CN106153661B - A kind of method for the noninvasive magnetic resonance detection of blood pressure and blood lipoid - Google Patents
A kind of method for the noninvasive magnetic resonance detection of blood pressure and blood lipoid Download PDFInfo
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- CN106153661B CN106153661B CN201610438569.5A CN201610438569A CN106153661B CN 106153661 B CN106153661 B CN 106153661B CN 201610438569 A CN201610438569 A CN 201610438569A CN 106153661 B CN106153661 B CN 106153661B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
- G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
Abstract
The present invention relates to a kind of method for the noninvasive magnetic resonance detection of blood pressure and blood lipoid, this method is realized by the noninvasive magnetic resonance detection module of the blood pressure and blood lipoid provided and the accurate detection module of the minimally invasive nuclear magnetic resonance of blood pressure and blood lipoid.Noninvasive module directly carries out magnetic resonance detection to human body, and the blood sampling minimally invasive to human body of minimally invasive module is carried out.Blood pressure and blood lipoid situation of change of the same individual of blood pressure and blood lipoid Non-invasive detection measurement in the different periods, is a blood pressure and blood lipoid relative value；Blood pressure and blood lipoid it is minimally invasive it is accurate detection measurement blood pressure and blood lipoid absolute value, measurement result can as calibrated first during non-invasive measurement or Non-invasive detection during correction.
Description
Technical field
The present invention relates to a kind of method for the noninvasive magnetic resonance detection of blood pressure and blood lipoid.
Background technology
Diabetes are a kind of dysbolism diseases, and Clinical symptoms shows as hyperglycaemia, therefore Blood Glucose is dense
Degree is the Main Basiss for judging diabetes.Clinically the common method of blood sugar test is to puncture blood drawing or hand by syringe needle at present
Refer to acupuncture treatment and take the laggard promoting circulation of blood biochemical analysis of blood.The biochemical analysis method of blood glucose has the characteristics of accuracy is high, but is due to glycosuria
Patient is general during diagnosis and treatment at least to be needed to measure more than 3 times blood sugar levels daily.Frequently carry out invasive blood sampling analysis
Not only need to expend substantial amounts of reagent, while also by the body of great increase patient and psychological burden, and also there is infection
Risk.Therefore studying a kind of method that can realize the accurate noninvasive low cost detection of blood sugar for human body has extremely important society
Value and economic implications.
But so far, not yet occur it is a kind of can be effectively applied to clinic non-invasive glucose monitoring method, and
Most of non-invasive glucose monitoring method of current research is other non-blood compositions based on measurement human body, such as water before the eye-chamber,
Skin, breathing label, saliva and urine etc..Can the feature of these non-blood compositions truly reflect the value of blood sugar for human body, if
Exist individual difference need clinic further further investigation.While clinical diagnosis shows, most of diabetic
Along with the exception of blood fat, and ultimately succumb to blood vessel kind disease, it is therefore necessary to blood pressure and blood lipoid is carried out to detect simultaneously, and it is current
The non-invasive glucose monitoring method of research is only capable of reaction blood glucose this index, it is impossible to while realizing the detection to blood fat in blood.
The content of the invention
It is examining for diabetes it is an object of the invention to provide a kind of method for the noninvasive magnetic resonance detection of blood pressure and blood lipoid
Disconnected and treatment improves the foundation of offer science.
To achieve these goals, the present invention provides a kind of method for the noninvasive magnetic resonance detection of blood pressure and blood lipoid, carries
For the noninvasive magnetic resonance detection module of blood pressure and blood lipoid and the accurate detection module of the minimally invasive nuclear magnetic resonance of blood pressure and blood lipoid；
Human body is taken a blood sample, blood sample the minimally invasive accurate measurement module of blood pressure and blood lipoid is delivered to specific magnetic bead, and adopt
Collect the NMR signal of blood sample, the difference characteristic such as nuclear magnetic resonance based on analysis various concentrations blood pressure and blood lipoid NMR signal
The relaxation rate of signal or other effectively NMR signal characteristic parameters.Set up blood pressure and blood lipoid nuclear magnetic resonance letter
Mapping relations number with concentration, provide the blood pressure and blood lipoid concentration value of collection blood sample；And it regard the blood pressure and blood lipoid concentration value as blood glucose
The initial value of blood fat Non-invasive detection module；
The initial NMR signal of human body is gathered by the noninvasive magnetic resonance detection module of blood pressure and blood lipoid again, and this is first
Beginning NMR signal matches above-mentioned initial value；
The NMR signal of human body is measured in different time sections afterwards, the fluctuation characteristic of signal is extracted, using multivariable
Analysis method such as least square method, principal component analysis or clustering etc. or other multivariable techniques, analysis are adopted
Longitudinally relaxed in the nuclear magnetic resonance characteristic parameter such as T2 that collect, longitudinal relaxation time, diffusion coefficient, rotating coordinate system
Henan time etc. or other effective nuclear magnetic resonance characteristic parameters, provide the blood glucose in the above-mentioned different period of human body
Blood Lipid situation.
Further, the minimally invasive accurate measurement module of the blood pressure and blood lipoid includes collection plate, and the collection plate is provided with micro-fluidic
Detection coil entrance, the screw type fluid channel for connecting micro-fluidic detection coil entrance, waste liquid outlet, magnetic bead outlet, connection
The detection coil of screw type fluid channel central outlets.
It is that blood sample and specific magnetic bead are delivered to the minimally invasive accurate survey of blood pressure and blood lipoid to the method that human body carries out minimally invasive blood sampling
Measure the micro-fluidic detection coil entrance of module, mixing and sorting in probe Jing Guo screw type fluid channel, magnetic bead and blood sample into
Reunite and enter in detection coil, waste liquid flows out from waste liquid outlet, free magnetic bead is discharged from magnetic bead outlet.
Double channel electronic control system, double channel electronic control system transmitting radio-frequency pulse, collection target inspection are provided in addition
The NMR signal of thing is surveyed, by Data Management Analysis, the blood pressure and blood lipoid concentration value of collection blood sample is provided.
One passage of double channel electronic control system is used to launch radio-frequency pulse and the noninvasive core of reception processing blood pressure and blood lipoid
The NMR signal of magnetic resonance detection module；Another passage is used to launch radio-frequency pulse and reception processing blood pressure and blood lipoid is minimally invasive
The NMR signal of the accurate detection module of nuclear magnetic resonance.
The noninvasive magnetic resonance detection module of blood pressure and blood lipoid includes collection coil and surrounds the magnet of collection coil.
Human body inserts the coil position of blood pressure and blood lipoid Non-invasive detection module, double channel electronic control system transmitting RF pulse-to-pulse
Punching, gathers the NMR signal of finger.
Beneficial effect：A kind of method for the noninvasive magnetic resonance detection of blood pressure and blood lipoid that the present invention is provided, can be to people
The blood pressure and blood lipoid data of body carry out Long term noninvasive detection, and medical worker can obtain long-term multipoint data from patient, can be with
The therapeutic effect of effective tracking disease, and improve therapeutic scheme in real time as needed, this method is also applied for patient and stayed at home
The situation of change of Real Time Observation oneself relevant disease index, the influence to disease such as science judgment diet, motion, sleep.In addition,
This method is also applied for therapeutic effect of scientific worker's research medicine to disease.
Brief description of the drawings
Fig. 1 is principle schematic of the invention.
Fig. 2 is Application Example schematic diagram of the invention.
Fig. 3 is Non-invasive detection module magnet and coil component schematic diagram of the invention.
Fig. 4 is minimally invasive accurate measurement module micro-fluidic detection coil schematic diagram of the invention.
Fig. 5 is the blood sugar concentration of the present invention and the relation map of NMR relaxation time.
Embodiment
The present invention is described in further detail below in conjunction with the accompanying drawings.
The electromagnetic induction letter that atom nuclear magnetic resonance technique is produced based on atomic nucleus under outside magnetic field environment during spin resonance
Number realize to the composition and analysis of the molecular structure of material, be a kind of lossless non-contact detection.Proton is in different chemical environments
Middle to there are different dynamics, so as to produce different relaxation behaviors, nuclear magnetic resonance technique realizes thing according to this characteristic
The discriminating of matter.There is substantial amounts of hydrogen nuclei in blood, the concentration of Blood Glucose blood fat is different, the chemistry residing for hydrogen nuclei
Environment is also by difference.Therefore, it can be realized and be detected while Blood Glucose blood fat from principle using nuclear magnetic resonance technique, this
Invention provides a kind of method for the noninvasive magnetic resonance detection of blood pressure and blood lipoid based on the principle.
A kind of method for the noninvasive magnetic resonance detection of blood pressure and blood lipoid of the present invention is common including the noninvasive nuclear-magnetism of blood pressure and blood lipoid
Shake detection module (201) and the accurate detection module of the minimally invasive nuclear magnetic resonance of blood pressure and blood lipoid (202).During measurement, human body is carried out first
Minimally invasive blood sampling, will gather blood sample and specific magnetic bead is delivered to the micro-fluidic detection coil of the minimally invasive accurate measurement module of blood pressure and blood lipoid
Middle entrance (401), being sufficiently mixed and sorting by screw type micro-channel structure (404), magnetic bead and target detection in probe
Thing formation is reunited and entered in detection coil (405), and waste liquid is filtered through filter membrane (406) and passed through from outlet (402) outflow, free magnetic bead
Lower floor's runner (407) is crossed from outlet (403) discharge.Double channel electronic control system (203) launches radio-frequency pulse, collection target inspection
The NMR signal of thing is surveyed, the difference characteristic such as nuclear magnetic resonance based on analysis various concentrations blood pressure and blood lipoid NMR signal is believed
Number relaxation rate or other effectively NMR signal characteristic parameter, set up blood pressure and blood lipoid NMR signal
With the mapping relations of concentration, the blood pressure and blood lipoid concentration value of collection blood sample is provided.A kind of embodiment is：The increasing of blood pressure and blood lipoid concentration
Plus, it can accelerate the transverse relaxation rate of the NMR signal of blood, the relaxation time reduces and (refers to Fig. 5), so sets up blood
The mapping relations of glucemia fat NMR signal and concentration.By this concentration value, the initial of blood pressure and blood lipoid Non-invasive detection module is used as
Value, human finger inserts coil (302) position of blood pressure and blood lipoid Non-invasive detection module, and it is empty that probe is located at a ring magnet (301)
The center of gap, double channel electronic control system (203) transmitting radio-frequency pulse, gathers the NMR signal of finger, and the signal is made
On the basis of signal, the blood pressure and blood lipoid NMR signal of finger can be measured in different period, the fluctuation for extracting signal is special
Levy, using multivariable technique such as least square method, principal component analysis or clustering etc. or other multivariables point
Analysis method, analyzes nuclear magnetic resonance characteristic parameter such as T2, longitudinal relaxation time, diffusion coefficient, the rotation collected
Longitudinal relaxation time etc. or other effective nuclear magnetic resonance characteristic parameters, by Data Management Analysis, are provided in coordinate system
The blood pressure and blood lipoid situation of change in the different periods of human body.For example, blood pressure and blood lipoid concentration is relaxed to T2, longitudinal direction
Longitudinal relaxation time has different degrees of influence in Henan time, diffusion coefficient, rotating coordinate system, using least square method, can be with
The optimal proportion coefficient that parameters index influences on blood pressure and blood lipoid concentration is determined, blood pressure and blood lipoid concentration and these parameters is obtained
Definite relation, makes measurement result minimum with actual error.Or the method for combining principal component analysis, multi-parameter index is converted into few
The several overall targets of number, so that quickly, maximized reflection blood pressure and blood lipoid change in concentration brings difference, obtains significantly more efficient
The change in concentration information of blood pressure and blood lipoid.
Only it is the preferred embodiment of the present invention described in upper, it should be pointed out that：Present invention application is not limited to introduce in invention
Application example, wherein the magnet and line of Non-invasive detection module can be other structures, the micro-fluidic detection of minimally invasive detection module
Coil can also be other structures, under the premise without departing from the principles of the invention, can also make and be suitably modified and retouch, be done
Improvements and modifications are all contained within protection scope of the present invention.
Claims (7)
1. a kind of method for the noninvasive magnetic resonance detection of blood pressure and blood lipoid, it is characterised in that：The noninvasive nuclear-magnetism of blood pressure and blood lipoid is provided
Resonate detection module (201) and the accurate detection module of the minimally invasive nuclear magnetic resonance of blood pressure and blood lipoid (202)；
Human body is taken a blood sample, blood sample the minimally invasive accurate measurement module (202) of blood pressure and blood lipoid is delivered to specific magnetic bead, and adopt
Collect the NMR signal of blood sample, the difference characteristic such as nuclear magnetic resonance based on analysis various concentrations blood pressure and blood lipoid NMR signal
The relaxation rate of signal, sets up the mapping relations of blood pressure and blood lipoid NMR signal and concentration, provides the blood glucose blood of collection blood sample
Lipid concentration value, and using the blood pressure and blood lipoid concentration value as blood pressure and blood lipoid Non-invasive detection module initial value；
Gather the initial NMR signal of human body by the noninvasive magnetic resonance detection module of blood pressure and blood lipoid again, and by the incipient nucleus
Magnetic resonance signal matches above-mentioned initial value；
The NMR signal of human body is measured in different time sections afterwards, the fluctuation characteristic of signal is extracted, using multi-variables analysis
Method such as least square method, principal component analysis or clustering, analyze the nuclear magnetic resonance characteristic parameter such as transverse relaxation collected
Longitudinal relaxation time in time, longitudinal relaxation time, diffusion coefficient, rotating coordinate system, provide human body when above-mentioned different
Between section blood pressure and blood lipoid situation of change.
2. the method according to claim 1 for the noninvasive magnetic resonance detection of blood pressure and blood lipoid, it is characterised in that：The blood
The minimally invasive accurate measurement module (202) of glucemia fat include collection plate, the collection plate provided with micro-fluidic detection coil entrance (401),
The screw type fluid channel (404) of connection micro-fluidic detection coil entrance (401), waste liquid outlet (402), magnetic bead outlet
(403) and connection screw type fluid channel (404) central outlets detection coil (405).
3. the method according to claim 2 for the noninvasive magnetic resonance detection of blood pressure and blood lipoid, it is characterised in that：To human body
The method for carrying out minimally invasive blood sampling is that with specific magnetic bead blood sample is delivered into the micro-fluidic of the minimally invasive accurate measurement module of blood pressure and blood lipoid
Detection coil entrance (401), mixing and sorting in probe Jing Guo screw type fluid channel (404), magnetic bead and blood sample are into reunion
And enter in detection coil (405), waste liquid is flowed out from waste liquid outlet (402), and free magnetic bead is arranged from magnetic bead outlet (403)
Go out.
4. the method according to claim 3 for the noninvasive magnetic resonance detection of blood pressure and blood lipoid, it is characterised in that：Carry in addition
For double channel electronic control system (203), double channel electronic control system (203) transmitting radio-frequency pulse gathers target detection thing
NMR signal, by Data Management Analysis, provide the blood pressure and blood lipoid concentration value of collection blood sample.
5. the method according to claim 4 for the noninvasive magnetic resonance detection of blood pressure and blood lipoid, it is characterised in that：Binary channels
One passage of electronic control system (203) is used to launch radio-frequency pulse and the noninvasive magnetic resonance detection of reception processing blood pressure and blood lipoid
The NMR signal of module (201)；Another passage is used to launch radio-frequency pulse and the minimally invasive nuclear-magnetism of reception processing blood pressure and blood lipoid
Resonate the NMR signals of accurate detection module (202).
6. the method according to claim 5 for the noninvasive magnetic resonance detection of blood pressure and blood lipoid, it is characterised in that：The blood
The noninvasive magnetic resonance detection module (201) of glucemia fat includes collection coil (302) and surrounds the magnet of collection coil (302)
(301)。
7. the method according to claim 6 for the noninvasive magnetic resonance detection of blood pressure and blood lipoid, it is characterised in that：Human body is inserted
Enter coil (302) position of blood pressure and blood lipoid Non-invasive detection module, double channel electronic control system (203) transmitting radio-frequency pulse is adopted
Collect the NMR signal of finger..
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| CN105433954B (en) * | 2015-12-18 | 2018-03-16 | 深圳市柳迪科技有限公司 | A kind of noninvasive dynamics monitoring equipment |
| CN109283206B (en) * | 2018-11-02 | 2021-07-06 | 东南大学 | Nuclear magnetic resonance rapid detection device and method for biomarkers |
| CN112068055B (en) * | 2020-08-27 | 2022-06-17 | 东南大学 | Halbach magnet for noninvasive nuclear magnetic resonance detection of blood sugar of human finger |
| CN114167333B (en) * | 2021-12-06 | 2022-07-22 | 无锡鸣石峻致医疗科技有限公司 | Longitudinal relaxation time measuring method and device, computer equipment and storage medium |
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| US4875486A (en) * | 1986-09-04 | 1989-10-24 | Advanced Techtronics, Inc. | Instrument and method for non-invasive in vivo testing for body fluid constituents |
| JP2938048B1 (en) * | 1998-06-30 | 1999-08-23 | 技術研究組合医療福祉機器研究所 | Metabolic function measurement device |
| RU2271741C2 (en) * | 2003-07-11 | 2006-03-20 | Евгений Александрович Протасов | Device for non-invasive finding of sugar content in patient's blood |
| CN101782539B (en) * | 2010-02-05 | 2012-05-23 | 东南大学 | Microfluidic biomone detection chip based on nuclear magnetic resonance |
| US20120197107A1 (en) * | 2011-01-31 | 2012-08-02 | Case Western Reserve University | Glucose analyzing blood examiner (gabe) |
| CN104688191A (en) * | 2015-03-31 | 2015-06-10 | 北京乐博康健康科技有限公司 | Noninvasive wearable physical examination system and method |
| CN104931902A (en) * | 2015-06-30 | 2015-09-23 | 东南大学 | Apparatus for integrating nuclear magnetic resonance magnet with probe |
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