CN205449811U - A device for breathing well acetone detects - Google Patents
A device for breathing well acetone detects Download PDFInfo
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- CN205449811U CN205449811U CN201521125748.0U CN201521125748U CN205449811U CN 205449811 U CN205449811 U CN 205449811U CN 201521125748 U CN201521125748 U CN 201521125748U CN 205449811 U CN205449811 U CN 205449811U
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Abstract
The utility model discloses a device for breathing well acetone detects, filter apron and second block including first block, first filtration apron, detecting tube, second, arrange first ampoule and second ampoule in proper order in the detecting tube from one end to the other end, first ampoule is equipped with liquid reagent, is equipped with the solid composition in the second ampoule, liquid reagent includes the aqueous ammonia, the solid composition includes ammonium sulfate, sodium nitroprussiate and silica, the stopper has first filtration apron in the one end opening of detecting tube, and the opening overcoat has first block, and the stopper has the second to filter the apron in the other end opening, and the opening overcoat has the second block. Can be used to with breathe in acetone the reaction takes place, but the acetone content level in breathing through colour variable intuitive judgment has high accuracy, repeatability and sensitivity.
Description
Technical field
This utility model relates to disposable medical instrument field, particularly relates to a kind of device of acetone detection in breathing.
Background technology
Diabetes are a series of metabolism disorder syndromes such as sugar, protein, fat, water and electrolyte.From medical angle, diabetes are the metabolism disorders definitely or relatively being lacked by insulin and causing complexity, and mainly showing as glucose content increases or intensive adipose tissure hyperplasia.Ketone, also referred to as " ketoboidies ", be the chemical substance that produces in human body when insufficient insulin of a class.Ketone (such as acetone) results from the middle of blood, and can be excreted by the channel such as urine and respiratory system.Gas phase acetone in blood reaches balance by alveolar and alveolar gas (expired gas), and acetone in respiratory gas concentration reflects the metabolic condition of diabetics to a certain extent.Having substantial amounts of acetone produce and spread all over each portion of whole body by blood, urine and respiratory system if internal, this situation does not has enough insulins or insulin can not be utilized to produce the energy required for human body cell by rights in generally meaning that human body.Therefore, when internal glucose directly cannot provide energy, metabolism, by burn fat, produces more ketoboidies in fat oxidation process.In the blood of healthy human body, the content of ketone remains certain level, but in diabetics body, ketone contents level has significantly increase, and it is a kind of modal pathological phenomenon that this ketone content caused by diabetes raises.Ketone includes acetoacetate (AcAc) and acetone.In diabetic ketoacidosis (DKA), low insulin content causes the generation of a large amount of ketone.Acetone is spontaneous for AcAc decarboxylation acid and produces, and is the contributor of fruit sweet taste in ketoacidosis patient respiratory gas.
The diagnosis of domestic diabetes DKA verifies as main with blood ketone and urine ketoboidies, the detection of blood ketone is diagnosis and the important laboratory checking index of assessment diabetes DKA conditions of patients change, but is all invasive, needs venous blood samples or finger, bring certain misery to patient, and need to detect overlong time；The fast diagnosis reagent of the auxiliary diagnosis of diabetes DKA is less, clinic often judges the concentration of ketoboidies in blood samples of patients indirectly with traditional urine ketone body detecting method at present, one of foundation as diagnosis DKA, although the method is simple and easy to do, but false positive or false-negative result easily occur, and also affected by renal function, tend not to the state of an illness accurately reflected at that time.
Utility model content
In view of this, this utility model provides a kind of device of acetone detection in breathing, and solves the problem of acetone during quicklook detection is breathed.
Further, this utility model provides a kind of device of acetone detection in breathing, and the device solving acetone detection is the most portable, the problem that operation is complicated.
This utility model additionally provides a kind of device of acetone detection in breathing, including the first block, the first filtration cover plate, detection pipe, the second filtration cover plate and the second block, pass through in described detection pipe and be arranged in order the first ampoule and the second ampoule, first ampoule is equipped with liquid reagent, second ampoule is built with solid composite, described liquid reagent includes that ammonia, described solid composite include ammonium sulfate, sodium nitroprusside and silicon dioxide；It is plugged with the first filtration cover plate in the one end open of detection pipe, is cased with the first block outside opening, is plugged with the second filtration cover plate in other end opening, outside opening, is cased with the second block.
Preferably, a kind of device of acetone detection in breathing, liquid reagent includes the ammonia that volumetric concentration is 5-25%, and described solid composite includes that ammonium sulfate, sodium nitroprusside and silicon dioxide, described ammonium sulfate, sodium nitroprusside and silica weight portion rate are 75～150:2.5～7.5:75～150
Preferably, detection pipe is transparent elastic PETG pipe.
Preferably, the first ampoule and the second ampoule are the transparent vial crumbed.
Use provided by the utility model a kind of for breathe in acetone detection device, can be used for breathe in acetone react, by color change can intuitive judgment breathing in content of acetone level, there is high accuracy, repeatability and susceptiveness.
Further, a kind of device that acetone detects in breathing of the present utility model is disposable rapid in-vitro diagnostic reagent product, quickly sensing, it is easy to carry about with one, ease of Use, for measuring the acetone level in experimenter's exhaled gas, belongs to qualitative detection, for the patient of ketone content elevated risk in blood, such as diabetics etc..The horizontal examination of ketone for earliest stages, and with treatment after monitoring, in order to carry out early treating and Disease epizootic.
Accompanying drawing explanation
Fig. 1 is a kind of structural representation of the device of acetone detection in breathing of the present utility model.
Detailed description of the invention
Being described principle of the present utility model and feature below, illustrated embodiment is served only for explaining this utility model, is not intended to limit scope of the present utility model.
A kind of device of acetone detection design on the basis of micropartical catalysis (MPC) biosensor technology principle in breathing of the present utility model.The material that this micropartical is catalyzed during (MPC) biosensor technology can be exhaled by seizure quickly identifies the health of experimenter.Detector uses little tube packaging, and built with two ampoules, ampoule, built with reacting substance, is successively crushed before use by ampoule, discharges reacting substance and is combined generation complex with the middle material of expiration, color change occurs then.Therefore experimenter can be easily accomplished detection within a few minutes.
Embodiment one:
A kind of for breathe in acetone detection sensor, including liquid reagent and solid composite, liquid reagent be volumetric concentration be the ammonia of 5%, it can accelerate reaction, accelerate developing time；Solid composite is 75mg ammonium sulfate, 2.5mg sodium nitroprusside and 75mg silicon dioxide, and silicon dioxide is used for adsorbing volatile letones, ammonium sulfate and sodium nitroprusside in expiration and is used for reacting with acetone.
Embodiment two:
A kind of for breathe in acetone detection sensor, including liquid reagent and solid composite, liquid reagent be volumetric concentration be the ammonia of 15%, it can accelerate reaction, accelerate developing time；Solid composite is 80mg ammonium sulfate, 5mg sodium nitroprusside and 110mg silicon dioxide.
Embodiment three:
A kind of for breathe in acetone detection sensor, including liquid reagent and solid composite, liquid reagent be volumetric concentration be the ammonia of 25%, it can accelerate reaction, accelerate developing time；Solid composite is 125mg ammonium sulfate, 7.5mg sodium nitroprusside and 125mg silicon dioxide.
Embodiment four:
Refer to Fig. 1, a kind of device of acetone detection in breathing, filter cover plate 2 including the first block 1, first, detection pipe 3, second filters cover plate 4 and the second block 5, detection pipe 3 is built with the first ampoule 31 and the second ampoule 32, first ampoule 31 and linear being arranged in of the second ampoule 32 are detected in pipe 3, first ampoule 31 is equipped with liquid reagent 311, liquid reagent 311 is the ammonia of 2ml volumetric concentration 5%, second ampoule 32 is equipped with solid composite 321, and solid composite 321 is 75mg ammonium sulfate, 2.5mg sodium nitroprusside and 75mg silicon dioxide.Detection pipe 3 one end is connected with the first filtration cover plate 2 and the first block 1, the other end is connected with the second filtration cover plate 4 and the second block 5, first filtration cover plate 2 and the second filtration cover plate 4 clog two openings of detection pipe 3 respectively, on the one hand the first ampoule 31 and the second ampoule 32 in spacing detection pipe 3, on the other hand can pass through breathing gas.First block 1 and the second block 5 are respectively fitted over the two ends of detection pipe, and detection pipe 3 is transparent elastic PETG pipe, and the first ampoule 31 and the second ampoule 32 are the transparent vial crumbed.
Filter cover plate and on the one hand can prevent the liquid reagent extravasation of reaction, on the other hand can pass through again breathing gas.
First ampoule and the second ampoule are the transparent vial crumbed；Detection pipe is transparent elastic PETG pipe.
A kind of in breathing the production method of device of acetone detection include；
The preparation of the first ampoule 31: dose volume concentration be 5% ammonia and in loading ampoule bottle embedding become the first ampoule 31；
The preparation of the second ampoule 32: in 75mg ammonium sulfate, 2.5mg sodium nitroprusside and 75mg silicon dioxide are added ampoule bottle, embedding becomes the second ampoule 32；
Assembling: the first filtration cover plate 2 is clogged detection pipe 3 one end open, the first ampoule 31 and the second ampoule 32 is put into from detection pipe 3 from the other end opening part of detection pipe 3, after by second filtration cover plate 4 clog, detection pipe two ends entangle with the first block 1 and the second block 5 respectively.
A kind of in breathing the using method of device of acetone detection include:
Take off the block at detection pipe two ends；Pinch detection pipe, makes to rupture equipped with the second ampoule 32 of solid composite；Deeply breathe, once blow in pipe 30 seconds with strength；
Again the block at detection pipe two ends is covered；Pinch detection pipe, makes to rupture equipped with the first ampoule 31 of liquid reagent, acutely rocks 5 seconds；
Flicking detection pipe, one end upward, makes all agent assembles to one end of detection pipe, waits 2min, observes color change；
By the color identification result in detection pipe, it is judged that standard is: reagent becomes lavender or bluish violet, show that the ketone level in blood is greater than or equal to 1.5mmol/l；Negative findings: reagent becomes light brown or yellow, shows that the ketone level in blood is less than 1.5mmol/l.
Embodiment five:
The difference of embodiment five and embodiment four is: liquid reagent be 1ml volumetric concentration be the ammonia of 15%；Solid composite is 80mg ammonium sulfate, 5mg sodium nitroprusside and 110mg silicon dioxide.
Embodiment six:
The difference of embodiment six and embodiment four is: liquid reagent is the ammonia of 0.5ml volumetric concentration 25%；Solid composite is 125mg ammonium sulfate, 7.5mg sodium nitroprusside and 125mg silicon dioxide.
Performance test: prepared by embodiment four to six be used for breathing in the device of acetone detection carry out performance test:
Comparison and detection experimental implementation: take off the top of atomizing cup, adds the acetone standard solution of the present embodiment in specimen cup, adds to graduation mark 6ml～8ml of atomizing cup labelling.Covering the top of atomizing cup, be connected the one of pipe with bottom of cups, one is connected with the gas outlet of nebulizer.The pipe being connected with breathing ketone detector is connected with atomizing cup top.Keep atomizing cup upright.Respectively by embodiment four to six be used for breathe in acetone detection each 5 of device.
30 draw blank solution (acetone concentration is 0.000mg/ml) detection；30 negative acetone standard solution (acetone concentration is 0.0056mg/ml) of drawing are detected；30 positive acetone titers (acetone concentration is 0.0224mg/ml) of drawing are detected.Result: blank solution, the most no positive；Negative standards's solution, is feminine gender；Positive criteria solution, is the positive.
Show that according to clinical test results the device of acetone detection, the blood ketone instrument testing result blood ketone >=1.5mmol/l in breathing that this utility model produces breathes ketone detector test positive；Blood ketone ＜ 1.5mmol/l, breathes ketone detector and is detected as feminine gender.The clinical test results positive coincidence rate 100.0% of 200 examples, negative match-rate 99.45%, total coincidence rate 99.50%.Breathe ketone detector and blood ketone marginal value 1.5mmol/l is had preferable qualitative effect, be conducive to hyperketonemia and the treatment of ketone acidosic examination detect and track clinically.
In sum, use provided by the utility model for breathe in acetone detection sensor, can be used for breathe in acetone react, by color change can intuitive judgment breathing in content of acetone level, there is high accuracy, repeatability and susceptiveness.
A kind of device that acetone detects in breathing of the present utility model is disposable rapid in-vitro diagnostic reagent product, quickly sensing, it is easy to carry about with one, ease of Use, for measuring the acetone level in experimenter's exhaled gas, belong to qualitative detection, for the patient of ketone content elevated risk in blood, such as diabetics etc..The horizontal examination of ketone for earliest stages, and with treatment after monitoring, in order to carry out early treating and Disease epizootic.
A kind of production method Simple assembled of the device of acetone detection in breathing of the present utility model, low cost, efficiency is high.
The foregoing is only preferred embodiment of the present utility model; not in order to limit this utility model; all within spirit of the present utility model and principle, any modification, equivalent substitution and improvement etc. done, should be included within the scope of this utility model protection.
Claims (3)
1. the device of acetone detection in breathing, it is characterized in that: include the first block, the first filtration cover plate, detection pipe, the second filtration cover plate and the second block, pass through in described detection pipe and be arranged in order the first ampoule and the second ampoule, first ampoule is equipped with liquid reagent, and the second ampoule is built with solid composite；It is plugged with the first filtration cover plate in the one end open of detection pipe, is cased with the first block outside opening, is plugged with the second filtration cover plate in other end opening, outside opening, is cased with the second block.
A kind of device of acetone detection in breathing the most according to claim 1, it is characterised in that: described detection pipe is transparent elastic PETG pipe.
A kind of device of acetone detection in breathing the most according to claim 1 and 2, it is characterised in that: described first ampoule and the second ampoule are the transparent vial crumbed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201521125748.0U CN205449811U (en) | 2015-12-30 | 2015-12-30 | A device for breathing well acetone detects |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201521125748.0U CN205449811U (en) | 2015-12-30 | 2015-12-30 | A device for breathing well acetone detects |
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| CN205449811U true CN205449811U (en) | 2016-08-10 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105445267A (en) * | 2015-12-30 | 2016-03-30 | 海南赛维埃克斯生物科技有限公司 | Sensor and device for detection of acetone during breathing, and production method of device |
| CN114009883A (en) * | 2022-01-04 | 2022-02-08 | 中南大学 | Novel visual quick noninvasive closed-loop mouth-nose mask for screening coronavirus and diabetes patients |
-
2015
- 2015-12-30 CN CN201521125748.0U patent/CN205449811U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105445267A (en) * | 2015-12-30 | 2016-03-30 | 海南赛维埃克斯生物科技有限公司 | Sensor and device for detection of acetone during breathing, and production method of device |
| CN114009883A (en) * | 2022-01-04 | 2022-02-08 | 中南大学 | Novel visual quick noninvasive closed-loop mouth-nose mask for screening coronavirus and diabetes patients |
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Effective date of registration: 20180223 Address after: 518000 Guangdong city of Shenzhen province Nanshan District Xili Street Tang Lang with rich industrial city 6 Building 2 floor B Patentee after: Shenzhen city Saiweiaikesi Biological Technology Co. Ltd. Address before: 570100 Hainan Haikou Haikou high tech Zone Nanhai Road No. 266 incubator center Patentee before: HAINAN SAVY -AKERS BIOSCIENCES CO., LTD. |