CN201063030Y

CN201063030Y - Experimental device for testing penetration of skin by medicament

Info

Publication number: CN201063030Y
Application number: CNU2007200799325U
Authority: CN
Inventors: 阮卫明; 张三钧
Original assignee: Individual
Current assignee: Individual
Priority date: 2007-06-15
Filing date: 2007-06-15
Publication date: 2008-05-21
Anticipated expiration: 2017-06-15

Abstract

The utility model discloses an experimental device for testing drug penetrating skin, which comprises an isothermal water-bath case, a controlling case, an operating board, a penetrating diffusion pool, a fluid infusion bottle and a connecting tube; the upper part of an internal bottle of the penetrating diffusion pool is provided with a fluid infusion port; the controlling case is respectively electrically connected with the isothermal water-bath case and the operating board through wire, the isothermal water-bath case is communicated with an external bottle of the penetrating diffusion pool through the connecting tube, the fluid infusion bottle is communicated with the fluid infusion port of the penetrating diffusion pool through the connecting tube, and the penetrating diffusion pool is positioned on the operating board. The utility model has simple structure and reasonable design; a plurality of experiments can be done at the same time without mutual interference and bubble and the experiment data is correct.

Description

A kind of experimental provision of testing drug transdermal

Technical field

The utility model relates to a kind of medical experimental provision, a kind of specifically experimental provision of testing drug transdermal.

Background technology

The research experiment device of skin penetration, absorption is to be used to study a kind of experimental provision of sustained release medicine by intact skin.That puts down in writing on the at present external data only penetrates diffusion cell (also being the transdermal diffusion cell), and referring to Fig. 4, its structure is made up of interior bottle and cover outer blank outside, and outer blank one side is provided with import and outlet, and interior bottle is tiltedly stretched out a liquid taking port, do not have the fluid infusion mouth.During practical operation, fluid infusion and get liquid and all carry out from liquid taking port.Get fluid infusion again behind the liquid, can produce bubble with receiving between the liquid at skin, this moment, medicine passed the useful area minimizing of skin, made test data inaccurate, influenced experiment effect.

The utility model content

The purpose of this utility model is to overcome the prior art deficiency, and a kind of experimental provision of testing drug transdermal is provided, it has improved the external diffusion cell that penetrates, and has overcome the problem that produces bubble, becomes complete, the experimental provision independently of a cover.

For reaching the foregoing invention purpose, the technical scheme that is adopted is: a kind of experimental provision of testing drug transdermal, and it comprises constant water bath box, control box, operator's console, penetrates diffusion cell, fluid infusion bottle and connecting pipe; Comprise in the described constant water bath box that water bath with thermostatic control produces pond and water pump; Battery main switch, display lamp, timer, thermostatic control switch, pump switch and stirring switch are set on the described control box panel; Described operator's console comprises aluminum shell, be arranged on the some speed-regulating switchs on the panel and be arranged on the motor of the equal number in the machine; The axle of described motor is gone up irony backing plate of horizontal fixed, and two blocks of magnet be arranged in parallel on the backing plate; The branch road parallel connection that battery main switch is controlled through timer and thermostatic control switch, pump switch and stirring switch, each motor and each contented speed-regulating switch form branch road and connect with the stirring switch in parallel; The described diffusion cell that penetrates comprises interior bottle and cover outer blank outside; The side of described outer blank is provided with import and the outlet that is communicated with constant water bath box, the top of bottle is provided with the fluid infusion mouth that is communicated with the fluid infusion bottle in described, the middle part is provided with the liquid taking port that stretches out through outer blank, in the bottom of bottle place the magnetic stirrer, the upper end bottle mouth position of interior bottle be provided with one cooperate with it release a pond.Described control line realizes that with constant water bath box, operator's console circuit connects respectively through electric wire, described constant water bath box is connected with the outer blank that penetrates diffusion cell through connecting pipe, described fluid infusion bottle is connected with the fluid infusion mouth that penetrates diffusion cell through connecting pipe, and the described diffusion cell that penetrates is placed on the operator's console.

In the such scheme, a fixed mount is set on the operator's console, geometrical clamp can move on fixed mount, and geometrical clamp clamps described bottleneck and the release pond that penetrates diffusion cell up and down.

In the such scheme, the rotational speed meters identical with speed-regulating switch quantity is set on the operator's console panel, rotational speed meters connects with described stirring switch in parallel.

The diffusion cell that penetrates of the present utility model has changed liquid taking port and fluid infusion mouth for structure flatly, is provided with fluid infusion mouth and liquid taking port respectively, makes in the experimentation, after the sampling fluid infusion, can not produce no bubble phenomenon, has guaranteed the accuracy of experimental data.Simultaneously can do plural experiment, eliminated the phenomenon of phase mutual interference, owing to adopt magnetic to stir, can only singlely do experiment usually, when testing more than two, need penetrate diffusion cell at a distance of bigger, otherwise the mutual interference of meeting phase, irony backing plate of the utility model design, magnet is arranged on the backing plate, can eliminate the phase mutual interference, not need wide apart just can do a plurality of experiments simultaneously.Form the device of independent completion, three casings organically link into an integrated entity by the connection of electric wire or pipeline, form a complete skin penetration diffusion experiment device that carries out.

Description of drawings

Fig. 1 is the utility model structural representation;

Fig. 2 is the utility model circuit theory diagrams;

Fig. 3 is the structural representation that the utility model penetrates diffusion cell;

Fig. 4 is the existing diffusion cell structural representation that penetrates;

Fig. 5 is the vertical view of the utility model motor

Embodiment

Below in conjunction with accompanying drawing the utility model is described in further detail:

Shown in Fig. 1,3,5, a kind of experimental provision of testing drug transdermal comprises constant water bath box 1, control box 2, operator's console 3, penetrates diffusion cell 4, fluid infusion bottle 5 and connecting pipe 6; Constant water bath box 1 is made up of water bath with thermostatic control occurred pool 11 and water pump 12; Battery main switch 21, display lamp 22, timer 23, thermostatic control switch 24, pump switch 25 are set on control box 2 panels and stir switch 26; Operator's console 3 comprises aluminium shell 31, is arranged on some speed-regulating switchs 32 with the speed-regulating switch 32 quantity identical motor 33 interior with being arranged on machine on the panel; The axle of each motor 33 is gone up irony backing plate 34 of horizontal fixed, and two blocks of magnet 35 be arranged in parallel on the backing plate 34.Battery main switch 21 is through timer 23 and thermostatic control switch 24, pump switch 25 and stir in parallel company of branch road that switch 26 is controlled, each motor 33 and the 32 formation branch roads of speed-regulating switch separately and with 26 parallel connections of stirring switch.

As shown in Figure 3, penetrate diffusion cell 4 and comprise interior bottle 41 and cover outer blank 42 outside; The right side of outer blank 42 is provided with import 43 and the outlet 44 that is communicated with constant water bath box 1, the top of interior bottle is provided with the fluid infusion mouth 45 that is communicated with fluid infusion bottle 5, the middle part is provided with through outer blank 42 stretches out liquid taking port 47, the magnetic stirrer is placed in the bottom of interior bottle 41, can be the tetrafluoro stirrer, the upper end bottle mouth position of interior bottle 41 be provided with a release pond 46 that cooperates with it.The bottle mouth position that discharges pond 46 and interior bottle 41 is placed intact skin, and the two outside flange is convenient to clamp.

Import 43 and the outlet 44 of constant water bath box 1 on connecting pipe 6 and the outer blank 42 that penetrates diffusion cell 4 is connected, and penetrates diffusion cell 4 and directly is placed on the shell 31 of operator's console 3.Fluid infusion bottle 5 positions can be placed arbitrarily as required, and the outlet 51 of its bottom communicates with fluid infusion mouth 45 on penetrating diffusion cell 4 by connecting pipe 52.

A fixed mount 36 is set on the operator's console 3, and geometrical clamp 37 can move horizontally on fixed mount 36, and geometrical clamp 37 can clamp the bottleneck that penetrates diffusion cell 4 up and down and discharge pond 46.

The rotational speed meters 38 identical with speed-regulating switch 32 quantity is set on operator's console 3 panels, and rotational speed meters 38 is used to measure actual speed,

rotational speed meters

38 and 26 parallel connections of stirring switch.

Motor 33 can adopt small-sized axial flow fan, both can drive magnet 35 and rotate, and can in time dispel the heat again.

As shown in Figure 4, the existing diffusion cell that penetrates comprises outer blank 91 and interior bottle 92; Outer blank 91 left sides are provided with import and the outlet that links to each other with water bath with thermostatic control, contain isothermal liquid 93 in the outer blank 91, and with the reception liquid 95 needed temperature in the bottle 92 in guaranteeing, the bottom of interior bottle 92 is provided with a magnetic stirrer 94, make to receive liquid 95 fast evenly; A liquid taking port 98 is tiltedly stretched out on interior bottle 92 right sides, also is the fluid infusion mouth simultaneously, and intact skin 96 is placed on bottleneck and discharges between the pond 97.

Claims

1. the experimental provision of a testing drug transdermal, it is characterized in that: it comprises constant water bath box (1), control box (2), operator's console (3), penetrates diffusion cell (4), fluid infusion bottle (5) and connecting pipe (6); Comprise in the described constant water bath box (1) that water bath with thermostatic control produces pond and water pump (12); Described control box (2) panel is provided with battery main switch (21), display lamp (22), timer (23), thermostatic control switch (24), pump switch (25) and stirs switch (26); Described operator's console (3) comprises aluminum shell, be arranged on several speed-regulating switchs (32) on the panel and be arranged on the motor (33) of the equal number in the machine; The axle of described motor (33) is gone up an irony backing plate of horizontal fixed (34), and two blocks of magnet (35) be arranged in parallel on the backing plate (34); Battery main switch (21) is connected in parallel through the branch road of timer (23) with thermostatic control switch (24), pump switch (25) and stirring switch (26) control, and each motor (33) and speed-regulating switch separately (32) form branch road and stir switch (26) and be connected in parallel; The described diffusion cell (4) that penetrates comprises interior bottle (41) and cover outer blank (42) outside; The side of described outer blank (42) is provided with import (43) and the outlet (44) that is communicated with constant water bath box (1), the top of bottle (41) is provided with the fluid infusion mouth (45) that is communicated with fluid infusion bottle (5) in described, the middle part is provided with the liquid taking port (47) that stretches out through outer blank (42), the magnetic stirrer is placed in the bottom of interior bottle (41), and the upper end bottle mouth position of interior bottle (41) is provided with a release pond (46) that cooperates with it; Described control box (2) realizes that with constant water bath box (1), operator's console (3) circuit connects respectively through electric wire, described constant water bath box (1) is communicated with the outer blank that penetrates diffusion cell (4) (42) through connecting pipe (6), described fluid infusion bottle (5) is connected with the fluid infusion mouth (45) that penetrates diffusion cell (4) through connecting pipe (6), and the described diffusion cell (4) that penetrates is placed on the operator's console (3).

2. the experimental provision of a kind of testing drug transdermal according to claim 1, it is characterized in that: described operator's console (3) is gone up and is placed a fixed mount (36), geometrical clamp (37) can be gone up at fixed mount (36) and move, and geometrical clamp (37) clamps described bottleneck and the release pond (46) that penetrates diffusion cell (4) up and down.

3. the experimental provision of a kind of testing drug transdermal according to claim 1, it is characterized in that: the rotational speed meters (38) identical with speed-regulating switch (32) quantity, rotational speed meters (38) and described stirring switch (26) parallel connection are set on described operator's console (3) panel.

4. the experimental provision of a kind of testing drug transdermal according to claim 1 is characterized in that: described motor (33) adopts axial flow blower.