CN109557295A - Vim and vigour test method, vim and vigour test host, reagent packet and vim and vigour test card - Google Patents
Vim and vigour test method, vim and vigour test host, reagent packet and vim and vigour test card Download PDFInfo
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- CN109557295A CN109557295A CN201710875455.1A CN201710875455A CN109557295A CN 109557295 A CN109557295 A CN 109557295A CN 201710875455 A CN201710875455 A CN 201710875455A CN 109557295 A CN109557295 A CN 109557295A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
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Abstract
A kind of vim and vigour test method, vim and vigour test host, reagent packet and vim and vigour test card, control platform is set on vim and vigour test host, peristaltic pump is set in control platform, the peristaltic pump pipe sleeve that reagent is wrapped is in peristaltic pump rotor, the reagent output interface of reagent packet and the reagent packet interface of test card are docked and connected, and hemostix is docked with the hemostix interface of test card.Cooperated by peristaltic pump rotor and peristaltic pump tube, it is rotated using peristaltic pump rotor and alternately squeezes and releases the peristaltic pump tube to pump fluid along direction initialization, flow calibration solution and test fluid in a manner of wriggling in the fluid path channel of test card, realize being precisely controlled for test fluid and calibration solution flow process, test fluid and calibration solution is greatly saved, and substantially reduce the length of waste fluid channel, save consumables cost, and the passage length that test sample touches becomes smaller, the temperature for also ensuring test sample gas improves the accuracy of test result.
Description
Technical field
The present invention relates to medical in-vitro diagnosis fields, are particularly applied to medical vim and vigour biochemistry and detect to micro blood
Equipment in realize fluid path be precisely controlled inanimate object pollution blood gas analysis method, host, reagent packet and test card.
Background technique
Vim and vigour detection is related to partial pressure of oxygen (PO2) etc. to pH value (pH), the carbon dioxide partial pressure (PCO2) in blood
Index is measured, and is commonly used for judging body with the presence or absence of the important hand of acid-base imbalance and anoxic and degree of oxygen deficiency etc.
Section.Vim and vigour detection technique also plays in acute respiratory failure diagnosis and treatment, surgical operation, rescue and monitoring process to Guan Chong always
The effect wanted.
The vim and vigour test of common medical in-vitro diagnosis equipment has the following deficiencies: in the market
1, vim and vigour test equipment usually require by hemostix acquire blood sample, and by sample be inserted into test equipment and
Injecting sample, however need could be by sample injection device by someone's boosting hemostix for partial test equipment, and manual operation
It is inevitably caused because of misoperation in the test droplets to equipment such as blood, causes equipment pollution；
2, vim and vigour test equipment in part has the test card independently of test host, such as the China of the applicant's earlier application
Patent CN203705445U, it discloses the vim and vigour test card and its blood gas analyzer of a kind of novel inanimate object pollution, tests
Card is equipped with calibration solution channel, test fluid channel and waste fluid channel, and calibration solution channel, test fluid channel and waste fluid channel are mutually converged
Collecting and pass through valve and realizes mutual on-off, calibration solution channel end connects reagent packet, and test fluid channel end connects hemostix,
Waste fluid channel end connects vacuum pump, when test, provides negative pressure by vacuum pump first and extracts calibration solution from reagent packet to waste liquid
The test section in channel, is calibrated, and vacuum pump is again started up after calibration, extracts the test fluids such as blood to waste fluid channel from hemostix
Test section complete vim and vigour test, and during extracting test fluid, be initially positioned at the calibration solution continuation of test section along waste liquid
A distance is flowed in channel, to be isolated with test fluid.
Since the power that the liquid of the blood gas analyzer flows is provided by vacuum pump, and since standard liquid channel and test fluid are logical
Road needs to be separately connected reagent packet and hemostix, therefore vacuum pump can only connect at waste fluid channel end, thus extract calibration solution or
When test sample, it is necessary to provide negative pressure to calibration solution channel or test fluid channel by waste fluid channel, and test section also can only
It is arranged in waste fluid channel, in order to which test section and waste liquid to be isolated, waste fluid channel has to long enough, and usual waste fluid channel is long
Degree is up to six times or more of calibration solution channel (or test fluid channel) length, causes pump housing cavity excessive, and have in cavity negative
Pressure, it is intracavitary to still remain negative pressure even if vacuum pump stops, reaching balance, liquid also will continue to flow, thus cannot accurately control
The position of sample preparation sheet, the sample size for resulting in the need for extraction is more, and sample is caused to waste.
3, test card is disposable consumptive material, and waste fluid channel is too long to be also unfavorable for controlling consumables cost.
4, similarly, since negative pressure, excessive vacuum pump can be generated during extraction by extracting liquid using vacuum pump
Vacuum cavity can make the air pressure inside test sample change so that in sample the measurement of gas inaccuracy.
Summary of the invention
The invention solves first technical problem be to provide it is a kind of it is pollution-free, sample dosage is few, at low cost, detection
As a result accurate vim and vigour test method.
The invention solves third technical problem be to provide and a kind of realize above-mentioned vim and vigour test method host.
The invention solves the 4th technical problem be to provide a kind of reagent packet for realizing above-mentioned vim and vigour test method.
The invention solves the 5th technical problem be to provide a kind of vim and vigour survey for realizing above-mentioned vim and vigour test method
Examination card.
In order to solve the above technical problems, the present invention proposes a kind of vim and vigour test method, comprising:
Respectively by hemostix and with peristaltic pump tube reagent packet docking have fluid path channel test card, make the wriggling
Pump line and the fluid path channel are connected；
It is rotated using peristaltic pump rotor and alternately squeezes and releases the peristaltic pump tube to pump fluid along direction initialization,
The calibration solution and the test fluid are successively pumped into the test section in the fluid path channel of the test card, is successively calibrated and is surveyed
Examination；
It reads calibration and test data and is handled and obtain test result.
In order to solve the above technical problems, the present invention proposes a kind of vim and vigour test host, including control platform, control platform tool
Have: platform support, rotary drive mechanism and peristaltic pump rotor, platform support, which is equipped with, passes through contact or untouchable mode
Detect the detection unit of test card；Rotary drive mechanism is arranged on the platform support and can export rotation function；It wriggles
Pump rotor includes: to be connected with rotary drive mechanism transmission and rotatable rotating member and fixation or be shaped in described
Multiple extrusions to squeeze external peristaltic pump tube for following the rotating member rotation on rotating member.
The radius of turn of each extrusion of the peristaltic pump rotor is equal and is in be spaced apart from each other distribution.
The extrusion is idler wheel, roll shaft or protrusion；The rotary drive mechanism is motor.
At least one controller to control test card valve on-off is also set up on the platform support；The platform branch
Be additionally provided on frame can controlled rotation threeway valve control；The threeway valve control is equipped with card slot or convex ribs.
There is the resettlement groove for placing test card, the resettlement groove penetrates through the side of the platform support on the platform support
And form a test card insert opening；Locating slot is provided with below the resettlement groove, the locating slot is formed on platform support
Two orthogonal positionable walls, the locating slot and the resettlement groove penetrate through, and the controller is arranged in the resettlement groove,
The threeway valve control is arranged in the locating slot；The detection unit is set at the resettlement groove, and the detection is single
Member includes exposed multiple signal lamps that the platform support surface is arranged in.
In order to solve the above technical problems, the present invention also proposes a kind of reagent packet, comprising: reagent incrustation, reagent bag body
And peristaltic pump tube, reagent incrustation is interior to have accommodating cavity, and surface is provided with reagent output interface；Reagent bag body is placed in
In the accommodating cavity, to fill calibration solution；Peristaltic pump tube one end is connected to the reagent bag body, and the other end is connected to the examination
Agent output interface to pump calibration solution outward to carry out alternately squeezing and releasing to it by peristaltic pump.
The reagent, which is wrapped, is additionally provided with peristaltic pump rotor, and the peristaltic pump pipe sleeve is in the peristaltic pump rotor；It is described
Peristaltic pump rotor includes: to be connected with rotary drive mechanism transmission and rotatable rotating member and fixation or be shaped in institute
Multiple extrusions that can be rotated with the driving member on rotating member are stated, the radius of turn of each extrusion is equal and is in be spaced apart from each other
Distribution.
The press section is idler wheel, roll shaft or protrusion.
It is additionally provided on the peristaltic pump tube and is connected to the peristaltic pump tube with the reagent bag body, or, by described compacted
The three-way valve that dynamic pump line is connected to outside air, the three-way valve are equipped with convex ribs or card slot.
Reagent incrustation side has boss, and at least part of peristaltic pump tube exposes to described from the boss
Except reagent incrustation, the reagent output interface is arranged on the boss.
In order to solve the above technical problems, the present invention also proposes a kind of test card, comprising: test card main body and be set to test card
Fluid path channel in main body, the fluid path channel include: calibration solution channel, test fluid channel and waste fluid channel, the calibration solution
The one end in channel, the test fluid channel and the waste fluid channel is gathered together, and the other end in the calibration solution channel is equipped with
Reagent packet interface, the other end in the test fluid channel are equipped with hemostix interface, and the other end of the waste fluid channel is equipped with exhaust
Hole is provided with test section on the calibration solution channel.
The test fluid channel has a sample valve at the convergence position of channel, and the waste fluid channel is converged close to channel
There is a waste liquid valve at poly- position.
Multiple reaction pole pieces are provided at correspondence test section in the calibration solution channel.
Compared with prior art, the invention has the following beneficial effects: vim and vigour test method of the invention and system, pass through
Peristaltic pump rotor and peristaltic pump tube cooperate, and flow calibration solution and test fluid in a manner of wriggling in the fluid path channel of test card,
Being precisely controlled for test fluid and calibration solution flow process is realized, test fluid and calibration solution is greatly saved, and substantially reduce
The length of waste fluid channel saves consumables cost, and the passage length that test sample touches becomes smaller, and also ensures test specimens
The temperature of this gas improves the accuracy of test result.
Detailed description of the invention
Fig. 1 is the decomposition diagram of a vim and vigour test macro of the present invention wherein embodiment；
Fig. 2 is the schematic diagram of reagent packet in vim and vigour test macro shown in Fig. 1；
Fig. 3 is the schematic diagram of test card in vim and vigour test macro shown in Fig. 1；
Fig. 4 is the schematic diagram of control platform in vim and vigour test macro shown in Fig. 1；
Fig. 5 be peristaltic pump tube and peristaltic pump rotor turn match schematic diagram；
Fig. 6 is peristaltic pump schematic illustration；
Fig. 7 is the assembled state figure of vim and vigour test macro shown in Fig. 1；
Fig. 8 is the operation principle schematic diagram that vim and vigour test macro shown in Fig. 1 extracts calibration solution；
Fig. 9 is the operation principle schematic diagram that vim and vigour test macro shown in Fig. 1 drains calibration solution；
Figure 10 is the operation principle schematic diagram that vim and vigour test macro shown in Fig. 1 extracts test sample；
Figure 11 is the operation principle schematic diagram that vim and vigour test macro shown in Fig. 1 drains test sample.
The reference numerals are as follows:
1, control platform；11, platform support；12, peristaltic pump rotor；122, turntable；123, shaft；F1, F2, F3, F4, roller
Axis；13, resettlement groove；131, card insert opening is tested；132, detection unit；133, signal lamp；134, sample valve controller；135,
Waste liquid valve positioner；14, locating slot；141, positionable wall；142, positionable wall；15, threeway valve control；151, card slot；2, it tries
Agent packet；21, reagent incrustation；211, cavity is accommodated；22, reagent bag body；23, peristaltic pump tube；24, three-way valve；241, convex
Muscle；242, air scoop；25, reagent output interface；26, boss；3, test card；31, test card main body；32, fluid path channel；321,
Calibration solution channel；3211, reagent packet interface；3212, test section；3213, pole piece is reacted；322, test fluid channel；3221, it takes a blood sample
Device interface；3222, sample valve；323, waste fluid channel；3231, gas vent；3232, waste liquid valve；4, hemostix.
Specific embodiment
Principle and structure in order to further illustrate the present invention carry out the preferred embodiment of the present invention now in conjunction with attached drawing detailed
It describes in detail bright.
Refering to fig. 1 and Fig. 7, the vim and vigour test macro of first embodiment of the invention include: reagent packet 2, test card 3, blood sampling
Device 4 and the vim and vigour analyzed blood gas data test host, are provided with docking 2 He of reagent packet respectively on vim and vigour test host
Test card 3 and control its work control platform 1 (control platform 1 is only shown in figure, vim and vigour test on host except control platform it
The prior art can be used in outer other structures, so omit).Control platform 1, reagent packet 2, test card 3 structure below will
It is described in detail in conjunction with attached drawing, hemostix 4 can be blood taking needle, heparin tube, capillary etc., can also include other for providing acquisition blood
The component or structure of liquid function.
Referring to Fig.2, reagent packet 2 includes: reagent incrustation 21, reagent bag body 22 and peristaltic pump tube 23.
There is accommodating cavity 211, reagent bag body 22 is placed in the accommodating in reagent incrustation 21 in reagent incrustation 21
In cavity 211, to fill calibration solution.The reagent output that 21 surface of reagent incrustation is provided with to dock test card 3 connects
Mouth 25.The reagent output interface 25 specifically includes the conduit 251 of a connection peristaltic pump tube 23 and covers the one of 251 periphery of conduit
Flexible rubber hose 252, when test card 3 is connected with reagent packet 2, flexible rubber hose 252 is for guaranteeing that reagent packet 2 is reliably docked with test card.
Reagent incrustation side has boss 26, and reagent output interface 25 is arranged on boss 26.
23 one end of peristaltic pump tube is connected to reagent bag body 22, and the other end is connected to reagent output interface 25.Peristaltic pump tube 23
At least part exposes to except reagent incrustation 21 from 26 position of boss, and the revealed section is to cover the wriggling in control platform 1
On pump rotor 12 (described below).
It is additionally provided with three-way valve 24 on peristaltic pump tube 23, tool is there are three port on the valve body of three-way valve 24, in valve body
With valve plate, valve body surface has the knob that valve plate can be driven to rotate, and three ports are respectively communicated with reagent bag body 22, peristaltic pump
Pipe 23 and air scoop 242 rotate the knob of three-way valve 24, can be connected to peristaltic pump tube 23 with reagent bag body 22, or will
Peristaltic pump tube 23 is connected to air scoop 242.On the three-way valve 24 of reagent packet 2 be equipped with convex ribs 241, the convex ribs 241 be used for
Threeway valve control 15 in control platform 1 matches (described below).
Refering to Fig. 3, test card 3 includes: test card main body 31 and the fluid path channel 32 in test card main body 31.Fluid path
Channel 32 includes: calibration solution channel 321, test fluid channel 322 and waste fluid channel 323, calibration solution channel 321, test fluid channel
322 and one end of waste fluid channel 323 be gathered together, the other end in calibration solution channel 321 is equipped with reagent packet interface 3211, test
The other end in liquid channel 322 is equipped with hemostix interface 3221, and the other end of waste fluid channel 323 is equipped with gas vent 3231, to be used for
Exclude the air in waste fluid channel 323.
It is provided with test section 3212 on calibration solution channel 321, multiple reaction pole pieces 3213 are provided at test section 3212, it is more
A reaction pole piece 3213 is arranged into a column in calibration solution channel 321.
Interchannel is realized by control valve between calibration solution channel 321, test fluid channel 322 and waste fluid channel 323
On-off.In the present embodiment, test fluid channel 322 has a sample valve 3222, waste fluid channel at the convergence position of channel
323 have a waste liquid valve 3232 at the convergence position of channel, and opening sample valve 3222 can be by test fluid channel 322 and fixed
Standard liquid channel 321 is connected to, and is closed sample valve 3222, can be blocked in test fluid channel 322 at sample valve 3222.Equally,
Opening waste liquid valve 3232 can be connected to waste fluid channel 323 with calibration solution channel 321, and waste liquid can be led to by closing waste liquid valve 3232
Road 323 blocks at waste liquid valve 3232.In other embodiments, sample valve 3222 and waste liquid valve 3232 also alternatively at
Three-way valve makes three ports of three-way valve be separately connected calibration solution channel 321, test fluid channel 322 and waste fluid channel
323, by rotating the knob of three-way valve, it can be achieved that calibration solution channel 321, test fluid channel 322 and waste fluid channel 323 are mutual
Between on-off.
Refering to Fig. 4 and Fig. 5, control platform 1 includes: that platform support 11 and the peristaltic pump being arranged on platform support 11 turn
Son 12, threeway valve control 15 and detection unit 132 etc..
The setting of peristaltic pump rotor 12 is provided in 11 surface of platform support, platform support 11 to be driven with peristaltic pump rotor 12
The rotary drive mechanism for being connected and peristaltic pump rotor 12 being driven to rotate.Rotary drive mechanism can to export rotation dynamic to be any
The power mechanism of energy.In the present embodiment, rotary drive mechanism is motor, is hidden in platform support 11.In other embodiments
In, rotary drive mechanism can also be the hand crank for exposing to 11 surface of platform support, be realized by manually handle hand crank compacted
Dynamic pump rotor rotation.
Peristaltic pump rotor 12 includes: two opposite and spaced two turntables 122, wears and be fixed on two turntables, 122 center
Shaft 123 and wear multiple roll shaft F1, F2, F3, the F4 for being fixed on two turntables 122 close to circumferential position.In the present embodiment,
Roll shaft is four, in other embodiments, can be required according to rate of pumping and the diameter of peristaltic pump tube 23 increase accordingly or subtracts
The quantity of few roll shaft, but roll shaft quantity should be no less than two.Shaft 123 is connected with the rotary drive mechanism in platform support 11,
And be driven in rotation mechanism and drive rotation, so that shaft 123 and two turntables 122 collectively form a rotating member and drive multiple rollers
Axis F1, F2, F3, F4 rotation.Multiple roll shaft F1, F2, F3, F4 are arranged in shaft 123 to make each roll shaft on the circumference in the center of circle
The radius of turn of F1, F2, F3, F4 are equal.
Refering to Fig. 5,23 sets of peristaltic pump tube on reagent packet 2 are at each roll shaft F1, F2, F3, F4 of peristaltic pump rotor 12, respectively
The corresponding part between two turntables 122 roll shaft F1, F2, F3, F constitutes the extrusion for squeezing peristaltic pump tube 23.Refering to figure
6, when each roll shaft F1, F2, F3, F4 in peristaltic pump rotor 12 rotate clockwise and when roll-in peristaltic pump tube 23, by roll-in
Peristaltic pump tube 23 can generate vacuum when being released and restoring its shape, to draw fluid into peristaltic pump tube 23, in roll shaft F1
" pillow " shape fluid A is formed in peristaltic pump tube 23 between roll shaft F4, as peristaltic pump rotor 12 continues to rotate clockwise, is wriggled
The front of the arrow direction in figure of pump line 23 generates vacuum, and " pillow " shape fluid A is attracted forward, while the fluid at rear is along arrow
Direction continues to be inhaled into peristaltic pump tube 23, forms " pillow " shape fluid B, and so on, when peristaltic pump rotor 12 rotates, by band
It moves each roll shaft F1, F2, F3, F4 and alternately squeezes and releases peristaltic pump tube 23, pump fluid along direction initialization, make fluid with compacted
Flowing mode reaches predetermined position.
Similarly, realize that fluid when arrow reverse flow, need to only rotate counterclockwise peristaltic pump rotor 12 along figure in advance.
The principle of fluid is pumped with peristaltic pump tube 23 according to above-mentioned peristaltic pump rotor 12, peristaltic pump rotor can also much become
Shape.Such as, above-mentioned each roll shaft F1, F2, F3, F4 are substituted for the extrusions such as idler wheel or convex block, 23 sets of peristaltic pump tube is in idler wheel or convex
The periphery of block, as peristaltic pump rotor 12 rotates, idler wheel or convex block alternately will squeeze and release peristaltic pump tube 23, make fluid along
The pumping of 12 direction of rotation of peristaltic pump rotor.Idler wheel, convex block and roll shaft can be also used in any combination.In addition, in above-described embodiment
Shaft 123 and turntable 122 can also integrally be substituted on an integrally formed rotating member or be substituted for it is multiple can synchronous follow-up
Rotating member, rotating member, which is driven to be connected by rotary drive mechanism, realizes rotation.Above-mentioned rollers, convex block and roll shaft can be with rotating members
Fission molding is mutually fixed with rotating member again, also can be integrally formed on rotating member.
Refering to Fig. 2 and Fig. 4, it is additionally provided with threeway valve control 15 on platform support 11, is provided in platform support 11
Valve driving machine structure.Threeway valve control 15 can be controlled by valve driving machine structure and be rotated relative to platform support 11.At other
In embodiment, the spinning movement of threeway valve control 15 is also manually operable.
Card slot 151 is provided on threeway valve control 15, when 23 sets of peristaltic pump tube of reagent packet 2 in peristaltic pump rotor 12
When, the three-way valve 24 on reagent packet 2 is just opposite with the threeway valve control 15 on platform support 11, and on three-way valve 24
Convex ribs 241 can be caught on the card slot 151 of threeway valve control 15, so that threeway valve control 15 be made to be linked to be with three-way valve 24
One is realized valve state and is switched to drive three-way valve 24 to rotate.
In other embodiments, the position of convex ribs 241 and card slot 151 is also interchangeable, i.e., convex ribs 241 is arranged in triple valve
On controller 15, and card slot 151 is arranged on three-way valve 24.
In conjunction with refering to Fig. 3 and Fig. 7, having the resettlement groove 13 for placing test card 3 on platform support 11, the perforation of resettlement groove 13 is flat
The side (top side in orientation in figure) of platform bracket 11 and form a test card insert opening 131, test card 3 is through the test card insert opening
131 are placed in resettlement groove 13.At least one is also set up in the resettlement groove 13 of platform support 11 to control 3 valve on-off of test card
Controller.Controller is two in the present embodiment, respectively sample valve controller 134 and waste liquid valve positioner 135, two
Controller is elastic press type press-button structure, to respectively correspond the sample valve 3222 and waste liquid of the elastic press type in control test card 3
Valve 3232.In other embodiments, if the valve of on-off is a triple valve between control channel in test card, controller
It mutually should be the structure of similar above-mentioned threeway valve control 15.
The detection unit 132 for measuring test card 3 is additionally provided on platform support 11, detection unit 132 includes: to be set to put down
Test circuit in platform bracket 11 and the signal acquisition unit for being exposed at 11 surface of platform support.Signal acquisition unit can pass through
3 signal acquisition of test card is realized in the test section 3212 of the direct engaged test card 3 of electrochemical measurement mode, and by collected letter
Number feed back to test circuit, after tested circuit computing and obtain testing result.Signal acquisition unit can also be by contactless
Light measurement method carries out signal acquisition to the test section 3212 of test card 3, and collected signal is then fed back to test electricity
Road, after tested circuit computing and obtain testing result.The present embodiment belongs to the latter, and in the present embodiment, detection unit 132 includes outer
Multiple signal lamps 133 on 11 surface of platform support are exposed at, multiple signal lamps 133 are arranged in a row, when test card 3 is placed in platform
When in the resettlement groove 13 of bracket 11, multiple signal lamp 133 correspond respectively illuminate it is multiple in 3 test section 3212 of test card
Pole piece 3213 is reacted, by receiving the reflective or transmitted light of test section 3212, and is fed back to test circuit, is allowed to believe light
It number is handled, and then obtains testing result.
Platform support 11 is additionally provided with locating slot 14 in the lower section of corresponding resettlement groove 13, and the setting of threeway valve control 15 is fixed
In the slot 14 of position, locating slot 14 is penetrated through with resettlement groove 13 to facilitate reagent packet 2 to be connected to each other with test card 3, and locating slot 14 is in platform branch
11 surface of frame forms two orthogonal positionable walls 141,142.
Test card 3 is placed on control platform first when the vim and vigour test macro works refering to Fig. 2, Fig. 3, Fig. 4 and Fig. 7
In 1 resettlement groove 13, then the peristaltic pump tube 23 of reagent packet 2 is socketed in the peristaltic pump rotor 12 of control platform 1, is tried at this time
For the boss 26 of agent packet 2 just in the locating slot 14 of platform support 11, appropriate adjustment reagent packet 2 makes 26 top surface of boss against fixed
The side of position wall 141, boss 26 abuts positionable wall 142, at this time the lucky face test card of reagent output interface 25 on reagent packet 2
3 reagent packet interface 3211, and the valve positioner 12 in the lucky face control platform 1 of three-way valve 24 on reagent packet 2,
That is positionable wall 141 and 142 one side of positionable wall are that the docking of reagent packet 2 test card 3 provides positioning and guiding, on the other hand
Also valve positioner 12 is docked for the three-way valve 24 of reagent packet 2 provide docking guiding；Later, by the threeway on reagent packet 2
The convex ribs 241 of valve 24 are caught on the card slot 151 of the threeway valve control 15 in control platform 1, and will complete adopting after taking a blood sample
Blood device 4 docks the hemostix interface 3221 of test card 3, and the reagent output interface 25 of reagent packet 2 is docked to the reagent packet of test card 3
Interface 3211, so far, test card 3 and reagent packet 2 are connected to one group of sealed passage.
Refering to Fig. 7 to Figure 11, the vim and vigour test macro course of work is as follows:
Extract calibration solution process: firstly, starting sample valve controller 134, makes it close sample valve 3222, and make to give up
Fluid valve controller 135 opens waste liquid valve 3232；Then, start threeway valve control 15, rotate three-way valve 24, it will
Reagent bag body 22 is connected to peristaltic pump tube 23；Later, starting peristaltic pump rotor 12 rotates forward, it is made alternately to squeeze and release wriggling
Pump line 23 is pumped into the calibration solution in reagent packet 2 the calibration solution channel 321 of test card 3 and the test section of coverage test card 3
3212, start to calibrate at this point, control platform 1 starts collection calibration data.
Drain calibration solution process: after the completion of calibration, the effect of sample valve controller 134 is lower to keep sample valve 3222 to close
It closes, the effect of waste liquid valve positioner 135 is lower to keep waste liquid valve 3232 to open；Later, threeway valve control 15 is made to rotate threeway
Valve 24 is connected to air scoop 242 with peristaltic pump tube 23；Then, starting peristaltic pump rotor 12 rotates forward, it is made alternately to squeeze and release
Peristaltic pump tube 23 is put, air is pumped into the calibration solution channel 321 of test card 3, to push determining for 3 test section 3212 of coverage test card
Standard liquid, and in the waste fluid channel 323 of calibration solution push-in test card 3.
Extract test sample process: starting sample valve controller 134 is opened sample valve 3222, and make waist valve
Door controller 135 closes waste liquid valve 3232；Start threeway valve control 15 later, rotates three-way valve 24, make air scoop 242
It is connected to peristaltic pump tube 23；Then, starting peristaltic pump rotor 12 inverts, it is made alternately to squeeze and release peristaltic pump tube 23, survey
The test fluid channel 322 of this suction of sample test card 3 and the test section 3212 of coverage test card 3, at this point, control platform 1 starts
Sample data is collected to start to test.
Drain test sample process: after the completion of test, starting sample valve controller 134, closes sample valve 3222, and
Start waste liquid valve positioner 135, it is made to open waste liquid valve 3232；Keep threeway valve control 15, guarantee air scoop 242 with
Peristaltic pump tube 23 is connected to；Then, starting peristaltic pump rotor 12 rotates forward, and so that it is alternately squeezed and released peristaltic pump tube 23, air
It is pumped into the calibration solution channel 321 of test card 3, pushes the test sample of 3 test section 3212 of coverage test card, and the test sample
It is pushed into the waste fluid channel 323 of test card.
Vim and vigour test macro of the invention is cooperated by peristaltic pump rotor 12 and peristaltic pump tube 23, makes calibration solution and test fluid
Flowed in a manner of wriggling in the fluid path channel of test card 3, compared with the prior art in by way of vacuum pump withdrawn fluid,
Fluid does not have in fluid path channel inertia flowing, peristaltic pump to position caused by large volume changes and does not just turn, and liquid is also
It does not flow, realizes being precisely controlled for test fluid and calibration solution flow process, test fluid and calibration solution is greatly saved, and significantly
The length for shortening waste fluid channel makes the length of waste fluid channel no more than three times of calibration solution passage length, also no more than test
Consumables cost is greatly saved in three times of liquid passage length, and the passage length that test sample touches becomes smaller, and also ensures
The temperature of test sample gas improves the accuracy of test result.
The above are Each part, principle and the course of work of vim and vigour test macro first embodiment of the present invention, vim and vigour are surveyed
The Each part of test system second embodiment is roughly the same with above-described embodiment, the difference is that, in second embodiment, peristaltic pump
The design of rotor 12 is nested together on reagent packet 2, and with the peristaltic pump tube of reagent packet 2 23, need to only be designed in control platform 1
The rotary drive mechanism for driving peristaltic pump rotor 12 to rotate, the rotary drive mechanism and peristaltic pump rotor 12 pass through detachable
Connection structure is connected, to facilitate the two to connect or separate.The vim and vigour test macro course of work of the embodiment and principle with it is upper
It is identical to state embodiment, details are not described herein again.
According to the operation principle and process of above-mentioned vim and vigour test macro, the present invention also provides a kind of vim and vigour test method,
Include the following steps:
Respectively by hemostix and with peristaltic pump tube reagent packet docking have fluid path channel test card, make peristaltic pump tube
It is connected with the fluid path channel of test card；
It is alternately squeezed using peristaltic pump rotor rotation or discharges peristaltic pump tube to pump fluid along direction initialization, will determined
Standard liquid and test fluid are successively pumped into the test section in the fluid path channel of test card, are successively calibrated and are tested；
It reads calibration and test data and is handled and obtain test result.
The vim and vigour test method is cooperated by peristaltic pump rotor and peristaltic pump tube, makes calibration solution and test fluid in test card
Fluid path is flowed in a manner of wriggling in channel, realizes being precisely controlled for test fluid and calibration solution flow process, survey is greatly saved
Test solution and calibration solution, and substantially reduce the length of waste fluid channel, save consumables cost, and test sample touch it is logical
Road length becomes smaller, and also ensures the temperature of test sample gas, improves the accuracy of test result.
The above is only preferable possible embodiments of the invention, not limit the scope of the invention, all with the present invention
The variation of equivalent structure made by specification and accompanying drawing content, is included within the scope of protection of the present invention.
Claims (14)
1. a kind of vim and vigour test method characterized by comprising
Respectively by hemostix and with peristaltic pump tube reagent packet docking have fluid path channel test card, make the peristaltic pump tube
It is connected with the fluid path channel；
It is rotated using peristaltic pump rotor and alternately squeezes and releases the peristaltic pump tube to pump fluid along direction initialization, by institute
State calibration solution and the test fluid be successively pumped into the test card fluid path channel test section, successively calibrated and tested；
It reads calibration and test data and is handled and obtain test result.
2. a kind of vim and vigour test host characterized by comprising control platform, the control platform include: platform support,
It is equipped with the detection unit that test card is detected by contact or untouchable mode；Rotary drive mechanism, setting is described flat
On platform bracket and rotation function can be exported；
Peristaltic pump rotor, comprising: be connected and rotatable rotating member and fixation or one with rotary drive mechanism transmission
Multiple extrusions to squeeze external peristaltic pump tube on the rotating member are taken shape in, the extrusion can follow described turn
Moving part rotation.
3. control platform as claimed in claim 2, which is characterized in that the radius of turn of each extrusion of the peristaltic pump rotor
It is equal and in being spaced apart from each other distribution.
4. control platform as claimed in claim 3, which is characterized in that the extrusion is idler wheel, roll shaft or protrusion；The rotation
Turning driving mechanism is motor.
5. control platform as claimed in claim 2, which is characterized in that also set up at least one on the platform support to control
The controller of test card valve on-off processed；Be additionally provided on the platform support can controlled rotation threeway valve control；It is described
Threeway valve control is equipped with card slot or convex ribs.
6. control platform as claimed in claim 5, which is characterized in that have the placement for placing test card on the platform support
Slot, the resettlement groove penetrate through the side of the platform support and form a test card insert opening；The lower section of the resettlement groove is arranged
There is locating slot, the locating slot forms two orthogonal positionable walls, the locating slot and the placement on platform support
Slot perforation, the controller are arranged in the resettlement groove, and the threeway valve control is arranged in the locating slot；The inspection
It surveys unit to be set at the resettlement groove, the detection unit includes exposed multiple signals that the platform support surface is arranged in
Lamp.
7. a kind of reagent packet characterized by comprising
Reagent incrustation, interior to have accommodating cavity, surface is provided with reagent output interface；
Reagent bag body is placed in the accommodating cavity, to fill calibration solution；And
Peristaltic pump tube, one end are connected to the reagent bag body, and the other end is connected to the reagent output interface, by peristaltic pump
It is carried out alternately to squeeze and release and to pump calibration solution outward.
8. reagent packet as claimed in claim 7, which is characterized in that the reagent, which is wrapped, is additionally provided with peristaltic pump rotor, described
Peristaltic pump pipe sleeve is in the peristaltic pump rotor；The peristaltic pump rotor include: with the rotary drive mechanism transmission be connected and
Rotatable rotating member and fixation or the multiple extrusions that can be rotated with the driving member being shaped on the rotating member,
The radius of turn of each extrusion is equal and is in be spaced apart from each other distribution.
9. reagent packet as claimed in claim 8, which is characterized in that the press section is idler wheel, roll shaft or protrusion.
10. reagent packet as claimed in claim 7, which is characterized in that be additionally provided on the peristaltic pump tube by the peristaltic pump
Pipe is connected to the reagent bag body, or, the three-way valve that the peristaltic pump tube is connected to outside air；The three-way valve
On be provided with convex ribs or card slot.
11. reagent packet as claimed in claim 7, which is characterized in that reagent incrustation side has boss, peristaltic pump tube
At least part exposed to from the boss except the reagent incrustation, the reagent output interface is arranged described convex
On platform.
12. a kind of test card characterized by comprising test card main body and the fluid path channel in test card main body, it is described
Fluid path channel includes: calibration solution channel, test fluid channel and waste fluid channel, the calibration solution channel, the test fluid channel and
One end of the waste fluid channel is gathered together, and the other end in the calibration solution channel is equipped with reagent packet interface, the test fluid
The other end in channel is equipped with hemostix interface, and the other end of the waste fluid channel is equipped with gas vent, sets on the calibration solution channel
It is equipped with test section.
13. test card as claimed in claim 12, which is characterized in that the test fluid channel has at the convergence position of channel
There is a sample valve, the waste fluid channel has a waste liquid valve at the convergence position of channel.
14. test card as claimed in claim 12, which is characterized in that be arranged at the correspondence test section in the calibration solution channel
There are multiple reaction pole pieces.
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| WO2022143929A1 (en) * | 2020-12-31 | 2022-07-07 | 深圳市理邦精密仪器股份有限公司 | Removable test card for in-vitro medical diagnosis device and control method thereof |
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