CN216247917U - Dynamic dissolution curve measuring device - Google Patents
Dynamic dissolution curve measuring device Download PDFInfo
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- CN216247917U CN216247917U CN202122612788.XU CN202122612788U CN216247917U CN 216247917 U CN216247917 U CN 216247917U CN 202122612788 U CN202122612788 U CN 202122612788U CN 216247917 U CN216247917 U CN 216247917U
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Abstract
The utility model belongs to the field of laboratory devices, and particularly relates to a dynamic dissolution curve measuring device. The device comprises a dissolution instrument main body, wherein the dissolution instrument main body comprises dissolution cups and a tank body, a flow control plate is arranged at the cup mouths of the dissolution cups and at the opening positions of the tank body, the flow control plate is connected with the tank body, openings corresponding to the dissolution cups are formed in the flow control plate, a conveying pipeline communicated with each dissolution cup is arranged in the flow control plate, a valve is arranged at each outlet close to the dissolution cup, one side of the flow control plate is connected with a flow pipeline, a flow channel is communicated with the conveying pipeline, one end of the flow pipeline, far away from the flow control plate, is connected with a flow pump, the outlet of the flow pump is connected with the flow pipeline, and the inlet of the flow pump is connected with a buffer solution storage tank; each dissolution cup is connected with a pH meter. The beneficial effect of this device does: the buffer solution storage tank, the flow pump and the flow control board are arranged to convey the buffer solution into the dissolution cup, and the pH value can be regulated and controlled by regulating the solute.
Description
Technical Field
The utility model belongs to the field of laboratory devices, and particularly relates to a dynamic dissolution curve measuring device.
Background
After the drug is prepared, in order to detect the dissolution rate of the drug in a human body, a dissolution apparatus is usually used to simulate a human body environment to detect the dissolution rate of the drug, and the existing dissolution apparatus generally comprises a tank body, a rotary basket, a dissolution cup, a heating pump, a temperature adjusting unit and the like. It adopts heat pump circulation to heat the dissolving medium in the tank to 37 deg.C, and makes constant temperature, and transfers the heat quantity into the dissolving cup, and after the dissolving medium is constant temperature, makes dissolution curve determination. However, the existing dissolution apparatus can only measure the dissolution curve of the drug in a certain fixed medium, cannot detect the dissolution curves of the drug in media with different pH values, and cannot simulate the environment of pH change in human body. Causes the difference between the actual dissolution rate of the medicine in a human body and the detected dissolution rate.
CN113359905A discloses a dissolution apparatus programmable temperature rising device and a dissolution apparatus, the dissolution apparatus is provided with a water bath, the dissolution apparatus programmable temperature rising device comprises: the water inlet of the circulating water bath is communicated with the water outlet of the water bath tank, and the water outlet of the circulating water bath is communicated with the water inlet of the water bath tank; and the temperature probe is inserted into the water bath tank to detect the water temperature, and feeds a detection result back to the circulating water bath tank to carry out heating control. The circulating water bath kettle has a temperature programming function, and can realize temperature control feedback through the temperature probe, namely the temperature probe is placed in the water bath, and the circulating water bath kettle controls the temperature in real time through the data of the temperature probe, so that the accuracy and uniformity of the temperature of the water bath of the dissolution instrument are ensured. Although the device realizes temperature regulation, the device still does not realize the problem of pH regulation.
In view of the above problems, it is desirable to provide a dissolution apparatus with adjustable pH.
Disclosure of Invention
In order to solve the problems, the utility model provides a dynamic dissolution curve measuring device which is mainly characterized in that a buffer solution storage tank, a flow pump and a flow control plate are arranged, the buffer solution is conveyed into a dissolution cup, and the pH value is adjustable by adjusting solute;
the device comprises a dissolution instrument main body, wherein the dissolution instrument main body comprises dissolution cups and a tank body, and is characterized in that a flow control plate is arranged at the cup mouths of the dissolution cups and at the opening positions of the tank body, the flow control plate is connected with the tank body, openings corresponding to the dissolution cups are formed in the flow control plate, a conveying pipeline communicated with each dissolution cup is arranged in the flow control plate, a valve is arranged at each outlet close to the dissolution cup, the valve can be a common valve or an electric valve, and is commercially available, a flow pipeline is connected to one side of the flow control plate, the flow pipeline is communicated with the conveying pipeline, one end of the flow pipeline far away from the flow control plate is connected with a flow pump, the outlet of the flow pump is connected with the flow pipeline, and the inlet of the flow pump is connected with a buffer solution storage tank; each dissolution cup is connected with a pH meter.
The pH meter is of a conventional construction and generally comprises a probe, a pH value display screen and a body.
The cross-sectional area of the flow control plate is the same as that of the groove body.
The flow control board and the pH meter are arranged into a whole, and the pH value display screen is positioned on the flow control board. The two are integrated, so that the structure is simpler and the operation is more convenient.
The flow control plate and the pH meter are not integrated, and the opening parts of the flow control plate and each dissolution cup are connected with the pH meter.
The opening size of the flow control plate is the same as the inner diameter of the mouth of the dissolution cup. Certainly, the dissolution cup can be different from the flow control plate when the opening is smaller than the cup opening; when the opening is larger than the cup mouth, the dissolving-out cup is placed in the groove body and is not fixed on the flow control plate.
The size of the opening of the flow control plate is smaller than the inner diameter of the cup mouth of the dissolving-out cup, and the outlet opening of the conveying pipeline is downward; the downward opening can effectively prevent the buffer solution from splashing.
The flow pump is a common water pump sold in the market.
The flow pump is electrically connected with the power supply of the dissolution instrument main body.
The buffer solution storage tank is a tank body filled with buffer solution and is connected with the flow pump through a pipeline.
The pH meter is electrically connected with a power supply or is provided with a battery.
The utility model has the beneficial effects that:
(1) the buffer solution storage tank, the flow pump and the flow control board are arranged to convey the buffer solution into the dissolution cup, and the pH value can be regulated and controlled by regulating solute.
(2) The flow control plate and the pH meter are integrated, the structure is simpler, the operation is more convenient, and the working efficiency is improved.
Drawings
FIG. 1 is a schematic view of the entire structure of embodiment 1;
FIG. 2 is a schematic view of the internal structure of embodiment 1;
FIG. 3 is an enlarged view of a part of the structure of embodiment 1;
FIG. 4 is an internal structure view of a flow control plate according to embodiment 1;
FIG. 5 is a schematic view of the entire structure of embodiment 2;
fig. 6 is an internal structure view of a flow rate control plate according to embodiment 2.
In the figure: 1. the elution instrument comprises a main body 11, an elution cup 12, a tank body 2, a flow control plate 21, a conveying pipeline 22, a valve 3, a flow pipeline 4, a flow pump 5, a buffer storage tank 6, a pH meter 61 and a pH value display screen.
Detailed Description
The present invention will now be further described with reference to specific embodiments in order to enable those skilled in the art to better understand the present invention.
Example 1
A dynamic dissolution curve measuring device comprises a dissolution instrument main body 1, wherein the dissolution instrument main body 1 comprises a dissolution cup 11 and a tank body 12, a flow control plate 2 is arranged at the cup mouth of the dissolution cup 11 and at the opening position of the tank body 12, the flow control plate 2 is connected with the tank body 12, an opening corresponding to the dissolution cup 11 is arranged on the flow control plate 2, a conveying pipeline 21 communicated with each dissolution cup 11 is arranged in the flow control plate 2, a valve 22 is arranged at each outlet close to the dissolution cup 11, the valve 22 is a common commercially available valve, a flow pipeline 3 is connected to one side of the flow control plate 2, the flow pipeline 3 is communicated with the conveying pipeline 21, one end of the flow pipeline 3 far away from the flow control plate 2 is connected with a flow pump 4, the outlet of the flow pump 4 is connected with the flow pipeline 3, and the inlet of the flow pump 4 is connected with a buffer solution storage tank 5; each dissolution cup 11 is connected with a pH meter 6.
The cross-sectional area of the flow control plate 2 is the same as the cross-sectional area of the tank body 12.
The flow control plate 2 and the pH meter 6 are integrated, and a pH value display screen 61 is arranged on the flow control plate 2. The two are integrated, so that the structure is simpler and the operation is more convenient.
The size of the opening of the flow control plate 2 is the same as the inner diameter of the rim of the dissolution cup 11.
The flow pump 4 is a commercially available ordinary water pump.
The flow pump 4 is electrically connected with the power supply of the dissolution instrument main body 1.
The buffer storage tank 5 is a tank filled with buffer and is connected with the flow pump 4 through a pipeline.
The pH meter 6 is electrically connected with a power supply.
Example 2
The difference from embodiment 1 is that, in embodiment 2:
the flow rate control plate 2 and the pH meter 6 are not integrated, and the pH meter 6 is connected to the flow rate control plate 2 at the opening corresponding to each dissolution cup 11.
The opening size of the flow control plate 2 is smaller than the inner diameter of the mouth of the dissolution cup 11; the dissolving cup 11 is fixed on the flow control plate 2;
the outlet opening of the delivery duct 21 is downward; the downward opening can effectively prevent the buffer solution from splashing.
The pH meter 6 is battery powered.
In the description of the present invention, it should be noted that the terms "upper", "lower", "inside", "outside", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience in describing the present invention and simplifying the description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention; furthermore, in the description of the present invention, unless otherwise explicitly specified or limited, the terms "connected" and "connected" are to be construed broadly, e.g., as meaning both detachably connected and integrally connected; can be electrically connected or connected by a pipeline; it is to be understood that the terms used in the present invention have the meanings as given in the detailed description, to those skilled in the art.
Claims (10)
1. A dynamic dissolution curve measuring device comprises a dissolution instrument main body, wherein the dissolution instrument main body comprises a dissolution cup and a groove body; the device is characterized in that a flow control plate is arranged at the position of a cup opening of the dissolving-out cup and positioned at an opening of the tank body, the flow control plate is connected with the tank body, an opening corresponding to the dissolving-out cup is formed in the flow control plate, a conveying pipeline communicated with each dissolving-out cup is arranged in the flow control plate, a valve is arranged at an outlet close to each dissolving-out cup, one side of the flow control plate is connected with a flow pipeline, the flow pipeline is communicated with the conveying pipeline, one end of the flow pipeline, far away from the flow control plate, is connected with a flow pump, an outlet of the flow pump is connected with the flow pipeline, and an inlet of the flow pump is connected with a buffer solution storage tank; each dissolution cup is connected with a pH meter.
2. The apparatus of claim 1, wherein the cross-sectional area of the flow control plate is the same as the cross-sectional area of the channel.
3. The apparatus according to claim 1, wherein the flow control plate is integrated with the pH meter, and the flow control plate is provided with a pH display.
4. The dynamic dissolution profile measuring apparatus according to claim 1, wherein the flow control plate and the pH meter are not integrally configured, and the pH meter is connected to the opening of the flow control plate corresponding to each dissolution cup.
5. The dynamic dissolution profile apparatus of claim 1, wherein the size of the opening of the flow control plate is the same as the inner diameter of the rim of the dissolution cup.
6. The dynamic dissolution profile apparatus of claim 1, wherein the flow control plate has an opening smaller than the inner diameter of the mouth of the dissolution cup, and the outlet of the delivery conduit opens downwardly.
7. A dynamic dissolution profile apparatus as claimed in claim 1, wherein the flow pump is a commercially available conventional water pump.
8. The dynamic dissolution profile apparatus of claim 1, wherein the flow pump is electrically connected to a dissolution meter body power source.
9. The dynamic dissolution profile apparatus of claim 1, wherein the buffer reservoir is a buffer-containing tank connected to a flow pump via a tube.
10. The dynamic dissolution profile apparatus of claim 1, wherein the pH meter is electrically connected to a power source or is equipped with a battery.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202122612788.XU CN216247917U (en) | 2021-10-28 | 2021-10-28 | Dynamic dissolution curve measuring device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202122612788.XU CN216247917U (en) | 2021-10-28 | 2021-10-28 | Dynamic dissolution curve measuring device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN216247917U true CN216247917U (en) | 2022-04-08 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202122612788.XU Active CN216247917U (en) | 2021-10-28 | 2021-10-28 | Dynamic dissolution curve measuring device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN216247917U (en) |
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2021
- 2021-10-28 CN CN202122612788.XU patent/CN216247917U/en active Active
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| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of utility model: A dynamic dissolution curve measuring device Effective date of registration: 20220718 Granted publication date: 20220408 Pledgee: Postal Savings Bank of China Limited Jinan Branch Pledgor: JINAN TONGLU PHARMACEUTICAL TECHNOLOGY DEVELOPMENT CO.,LTD. Registration number: Y2022980010683 |