view of the measurement probe 18 of Embodiment 3. FIG. 22 is a view in the direction of arrow XXII in FIG. 21. FIG. FIG. 23 is a cross-sectional view taken along line XXIII--XXIII in FIG.

The measurement probe 18 includes an adapter 185, a plug 196, and a sensor probe 40. The adapter 185 includes a first connecting portion 181 having a substantially frusto-conical shape. A lock portion 184 having a luer lock structure is provided on the side surface of the first connection portion 181 . Since the luer lock structure has been widely used in the past, a detailed description thereof will be omitted. The locking portion 184 is an example of the connector fixing portion of this embodiment, which is used when fixing the measurement probe 18 to the connector 163 .

As shown in FIG. 23 , the adapter 185 has two independent pipelines, a first pipeline 191 and a sensor pipeline 194 . The first conduit 191 is a through hole extending along the central axis of the first connecting portion 181 . A stepped portion having a larger diameter on the opening side is provided in the opening on the larger diameter side of the first connecting portion 181, and a plug 196 is attached thereto. As shown in FIG. 22, first conduit 191 has a semi-circular cross-section.

The sensor conduit 194 extends substantially parallel to the first conduit 191 from the end face of the first connecting part 181 on the small diameter side, and bends in the middle to open on the side surface of the first connecting part 181 . An optical fiber 41 is inserted into the sensor conduit 194 and fixed in a liquid-tight manner. The light emitter 24 fixed to the tip of the optical fiber 41 is arranged near the end surface of the first connection portion 181 .

According to this embodiment, it is possible to provide the measuring probe 18 that can be easily fixed to the connector 163 by the luer lock structure. According to this embodiment, it is possible to provide the measurement probe 18 that is difficult to come off even when the internal pressure of the catheter 161 is high.

[Embodiment 4]
This embodiment relates to a measurement probe 18 having a conduit fixing portion 198 fixed to a catheter 161. FIG. Descriptions of parts common to the first embodiment are omitted.

FIG. 24 is a front view of the measurement probe 18 of Embodiment 4. FIG. 25 is a XXV arrow view in FIG. 24. FIG.

The measurement probe 18 includes an adapter 185, a plug 196, and a sensor probe 40. The adapter 185 includes a plate-like portion 183 and a first connecting portion 181 protruding from one surface of the plate-like portion 183 . A plug 196 and an abutting portion 195 are attached to the side surface of the first connecting portion 181 in order from the plate-like portion 183 side. The plug 196 has a second connection portion 182 . Although not shown in the present embodiment, a valve body 197 is attached inside the second connecting portion 182 .

The abutting portion 195 has a flat plate shape, and has two pipeline fixing portions 198 projecting to the side opposite to the plate-like portion 183 . The conduit fixing portion 198 has a substantially C-shaped plate shape. The pipeline fixing part 198 is an example of the medical pipeline fixing part of this embodiment, which is used when fixing the measurement probe 18 to the catheter 161 .

FIG. 26 is an explanatory diagram explaining how to use the measurement probe 18 of the fourth embodiment. 27 is a cross-sectional view taken along line XXVII in FIG. 26. FIG. The abutting portion 195 abuts against the upper surface of the connector 163 , and the first connecting portion 181 is inserted into the connector 163 . As indicated by the dashed line in FIG. 26, the optical fiber 41 protrudes from the tip of the first connecting portion 181 and is inserted inside the catheter 161 .

As shown in FIG. 27, the conduit fixing portion 198 is fitted around the outer circumference of the catheter 161. As shown in FIG. The conduit fixing portion 198 is an example of a fastener of the present embodiment that fastens the sensor probe 40 to the catheter 161 . Note that the shape of the pipeline fixing portion 198 shown in FIGS. 24 and 25 is an example. The channel fixing portion 198 may have a fixing metal fitting or the like that connects both ends of the C-shaped plate and firmly fixes the measurement probe 18 from the catheter 161 so that it does not come off.

A band hole 189 through which the binding band 199 can be inserted may be provided in the abutting portion 195 . By using the conduit fixing portion 198 and the binding band 199 together, the connector 163 and the measurement probe 18 can be firmly fixed.

A second sensor (not shown) may be embedded in the conduit fixing portion 198 . The second sensor is a non-wetted sensor that can measure the state of the fluid without contacting the fluid in the catheter 161 . The second sensor is for example a thermocouple or a thermistor.

The second sensor may be a sensor of a laser flowmeter, a thermal flowmeter, or an ultrasonic flowmeter. For example, a transmitting sensor such as a laser or an ultrasonic wave may be arranged on one pipeline fixing portion 198 , and a receiving sensor may be arranged on the other pipeline fixing portion 198 . That is, the pipeline fixing portion 198 realizes the function of the sensor attachment portion of the present embodiment.

According to this embodiment, it is possible to provide the measurement probe 18 that can be firmly fixed to the catheter 161 .

[Embodiment 5]
This embodiment relates to a measurement device 30 that includes a filter 57 that separates excitation light and fluorescence. Descriptions of parts common to the first embodiment are omitted.

FIG. 28 is an explanatory diagram for explaining the configuration of the measuring device 30 of Embodiment 5. FIG. A filter 57 is arranged between the beam splitter 56 and the input connector 371 via the light guide path 55 . The control unit 31 can adjust the wavelength range of light transmitted by the filter 57 . The light source 51 of the present embodiment emits broadband light that includes fluorescence wavelengths in addition to excitation light wavelengths. Light source 51 is, for example, a white LED.

FIG. 29 is a time chart explaining the operation of the measuring device 30 of Embodiment 5. FIG. FIG. 29A shows ON and OFF timings of the light source 51 . 29B shows the timing of the operation of filter 57. FIG. b1 indicates that the filter 57 transmits the excitation light. b2 indicates that the filter 57 transmits fluorescence. FIG. 29C shows the timing at which the optical analyzer 52 operates. ON indicates the operation of analyzing the properties of fluorescence. OFF indicates an operation in which fluorescence characteristics are not analyzed. The horizontal axes in FIGS. 29A to 29C all indicate time.

The light source 51 is in the ON state during the period from time t1 to time t2. During this period, the filter 57 transmits the excitation light. Optical analyzer 52 does not operate. The excitation light irradiates the light emitter 24 . When the luminous body 24 is in contact with fluid such as blood or infusion, fluorescence corresponding to the state of the fluid is emitted.

The light source 51 is turned off during the period from time t2 to t3. During this period, filter 57 is transparent to fluorescence. The optical analyzer 52 analyzes the fluorescence properties and outputs the partial pressure of oxygen in the fluid to the bus. After time t3, the same operation is repeated.

According to the present embodiment, it is possible to provide the measurement system 10 that can perform accurate measurements even when the light emitted by the light source 51 contains the wavelength of fluorescence.

[Embodiment 6]
This embodiment relates to a measurement system 10 that can simultaneously measure a plurality of items using a single light source 51. FIG. Descriptions of the portions common to the fifth embodiment are omitted.

Two types of phosphors are mixed in the luminous body 24 of the present embodiment. That is, in this embodiment, two types of sensors are fixed to the tip of the bundle of optical fibers 41 . The two types of phosphors are referred to as phosphor J and phosphor K in the following description. The wavelengths of the fluorescence emitted by the phosphor J and the phosphor K are sufficiently separated.

FIG. 30 is a time chart explaining the operation of the measuring device 30 of Embodiment 6. FIG. FIG. 30A shows ON and OFF timings of the light source 51 . 30B shows the timing of the operation of filter 57. FIG. b1j indicates that the filter 57 allows the excitation light of the phosphor J to pass therethrough. b2j indicates that the filter 57 allows the fluorescence emitted by the phosphor J to pass through. b1k indicates that the filter 57 allows the excitation light of the phosphor K to pass therethrough. b2k indicates that the filter 57 allows the fluorescence emitted by the phosphor K to pass through.

FIG. 30C shows the timing at which the optical analyzer 52 operates. cj indicates the operation of analyzing the characteristics of the fluorescence emitted by the phosphor J; ck indicates the operation of analyzing the properties of the fluorescence emitted by the phosphor K; OFF indicates an operation in which fluorescence characteristics are not analyzed. The horizontal axes in FIGS. 30A to 30C all indicate time.

The light source 51 is in the ON state during the period from time t1 to time t2. During this period, the filter 57 allows the excitation light of the phosphor J to pass therethrough. Optical analyzer 52 does not operate. The excitation light irradiates the light emitter 24 . When the light emitter 24 is in contact with fluid such as blood or infusion, the phosphor J emits fluorescence corresponding to the state of the fluid.

The light source 51 is turned off during the period from time t2 to time t3. During this period, the filter 57 allows the fluorescence emitted by the phosphor J to pass therethrough. The light analyzer 52 analyzes the properties of the fluorescence and outputs items related to the phosphor J on the bus.

The light source 51 is in the ON state during the period from time t3 to time t4. During this period, the filter 57 allows the excitation light of the phosphor K to pass therethrough. Optical analyzer 52 does not operate. The excitation light irradiates the light emitter 24 . When the light-emitting body 24 is in contact with fluid such as blood or infusion, the phosphor K emits fluorescence corresponding to the state of the fluid.

The light source 51 is turned off during the period from time t4 to time t5. During this period, the filter 57 allows the fluorescence emitted by the phosphor K to pass therethrough. The light analyzer 52 analyzes the properties of the fluorescence and outputs items related to the phosphor K on the bus. After time t6, the same operation is repeated.

According to the present embodiment, it is possible to provide the measurement system 10 that can measure a plurality of items using one light source 51. Note that the light emitter 24 may have three or more types of phosphors. The filter 57 sequentially transmits excitation light and fluorescence of each phosphor.

[Modification 6-1]
FIG. 31 is a perspective view of the distal end portion of the sensor probe 40 of modification 6-1. In this modification, a first light emitter 241 mixed with phosphor K and a second light emitter 242 mixed with phosphor J are arranged on the end face of optical fiber 41 .

Although FIG. 31 shows an example in which both the first light emitter 241 and the second light emitter 242 are semicircular, the first light emitter 241 and the second light emitter 242 are arranged concentrically. may The size of the first light emitter 241 and the size of the second light emitter 242 may be different.

The sensor probe 40 shown in FIG. 31 includes an optical fiber connector 411 to which a fiber bundle that guides the light emitted from the first light emitter 241 is connected, and a fiber that guides the light emitted from the second light emitter 242. and a fiber optic connector 411 to which the bundle is connected. Two optical fiber connectors 411 can be used to connect to separate measurement devices 30, respectively.

[Modification 6-2]
This modification relates to a measuring device 30 that displays time-series data on a display unit 35. FIG. Descriptions of the parts common to the sixth embodiment are omitted.

FIG. 32 is a screen example of modification 6-2. In this modification, the measuring device 30 measures oxygen partial pressure and temperature in real time. The measuring device 30 of this modified example has a relatively large display section 35 .

An index field 67, a date and time field 61, an oxygen partial pressure field 62, a temperature field 63 and a graph field 68 are displayed on the screen. The index column 67 displays indices representing the state of the kidney. The user can easily grasp the patient's kidney condition by combining the alphabet and the symbol "+" or "-".

The date and time column 61 displays the date, day of the week and time. The oxygen partial pressure column 62 displays the oxygen partial pressure in the fluid. Temperature is displayed in the temperature column 63 . Time-series data of the oxygen partial pressure in the fluid and the temperature are displayed in the graph field 68 by line graphs. In graph column 68, the dashed line indicates time series data of oxygen partial pressure in the fluid, and the solid line indicates time series data of temperature. A dashed line displayed under the word "pO2" and a solid line displayed under the word "temperature" in the oxygen partial pressure column 62 function as a so-called legend column. The user can easily grasp which graph means what.

The line graph shown in the graph column 68 is an example of the graph format. Any type of graph that is convenient for a user to use in a clinical setting can be used in graph field 68 . For example, when the value per unit time is emphasized, a bar graph is used for displaying the graph field 68 . The user may be able to specify the format of the graph as appropriate.

Time series data may be displayed in tabular format instead of graphical format. Note that the control unit 31 may appropriately receive a setting change of the items and layout to be displayed on the display unit 35 by the user. The user can use the measurement system 10 with settings that are easy to use depending on the situation.
[Embodiment 7]
The present embodiment relates to a measurement system 10 using a light source 51 that radiates a plurality of narrowband excitation lights by switching. Descriptions of the portions common to the fifth embodiment are omitted. FIG. 33 is an explanatory diagram illustrating the configuration of the measuring device 30 according to the seventh embodiment. In this embodiment, filter 57 is placed between beam splitter 56 and optical analyzer 52 .

FIG. 34 is a time chart explaining the operation of the measuring device 30 of the seventh embodiment. FIG. 34A shows timing when the light source 51 operates. aj indicates that the light source 51 emits excitation light for the phosphor J; ak indicates that the light source 51 emits excitation light for the phosphor K;

34B shows the timing of the operation of the filter 57. FIG. ALL indicates that filter 57 transmits all light. bj indicates that the filter 57 allows the fluorescence emitted by the phosphor J to pass through. bk indicates that the filter 57 allows the fluorescence emitted by the phosphor K to pass through.

FIG. 34C shows the timing at which the optical analyzer 52 operates. cj indicates the operation of analyzing the characteristics of the fluorescence emitted by the phosphor J; ck indicates the operation of analyzing the properties of the fluorescence emitted by the phosphor J; OFF indicates an operation in which fluorescence characteristics are not analyzed. The horizontal axes in FIGS. 34A to 34C all indicate time.

The light source 51 emits excitation light that excites the phosphor J during the period from time t1 to time t2. During this period, filter 57 transmits all light. Optical analyzer 52 does not operate. The excitation light irradiates the light emitter 24 . When the light emitter 24 is in contact with fluid such as blood or infusion, the phosphor J emits light according to the state of the fluid.

The light source 51 is turned off during the period from time t2 to time t3. During this period, the filter 57 allows the fluorescence emitted by the phosphor J to pass therethrough. Optical analyzer 52 analyzes the properties of the fluorescence emitted by phosphor J and outputs the results on a bus.

The light source 51 emits excitation light that excites the phosphor K during the period from time t3 to time t4. During this period, filter 57 transmits all light. Optical analyzer 52 does not operate. The excitation light irradiates the light emitter 24 . When the light emitter 24 is in contact with fluid such as blood or infusion, the phosphor K emits light according to the state of the fluid.

The light source 51 is turned off during the period from time t4 to time t5. During this period, the filter 57 allows the fluorescence emitted by the phosphor K to pass therethrough. Optical analyzer 52 analyzes the properties of the fluorescence emitted by phosphor K and outputs the results on a bus. After time t5, the same operation is repeated.

According to this embodiment, one light source 51 and one light emitter 24 can be used to provide the measurement system 10 capable of measuring a plurality of items. Note that the light emitter 24 may have three or more types of phosphors. The filter 57 sequentially switches the wavelength of light to be transmitted according to each phosphor.

The light source 51 may emit broadband light including both the excitation light for the phosphor J and the excitation light for the phosphor K. For example, light source 51 may emit white light. In that case, both aj and ak in FIG. 34A indicate that the light source 51 is in the ON state.

[Embodiment 8]
This embodiment relates to a measuring device 30 having a plurality of optical analyzers 52. FIG. The description of the parts common to the seventh embodiment is omitted.

FIG. 35 is an explanatory diagram for explaining the configuration of the measuring device 30 according to the eighth embodiment. The measurement device 30 includes two optical analyzers 52 , a first optical analyzer 521 and a second optical analyzer 522 , and two beam splitters 56 , a first beam splitter 561 and a second beam splitter 562 .

A first beam splitter 561 is connected between the light source 51 and the input connector 371 . A second beam splitter 562 is connected between the first beam splitter 561 and the first optical analyzer 521 and the second optical analyzer 522 . The second beam splitter 562 is a dichroic beam splitter that separates incident light based on wavelength. The second beam splitter 562 realizes the function of a spectroscopic section that spectroscopically separates fluorescence emitted by a plurality of phosphors.

In the following description, it is assumed that the first optical analyzer 521 analyzes the characteristics of the fluorescence emitted from the phosphor J, and the second optical analyzer 522 analyzes the characteristics of the fluorescence emitted from the phosphor K. to explain. The light source 51 emits excitation light capable of exciting both the phosphor J and the phosphor K. FIG.

Note that the phosphor J and the phosphor K are mixed in one light emitter 24, for example. 31, when the sensor probe 40 has a plurality of light emitters 24 of the first light emitter 241 and the second light emitter 242, one of the light emitters 24 is mixed with the phosphor J, The phosphor K may be mixed with the other light emitter 24 .

The excitation light irradiates the light emitter 24 through the light guide 55 , beam splitter 56 and optical fiber 41 . When the light-emitting body 24 contacts fluid such as blood or infusion, phosphor J and phosphor K respectively emit fluorescence.

The fluorescence emitted by phosphor J and phosphor K enters the optical fiber 41 in a mixed state. Fluorescence light guided by the optical fiber 41 enters the first beam splitter 561 via the input connector 371 and the light guide path 55 . The first beam splitter 561 causes the fluorescence to enter the light guide path 55 leading to the second beam splitter 562 . The second beam splitter 562 separates the fluorescence into the fluorescence emitted by the phosphor J and the other light. The fluorescence emitted by the phosphor J enters the first optical analyzer 521 and the other light enters the second optical analyzer 522 .

The first optical analyzer 521 analyzes the characteristics of the fluorescence emitted by the phosphor J and outputs the results to the bus. A second optical analyzer 522 analyzes the properties of the fluorescence emitted by the phosphor K and outputs the results on a bus. An optical filter that transmits only the fluorescence emitted by the phosphor K may be arranged between the second beam splitter 562 and the second optical analyzer 522 .

According to this embodiment, it is possible to provide the measurement system 10 that simultaneously analyzes the fluorescence emitted by two types of phosphors. The light emitter 24 may include three or more types of phosphors, and the measurement device 30 may include the light analyzers 52 and beam splitters 56 corresponding to the number of phosphors. In order to adjust the wavelength of the light passing through the light guide 55 to an arbitrary wavelength, an optical filter that passes only a specific wavelength may be arranged in the middle of the light guide 55 .

[Embodiment 9]
FIG. 36 is a functional block diagram of the measurement system 10 of the ninth embodiment. Measurement system 10 includes measurement probe 18 and measurement device 30 . The measurement probe 18 includes a first connection portion 181 , a second connection portion 182 , a valve body 197 and a sensor 24 .

The first connecting part 181 is attachable to and detachable from a connector 163 arranged in the middle of the medical conduit 161 and has a first conduit 191 that communicates with the medical conduit 161 when attached to the connector 163 . The second connecting portion 182 has a second pipeline 192 to which the syringe 168 can be attached and detached and communicates with the first pipeline 191 . The valve body 197 keeps the second pipeline 192 liquid-tight when the syringe 168 is not attached to the second connecting portion 182 . Sensor 24 measures the state of the fluid flowing through medical conduit 161 .

The measurement device 30 includes a data acquisition section 85 and a display section 86. The data acquisition unit 85 acquires data from the sensor 24 . The display unit 86 displays information about the patient to whom the medical pipeline 161 is connected based on the acquired data.

The technical features (constituent elements) described in each embodiment can be combined with each other, and new technical features can be formed by combining them.
The embodiments disclosed this time are illustrative in all respects and should be considered not restrictive. The scope of the present invention is not defined by the above-described meaning, but is indicated by the scope of claims, and is intended to include all modifications within the meaning and scope equivalent to the scope of claims.

10 measurement system 161 catheter (medical conduit)
162 infusion bag 163 connector 168 syringe 169 blood vessel 18 measurement probe 181 first connecting portion 182 second connecting portion 183 plate-like portion 184 locking portion 185 adapter 186 plug attaching portion 188 band attaching portion 189 band hole 191 first conduit 192 second 2 pipes 194 sensor pipe 195 abutting part 196 plug 197 valve body 198 pipe fixing part 199 binding band 24 luminous body (sensor)
241 first light emitter 242 second light emitter 248 light guide section 249 adhesive layer 30 measuring device 31 control section 32 main storage device 33 auxiliary storage device 34 communication section 35 display section 36 input section 371 input connector 40 sensor probe 41 optical fiber 42 Fiber plug 411 Optical fiber connector 51 Light source 52 Optical analyzer 521 First optical analyzer 522 Second optical analyzer 55 Light guiding path 56 Beam splitter 561 First beam splitter 562 Second beam splitter 57 Filter 61 Date and time field 62 Oxygen partial pressure field 63 temperature column 67 index column 68 graph column 85 data acquisition unit 86 display unit

Claims

a first connecting part that is attachable to and detachable from a connector arranged in the middle of a medical duct and has a first duct that communicates with the medical duct when attached to the connector;
A second connection part having a second conduit that allows a syringe to be attached and detached and that communicates with the first conduit;
a valve body that keeps the second pipeline liquid-tight when the syringe is not attached to the second connection;
and a sensor that measures the state of the fluid flowing through the medical pipeline.
2. The measuring probe according to claim 1, wherein said sensor is arranged within said first conduit.
a sensor conduit having one end arranged parallel to the first conduit;
2. The measuring probe of claim 1, wherein the sensor is positioned within the sensor conduit.
The sensor includes a luminous body that emits light when in contact with the component to be measured,
The measurement probe according to any one of claims 1 to 3, further comprising a light guide body that guides the radiation light emitted from the light emitter.
The measuring probe according to claim 4, wherein the emitted light is fluorescence.
The measurement probe according to claim 4 or 5, wherein the luminous body contains a fluorescent dye.
The measuring probe according to any one of claims 4 to 6, wherein the luminous body changes its luminous state according to each of a plurality of measurement items.
The measuring probe according to any one of claims 4 to 7, comprising an optical connector connected to the light guide.
The measurement probe according to claim 8, wherein the light guide is an optical fiber having one end connected to the optical connector.
The measuring probe according to any one of claims 4 to 9, wherein the sensor is fixed to the light guide.
A plurality of the sensors are fixed to one light guide,
10. The measurement probe according to claim 8, wherein the light guide body guides the emitted light emitted from each of the plurality of sensors to one of the optical connectors.
12. The measuring probe according to any one of claims 4 to 11, further comprising a light blocking body that prevents light other than the emitted light from entering the light guide.
13. A measuring probe according to any one of claims 4 to 12, further comprising a second sensor.
14. The measuring probe of claim 13, wherein the second sensor is positioned so as not to contact fluid flowing through the medical line.
The measuring probe according to claim 13 or 14, wherein the second sensor is a sensor of an ultrasonic flowmeter or a thermal flowmeter.
The luminous body depends on the partial pressure of oxygen in the fluid, the partial pressure of carbon dioxide in the fluid, the hydrogen ion exponent of the fluid, the amount of potassium ions in the fluid, the amount of sodium ions in the fluid, the temperature of the fluid, or the pressure of the fluid. 15. A measuring probe according to any one of claims 4 to 14, wherein the emitted light changes accordingly.
The sensor detects the partial pressure of oxygen in the fluid, the partial pressure of carbon dioxide in the fluid, the hydrogen ion exponent of the fluid, the amount of potassium ions in the fluid, the amount of sodium ions in the fluid, the amount of creatinine in the fluid, and the amount of chloride ions in the fluid. amount, specific gravity of fluid, amount of urea nitrogen in fluid, amount of lactic acid in fluid, amount of glucose in fluid, HbA1c value in fluid, amount of CRP (C-reactive protein) in fluid, amount of uric acid in fluid, fluid The output changes according to the amount of hemoglobin in the fluid, the hematocrit value of the fluid, the amount of albumin in the fluid, the amount of globmin in the fluid, the amount of bilirubin in the fluid, the temperature of the fluid, or the pressure of the fluid. 17. The measuring probe according to any one of 16.
The medical conduit is a conduit that connects a patient's blood vessel and an extracorporeal instrument,
The sensor detects the partial pressure of oxygen in the fluid, the partial pressure of carbon dioxide in the fluid, the hydrogen ion exponent of the fluid, the amount of potassium ions in the fluid, the amount of sodium ions in the fluid, the amount of creatinine in the fluid, and the amount of chloride ions in the fluid. amount, specific gravity of fluid, amount of urea nitrogen in fluid, amount of lactic acid in fluid, amount of glucose in fluid, HbA1c value in fluid, amount of CRP in fluid, amount of uric acid in fluid, amount of hemoglobin in fluid, fluid The output changes according to the hematocrit value of the fluid, the amount of albumin in the fluid, the amount of globmin in the fluid, the amount of bilirubin in the fluid, the temperature of the fluid, or the pressure of the fluid. The measurement probe described in .
wherein the medical line is a catheter that drains urine from the patient's bladder;
The sensor detects the partial pressure of oxygen in the fluid, the partial pressure of carbon dioxide in the fluid, the hydrogen ion exponent of the fluid, the amount of potassium ions in the fluid, the amount of sodium ions in the fluid, the amount of creatinine in the fluid, and the amount of chloride ions in the fluid. 17. The output changes according to the amount, the specific gravity of the fluid, the amount of glucose in the fluid, the amount of lactic acid in the fluid, the amount of free hemoglobin in the fluid, the temperature of the fluid, or the pressure of the fluid. 1. A measuring probe according to claim 1.
The measuring probe according to any one of claims 1 to 19, wherein the second connecting part has a structure that can be sterilized before the syringe is attached.
21. The measuring probe according to any one of claims 1 to 20, wherein the connector is for injecting fluid into the medical line or taking a sample from the medical line.
The measuring probe according to any one of claims 1 to 21, further comprising a connector fixing portion used for fixing to the connector.
23. The measuring probe according to any one of claims 1 to 22, further comprising a medical conduit fixing portion fixed to the medical conduit.
a first connecting part that is attachable to and detachable from a connector arranged in the middle of a medical duct and has a first duct that communicates with the medical duct when attached to the connector;
A second connection part having a second conduit that allows a syringe to be attached and detached and that communicates with the first conduit;
a valve body that keeps the second pipeline liquid-tight when the syringe is not attached to the second connection;
and a sensor mounting portion to which a sensor that measures the state of the fluid flowing through the medical pipeline can be mounted.
25. The adapter of Claim 24, having a sensor conduit arranged parallel to said first conduit at one end.
A measuring system comprising a measuring probe and a measuring device,
The measurement probe is
a first connection part that is attachable to and detachable from a connector arranged in the middle of a medical duct and has a first duct that communicates with the medical duct when attached to the connector;
A second connection part having a second conduit that allows a syringe to be attached and detached and that communicates with the first conduit;
a valve body that keeps the second pipeline liquid-tight when the syringe is not attached to the second connection;
a sensor that measures the state of the fluid flowing through the medical pipeline;
The measuring device is
a data acquisition unit that acquires data from the sensor;
a display that displays information about a patient to whom the medical pipeline is connected based on the acquired data.
27. The measurement system of claim 26, wherein said sensor is positioned within said first conduit.
The measuring probe has a sensor conduit with one end arranged parallel to the first conduit,
27. The measurement system of Claim 26, wherein the sensor is disposed within the sensor conduit.
The sensor has a luminous body that emits light when it comes into contact with the component to be measured,
The measurement probe has a light guide that guides the emitted light emitted from the light emitter,
The measuring device is
a light source that irradiates the light emitter with excitation light through the light guide;
a light receiving unit that receives the emitted light guided by the light guide;
and an optical analyzer that analyzes the radiated light,
29. The measurement system according to any one of claims 26 to 28, wherein the data acquisition unit acquires data related to the light emitting state of the light emitter from the light analyzer.
30. The measurement system according to claim 29, wherein the measurement probe includes a light block that prevents light other than the emitted light from entering the light guide.
The luminous body depends on the partial pressure of oxygen in the fluid, the partial pressure of carbon dioxide in the fluid, the hydrogen ion exponent of the fluid, the amount of potassium ions in the fluid, the amount of sodium ions in the fluid, the temperature of the fluid, or the pressure of the fluid. 31. A measurement system according to claim 29 or claim 30, wherein the emitted light changes accordingly.
32. The measurement system of any one of claims 29-31, wherein the emitted light is fluorescence.
The sensor has a plurality of light emitters corresponding to each of a plurality of measurement items,
33. The measurement system according to any one of claims 29 to 32, wherein the light guide guides the emitted light emitted from each of the plurality of light emitters in a mixed state.
the sensor is a plurality,
34. The measurement system according to any one of claims 29 to 33, wherein the light guide guides the emitted light emitted from the light emitters of the plurality of sensors in a mixed state.
The measuring device is
a spectroscopic unit that spectroscopically disperses the emitted light;
35. The measurement system according to claim 33 or 34, further comprising a plurality of said light analyzers for analyzing respective lights separated by said spectroscopic section.
The measuring device is
A filter that transmits a specific band of the emitted light,
36. The measurement system of any one of claims 33-35, wherein the light analyzer analyzes light transmitted through the filter.
The measurement according to any one of claims 29 to 36, wherein the light guide is an optical fiber having one end where the light emitter is arranged and the other end which is connected to an optical connector connected to the light receiving section. system.
38. The measurement system of claim 37, comprising fasteners for fastening the optical fiber to the medical line.
39. The measurement system of any one of claims 26-38, further comprising a second sensor.
40. The measurement system of claim 39, wherein the second sensor is an ultrasonic flow meter, thermal flow meter, or laser flow meter sensor.
41. The measurement system according to claim 39 or 40, wherein the second sensor is a non-wetted sensor that does not come into contact with the fluid flowing through the medical pipeline.
42. The measurement system according to any one of claims 26 to 41, wherein the display unit displays information about the patient in chronological order.
43. The measurement system according to any one of claims 26 to 42, wherein the display displays patient-related indicators.