CN213957074U

CN213957074U - Sample plate and negative pressure-based blood viscosity detection device matched with same

Info

Publication number: CN213957074U
Application number: CN202022959676.7U
Authority: CN
Inventors: 曹世芬; 刘国文; 袁智豪; 周定东; 黄逖
Original assignee: Chongqing Yifu Scientific Instrument Co ltd
Current assignee: Chongqing Yifu Scientific Instrument Co ltd
Priority date: 2020-12-09
Filing date: 2020-12-09
Publication date: 2021-08-13
Anticipated expiration: 2030-12-09

Abstract

The utility model belongs to the technical field of medical instrument, specifically disclose a sample board and rather than the blood viscosity detection device of complex based on negative pressure, this sample board includes the sample board main part, is provided with the capillary in the sample board main part, and the one end of capillary is equipped with the sample and adds the mouth, and the other end of capillary is provided with sample test interface, and sample interpolation mouth department can dismantle and be provided with plasma filtration membrane, and the device includes the negative pressure adjustment mechanism of pressure storehouse and regulated pressure storehouse pressure. By adopting the technical scheme, the blood viscosity can be quickly detected by combining the sample plate and the blood viscosity detection device, the structure of the device is simplified, and the operation is simple and convenient.

Description

Sample plate and negative pressure-based blood viscosity detection device matched with same

Technical Field

The utility model belongs to the technical field of medical instrument, a sample board reaches rather than complex blood viscosity detection device based on negative pressure is related to.

Background

In the medical field, measuring the viscosity of blood and other physiological fluids is a newly developed diagnostic means, and particularly, the application of the method in diagnosis of cardiovascular diseases, cancer, tumor and other difficult and complicated diseases is relatively wide. However, the conventional medical blood viscosity measuring instrument is complicated to operate and requires a large amount of blood to be collected. The existing blood viscosity measurement methods mainly include capillary methods, rotational methods, falling body methods, vibration methods, plate methods and the like. The simplest measurement method is the capillary method, i.e. the Pinkevitch viscometer. For example: the invention discloses a viscometer of an intelligent capillary blood viscometer with a Chinese patent No. 98239208.3, which comprises a glass vertical tube, a glass capillary tube horizontally arranged and communicated with a lower port of the vertical tube, wherein the vertical tube and the glass capillary tube are both arranged in a constant temperature water bath box, a load sensor is arranged at the lower end of the glass capillary tube, the sensor transmits signals to a computer through an A/D acquisition card, a plastic tube is communicated with an inlet of the glass vertical tube, and a sample inlet tube, a test tube and a blow-dry tube are communicated with the plastic tube. However, the capillary tube used in this viscometer has an inner diameter of millimeter order, and because the capillary tube has a large inner diameter, it is necessary to draw a large amount of blood for a patient in clinical use, the amount of blood required is generally more than 10ml, and the sample amount is large, so that the instrument is not suitable for hospital clinical use. Meanwhile, the device is also provided with a temperature control unit, the structure is complex, the operation is not simple and convenient enough, and if the range of the measured temperature is wider, the constant temperature unit has high manufacturing cost and large volume, and is not suitable for clinical use in hospitals.

In the conventional detection method, when the viscosity of the whole blood and the plasma is detected, different detection devices for the whole blood or the plasma are required, the viscosity of the whole blood and the viscosity of the plasma cannot be detected on one detection device, a user must purchase a plurality of detection devices to obtain the viscosity detection data of the whole blood and the plasma, the detection cost is increased, and the use is not facilitated.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a sample board reaches rather than the complex blood viscosity detection device based on negative pressure, realizes the short-term test of blood viscosity, simplifies the structure, and whole blood and plasma homoenergetic simultaneously can utilize this equipment to detect, do benefit to the use.

In order to achieve the above object, the basic scheme of the utility model is: a sample plate comprises a sample plate main body, wherein a capillary tube is arranged in the sample plate main body, one end of the capillary tube is provided with a sample adding port, and the other end of the capillary tube is provided with a sample testing interface;

and a plasma filtering membrane is detachably arranged at the sample adding opening.

The working principle and the beneficial effects of the basic scheme are as follows: the capillary tube is arranged on the sample plate, so that the volume of the capillary tube is enlarged, an operator can take and place the capillary tube conveniently, and the use of the capillary tube is not influenced. The sample adds the mouth and is used for adding the sample, and is easy and simple to handle, and the plasma filtration membrane that the sample adds mouthful department can dismantle the setting in addition, when detecting whole blood, adds mouthful department with plasma filtration membrane from the sample and demolishs, and when detecting plasma, installs plasma filtration membrane in sample adds mouthful department, realizes the automatic filtration separation plasma to whole blood. The sample testing interface is used for being externally connected with detection equipment, and ensures that subsequent operation is smoothly carried out.

Furthermore, the side wall of the sample adding port is provided with a vent hole, the vent hole is connected with a vent pipe, the vent pipe extends upwards from the vent hole, and the vent hole is positioned below the plasma filtering membrane.

Set up air vent intercommunication atmosphere, guarantee that the sample adds intraoral atmospheric pressure and is normal, make plasma filtration membrane can filter plasma smoothly, avoid leading to filtering excessively because of the negative pressure and make unnecessary blood cell also get into plasma filtration membrane below and cause test error to the testing result. Meanwhile, the vent hole is connected with the vent pipe, so that the sample is prevented from leaking from the vent hole to influence the detection result.

Further, the sample addition port is formed in a funnel shape.

The caliber of the placing port of the sample adding port is enlarged in a funnel shape, and the sample is placed in the sample adding port more conveniently.

Further, a first sealing ring is arranged at the sample testing interface.

The sealing ring enhances the sealing performance of the sample testing interface and ensures that the sample testing interface is tightly connected with subsequent detection equipment.

The utility model also provides a with foretell sample board complex blood viscosity detection device based on negative pressure, including pressure chamber and regulation the negative pressure adjustment mechanism of pressure chamber pressure, pressure chamber intercommunication has device sample detection port, and pressure chamber is connected with pressure sensor, during the test, device sample detection port and sample board's sample test interface sealing connection.

The sample detection port of the device is connected with the sample test interface of the sample plate in a sealing manner, so that the communication between the pressure chamber and the sample test interface is ensured, and the negative pressure in the pressure chamber is controlled, thereby guiding the sample in the capillary to move from the sample adding port to the sample test interface, detecting the change of the pressure value in the pressure chamber in the sample moving process by the pressure sensor, and judging the blood viscosity condition by an operator according to the change of the pressure value.

Further, the negative pressure adjusting mechanism comprises a first pipeline and a second pipeline, one end of the first pipeline, which is far away from the pressure adjusting bin, of the second pipeline is communicated with the atmosphere, a first electromagnetic valve and a decompression air pump are arranged on the first pipeline, and a second electromagnetic valve is arranged on the second pipeline.

The first solenoid valve combines the decompression that realizes the pressure storehouse with the pump, and the second solenoid valve can realize the pressurization fine setting of pressure value in the pressure storehouse, and the pressure value in the pressure storehouse is unanimous basically when guaranteeing to detect at every turn, reduces and detects the error.

Further, the communicating position of the pressure bin and the device sample detection port is provided with a three-way valve, the outlet of the three-way valve is connected with the device sample detection port, the first inlet of the three-way valve is connected with the pressure bin, and the second inlet of the three-way valve is connected with the atmosphere.

The three-way valve can meet the requirements of equipment use, and controls the sample testing interface to be communicated with the pressure bin and be sealed with the external atmosphere when in detection, so that the detection process is ensured to be carried out smoothly.

Furthermore, a second sealing ring is arranged at the sample detection port of the device.

The sealing ring is also arranged at the sample detection port of the device, so that the connection tightness between the sample detection port of the device and the sample test interface is enhanced.

Drawings

Fig. 1 is a schematic structural diagram of a sample plate according to the present invention;

FIG. 2 is a schematic structural diagram of the blood viscosity detection device based on negative pressure according to the present invention;

fig. 3 is a schematic structural diagram of a sample adding port of the sample plate of the present invention.

Reference numerals in the drawings of the specification include: sample plate body 1, sample addition port 2, sample test interface 3, capillary 4.

Detailed Description

Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the drawings are exemplary only for the purpose of explaining the present invention, and should not be construed as limiting the present invention.

In the description of the present invention, it is to be understood that the terms "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like, indicate orientations or positional relationships based on the orientations or positional relationships illustrated in the drawings, and are used merely for convenience of description and for simplicity of description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore, should not be construed as limiting the present invention.

In the description of the present invention, unless otherwise specified and limited, it is to be noted that the terms "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, mechanically or electrically connected, or may be connected between two elements through an intermediate medium, or may be directly connected or indirectly connected, and specific meanings of the terms may be understood by those skilled in the art according to specific situations.

As shown in fig. 1, the utility model discloses a sample plate, including sample plate main part 1, sample plate main part 1 surfacing is provided with capillary 4 on the sample plate main part 1, and capillary 4 can be located the inside of sample plate main part 1, also can be located the surface of sample plate main part 1, and preferred capillary 4 inlays on sample plate main part 1. One end of the capillary 4 is provided with a sample adding port 2, and the other end of the capillary 4 is provided with a sample testing interface 3, as shown in fig. 3, preferably, the sample adding port 2 is funnel-shaped, which is more beneficial for feeding. The sample adds 2 departments of mouthful and can dismantle and be provided with plasma filtration membrane, for example set up the draw-in groove on the lateral wall that the sample added mouthful 2, plasma filtration membrane's edge can the joint in the draw-in groove, realizes connecting, for the compactness of reinforcing connection, preferably add sealing member such as sealing rubber circle in the draw-in groove behind plasma filtration membrane and draw-in groove joint, plasma filtration membrane can be preferred with plasma filter paper. More preferably, the side wall of the sample adding port 2 is provided with a vent hole, the vent hole is connected with a vent pipe, the vent pipe extends upwards from the vent hole, the vent hole is positioned below the plasma filtering membrane, and the sample testing interface 3 is provided with a sealing ring.

As shown in fig. 2, the present invention further provides a negative pressure-based blood viscosity detecting device, which is matched with the sample plate, and comprises a pressure chamber and a negative pressure adjusting mechanism for adjusting the pressure of the pressure chamber. The pressure chamber is communicated with a device sample detection port, the pressure chamber is connected with a pressure sensor, and the device sample detection port is hermetically connected with a sample test interface 3 of the sample plate during testing. The communicating position of the pressure bin and the device sample detection port is provided with a three-way valve, the outlet of the three-way valve is connected with the device sample detection port, the first inlet of the three-way valve is connected with the pressure bin, and the second inlet of the three-way valve is connected with the atmosphere.

The negative pressure adjusting mechanism comprises a first pipeline and a second pipeline, one end of the first pipeline, which is far away from the pressure adjusting bin, of the second pipeline is communicated with the atmosphere, a first electromagnetic valve and a decompression air pump are arranged on the first pipeline, a second electromagnetic valve is arranged on the second pipeline, and the negative pressure adjusting mechanism is connected with a power supply device for supplying power.

The specific operation process comprises the following steps: the sample testing interface 3 of the capillary 4 on the sample plate is connected with the sample testing port of the pressure chamber (such as clamping connection and the like), the first electromagnetic valve is opened, the second electromagnetic valve is closed, and meanwhile, the second inlet of the three-way valve is controlled to be opened, so that the sample testing port of the device is communicated with the external atmosphere, and the normal initial air pressure in the sample testing port of the device is ensured. And then starting the decompression air pump, exhausting air from the decompression air pump to the outside of the pressure bin for decompression, stopping the decompression air pump after the pressure in the pressure bin reaches a certain value, and closing the first electromagnetic valve. In order to ensure that the pressure value in the pressure chamber is kept constant, the second electromagnetic valve can be opened to enable external air to enter the pressure chamber to realize pressurization fine adjustment.

After the pressure value in the pressure chamber is adjusted, the sample is put into the sample adding port 2, the second inlet of the control three-way valve is closed, the connection between the sample detection port of the device and the external atmosphere is closed, the first inlet of the three-way valve is opened simultaneously, the sample detection port of the device is communicated with the pressure chamber, the outlet of the control three-way valve is communicated, and the sample detection port of the device is communicated with the sample testing interface 3. After the operation is finished, pressure detection is started, data collected by the pressure sensor is recorded, and a user can judge the condition of blood viscosity according to the collected data. After the detection is finished, the three-way valve is controlled, the communication position of the pressure bin and the sample testing interface 3 is closed, the sample testing interface 3 is communicated with the atmosphere, and the device sample detection port of the pressure bin is detached from the sample testing interface 3. In the use, the sample plate adopts disposable design, has avoided the routine maintenance of detection pipeline part, convenient to use. The dosage of the detection sample is 30-60uL, the test process does not exceed 10 seconds, the detection dosage of the sample is reduced, and the detection speed is improved.

In the description herein, references to the description of the term "one embodiment," "some embodiments," "an example," "a specific example," or "some examples," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

While embodiments of the present invention have been shown and described, it will be understood by those of ordinary skill in the art that: various changes, modifications, substitutions and alterations can be made to the embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and their equivalents.

Claims

1. A sample plate is characterized by comprising a sample plate main body, wherein a capillary tube is arranged on the sample plate main body, a sample adding port is arranged at one end of the capillary tube, and a sample testing interface is arranged at the other end of the capillary tube;

2. The sample plate of claim 1, wherein the side wall of the sample addition port is provided with a vent hole, the vent hole is connected with a vent pipe, the vent pipe extends upwards from the vent hole, and the vent hole is positioned below the plasma filtering membrane.

3. The sample plate of claim 1, wherein the sample addition port is funnel-shaped.

4. The sample plate of claim 1, wherein the sample testing interface is provided with a first sealing ring.

5. A negative pressure-based blood viscosity test device matched with the sample plate of any one of claims 1 to 4, which comprises a pressure chamber and a negative pressure regulating mechanism for regulating the pressure of the pressure chamber, wherein the pressure chamber is communicated with a device sample detection port, the pressure chamber is connected with a pressure sensor, and the device sample detection port is hermetically connected with a sample test interface of the sample plate during testing.

6. The negative-pressure-based blood viscosity detecting device according to claim 5, wherein the negative pressure adjusting mechanism comprises a first pipeline and a second pipeline, ends of the first pipeline and the second pipeline, which are far away from the pressure adjusting chamber, are both communicated with the atmosphere, the first pipeline is provided with a first electromagnetic valve and a decompression air pump, and the second pipeline is provided with a second electromagnetic valve.

7. The negative pressure-based blood viscosity measuring device of claim 5, wherein a three-way valve is disposed at a connection between the pressure chamber and the sample detection port, an outlet of the three-way valve is connected to the sample detection port, a first inlet of the three-way valve is connected to the pressure chamber, and a second inlet of the three-way valve is connected to the atmosphere.

8. The negative-pressure based blood viscosity measuring device of claim 5, wherein a second sealing ring is provided at the device sample detection port.