WO2021004240A1

WO2021004240A1 - Ion selective electrode electrolyte module

Info

Publication number: WO2021004240A1
Application number: PCT/CN2020/096450
Authority: WO
Inventors: 曾爱良
Original assignee: 深圳市康立生物医疗有限公司; 梅州康立高科技有限公司
Priority date: 2019-07-08
Filing date: 2020-06-17
Publication date: 2021-01-14
Also published as: CN110261457A

Abstract

An ion selective electrode electrolyte module, comprising an ion selective electrode module (1), a pump module (2), and a reagent pack module (3); a liquid outlet of the reagent pack module (3) is connected to a liquid inlet of the ion selective electrode module (1) by means of the pump module (2); a waste liquid outlet of the ion selective electrode module (1) is connected to a waste liquid inlet of the reagent pack module (3) by means of the pump module (2); and a liquid flow channel (111) enables the communication between the liquid inlet and the waste liquid outlet of the ion selective electrode module (1), and the liquid flow channel (111) is perpendicular to the horizontal plane. The ion selective electrode electrolyte module is used as a completely independent module, being able to, together with a full-automatic biochemical analyzer, greatly reduce the probability of a sample error; and a flow path uses a perpendicular flow path solution, being able to eliminate bubbles in standard liquids A and B or samples, and preventing bubbles in a flow path pipeline from entering an electrode sample testing pipeline and affecting a test result.

Description

Ion selective electrode electrolyte module

Technical field

The invention relates to an electrolyte module, in particular to an ion selective electrode electrolyte module.

Background technique

At present, the domestic instrument for measuring the plasma concentration of Li ⁺ , Na ⁺ , K ⁺ , and Cl ^-in serum, plasma, and diluted urine is a stand-alone electrolyte analyzer. The same sample is tested on both the electrolyte analyzer and the biochemical analyzer. In this way, the information is prone to error in the process of dispensing or moving the sample. For large hospitals with a large number of samples, the single-unit electrolyte analyzer test requires a lot of manpower and material resources, is low in efficiency, and is not convenient and fast.

Domestic single-unit electrolyte analyzers such as Shanghai Schindler, Shenzhen Yuehua, Nanjing Panstar and other manufacturers generally use sampling racks to complete the sample suction, and transport the samples to the flow cell for sampling through a section of pipeline. The flow path in the flow cell It is a horizontal method, so the entire flow path is long, and the bubbles generated in the flow path pipe from the sampling needle to the front end of the flow cell are easily sucked into the electrode pipe of the flow cell, causing the electrode to be unstable and affecting the sample measurement result.

Personnel are required to maintain the electrode, and the probability of electrode instability increases. The electrode filling liquid of the electrode used in the stand-alone electrolyte analyzer will cause the electrode to be unstable if the filling liquid is reduced after a period of use, and the inner filling liquid of the electrode needs to be replaced manually, and the connection between the electrode and the electrode has no positioning structure, resulting in flow after assembly It is easy to dislocation between the roads, and the electrode is not stable due to not smooth, which affects the test results.

Summary of the invention

technical problem

The solution to the problem

Technical solutions

In order to solve the problems in the prior art, the present invention provides an ion selective electrode electrolyte module.

The present invention provides an ion selective electrode electrolyte module, including an ion selective electrode module, a pump module, and a reagent pack module. The liquid outlet of the reagent pack module passes through the pump module and the ion selective electrode module. The liquid inlet is connected, the waste liquid outlet of the ion selective electrode module is connected to the waste liquid inlet of the reagent pack module through the pump module, and the liquid inlet and waste of the ion selective electrode module A fluid channel is communicated between the liquid outlets, and the fluid channel is perpendicular to the horizontal plane.

As a further improvement of the present invention, the ion selective electrode module includes a housing in which a liquid inlet barrel assembly, a front-end liquid inspection, an electrode assembly, a pressure plate and a pressure plate adapter are arranged in sequence along the liquid flow direction. The liquid inlet of the ion selective electrode module is arranged on the liquid inlet barrel assembly, and the fluid channel passes through the liquid inlet barrel assembly, the front end liquid inspection, the electrode assembly, the pressure plate and the pressure plate adapter in sequence, and the ion The waste liquid outlet of the selective electrode module is arranged on the pressure plate adapter.

As a further improvement of the present invention, the ion selective electrode module further includes an impedance plate and an electrode probe, and the electrode assembly is connected to the impedance plate through the electrode probe.

As a further improvement of the present invention, the electrode assembly includes at least two electrodes, the electrodes are vertically stacked on a horizontal surface, and the electrodes are in one-to-one correspondence with the electrode probes, and the electrode probes are fixed on the housing. On the body, the electrode probe is connected to the impedance plate through a conductive elastic sheet, and the electrode is in reliable contact with the electrode probe.

As a further improvement of the present invention, the adjacent electrodes are positioned and installed by a positioning structure, and a sealing ring is arranged between the adjacent electrodes.

As a further improvement of the present invention, the liquid inlet barrel assembly and the front end liquid test are positioned and installed by a positioning structure, the front end liquid test and the electrode assembly are positioned and installed by the positioning structure, and the electrode assembly and the pressure plate pass between Positioning structure positioning installation.

As a further improvement of the present invention, a sealing ring is provided between the liquid inlet barrel assembly and the front end liquid test, a sealing ring is provided between the front end liquid test and the electrode assembly, and a seal is provided between the electrode assembly and the pressure plate. ring.

As a further improvement of the present invention, the positioning structure is a positioning structure in which a positioning protrusion matches a positioning recess.

As a further improvement of the present invention, the reagent pack module includes a first type of standard liquid outlet, a second type of standard liquid outlet, a waste liquid inlet, and a chip for recording information such as reagent residuals. The pump module It includes a first peristaltic pump, a second peristaltic pump and a third peristaltic pump. The liquid inlet of the first peristaltic pump is connected to the liquid outlet of the second standard liquid, and the liquid outlet of the first peristaltic pump is connected to The liquid inlet barrel assembly is connected, the liquid inlet of the second peristaltic pump is connected with the first standard liquid outlet, and the liquid outlet of the second peristaltic pump is connected with the liquid inlet barrel assembly, The liquid inlet of the third peristaltic pump is connected with the pressure plate adapter, and the liquid outlet of the third peristaltic pump is connected with the waste liquid inlet.

As a further improvement of the present invention, the pressure plate is connected to the housing through a double torsion spring.

The beneficial effects of the invention

Beneficial effect

The beneficial effects of the present invention are: through the above scheme, the ion selective electrode electrolyte module is taken as a completely independent module, and together with the automatic biochemical analyzer, etc., the probability of sample error can be greatly reduced, a lot of manpower and material resources are saved, and the Efficiency and cost savings; the flow path adopts the vertical flow path scheme, which can eliminate the bubbles in the A and B standard solutions or samples, and prevent the bubbles in the flow path pipe from entering the electrode test pipe and affecting the test results, and the flow path of this scheme is short , Which can make the sample test faster, the electrode more stable, save reagents, improve the efficiency and save the cost.

Brief description of the drawings

Description of the drawings

Figure 1 is a schematic diagram of an ion selective electrode electrolyte module of the present invention.

2 is a cross-sectional view of an ion selective electrode module of an ion selective electrode electrolyte module of the present invention.

3 is a partial cross-sectional view of an ion selective electrode module of an ion selective electrode electrolyte module of the present invention.

Fig. 4 is a flow path diagram of an ion selective electrode electrolyte module of the present invention.

Fig. 5 is a schematic diagram of an ion selective electrode module of an ion selective electrode electrolyte module of the present invention.

FIG. 6 is a schematic diagram of the front end liquid inspection of an ion selective electrode electrolyte module of the present invention.

Fig. 7 is a schematic diagram of a pressing plate of an ion selective electrode electrolyte module of the present invention.

Invention embodiment

Embodiments of the invention

The present invention will be further described below in conjunction with the description of the drawings and the specific embodiments.

As shown in Figures 1 to 7, an ion selective electrode electrolyte module includes an ion selective electrode module 1, a pump module 2, a reagent pack module 3, and the liquid outlet of the reagent pack module 3 passes through the pump module 2 is connected to the liquid inlet of the ion selective electrode module 1, and the waste liquid outlet of the ion selective electrode module 1 is connected to the waste liquid inlet of the reagent pack module 3 through the pump module 2 A fluid channel 111 is communicated between the liquid inlet and the waste liquid outlet of the ion selective electrode module 1, and the fluid channel 111 is perpendicular to the horizontal plane.

As shown in Figures 1 to 7, the ion selective electrode module 1 includes a housing 16, and the housing 16 is provided with a liquid inlet barrel assembly 11, a front end liquid inspection 12, and an electrode assembly arranged in sequence along the liquid flow direction. 13. The pressure plate 14 and the pressure plate adapter 15, the liquid inlet of the ion selective electrode module 1 is arranged on the liquid inlet barrel assembly 11, and the fluid channel 111 sequentially passes through the liquid inlet barrel assembly 11 and the front end The liquid test 12, the electrode assembly 13, the pressure plate 14, and the pressure plate adapter 15, the waste liquid outlet of the ion selective electrode module 1 is arranged on the pressure plate adapter 15, and the fluid channel 111 includes a flow path pipe and an electrode For the sampling pipeline, the fluid channel 111 is mainly composed of the liquid inlet barrel assembly 11 and the front end liquid detection 12, and the electrode sampling pipeline is mainly composed of the electrode assembly 13.

As shown in FIGS. 1 to 7, the ion selective electrode module 1 further includes a main board 110, an impedance board 17 and an electrode probe 18. The electrode assembly 13 is connected to the impedance board 17 through the electrode probe 18 .

As shown in FIGS. 1 to 7, the electrode assembly 13 includes at least two electrodes, preferably five electrodes, which are stacked vertically on a horizontal surface, and the electrodes correspond to the electrode probes 18 one by one. The electrode probe 18 is fixed on the housing 16, the electrode probe 18 is connected to the impedance plate 17 through a conductive elastic sheet, and the electrode 13 is in reliable contact with the electrode probe 18.

As shown in FIGS. 1 to 7, the adjacent electrodes are positioned and installed by a positioning structure, and a sealing ring 112 is provided between the adjacent electrodes.

As shown in Figures 1 to 7, the liquid inlet barrel assembly 11 and the front end liquid test 1 are positioned and installed by a positioning structure, and the front end liquid test 12 and the electrode assembly 13 are positioned and installed by a positioning structure. The assembly 13 and the pressure plate 14 are positioned and installed by a positioning structure.

As shown in Figures 1 to 7, a sealing ring 112 is provided between the liquid inlet barrel assembly 11 and the front end liquid test 12, and a sealing ring 112 is provided between the front end liquid test 12 and the electrode assembly 13. A sealing ring 112 is provided between the assembly 13 and the pressure plate 14.

As shown in FIGS. 1 to 7, the positioning structure is a positioning structure in which the positioning protrusion 113 and the positioning recess 114 cooperate. Taking the front end liquid test 12 as an example, the front end liquid test 12 has flow path holes and positioning holes on the top. There are positioning shafts 121 and positioning ribs 122 below. Taking the pressure plate 14 as an example, the pressure plate 14 has flow passage holes, positioning holes 141 and positioning grooves 142 on the upper surface.

As shown in Figure 4, the reagent pack module 3 includes a first type of standard solution outlet (ie A standard solution), a second type of standard solution outlet (ie B standard solution), a waste liquid inlet and a record A chip (L) for information such as reagent balance. The pump module 2 includes a first peristaltic pump 21, a second peristaltic pump 22, and a third peristaltic pump 23. The liquid inlet of the first peristaltic pump 21 (that is, the I port) ) Is connected to the second type of standard liquid outlet, the liquid outlet of the first peristaltic pump 21 (ie J port) is connected to the liquid inlet barrel assembly 11, and the liquid inlet of the second peristaltic pump 22 The port (namely port D) is connected to the outlet port of the first standard solution, the outlet port (namely port E) of the second peristaltic pump 22 is connected to the liquid inlet barrel assembly 11, and the third peristaltic pump The liquid inlet (ie, G port) of the pump 23 is connected with the pressure plate adapter 15, and the liquid outlet (ie, H port) of the third peristaltic pump 23 is connected with the waste liquid inlet.

As shown in FIGS. 1 to 7, the pressure plate 14 is connected to the housing through a double torsion spring 19.

As shown in Figure 1 to Figure 7, the ion selective electrode electrolyte module provided by the present invention is a completely independent module. The MCU of the motherboard 110 runs the program, and the serial port receives the user's operating information and transmits it to the motherboard MCU for processing. , Control the operation of the three peristaltic pumps in the pump module 2, collect the analog channel data and convert, calculate, the main board MCU will transmit the test results to the PC.

As shown in Figures 1 to 7, the ion selective electrode electrolyte module is used to measure the plasma concentration of Li ⁺ , Na ⁺ , K ⁺ , Cl ^-in serum, plasma, and diluted urine. The impedance plate 17 and the main board 110 are inserted The needle and the socket are directly connected, and the electrode is in reliable contact with the electrode probe 18 on the impedance plate 17 through the elastic sheet contact, and no cable connection is required, which can minimize electrical noise. The liquid inlet barrel assembly 11 is fixed as a whole with the front end liquid test 12 through the housing 16 of the ion selective electrode module 1, and 5 electrode probes 18 are installed longitudinally in the housing 16. The number of electrode probes 18 is not limited to that shown in the figure. The five electrodes installed in the housing 16 are in reliable contact with the electrode probe 18. The pressure plate 14 and the pressure plate adapter 15 are located next to the lower end of the bottom electrode. The upper end of the pressure plate 14 has a positioning hole 141 and a positioning groove 142. There are flow holes. There are flow path holes, positioning holes, and positioning grooves in the middle part of the top of the electrode, positioning shafts and positioning ribs below, positioning shaft 121 and positioning ribs 122 at the lower end of the front end liquid test 12, and flow path holes in the middle. The above positioning structure can make the front end liquid Check 12, when multiple electrodes and pressure plate 14 are connected, the flow path holes are automatically aligned to ensure a smooth vertical flow path, which can avoid unstable test data due to unsmooth flow paths. This vertical flow path solution has a compact structure and a short flow path, which can prevent air bubbles in the flow path pipe from entering the electrode sample pipe and affecting the test results. This solution has faster sample testing speed, more stable electrodes, and more reagent saving.

As shown in Figures 1 to 7, the working mode of an ion selective electrode electrolyte module provided by the present invention is as follows:

The sample is sucked by the sampling needle of the automatic biochemical analyzer from the sample cup or original blood collection tube placed in the corresponding position of the sample tray, and injected into the inner cavity of the liquid inlet barrel assembly 11 on the top of the ion selective electrode module 1. Air bubbles are eliminated in the inner cavity of the liquid inlet barrel assembly 11. The MCU running program of the main board 110 of the ion selective electrode module 1, the serial port receives the user's operation information and transmits it to the MCU of the main board 110 for processing, controls the operation of the third peristaltic pump 23, and the sample is moved to the vertically arranged electrode pipeline for sampling. The front end of the electrode is equipped with a front-end liquid test 12, which can detect bubbles in the liquid and whether there is or without liquid, collect analog channel data and convert and calculate, the MCU of the main board 110 transmits the test results to the PC, and the liquid after the test is completed The waste liquid (inlet) of the adapter box is sent to the waste liquid bag in the reagent pack. The sample flow path is: liquid inlet barrel assembly 11 (sample inlet)-front liquid inspection 12-electrode assembly 13-pressure plate 14-pressure plate adapter 15-F-G-H-waste liquid of the adapter box.

In the same way, the A standard solution is sucked by the second peristaltic pump 22 from the A standard solution in the adapter box on the reagent pack, and injected into the inner cavity of the liquid inlet barrel assembly 11 through A. A is located on the side wall of the liquid inlet barrel assembly 11, At a distance of 2 mm from the upper end surface, the B standard solution is sucked by the first peristaltic pump 21 from the B standard solution in the adapter box on the reagent pack, and injected into the inner cavity of the liquid inlet barrel assembly 11 through B, and B is located on the side of the liquid inlet barrel assembly 11 At 3.7mm directly below wall A, after the bubbles in the standard solutions A and B are injected into the cavity of the liquid barrel assembly 11, they are automatically eliminated in this cavity and will not be sucked into the electrode pipe at the lower end. The standard solution A and The B standard solution is respectively sucked into the electrode pipes arranged vertically at the lower end under the cooperation of the third peristaltic pump 23 for sampling to complete the calibration or to clean the flow path. A standard liquid flow path: adapter box A standard solution-DE-inlet tank assembly 11 A-front end liquid inspection 12-electrode assembly 13-pressure plate 14-pressure plate adapter 15-FGH-adapter box waste liquid; B Standard fluid flow path: Adapter box B standard fluid-IJ-inlet tank assembly 11 B-front end fluid check 12-electrode assembly 13-press plate 14-press plate adapter 15-FGH-adapter box waste liquid.

Compared with the traditional single-unit electrolyte analyzer, the ion selective electrode electrolyte module provided by the present invention has the following beneficial effects:

1. The flow path adopts a vertical flow path. The liquid inlet barrel assembly 11 is directly connected to the front end liquid test 12 through the housing 16 of the ion selective electrode module 1, and the front end liquid test 12 is directly connected to the pressure plate 14 through the vertically arranged electrode assembly 13 Connection, compact structure, the inner cavity of the liquid inlet barrel assembly 11 can eliminate the bubbles in the A and B standard solutions or samples, and prevent the bubbles in the flow path pipe from entering the electrode test pipe to affect the test results, and this solution has a short flow path. It can make the sampling speed faster, the electrode more stable, save the reagent, improve the efficiency and save the cost;

2. The positioning structure can automatically align the flow path holes when the front-end liquid test 12, multiple electrodes and the pressure plate 14 are connected to ensure a smooth vertical flow path, which can avoid unstable test data due to unsmooth flow paths and affect test results;

3. The inner filling liquid of the electrode can be replaced for more than three months, and the electrode does not need direct maintenance by personnel. Only the instrument is required to periodically clean the electrode, which saves manpower and avoids unstable electrode when changing the inner filling liquid, which affects the test results ；

4. As a completely independent module, the ion selective electrode electrolyte module, together with the automatic biochemical analyzer, can greatly reduce the probability of sample error, save a lot of manpower and material resources, and improve efficiency. Saved costs.

An ion selective electrode electrolyte module provided by the present invention, as a completely independent module, is assembled to clinical testing equipment such as an automatic biochemical analyzer for measuring Li ⁺ , Na ⁺ , and Na ⁺ in serum, plasma, and diluted urine. The concentration of K ⁺ , Cl ^- plasma.

The above content is a further detailed description of the present invention in combination with specific preferred embodiments, and it cannot be considered that the specific implementation of the present invention is limited to these descriptions. For those of ordinary skill in the technical field to which the present invention belongs, several simple deductions or substitutions can be made without departing from the concept of the present invention, which should be regarded as falling within the protection scope of the present invention.

Claims

An ion selective electrode electrolyte module, characterized in that it comprises an ion selective electrode module, a pump module, and a reagent pack module. The liquid outlet of the reagent pack module passes through the connection between the pump module and the ion selective electrode module. The liquid inlet is connected, the waste liquid outlet of the ion selective electrode module is connected to the waste liquid inlet of the reagent pack module through the pump module, and the liquid inlet and waste of the ion selective electrode module A fluid channel is communicated between the liquid outlets, and the fluid channel is perpendicular to the horizontal plane.
The ion selective electrode electrolyte module according to claim 1, characterized in that: the ion selective electrode module comprises a housing, and the housing is provided with a liquid inlet barrel assembly and a front end liquid detection device arranged in sequence along the liquid flow direction. , An electrode assembly, a pressure plate and a pressure plate adapter, the liquid inlet of the ion selective electrode module is arranged on the liquid inlet barrel assembly, and the flow channel sequentially passes through the liquid inlet barrel assembly, the front end liquid inspection, and the electrode The component, the pressing plate and the pressing plate adapter, the waste liquid outlet of the ion selective electrode module is arranged on the pressing plate adapter.
The ion selective electrode electrolyte module according to claim 2, wherein the ion selective electrode module further comprises an impedance plate and an electrode probe, and the electrode assembly is connected to the impedance plate through the electrode probe .
The ion selective electrode electrolyte module according to claim 3, wherein the electrode assembly includes at least two electrodes, the electrodes are arranged vertically to the horizontal plane and stacked up and down, and the electrodes correspond to the electrode probes one-to-one The electrode probe is fixed on the housing, the electrode probe is connected to the impedance plate through a conductive elastic sheet, and the electrode is in reliable contact with the electrode probe.
4. The ion selective electrode electrolyte module according to claim 4, wherein the adjacent electrodes are positioned and installed by a positioning structure, and a sealing ring is provided between the adjacent electrodes.
The ion selective electrode electrolyte module according to claim 2, characterized in that: the liquid inlet barrel assembly and the front end liquid test are positioned and installed by a positioning structure, and the front end liquid test and the electrode assembly are positioned by a positioning structure. For installation, the electrode assembly and the pressure plate are positioned and installed through a positioning structure.
The ion selective electrode electrolyte module according to claim 6, wherein a sealing ring is provided between the liquid inlet barrel assembly and the front end liquid test, and a sealing ring is provided between the front end liquid test and the electrode assembly, A sealing ring is arranged between the electrode assembly and the pressing plate.
The ion selective electrode electrolyte module according to claim 6, wherein the positioning structure is a positioning structure in which a positioning protrusion and a positioning recess are matched.
The ion selective electrode electrolyte module according to claim 2, wherein the reagent pack module includes a first type of standard solution outlet, a second type of standard solution outlet, a waste liquid inlet, and a recording reagent A chip for margin information, the pump module includes a first peristaltic pump, a second peristaltic pump, and a third peristaltic pump. The liquid inlet of the first peristaltic pump is connected to the liquid outlet of the second standard liquid. The liquid outlet of the first peristaltic pump is connected to the liquid inlet barrel assembly, the liquid inlet of the second peristaltic pump is connected to the first standard liquid outlet, and the liquid outlet of the second peristaltic pump The inlet is connected with the liquid inlet barrel assembly, the liquid inlet of the third peristaltic pump is connected with the pressure plate adapter, and the liquid outlet of the third peristaltic pump is connected with the waste liquid inlet.
3. The ion selective electrode electrolyte module according to claim 2, wherein the pressure plate is connected to the housing through a double torsion spring.