CN220064066U

CN220064066U - Biochemical analyzer

Info

Publication number: CN220064066U
Application number: CN202320762411.9U
Authority: CN
Inventors: 王伟; 郁琦; 杨理想
Original assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Current assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Priority date: 2022-03-31
Filing date: 2023-03-31
Publication date: 2023-11-21
Anticipated expiration: 2033-03-31
Also published as: WO2023186095A1

Abstract

The utility model provides a biochemical analyzer, which comprises a sample bearing component, a first sample dispensing component, a second sample dispensing component, a reagent bearing component, a reagent dispensing component, a first measuring component and an electrolyte measuring module, wherein the electrolyte measuring module comprises a sample container, an electrode component and a second measuring component; the electrolyte measurement module includes a sample container, an electrode assembly, and a second measurement assembly; the electrode assembly comprises a plurality of electrodes, each electrode of the electrode assembly is sequentially arranged to form a sample flow channel for the second sample to be tested to flow through each electrode, the included angle between the sample flow channel and the horizontal plane is smaller than or equal to 10 degrees, and the sample flow channel is communicated with the sensitive film of each electrode of the electrode assembly. The biochemical analyzer uses the electrolyte measuring module as a completely independent module, and the sample flow channel is slightly inclined or horizontally arranged, so that the ion concentration detection result is more stable.

Description

Biochemical analyzer

Technical Field

The utility model relates to the field of medical instruments, in particular to a biochemical analyzer.

Background

Biochemical analyzers are common devices of clinical laboratory in hospitals for performing various tests on blood of patients, such as liver function tests, kidney function tests, blood lipid tests, blood glucose tests, etc. With the increasing importance of people on life health, the detection needs are increasing. Such as the detection of ion concentrations in blood, is becoming more and more common. In the prior art, clinical laboratory generally uses an electrolyte analyzer to detect ion concentration in the blood of a patient. Blood samples from the same patient need to be tested on multiple devices, which results in multiple blood samples from the patient to meet the needs of biochemical analysis and ion detection. And the clinical laboratory of the hospital also needs to manage various devices such as a biochemical analyzer, an electrolyte analyzer and the like. It can be seen that the existing biochemical analyzer has single function and cannot meet the requirements of patients and clinical departments.

In addition, the current electrode assembly has the problem of unstable ion concentration detection results, and a source practitioner of the problem is also under exploration, which is one of the problems to be solved or improved in the current electrolyte measuring equipment.

Disclosure of Invention

The utility model mainly provides a biochemical analyzer, which aims to increase the ion concentration detection function of the biochemical analyzer and has more stable ion concentration detection.

In one embodiment of the present utility model, a biochemical analyzer is provided, comprising a sample carrier assembly, a first sample dispensing assembly, a second sample dispensing assembly, a reagent carrier assembly, a reagent dispensing assembly, a first measurement assembly, and an electrolyte measurement module comprising a sample container, an electrode assembly, and a second measurement assembly, wherein:

the sample bearing assembly is used for bearing a sample to be tested;

the first sample dispensing component is used for dispensing a first sample to be tested in the sample bearing component to the first measuring component;

the reagent bearing assembly is used for bearing a reagent;

the reagent dispensing assembly is used for transferring the reagent in the reagent bearing assembly to the first measuring assembly;

The first measuring component is used for carrying out light detection on a reaction liquid formed by mixing at least a first sample to be detected and the reagent so as to obtain a light detection project result;

the second sample dispensing assembly dispenses a second sample to be tested in the sample bearing assembly to the sample container;

the electrode assembly comprises a plurality of electrodes, each electrode is provided with a channel, a sensitive film is arranged in each channel of each electrode, the channels of each electrode are communicated to form a sample flow channel for the second sample to be tested to flow through, the output end of each electrode is electrically connected with the second measuring assembly, and when the second sample to be tested flows through the sample flow channel, the included angle between the axis of the sample flow channel and the horizontal plane is smaller than or equal to 10 degrees;

the detection outlet of the sample container is communicated with the sample flow channel, so that a second sample to be detected in the sample container sequentially flows through the sensitive films of the electrodes of the electrode assembly;

the second measuring component is used for obtaining an ion concentration detection result of the second sample to be measured according to the electric signal output by the electrode when the second sample to be measured flows through the sensitive film.

In some embodiments, the first test sample and the second test sample are from the same subject.

In some embodiments, the electrolyte measurement module further comprises a sample hydrodynamic device in communication with the sample flow channel for powering the flow of the second sample to be measured through the sample flow channel.

In some embodiments, the first sample dispensing assembly and the second sample dispensing assembly are the same sample dispensing assembly.

In some embodiments, the axis of the sample flow channel forms an angle of 0 ° with the horizontal plane when the second sample to be measured flows through the sample flow channel.

In some embodiments, the inner diameter of the sample flow channel is greater than or equal to 0.9 millimeters.

In some embodiments, the electrolyte measurement module further includes a mounting seat for placing an electrode assembly, the second measurement assembly includes a plurality of conductive members disposed on the mounting seat, the plurality of conductive members correspond to the plurality of electrodes, and each electrode of the electrode assembly is electrically connected to the respective corresponding conductive member.

In some embodiments, the mounting base includes a movable adjusting member, two abutting members arranged oppositely in a horizontal direction, and a mounting platform, a plurality of electrodes of the electrode assembly are arranged on the mounting platform, the plurality of electrodes are fixed between the two abutting members, and at least one of the two abutting members can move horizontally according to the movement of the adjusting member to adjust the distance between the two abutting members to mount the plurality of electrodes.

In some embodiments, the plurality of conductive elements are disposed on the mounting base at intervals along a first direction, the plurality of electrodes include a reference electrode and at least one detection electrode, the reference electrode and the at least one detection electrode are disposed along the first direction, the reference electrode is disposed on one side of a corresponding conductive element along a second direction, the second direction is different from the first direction, the reference electrode has a first accommodating cavity, the first accommodating cavity is used for accommodating a first internal reference solution to form a reference potential, and orthographic projections of the first accommodating cavity and at least two conductive elements along the second direction are at least partially overlapped.

In some embodiments, the plurality of conductive elements are disposed on the mounting base at intervals along a first direction, the plurality of electrodes include a reference electrode and at least one detection electrode, the reference electrode and the at least one detection electrode are disposed along the first direction, the detection electrode has a second accommodating cavity, the second accommodating cavity is used for accommodating a second internal reference solution to form a membrane potential, the reference electrode has a first accommodating cavity, the first accommodating cavity is used for accommodating the first internal reference solution to form the reference potential, and a width of the first accommodating cavity in the first direction is twice or more than twice a width of the second accommodating cavity in the first direction.

In some embodiments, the conductive elements include an end surface for abutting the electrodes, at least one of the end surfaces of the conductive elements being convex.

In some embodiments, the plurality of electrodes includes a K ion electrode, a Cl ion electrode, and a Na ion electrode, wherein the sensitive film color of the Cl ion electrode is: the R has a value in the range of [ 50, 99 ], and the G has a value in the range of [ 10, 100 ].

In some embodiments, the electrolyte measurement module further comprises a calibration liquid module, the calibration liquid module comprises a calibration liquid bin for placing a calibration liquid container for carrying a calibration liquid, a calibration liquid pipeline, and a calibration liquid power device connected to the calibration liquid pipeline for providing power, an inlet end of the calibration liquid pipeline is communicated with the calibration liquid container, an outlet end of the calibration liquid pipeline is communicated with the sample container or the sample flow channel so that the calibration liquid is conveyed to the sample flow channel, and the second measurement assembly is further used for calibrating according to an electric signal generated by the electrode assembly when the calibration liquid flows through the sample flow channel.

In some embodiments, the calibration liquid bin is used for detachably mounting a calibration liquid package, and the calibration liquid package comprises the calibration liquid container and a chip assembly for at least recording calibration liquid information; and an information reading assembly for reading the calibration liquid information recorded in the chip assembly is further arranged in the calibration liquid bin.

In some embodiments, the inlet end of the calibration liquid pipeline is arranged in the calibration liquid bin; the calibration liquid bin further comprises an on-site detection component, and the on-site detection component generates state change when the connection state of the calibration liquid container and the inlet end of the calibration liquid pipeline is switched between disconnection and connection.

In some embodiments, the biochemical analyzer further comprises an indicator light that switches from on to off or from off to on when the status change occurs in the in-situ detection assembly.

In some embodiments, the calibration fluid container comprises a first calibration fluid container carrying a first calibration fluid and a second calibration fluid container carrying a second calibration fluid, the calibration fluid lines comprise a first calibration fluid line with an inlet end in communication with the first calibration fluid container and a second calibration fluid line with an inlet end in communication with the second calibration fluid container, the sample container has a first calibration fluid inlet in communication with an outlet end of the first calibration fluid line and a second calibration fluid inlet in communication with an outlet end of the second calibration fluid line, the first calibration fluid inlet is located below the second calibration fluid inlet in a height direction of the sample container; the frequency of use of the first calibration liquid is higher than that of the second calibration liquid.

In some embodiments, the calibration fluid container comprises a first calibration fluid container carrying a first calibration fluid and a second calibration fluid container carrying a second calibration fluid, the calibration fluid lines comprise a first calibration fluid line with an inlet end in communication with the first calibration fluid container and a second calibration fluid line with an inlet end in communication with the second calibration fluid container, an outlet end of the first calibration fluid line is in communication with the sample container or the sample flow channel such that the first calibration fluid is delivered to the sample flow channel, and an outlet end of the second calibration fluid line is in communication with the sample container or the sample flow channel such that the second calibration fluid is delivered to the sample flow channel; the electrolyte measuring module further comprises a sample hydrodynamic device communicated with the sample flow passage, and the sample hydrodynamic device is used for providing power for the second sample to be measured, the first calibration liquid and the second calibration liquid flowing through the sample flow passage.

In some embodiments, the biochemical analyzer further comprises a frame, and the electrolyte measurement module further comprises a first mounting bracket, a second mounting bracket, and a third mounting bracket respectively mounted on the frame; the sample container, electrode assembly and second measurement assembly are mounted on the first mounting bracket; the first power device, the second power device and the sample hydrodynamic device are arranged on the second mounting bracket; the calibration liquid bin is mounted on the third mounting bracket.

In some embodiments, the first measurement component includes a light source and a light detection module, the light source is configured to emit light to irradiate the reaction solution, the light detection module is configured to receive the light of the light source irradiated by the reaction solution to obtain a result of a light detection item, the calibration liquid module and the light source are respectively disposed on opposite angles or two sides of the biochemical analyzer, and/or the sample container and the light source are respectively disposed on opposite angles or two sides of the biochemical analyzer.

In some embodiments, the second sample dispensing assembly includes a second sampling needle for injecting the second sample to be tested into the sample container, the top of the sample container has an opening for the sampling needle to inject the second sample to be tested into the sample container, the bottom of the sample container has a detection outlet communicated with the sample flow channel for the second sample to be tested to flow out, and the projection of the liquid discharge axis of the second sampling needle when injecting the second sample to be tested into the sample container at the bottom of the sample container is not coincident with the center of the detection outlet at the bottom of the sample container.

In some embodiments, the biochemical analyzer further comprises a waste liquid tank for containing a waste liquid for washing at least one of the sample dispensing assembly, the reagent dispensing assembly, and a reaction cup carrying a reaction liquid; the top of the sample container is provided with an opening for the second sample dispensing component to inject the second sample to be tested into the sample container, the sample container is also provided with an overflow port penetrating through the side wall of the sample container and an overflow groove for collecting liquid overflowing from the overflow port, and the overflow groove is connected to the waste liquid tank through an overflow pipeline.

According to the biochemical analyzer of the embodiment, besides the detection of biochemical items, the biochemical analyzer is also provided with the electrolyte measuring module, K, cl and Na ion concentration of a sample to be detected can be detected, the ion detection function of the biochemical analyzer is increased, blood sampling times are reduced for patients needing to detect biochemical items and ion detection, and in addition, the stability of ion concentration detection is improved by slightly inclining or horizontally setting a sample flow channel.

Drawings

FIG. 1 is a block diagram showing the structure of a biochemical analyzer according to an embodiment;

FIG. 2 is a schematic diagram showing a functional module of the biochemical analyzer according to an embodiment;

FIG. 3 is a block diagram showing the structure of an electrolyte measurement module in the biochemical analyzer according to an embodiment;

FIG. 4 is a schematic view of a portion of the structure of a sample container according to one embodiment;

FIG. 5 is a physical diagram of a Cl ion electrode according to one embodiment;

FIG. 6 is a graph showing the slope of Cl ion electrode versus time of use according to one embodiment;

FIG. 7 is a graph showing the slope statistics of a conventional Cl ion electrode;

FIG. 8 is a graph showing the slope statistics of Cl ion electrode according to one embodiment of the present application;

FIG. 9 is a front view of an electrolyte measurement module of an embodiment;

Fig. 10 is a side view of a reference electrode of the electrolyte measurement module shown in fig. 9;

fig. 11 is a cross-sectional view of the reference electrode of fig. 10 taken along the direction A-A;

FIG. 12 is a side view of a sensing electrode of the electrolyte measurement module of FIG. 9;

FIG. 13 is a cross-sectional view of the detection electrode shown in FIG. 12 taken along the direction B-B;

FIG. 14 is an enlarged view of a portion of the electrolyte measurement module of FIG. 9 at X;

FIG. 15 is a schematic view showing the structure of an electrolyte measurement module according to an embodiment;

FIG. 16 is a schematic diagram showing the structure of a biochemical analyzer according to an embodiment;

10. a sample container; 10a, a receiving cavity; 10b, a first calibration liquid inlet; 10c, a second calibration liquid inlet; 11. an overflow port; 12. an overflow trough; 13. an overflow line;

20. an electrode assembly;

21. a sample flow channel; 22a, a liquid inlet; 22b, a liquid outlet;

23. a reference electrode; 231. a first accommodation chamber; 232. a first housing; 233. a first ion sensitive membrane; 234. a first electrode core; 2341. a first end face; 235. a first flow passage; 236. a first mounting hole; 237. a first cover; 238. a second mounting hole; 239. a first elastic seal;

24. a detection electrode; 241. a second accommodation chamber; 242. a second housing; 243. a second ion sensitive membrane; 244. a second electrode core; 2441. a second end face; 245. a second flow passage; 246. a third mounting hole; 247. a second elastic seal;

30. A second measurement assembly; 31. a conductive member; 311. a third end face;

40. a sample fluid power device;

51. calibrating a liquid bin; 51a, a calibration liquid bag;

52a, a first calibration fluid container; 52b, a second calibration fluid container;

53a, a first calibration liquid line; 53b, a second calibration liquid pipeline;

54a, a first power device; 54b, a second power device;

60. a mounting base; 61. an adjusting member; 62. an abutment; 63. a mounting platform; 64. a mounting cavity;

70. a frame; 70a, a first mounting bracket; 70b, a second mounting bracket; 70c, a third mounting bracket;

100. an electrolyte measurement module;

200. a functional module; 201. a sample carrier assembly; 202. a first sample dispensing assembly; 203. a reagent carrying assembly; 204. a reagent dispensing assembly; 205. a mixing mechanism; 206. a reaction assembly; 207. a first measurement assembly;

300. an input module;

400. a display module;

500. a memory;

600. a processor;

700. an alarm module;

800. a waste liquid tank.

Detailed Description

The utility model will be described in further detail below with reference to the drawings by means of specific embodiments. Wherein like elements in different embodiments are numbered alike in association. In the following embodiments, numerous specific details are set forth in order to provide a better understanding of the present utility model. However, one skilled in the art will readily recognize that some of the features may be omitted, or replaced by other elements, materials, or methods in different situations. In some instances, related operations of the present utility model have not been shown or described in the specification in order to avoid obscuring the core portions of the present utility model, and may be unnecessary to persons skilled in the art from a detailed description of the related operations, which may be presented in the description and general knowledge of one skilled in the art.

Furthermore, the described features, operations, or characteristics of the description may be combined in any suitable manner in various embodiments. Also, various steps or acts in the method descriptions may be interchanged or modified in a manner apparent to those of ordinary skill in the art. Thus, the various orders in the description and drawings are for clarity of description of only certain embodiments, and are not meant to be required orders unless otherwise indicated.

The numbering of the components itself, e.g. "first", "second", etc., is used herein merely to distinguish between the described objects and does not have any sequential or technical meaning. The term "coupled" as used herein includes both direct and indirect coupling (coupling), unless otherwise indicated.

The sensitive membrane of the electrode is a selective penetrating membrane, which determines the characteristics of the electrode such as selectivity, sensitivity, stability, detection range, service life and the like.

The most important conception of the utility model is that the influence of the vertical arrangement of the sample flow channel on the ion concentration detection is found, and the sample flow channel is slightly inclined or horizontally arranged, so that the ion concentration detection result is more stable.

The biochemical analyzer provided by the utility model can detect ions in addition to biochemical items, and specifically as shown in fig. 1, the biochemical analyzer comprises an electrolyte measuring module 100, at least one functional module 200 (or one or more functional modules 200), an input module 300, a display module 400, a memory 500, a processor 600 and an alarm module 700, which are described below.

Each of the functional modules 200 is configured to perform at least one function required in the sample analysis process, and the functional modules 200 cooperate together to perform the sample analysis to obtain a result of the sample analysis. Referring to fig. 2, a biochemical analyzer according to an embodiment is shown, in which a functional module 200 is illustrated. For example, the functional module 200 may include a sample carrier assembly 201, a first sample dispensing assembly 202, a second sample dispensing assembly (not shown), a reagent carrier assembly 203, a reagent dispensing assembly 204, a mixing mechanism 205, a reaction assembly 206, and a first assay assembly 207, among others.

The sample carrying assembly 201 is used for carrying a sample to be tested. The specific type of the sample to be measured is not limited, and may be a solution derived from a living body such as serum, blood, plasma, marrow fluid, urine, gastric juice, intestinal juice, bile, saliva, tear fluid, or cell extract, or a solution used in medical treatment such as dialysis solution, infusion solution, nutritional agent, and pharmaceutical agent. In some embodiments, the sample carrier assembly 201 may include a sample distribution module (SDM, sample Del ivery Module) and a front end rail; in other examples, the sample carrier assembly 201 may be a sample tray comprising a plurality of sample locations where samples, such as sample tubes, may be placed, and the sample tray may be maneuvered to a corresponding position by rotating its tray structure, such as a position where the first sample dispensing assembly 202 draws the first sample to be tested.

The first sample dispensing assembly 202 is used to dispense a first sample to be measured in the sample carrier assembly 201 to the first assay assembly 207. For example, the first sample dispensing assembly 202 includes a first sampling needle that is spatially moved in two or three dimensions by a two or three dimensional drive mechanism such that the first sampling needle can be moved to aspirate a first sample to be measured carried by the sample carrier assembly 201.

The reagent carrying assembly 203 is for carrying a reagent. In an embodiment, the reagent carrying assembly 203 may be a reagent disk, where the reagent disk is configured in a disk-shaped structure and has a plurality of positions for carrying reagent containers, and the reagent carrying assembly 203 can rotate and drive the reagent containers carried by the reagent carrying assembly to rotate to a specific position, for example, a position where the reagent is sucked by the reagent dispensing assembly 204. The number of reagent carrier assemblies 203 may be one or more.

The reagent dispensing assembly 204 is configured to transfer the reagent in the reagent carrier assembly 203 to the first assay assembly 207. In one embodiment, reagent dispensing assembly 204 may include a reagent needle that is spatially moved in two or three dimensions by a two or three dimensional drive mechanism.

The mixing mechanism 205 is used for mixing the reaction liquid to be mixed in the reaction cup. The number of blending mechanisms 205 may be one or more. The reaction liquid is obtained by mixing at least a first sample to be tested and a reagent.

The reaction module 206 has at least one placement site for placing a reaction cup and incubating the reaction solution in the reaction cup. For example, the reaction module 206 may be a reaction disk having a disk-like configuration with one or more placement sites for placement of reaction cups, the reaction disk being capable of rotating and driving the reaction cups in its placement sites for scheduling reaction cups within the reaction disk and incubating reaction fluids in the reaction cups.

The first measurement component 207 is configured to perform optical detection on the reaction solution to obtain a result of an optical detection item, for example, perform optical measurement on the reaction solution after incubation is completed, so as to obtain reaction data of the sample. In some embodiments, the first measurement assembly 207 includes a light source for emitting light to irradiate the first sample to be measured, and a light detection module for receiving the light from the light source after irradiating the first sample to be measured to obtain a result of the light detection item.

The foregoing is illustrative of some of the functional modules 200 and the following description of other components and structures in a biochemical analyzer continues.

The input module 300 is used to receive input from a user. Typically, the input module 300 may be a mouse, a keyboard, etc., and in some cases, a touch display screen, which provides a function for a user to input and display content, so the input module 300 and the display module 400 are integrated in this example. Of course, in some examples, the input module 300 may even be a voice input device or the like that brings up recognition voice.

The display module 400 may be used to display information. In some embodiments, the biochemical analyzer itself may incorporate the display module 400, and in some embodiments, the biochemical analyzer may be connected to a computer device (e.g., a computer) to display information via a display unit (e.g., a display screen) of the computer device, which falls within the scope of the display module 400 defined and protected herein.

Typically, the biochemical analyzer further includes a waste liquid tank 800 for collecting at least one of a sample dispensing component, a reagent dispensing component, and a washing waste liquid of a reaction cup carrying a reaction liquid. It will be appreciated that the waste tank 800 may also be used to collect cleaning waste after puddler cleaning.

The electrolyte measurement module 100 (ISE) is used to detect the ion concentration of the second sample to be measured. As shown in fig. 3, the electrolyte measurement module 100 includes: a sample container 10, an electrode assembly 20 and a second assay assembly 30.

The second sample dispensing assembly is used to dispense a second sample to be measured in the sample carrier assembly 201 to the sample container 10. In some embodiments, the first test sample and the second test sample are from the same subject. In other embodiments, the first test sample and the second test sample are from different subjects, that is, the first assay component 207 and the second assay component 30 are capable of obtaining relevant test results for different subjects.

In some embodiments, the second sample dispensing assembly includes a second sampling needle that is spatially moved in two or three dimensions by a two or three dimensional drive mechanism such that the second sampling needle can be moved to aspirate a second sample to be measured carried by the sample carrier assembly 201.

In some embodiments, the first sample dispensing assembly 202 is the same sample dispensing assembly as the second sample dispensing assembly, e.g., the first and second sampling needles are the same sampling needle, i.e., the electrolyte measurement module 100 and the other functional modules 200 share a sample dispensing assembly, which can save both analyzer volume and cost. In other embodiments, the first sample dispensing assembly 202 is a different sample dispensing assembly than the second sample dispensing assembly.

In some embodiments, as shown in fig. 4, the sample container 10 includes a receiving cavity 10a, where the top of the receiving cavity 10a has an opening for the second sample to be tested to be injected into the sample container 10 by the second sampling needle, and a detection outlet (not shown) is provided at the bottom of the sample container 10 for the second sample to be tested to flow out. The projection of the liquid discharge axis at the time of the second sampling needle injecting the second sample to be measured into the sample container 10 at the bottom of the sample container 10 is not coincident with the center of the detection outlet at the bottom of the sample container 10. Thus, when the second sample needle adds the second sample to be measured or other liquid to the sample container 10, the liquid is discharged from the detection outlet after flowing in the sample container 10, and the flowing of the liquid can stabilize the flow rate, so that the generation of bubbles is reduced or the generated bubbles are reduced.

In some examples, the sample vessel 10 also has an overflow port 11 extending through a sidewall of the sample vessel 10 and an overflow trough 12 collecting liquid that overflows from the overflow port 11, the overflow trough 12 being connected to the waste tank 800 by an overflow line 13. In this embodiment, the liquid overflowed from the overflow port 11 enters the overflow groove 12 and then enters the overflow pipeline 13, and the overflow groove 12 has the function of buffering the liquid, so that the overflow pipeline 13 can be flexibly arranged.

In the related art, the liquid overflowed from the sample container 10 is collected by using one overflow bottle alone, and an operator is required to periodically check and timely pour the liquid in the overflow bottle, thereby increasing maintenance workload of the biochemical analyzer. In addition, as the overflow probability is smaller and the overflow amount is smaller, the volume of the overflow bottle is not large, so that operators easily forget to check the overflow bottle, and the overflow bottle is at risk of overflow; when the operator is not present, overflow occurs, biological risks remain unavoidable, and electrical safety risks are caused in serious cases. According to the biochemical analyzer disclosed by the embodiment of the application, the overflow pipeline 13 is used for guiding the liquid overflowed from the sample container 10 in time, so that the safety protection function is realized, and the electrical safety and the biological safety of the biochemical analyzer are improved. In addition, the overflow pipeline 13 guides the overflowed liquid to the waste liquid tank 800, so that an operator only needs to maintain the waste liquid tank 800 of the whole biochemical analyzer, and the maintenance workload of the biochemical analyzer is not increased additionally. The waste liquid tank 800 is an important maintenance object for the biochemical analyzer, and on the one hand, the capacity is relatively large, on the other hand, maintenance is hardly forgotten, and the risk of overflow of the waste liquid tank 800 is relatively low.

The specific shape of the overflow 11 may be different, for example, in some embodiments, the overflow 11 is a hole penetrating through the sidewall of the accommodating cavity 10a, and the shape of the hole may be a circular hole, a polygonal hole, an elliptical hole, or the like.

In other embodiments, referring to fig. 4, the overflow port 11 is configured as a notch penetrating the top end surface of the side wall of the accommodating chamber 10 a. In this embodiment, on the one hand, it is convenient to make a notch in the side wall of the housing chamber 10 a; on the other hand, since the notch extends all the way to the top end face of the side wall of the accommodating chamber 10a, when the liquid level is higher than the bottom edge of the notch, the overflow area of the notch is larger as the liquid level is higher, the overflow capacity is stronger, so that the liquid does not spread to the top end face of the side wall of the accommodating chamber 10 a.

The shape of the isopipe 12 is not limited. The overflow trough 12 may surround the side wall of the receiving chamber 10a or may be located on one side of the side wall of the receiving chamber 10 a.

Illustratively, the drain height of the second sampling needle discharging the sample to the accommodation chamber 10a is lower than the bottom wall of the overflow port 11. Thus, the liquid discharge height of the second sampling needle is lower, and the probability of introducing bubbles when discharging the sample is reduced. Wherein the liquid discharge height refers to the height of the sample in the second sampling needle when it leaves the second sampling needle. For example, when the sample is discharged from the tip of the second sampling needle, the height at which the tip of the second sampling needle is located is the liquid discharge height.

In some embodiments, if the receiving chamber 10a overflows, the second sampling needle will contact the liquid surface when the second sampling needle extends into the receiving chamber 10a to drain, and it can be detected that overflow has occurred in the receiving chamber 10a based on some impedance characteristics of the second sampling needle.

Illustratively, the electrolyte measurement module 100 includes a detection circuit for detecting whether the holding chamber 10a has residual liquid based on a change in impedance of the second sampling needle as a variable impedance access detection circuit.

In this embodiment, the second sampling needle is used as a generalized impedance access detection circuit, for example, the second sampling needle is used as a capacitor in the detection circuit, the detection circuit can calculate the current capacitance of the second sampling needle through the working voltage, when the second sampling needle contacts the liquid level, the capacitance of the second sampling needle changes greatly, and at this time, the working voltage also changes, so that whether the second sampling needle contacts the liquid level can be judged according to the change of the working voltage. The biochemical analyzer can suspend the detection step according to the detection result of the detection circuit and output alarm information.

In other embodiments, the electrolyte measurement module 100 includes a sensor disposed on the sample container 10 for detecting the presence of the liquid in the receiving cavity 10 a. It will be appreciated that there is normally no liquid remaining in the holding chamber 10a just before the second sampling needle will discharge the sample, at which point the sensor detects that there is no liquid in the holding chamber 10 a. If a blockage or the like occurs, resulting in residual liquid in the receiving chamber 10a, the sensor indicates a risk of overflow if it detects liquid in the receiving chamber 10a immediately before the second sampling needle will discharge the sample, and the sensor sends an overflow signal indicating a risk of overflow. The biochemical analyzer can pause the detection step according to the overflow signal of the sensor and output alarm information.

Because the light source of the first measurement assembly 207 generates a large amount of heat and has a high temperature, in some embodiments, the sample container 10 and the light source are disposed on opposite corners or sides of the biochemical analyzer, respectively, so as to prevent the light source from interfering with the second sample to be measured in the sample container 10.

The electrode assembly 20 includes a plurality of electrodes, each electrode is provided with a channel and a sensitive film is arranged in the channel of each electrode, the channels of each electrode are communicated to form a sample flow channel 21 for a second sample to be measured to flow through, and the output end of each electrode is electrically connected with the second measuring assembly 30. The sample flow channel 21 has a liquid inlet 22a and a liquid outlet 22b, the liquid inlet 22a of the sample flow channel 21 is communicated with the detection outlet of the sample container 10, the liquid outlet 22b of the sample flow channel 21 is communicated with the waste liquid tank 800, and the second sample to be detected, which is dispensed into the sample container 10, flows into the sample flow channel 21 through the detection outlet and then flows from the sample flow channel 21 to the waste liquid tank 800. The second sample to be measured flows into the sample flow channel 21 and then sequentially contacts with the sensitive membranes (also referred to as ion sensitive membranes) of the electrodes of the electrode assembly 20, that is, in this embodiment, the electrode assembly 20 detects the ion concentration by a direct method, in other words, the second sample to be measured flows through the sensitive membranes of the electrodes sequentially from the sample container 10 without being diluted, and the corresponding ions selectively permeate through the sensitive membranes, so as to be detected by the electrodes. In some embodiments, the electrolyte measurement module 100 further includes a sample fluid power device 40 in communication with the sample flow channel 21, the sample fluid power device 40 for powering the flow of the second sample to be measured through the sample flow channel 21.

In this embodiment, the angle between the axis of the sample flow channel 21 and the horizontal plane is less than or equal to 10 ° when the second sample to be measured flows through the sample flow channel 21, and in some embodiments, the angle between the axis of the sample flow channel 21 and the horizontal plane is 0 ° when the second sample to be measured flows through the sample flow channel 21. The conventional electrolyte measurement module 100 has a problem that the measurement result is unstable due to the fluctuation of the liquid, and through intensive observation and analysis, the inventor has found that although the conventional ISE module sets the inner diameter of the sample flow channel 21 to be small to reduce the flow of the second sample to be measured during the detection, the second sample to be measured still flows during the detection of the ion concentration to cause the detection result to be unstable because the sample flow channel 21 is perpendicular to the horizontal plane. The sample flow channel 21 in this example has a smaller angle with the horizontal plane or is arranged parallel to the horizontal plane, so that the detection process is more stable and the tightness is better. In addition, with the use of the electrodes, the internal reference solution in each electrode is lost, and when the sample flow channel 21 is horizontally arranged or slightly obliquely arranged, the internal reference solution in each electrode in the electrode assembly 20 can still be better contacted with the electrode core in the electrodes after being lost, especially when the included angle between the sample flow channel 21 and the horizontal plane is smaller than or equal to 10 degrees, the service life of most of the electrodes can be longer than nine months, so that the use requirement can be better met.

In the process of manufacturing and installing the electrode assembly 20, firstly, the inner diameter of the sample flow channel 21 can be larger, for example, the inner diameter can be larger than or equal to 0.9 millimeter, so that the manufacturing difficulty of the electrode assembly 20 is reduced, and the electrode assembly is less prone to blockage.

The output terminals of the respective electrodes of the electrode assembly 20 are electrically connected to the second measuring assembly 30. That is, each electrode outputs the electric signal generated by the detection to the second measuring unit 30, and the second measuring unit 30 obtains the ion concentration detection result of the second sample to be measured from the electric signal output from each electrode of the electrode unit 20.

In some embodiments, the plurality of electrodes in the electrode assembly 20 includes a K ion electrode, a Cl ion electrode, a Na ion electrode. The K ion electrode, cl ion electrode, and Na ion electrode each have a predetermined lifetime and need to be replaced periodically, and the lifetime of the K ion electrode and Na ion electrode can be prolonged to 9 months or more by setting the sample flow path 21 to have an angle of 10 ° or less with the horizontal plane. The sensitive film of chloride ion electrode on the market generally uses alkyl ammonium chloride as ion exchanger. The sensitive film of the chloride ion electrode in the market at home and abroad has the defects of poor selectivity, poor stability, short service life and the like due to the limitation of the adopted electrode material.

In contrast, the Cl ion electrode of the present utility model, as shown in FIG. 5, employs a sensitive film L having a color different from that of the conventional sensitive film. The color of the sensitive film L is as follows in terms of RGB color: the values of R (red) are in the range of [ 50, 99 ], G (green) are in the range of [ 10, 100 ], and B (blue) are not limited. The color sensitive film has improved selectivity, stability, life and other properties, and the service life of the electrode is prolonged to more than 6 months as shown in figure 6.

In this embodiment, the sensitive film L of the Cl ion electrode is a polyvinyl chloride (PVC) film, and the sensitive film L of the Cl ion electrode is tan/chestnut. Specifically, the color of the sensitive film L of the Cl ion electrode is as follows: the values of RGB were 96,40,30 colors, respectively. If classified by color of CMYK, the color of the sensitive film L of the Cl ion electrode is: the values of CMYK (C: cyan=cyan, M: magenta=y: yellow=yellow, and K: blank=black, i.e., printed four colors) are 37,82,82,52 colors, respectively. If classified by color of CSS, the color of the sensitive film L of the Cl ion electrode is: the HEX value (hexadecimal integer) in the CSS color is the color #60281 e.

The cleaning solution of the electrolyte measurement module 100 is mainly sodium hypochlorite, has strong oxidizing property, and excessive cleaning can damage the sensitive film structure of the electrode, so that the electrode is invalid. The existing chloridion electrode has weak sodium hypochlorite cleaning resistance, and after daily cleaning/weekly cleaning maintenance, the slope of the electrode can be recovered to be normal after multiple times of calibration, and the slope of the electrode is shown in figure 7. The chlorine ion electrode of the above color employed in the present utility model is enhanced in cleaning resistance, which is also an aspect factor of the extension of the electrode life. It is apparent from fig. 8 that the chloride ion electrode employed in the present utility model has a more stable slope under frequent cleaning.

In some embodiments, as shown in fig. 9, electrolyte measurement module 100 further includes a mount 60 for placement of electrode assembly 20. The mounting seat 60 includes a movable adjusting member 61, two abutting members 62 disposed opposite to each other in a horizontal direction, and a mounting platform 63, a plurality of electrodes of the electrode assembly 20 are disposed on the mounting platform 63 in a row, and the plurality of electrodes are fixed between the two abutting members 62, at least one of the two abutting members 62 can move horizontally according to the movement of the adjusting member 61 to adjust the distance between the two abutting members 62 to mount the plurality of electrodes, and when the included angle between the axis of the sample flow channel and the horizontal plane is smaller, the user can complete the mounting of the electrodes by one hand, which is very convenient.

The second measuring assembly 30 further includes a plurality of conductive members 31 disposed on the mounting base 60, each electrode of the electrode assembly 20 has a corresponding conductive member 31, and each electrode is electrically connected to a corresponding conductive member 31, so that the conductive member 31 can be understood as an electrical contact for connecting the electrode mounted on the mounting base 60, so as to receive the electrical signal output by each electrode. When the second sample to be measured is in the sample flow channel 21, each electrode can be contacted with the second sample to be measured to form a potential, and the formed potential is different according to the electrode, specifically, the plurality of electrodes comprise at least one detection electrode 24 and a reference electrode 23, each detection electrode 24 can form a membrane potential, and the reference electrode 23 forms a reference potential.

With continued reference to fig. 10 and 11, fig. 10 is a side view of the reference electrode 23 of the electrolyte measurement module 100 of fig. 9, and fig. 11 is a cross-sectional view of the reference electrode 23 of fig. 10 taken along the direction A-A. It is understood that reference electrode 23 can be considered as a consumable in electrolyte measurement module 100. As shown in fig. 11, the reference electrode 23 has a first accommodating cavity 231 therein, and the first accommodating cavity 231 is used for accommodating a first internal reference solution to form the reference potential. In general, the more the volume of the first internal reference solution, the longer the useful life of the reference electrode 23. Based on this, the service life of the reference electrode 23 can be improved by increasing the volume of the first receiving chamber 231 so that more of the first reference solution can be received inside the reference electrode 23.

Referring to fig. 9 and 11 together, in one embodiment of increasing the volume of the first accommodating cavity 231, the plurality of conductive members 31 are disposed on the mounting base 60 at intervals along the first direction (the left-right direction shown in fig. 9). The reference electrode 23 is provided on one side of its corresponding conductive member 31 in the second direction (vertical direction shown in fig. 9). The second direction is different from the first direction, and the reference electrode 23 and the plurality of detection electrodes 24 are arranged along the first direction. Wherein the first accommodating cavity 231 at least partially coincides with the orthographic projection of the at least two conductive members 31 in the second direction. For example, the first receiving cavity 231 may be at least partially coincident with the orthographic projection of two, three, four or five conductive members 31 in the second direction, which is not limited by the embodiment of the present application.

In other embodiments, the first direction may be a vertical direction, the second direction may be a horizontal direction, or the first direction may be a substantially vertical direction, and the second direction may be a downward-inclined direction. In the following, taking the first direction as the horizontal direction and the second direction as the vertical direction relative to the horizontal direction as an example, several specific embodiments are listed to explain and explain that the above-mentioned orthographic projection of the first accommodating cavity 231 and the at least two conductive members 31 in the second direction at least partially overlap, and possible cases are:

of the two conductive members 31, one conductive member 31 is completely overlapped with the orthographic projection of the first accommodating chamber 231 in the vertical direction, and the other conductive member 31 is partially overlapped with the orthographic projection of the first accommodating chamber 231 in the vertical direction; alternatively, both conductive members 31 completely overlap with the orthographic projection area of the first accommodating cavity 231 in the vertical direction; alternatively, among the four conductive members 31, three conductive members 31 are completely overlapped with the orthographic projection area of the first accommodating cavity 231 in the vertical direction, and the remaining one conductive member 31 is overlapped with the orthographic projection area of the first accommodating cavity 231 in the vertical direction.

On the one hand, compared to the superposition of only one conductive member 31 with the orthographic projection of the first receiving cavity 231 in the second direction (the vertical direction shown in fig. 9), the embodiment of the present application can be understood that the width of the first receiving cavity 231 of the reference electrode 23 in the first direction (the left-right direction shown in fig. 9) is wider, thereby making the volume of the first receiving cavity 231 of the reference electrode 23 larger to receive more of the first internal reference solution; eventually, the service life of the reference electrode 23 can be increased to reduce the replacement frequency of the reference electrode 23.

On the other hand, referring to fig. 9, taking the installation seat 60 provided with six conductive members 31 as an example, the installation seat 60 may be provided with an installation space in advance to accommodate and install five detection electrodes 24 and a reference electrode 23 with a smaller volume. However, in the conventional clinical test, the types of ions to be detected in the solution to be detected are small, so that the volume of the reference electrode 23 with a small original volume can be increased to form the reference electrode 23 with a large volume in the embodiment of the application, and the reference electrode 23 in the embodiment of the application can be increased to a position occupying the installation space where one reference electrode 23 with a small volume is reserved and a position occupying the installation space where at least one detection electrode 24 is not commonly used. Based on this, the volume of the first accommodating cavity 231 of the reference electrode 23 can also be made larger, so as to achieve the purpose that the orthographic projection of the first accommodating cavity 231 and the at least two conductive members 31 in the second direction at least partially coincides.

With continued reference to fig. 12 and 13, fig. 12 is a side view of the detection electrode 24 of the electrolyte measurement module 100 shown in fig. 9, and fig. 13 is a cross-sectional view of the detection electrode 24 along the direction B-B shown in fig. 12. In another embodiment for increasing the volume of the first accommodating cavity 231, the plurality of conductive members 31 are disposed at intervals along the first direction on the mounting base 60. The reference electrode 23 and the plurality of detection electrodes 24 are arranged in the first direction. The detection electrode 24 has a second accommodation chamber 241, and the second accommodation chamber 241 is used for accommodating a second internal reference solution to form the membrane potential. Wherein, in combination with fig. 11 and 13, the width of the first receiving chamber 231 in the first direction (the left-right direction shown in fig. 9) is twice or more than the width of the second receiving chamber 241 in the first direction, thereby allowing the first receiving chamber 231 of the reference electrode 23 to be wider in the first direction.

Of course, in order to avoid excessive space occupation of the reference electrode 23 or even inability to fit into the mount 60 due to excessive volume, the width of the first receiving cavity 231 in the first direction is four times or less than the width of the second receiving cavity 241 in the first direction. For example, the width of the first receiving chamber 231 in the first direction is twice, six times, three times, five times, or four times the width of the second receiving chamber 241 in the first direction.

It is further understood that when the width of the first receiving cavity 231 in the first direction (the left-right direction shown in fig. 9) is twice or more than the width of the second receiving cavity 241 in the first direction, the first receiving cavity 231 may at least partially overlap with the orthographic projection of at least two conductive members 31 in the second direction, or as shown in fig. 9, three conductive members 31 located directly above the first receiving cavity 231 are mounted on the mounting base 60, and only the right-most conductive member 31 of the three conductive members 31 is abutted with the reference electrode 23 to form an electrical connection.

The increase in the size of the reference electrode 23 in the embodiment of the present application will be further explained and illustrated with reference to one of the sizes of the reference electrode 23 and the detection electrode 24.

As shown in fig. 9, the mounting base 60 has a mounting cavity 64, and the plurality of conductive members 31, the plurality of detection electrodes 24, and the reference electrode 23 are all at least partially disposed within the mounting cavity 64. For example, six conductive members 31 are arranged in the left-right direction and provided at the upper portion in the mounting chamber 64. The three detection electrodes 24 and one reference electrode 23 are arranged on a mounting platform 63 in the left-right direction, and the mounting platform 63 is provided at the lower part in a mounting chamber 64. At this time, the widths of the three detection electrodes 24 in the left-right direction are all between 12 mm and 13 mm, the widths of the reference electrode 23 in the left-right direction are between 45 mm and 46 mm, and the three detection electrodes 24 and one reference electrode 23 can be locked in the installation cavity 64 after being aligned in the left-right direction.

Referring to fig. 11, the reference electrode 23 may have a width of 46 mm in the first direction (left-right direction shown in fig. 11), and the first receiving chamber 231 may have a width of 45 mm in the first direction. At this time, only one conductive member 31 may be located directly above the first receiving chamber 231, and the reference electrode 23 is electrically connected to the conductive member 31. Alternatively, three conductive members 31 are located directly above the first receiving chamber 231, and the reference electrode 23 is electrically connected to only one of the conductive members 31.

In the following, a technical solution of the embodiment of the present application will be further explained and illustrated by taking one of the structures of the reference electrode 23 as an example with reference to fig. 11.

The reference electrode 23 includes a first housing 232, a first ion-sensitive membrane 233, a first electrode core 234, and a first internal reference solution (not shown) as described above.

The first housing 232 is detachably mounted to the mounting base 60, such as the first housing 232 is clamped, sleeved, screwed, magnetically attracted, etc. with respect to the mounting base 60, which is not limited in this embodiment of the present application. The first housing 232 has a first accommodating chamber 231 and a first flow channel 235 communicating with the first accommodating chamber 231, the first flow channel 235 being for accommodating a second sample to be tested. The first ion-sensitive membrane 233 is disposed on the first housing 232, and the first ion-sensitive membrane 233 blocks the first accommodating cavity 231 and the first flow passage 235. The first electrode core 234 is disposed on the first housing 232, one end of the first electrode core 234 is located in the first accommodating cavity 231, and the other end of the first electrode core 234 abuts against the corresponding conductive member 31 to form an electrical connection. At this time, the first internal reference solution is accommodated in the first accommodation chamber 231, and the first internal reference solution submerges the first ion-sensitive membrane 233 and at least part of the first electrode core 234, so that the interface of the first internal reference solution and the first electrode core 234 forms the reference potential described above.

It will be appreciated that when the second sample to be measured flows through the first flow channel 235 and contacts the first ion sensitive membrane 233, the first electrode core 234 of the reference electrode 23 is electrically connected to the second sample to be measured sequentially through the first internal reference solution and the first ion sensitive membrane 233. At this time, if the detection electrode 24 is also contacted with the second sample to be measured to form a membrane potential, the second measurement component 30, the reference electrode 23, the second sample to be measured and the detection electrode 24 form a loop, so that the second measurement component 30 can detect the ion concentration of the second sample to be measured through the reference potential and the membrane potential.

In some embodiments, the first housing 232 may further be provided with a first mounting hole 236 communicating with the first receiving chamber 231. The first mounting hole 236 faces the first ion-sensitive membrane 233, and the first ion-sensitive membrane 233 can pass through the first mounting hole 236. Further, the operator may insert the first ion sensitive membrane 233 into the first receiving chamber 231 through the first mounting hole 236 to block the first receiving chamber 231 and the first flow passage 235, or remove the first ion sensitive membrane 233, which needs to be replaced, through the first mounting hole 236. Of course, the first mounting hole 236 may also be used to inject the first internal reference solution into the first receiving cavity 231, or to pour the first internal reference solution out of the first receiving cavity 231, which is not limited in the embodiment of the present application.

Accordingly, the reference electrode 23 may further include a first cover 237, the first cover 237 being configured to open or close the first mounting hole 236. For example, the first mounting hole 236 may be a threaded hole, and the first cover 237 may be screwed into the first mounting hole 236, and the structure of the first cover 237 closing or opening the first mounting hole 236 is not limited in the embodiment of the present application.

In some embodiments, the first housing 232 may also be provided with a second mounting hole 238 in communication with the first receiving cavity 231. The second mounting hole 238 is used for mounting the first electrode core 234, and the first electrode core 234 is detachably disposed on the first housing 232 through the second mounting hole 238. Illustratively, the second mounting hole 238 may be a threaded hole and the first electrode core 234 sidewall may have external threads to enable threaded engagement with the second mounting hole 238. Of course, when the first electrode core 234 is removed from the first housing 232, the second mounting hole 238 is opened, and the second mounting hole 238 may be used to inject the first internal reference solution into the first receiving cavity 231 or pour the first internal reference solution out of the first receiving cavity 231, which is not limited in the embodiment of the present application.

The first internal reference solution may be a potassium chloride solution. In the related art, the potassium chloride solution is a saturated solution, or the first internal reference solution is a saturated potassium chloride solution. Potassium ions in the saturated potassium chloride solution easily pass through the first ion-sensitive membrane 233 and precipitate crystals, eventually resulting in clogging of the surface of the first ion-sensitive membrane 233 facing the first flow passage 235 by the precipitated crystals.

Based on this, in an embodiment of the present application, the first internal reference solution is an unsaturated potassium chloride solution. It will be appreciated that the unsaturated potassium chloride solution is less prone to crystallize during use than the saturated potassium chloride solution, and thus the risk of clogging of the first ion sensitive membrane 233 can be reduced to improve the reliability and lifetime of the reference electrode 23.

Wherein the unsaturated potassium chloride solution may be a potassium chloride solution having a concentration of less than 15% w/v. For example, the unsaturated potassium chloride solution may be a potassium chloride solution having a concentration of 14% w/v, a potassium chloride solution having a concentration of 7.6% w/v, or a potassium chloride solution having a concentration of 1% w/v.

In the following, a technical solution of the embodiment of the present application will be further explained and illustrated by taking one of the structures of the detection electrode 24 as an example with reference to fig. 13.

The detection electrode 24 may include a second housing 242, a second ion-sensitive membrane 243, a second electrode core 244, and a second internal reference solution (not shown).

The second housing 242 is detachably mounted to the mounting base 60, such as, for example, the second housing 242 is clamped, sleeved, screwed, magnetically attracted, etc. with respect to the mounting base 60, which is not limited in the embodiment of the present application. The second housing 242 has a second accommodating chamber 241 and a second flow channel 245 communicating with the second accommodating chamber 241, and the second flow channel 245 is used for accommodating a second sample to be tested. The second ion sensitive film 243 is connected to the second housing 242, and the second ion sensitive film 243 blocks the second accommodating chamber 241 from the second flow passage 245. The second electrode core 244 is connected to the second housing 242, one end of the second electrode core 244 is located in the second accommodating cavity 241, and the other end of the second electrode core 244 abuts against the corresponding conductive member 31 to form an electrical connection. The second internal reference solution is accommodated in the second accommodating chamber 241, and the second internal reference solution submerges the ion sensitive membrane and at least part of the second electrode core 244, so that the second internal reference solution and the second sample to be measured accommodated in the second flow channel 245 can form the membrane potential at the ion sensitive membrane.

It will be appreciated that when the second sample to be measured flows through the second flow channel 245 and contacts the ion sensitive membrane, if the first ion sensitive membrane 233 of the reference electrode 23 is also contacted with the second sample to be measured, the second measurement assembly 30, the reference electrode 23, the second sample to be measured and the detection electrode 24 form a loop, so that the second measurement assembly 30 can perform the measurement operation of the ion concentration on the second sample to be measured through the membrane potential and the reference potential.

In some embodiments, as shown in fig. 13, at least one end of each second flow passage 245 may be provided with a second elastic seal 247, as shown in fig. 11, at least one end of the first flow passage 235 may be provided with a first elastic seal 239, so that the two connected second flow passages 245 can be sealed by the at least one second elastic seal 247, and the connected first flow passage 235 and second flow passage 245 can be sealed by the first elastic seal 239 and/or the second elastic seal 247. It will be readily appreciated that when the sample flow channel 21 is arranged horizontally, a good seal is achieved by means of the resilient seal, whereas if the sample flow channel 21 is arranged vertically, more expensive and/or more complex sealing means are required.

In some embodiments, as shown in fig. 13, the second housing 242 may further be provided with a third mounting hole 246 communicating with the second receiving chamber 241. The third mounting hole 246 is used for mounting the second electrode core 244, and the second electrode core 244 is detachably disposed on the second housing 242 through the third mounting hole 246.

Illustratively, the third mounting hole 246 may be a threaded hole, and the sidewall of the second electrode core 244 has external threads to be threadably coupled with the third mounting hole 246. Of course, when the second electrode core 244 is removed from the second housing 242, the third mounting hole 246 is opened, and the third mounting hole 246 may be used to inject the second internal reference solution into the second receiving cavity 241 or pour the second internal reference solution in the second receiving cavity 241, which is not limited in the embodiment of the present application.

With continued reference to fig. 14, fig. 14 is an enlarged view of a portion X of the electrolyte measurement module 100 shown in fig. 9. The conductive members 31 include a third end surface 311 that abuts against the corresponding detection electrode 24 or the reference electrode 23 to form an electrical connection, and the third end surface 311 of each conductive member 31 may be a plane, a convex surface or a concave surface, which is not limited in the embodiment of the present application.

As shown in fig. 9 or 14, the third end surface 311 of at least one conductive member 31 may be provided as a convex surface for the convenience of maintenance and inspection of the conductive member 31. It will be appreciated that repeated removal and attachment of the reference electrode 23 and the detection electrode 24 can easily result in the third end face 311 being worn or stained with other contaminants. In the embodiment of the present application, the third surface 311 is set to be convex, so that an operator can directly observe whether the third surface 311 has stains or wear, and the hidden trouble of electrical connection between the conductive member 31 and the corresponding detection electrode 24 or reference electrode 23 is further formed. It can be seen that the conductive member 31 of the embodiment of the present application improves the safety of the electrolyte measurement module 100 and makes the electrolyte measurement module 100 convenient to maintain and check.

The third end surface 311 having the convex surface may be spherical, or it may be understood that the third end surface 311 of the at least one conductive member 31 is spherical. Setting the third end surface 311 to be a spherical surface can avoid sharp corners of the third end surface 311, and further lead to scratch or abrasion of the corresponding parts of the reference electrode 23, the detection electrode 24 and the conductive piece 31 in the process of disassembling the reference electrode 23 or the detection electrode 24, thereby improving the safety and the service life of the electrolyte measurement module 100.

Accordingly, as shown in fig. 11, the reference electrode 23 may have a first end surface 2341 that abuts against the third end surface 311 of the conductive member 31 to form an electrical connection. In combination with one of the above structures of the reference electrode 23, the first end face 2341 may be disposed at the end of the first electrode core 234 facing the conductive member 31. The first end surface 2341 may be convex, planar, or concave to mate with the third end surface 311, which is not limited in this embodiment of the present application.

In the solution where the third end face 311 is spherical and the first end face 2341 is also spherical, in an ideal state, the lower vertex of the third end face 311 and the upper vertex of the first end face 2341 are both accurately located at the preset position to form point contact, so that the conductive member 31 and the reference electrode 23 form an electrical connection. However, in actual operation, there are necessarily manufacturing tolerances, assembly tolerances, etc. of the conductive member 31 and the reference electrode 23, and when the electrolyte measurement module 100 vibrates, the conductive member 31 and the reference electrode 23 are easily subject to vibration to be displaced, and these factors may cause the upper vertex of the first end face 2341 and the lower vertex of the third end face 311 to be displaced in the horizontal direction, and thus the electrical contact between the first end face 2341 and the third end face 311 is broken. From this, it can be seen that if third end surface 311 is spherical and first end surface 2341 is also spherical, the electrical connection between conductive element 31 and reference electrode 23 is not stable.

Thus, in a preferred embodiment, the first end face 2341 may be planar or concave to mate with the third end face 311. When the first end surface 2341 is planar, even if there is a certain position error between the conductive element 31 and the first electrode core 234, the lower vertex of the third end surface 311 may still be abutted to a different position of the first end surface 2341, so as to improve the stability of the electrical connection between the conductive element 31 and the first electrode core 234. If the first end surface 2341 is concave, the first end surface 2341 may wrap the third end surface 311 to position the conductive member 31 and the first electrode core 234, thereby improving the stability of the electrical connection between the conductive member 31 and the first electrode core 234.

Accordingly, as shown in fig. 13 or 14, the detection electrode 24 may have a second end surface 2441 that abuts against the third end surface 311 of the conductive member 31 to form an electrical connection. In combination with one of the above structures of the detection electrode 24, the second end surface 2441 may be disposed at an end of the second electrode core 244 facing the conductive member 31. Second end surface 2441 may be convex, planar, or concave in cooperation with third end surface 311, which is not limited in this embodiment of the application.

It is understood that in the scheme that the third end surface 311 is spherical and the second end surface 2441 is also spherical, in an ideal state, the lower vertex of the third end surface 311 and the upper vertex of the second end surface 2441 are accurately located at the preset position to form point contact, so that the detection electrode 24 and the conductive member 31 are electrically connected. However, in actual operation, there are necessarily manufacturing tolerances, assembly tolerances, etc. of the conductive member 31 and the detection electrode 24, and vibration of the electrolyte measurement module 100 is likely to occur in the conductive member 31 and the reference electrode 23, which may cause misalignment of the upper vertex of the second end surface 2441 and the lower vertex of the third end surface 311 in the horizontal direction, and thus the electrical contact between the first end surface 2341 and the third end surface 311 is broken. From this, it can be seen that the electrical connection between the conductive member 31 and the detection electrode 24 is not stable when the third end surface 311 is spherical and the second end surface 2441 is also spherical.

Thus, in a preferred embodiment, second end surface 2441 may be planar or concave to mate with third end surface 311. When the second end surface 2441 is planar, even if there is a certain position error between the conductive element 31 and the second electrode core 244, the lower vertex of the third end surface 311 can be abutted to different positions of the second end surface 2441, so as to improve the stability of the electrical connection between the conductive element 31 and the first electrode core 234. If the second end surface 2441 is concave, the second end surface 2441 can wrap the third end surface 311 to position the conductive member 31 and the second electrode core 244, thereby improving the stability of the electrical connection between the conductive member 31 and the second electrode core 244.

In some embodiments, the third end face 311 of the at least one conductive member 31 may have a metallic conductive layer (not labeled in the figures). The metal conductive layer may be formed of a metal material with better conductivity, such as gold or copper, plated on the conductive member 31, so as to improve the conductivity of the conductive member 31.

In some embodiments, the electrolyte measurement module 100 further comprises a calibration fluid module including a calibration fluid reservoir 51 for receiving a calibration fluid container for holding the calibration fluid, a calibration fluid line, and a calibration fluid power device coupled to the calibration fluid line for providing power, an inlet end of the calibration fluid line being in communication with the calibration fluid container, and an outlet end of the calibration fluid line being in communication with the sample container 10 for delivering the calibration fluid through the sample container 10 to the sample flow channel 21, and the second measurement assembly 30 further being configured to scale based on an electrical signal generated by the electrode assembly 20 as the calibration fluid flows through the sample flow channel 21. In some embodiments, the outlet end of the calibration fluid line may also be in direct communication with the sample flow channel 21, as will be described below by way of example in which the calibration fluid line communicates with the sample container 10.

In some embodiments, as shown in fig. 15, the calibration fluid cartridge 51 is configured to removably mount a calibration fluid pack 51a, the calibration fluid pack 51a including a calibration fluid container and a chip assembly for recording at least calibration fluid information, including, but not limited to, the type of calibration fluid, the amount of calibration fluid remaining, and the like. An information reading component for reading the calibration liquid information recorded in the chip component is further arranged in the calibration liquid bin 51, for example, the information reading component reads the calibration liquid information in a near field communication mode. In general, when the calibration liquid in the calibration liquid bag 51a is exhausted or insufficient, the calibration liquid bag 51a needs to be replaced, and the insertion loss of the wired connection to the electrolyte measurement module 100 can be reduced by reading the residual amount of the calibration liquid through near field communication, so that the service life of the electrolyte measurement module 100 is prolonged.

To more intuitively view the connection state of the calibration liquid container and the inlet of the calibration liquid line, in some embodiments, the calibration liquid bin 51 further includes an in-place detecting component that generates a state change when the connection state of the calibration liquid container and the inlet of the calibration liquid line is switched between off and on, for example, the biochemical analyzer further includes an indicator lamp that switches from on to off based on the state change generated by the in-place detecting component when the connection state of the calibration liquid container and the calibration liquid line is switched from off to on based on the state change generated by the in-place detecting component when the connection state of the calibration liquid container and the calibration liquid line is switched from on to off.

In some embodiments, as shown in fig. 3, the calibration fluid container includes a first calibration fluid container 52a carrying a first calibration fluid and a second calibration fluid container 52b carrying a second calibration fluid, the calibration fluid lines include a first calibration fluid line 53a having an inlet end in communication with the first calibration fluid container 52a and a second calibration fluid line 53b having an inlet end in communication with the second calibration fluid container 52b, and the sample container 10 has a first calibration fluid inlet 10b in communication with an outlet end of the first calibration fluid line 53a and a second calibration fluid inlet 10c in communication with an outlet end of the second calibration fluid line 53 b. Generally, after the biochemical analyzer is started, the first calibration liquid and the second calibration liquid can be sequentially used for one-time test flow to perform calibration together, and then sample detection can be started. After each electrode detects the second sample to be detected, the first calibration liquid sequentially flows through each electrode, each electrode outputs the detection signal of the first calibration liquid to the second measurement assembly 30, and the second measurement assembly 30 corrects the ion concentration detection result of the second sample to be detected according to the detection signal so as to improve the detection accuracy. It can also be seen from the above description that the frequency of use of the first calibration liquid is higher than the frequency of use of the second calibration liquid, for example, the K ion concentration of the first calibration liquid is smaller than the K ion concentration of the second calibration liquid, and this feature may cause the frequency of use of the first calibration liquid to be higher than the frequency of use of the second calibration liquid in calibration. Therefore, in some embodiments, as shown in fig. 4, the first calibration liquid inlet 10b is disposed below the second calibration liquid inlet 10c in the height direction of the sample container 10, so that the use of the second calibration liquid affects the first calibration liquid to the minimum, and cleaning is facilitated, and in addition, the lower the inlet on the side wall of the sample container 10, the fewer or smaller the bubbles generated from the liquid entering the sample container 10 from the inlet, the smaller the effect on the ion concentration detection result, so that the first calibration liquid inlet 10b corresponding to the first calibration liquid with higher frequency is disposed at a position closer to the bottom of the sample container 10, so that the fewer or smaller the bubbles generated in calibration are.

In some embodiments, the calibration fluid power means comprises a first power means 54a provided on the first calibration fluid line 53a and a second power means 54b provided on the second calibration fluid line 53 b. The first power device 54a is used to transfer the first calibration fluid in the first calibration fluid container 52a to the sample container 10, and the first power device 54a may be a pump or a syringe. The second power device 54b is used to transfer the second calibration fluid in the second calibration fluid container 52b to the sample container 10, and the second power device 54b may be a pump or a syringe.

In some embodiments, the sample fluid power device 40 is further configured to power the flow of the first calibration fluid and the second calibration fluid through the sample channel 21. That is, the first calibration liquid, the second calibration liquid and the second sample to be measured all flow from the detection outlet at the bottom of the sample container 10 into the sample flow channel 21, and then enter the waste liquid tank 800, and the three share one power device from the sample container 10 to the sample flow channel 21. In other embodiments, the first and second calibration fluids may also flow into the sample flow channel 21 by a different power device than the sample fluid power device 40.

Because the light source of the first measurement assembly 207 generates a large amount of heat and has a high temperature, in some embodiments, the calibration fluid module and the light source are disposed on opposite corners or sides of the biochemical analyzer, respectively, so as to prevent the light source from interfering with the calibration fluid in the calibration fluid module.

In some embodiments, as shown in fig. 15 and 16, the biochemical analyzer further includes a frame 70, and the electrolyte measuring module 100 further includes a first mounting bracket 70a, a second mounting bracket 70b, and a third mounting bracket 70c, which are respectively mounted on the frame 70. The sample container 10, the electrode assembly 20, and the second measurement assembly 30 are mounted on the first mounting bracket 70a, that is, the mount 60 is also mounted on the first mounting bracket 70a; the first power unit 54a, the second power unit 54b and the sample fluid power unit 40 are arranged on the second mounting bracket 70b; the calibration fluid tank 51 is mounted on the third mounting bracket 70c. The calibration liquid chamber 51 of the electrolyte measurement module 100 is located on the operation side of the biochemical analyzer, that is, on the side of the biochemical analyzer where a user operates the biochemical analyzer, and the calibration liquid chamber 51 is mounted on the operation side, so that the user can easily replace the calibration liquid bag 51a.

In other embodiments, the electrolyte measurement module 100 further includes a controller, where the controller is configured to collect the operation state information of the electrolyte measurement module 100 and/or the ion concentration detection result of the second sample to be measured, and send the operation state information of the electrolyte measurement module 100 and/or the ion concentration detection result of the second sample to be measured to the processor 600 of the biochemical analyzer when the electrolyte measurement module 100 meets a preset condition, where the operation state information of the electrolyte measurement module 100 includes, but is not limited to, an operation condition of the electrolyte measurement module 100, whether an abnormality occurs in the electrolyte measurement module 100, whether each component works normally, and the preset condition includes: the electrolyte measurement module 100 works for at least one of meeting a preset time, detecting that the second sample to be measured meets a preset number of times, receiving a start-up instruction and receiving a shut-down instruction by the electrolyte measurement module 100. That is, the electrolyte measuring module 100 has a function of monitoring or collecting information, and the collected information is not always stored in the electrolyte measuring module 100, but is automatically transmitted to the processor 600 of the biochemical analyzer under certain conditions, for example, when the electrolyte measuring module 100 is turned on or off, the collected information is automatically transmitted to the processor 600 of the biochemical analyzer, and for example, the collected information is automatically transmitted to the processor 600 of the biochemical analyzer every time the electrolyte measuring module 100 is operated for a certain period of time or every time a certain number of second samples to be measured are detected. In the existing biochemical analyzer, the hardware standard requirement for the electrolyte measurement module 100 is high, and the inventor finds that one reason is that the information collected by the electrolyte measurement module 100 is sent to the processor 600 of the biochemical analyzer in response to the request of the user, which results in that the information collected by the electrolyte measurement module 100 is stored locally at ordinary times, and the memory capacity requirement for the memory chip of the electrolyte measurement module 100 is high, and in this embodiment, the hardware requirement for the controller of the electrolyte measurement module 100 itself can be reduced by automatically sending the information to the processor 600 of the biochemical analyzer when the preset condition is satisfied.

In some embodiments, the electrolyte measurement module 100 further includes a power supply interface and a communication interface, the biochemical analyzer further includes a power supply module, the power supply module supplies power to the electrolyte measurement module 100 through the power supply interface, the processor 600 sends a control instruction to the controller through the communication interface, and the controller controls the operation of the electrolyte measurement module 100 according to the control instruction, that is, the whole electrolyte measurement module 100 and the biochemical analyzer can be electrically connected and communicatively connected only through two interfaces, and the electrolyte measurement module 100 can be replaced as a module between different biochemical analyzers. In this embodiment, the biochemical analyzer may further comprise an information transmission device, where the information transmission device is configured to connect to an LIS system signal [ laboratory (clinical laboratory) information system ], and the processor 600 is configured to send the result of the optical detection item of the first sample to be tested to the LIS system through the information transmission device; the controller is connected with the information transmission device through the communication interface, and the controller is used for sending the ion concentration detection result of the second sample to be detected to the LIS system through the information transmission device. In other embodiments, the controller is connected to the processor 600 through the communication interface, and the controller sends the ion concentration detection result of the second sample to be tested to the processor 600, and the processor 600 is configured to send both the light detection item result of the first sample to be tested and the ion concentration detection result of the second sample to be tested to the LIS system through the information transmission device. And the user can check and count the information of the first sample to be tested and the second sample to be tested on other equipment conveniently.

In some embodiments, the first power device 54a, the second power device 54b and the sample fluid power device 40 receive the electric power and the communication signal through the same interface, for example, the interface may be connected with a power supply interface of the electrolyte measurement module 100, so as to receive the power supply of the biochemical analyzer, and the advantage of using one interface for receiving the electric power by the three power devices is that the required wire data can be effectively reduced, so as to reduce the mutual interference between wires, and also facilitate the installation and maintenance of the electrolyte measurement module 100 when the electrolyte measurement module 100 is integrated in the scene of the biochemical analyzer. Meanwhile, the interface may be electrically connected to the controller, so as to receive a control command sent by the controller, where the control command can control the first power device 54a, the second power device 54b, and the sample fluid power device 40 to operate according to a certain time sequence.

Reference is made to various exemplary embodiments herein. However, those skilled in the art will recognize that changes and modifications may be made to the exemplary embodiments without departing from the scope herein. For example, the various operational steps and components used to perform the operational steps may be implemented in different ways (e.g., one or more steps may be deleted, modified, or combined into other steps) depending on the particular application or taking into account any number of cost functions associated with the operation of the system.

While the principles herein have been shown in various embodiments, many modifications of structure, arrangement, proportions, elements, materials, and components, which are particularly adapted to specific environments and operative requirements, may be used without departing from the principles and scope of the present disclosure. The above modifications and other changes or modifications are intended to be included within the scope of this document.

The foregoing detailed description has been described with reference to various embodiments. However, those skilled in the art will recognize that various modifications and changes may be made without departing from the scope of the present disclosure. Accordingly, the present disclosure is to be considered as illustrative and not restrictive in character, and all such modifications are intended to be included within the scope thereof. Also, advantages, other advantages, and solutions to problems have been described above with regard to various embodiments. The benefits, advantages, solutions to problems, and any element(s) that may cause any benefit, advantage, or solution to occur or become more pronounced are not to be construed as a critical, required, or essential feature. The terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, system, article, or apparatus. Furthermore, the term "couple" and any other variants thereof are used herein to refer to physical connections, electrical connections, magnetic connections, optical connections, communication connections, functional connections, and/or any other connection. Those skilled in the art will recognize that many changes may be made to the details of the above-described embodiments without departing from the underlying principles of the utility model.

Claims

1. A biochemical analyzer, comprising: sample carrier assembly, first sample dispensing assembly, second sample dispensing assembly, reagent carrier assembly, reagent dispensing assembly, first assay assembly and electrolyte measurement module, electrolyte measurement module includes sample container, electrode assembly and second assay assembly, wherein:

the sample bearing assembly is used for bearing a sample to be tested;

the reagent bearing assembly is used for bearing a reagent;

2. The biochemical analyzer of claim 1, wherein said first test sample and said second test sample are from the same subject.

3. The biochemical analyzer of claim 1, wherein said electrolyte measurement module further comprises a sample hydrodynamic device in communication with said sample flow channel, said sample hydrodynamic device for powering the flow of said second sample to be measured through said sample flow channel.

4. The biochemical analyzer of claim 1, wherein said first sample dispensing assembly and said second sample dispensing assembly are the same sample dispensing assembly.

5. The biochemical analyzer according to claim 1, wherein an angle between an axis of the sample flow channel and a horizontal plane is 0 ° when the second sample to be measured flows through the sample flow channel.

6. The biochemical analyzer of claim 1, wherein said sample flow path has an inner diameter greater than or equal to 0.9 mm.

7. The biochemical analyzer of claim 1, wherein the electrolyte measurement module further comprises a mounting seat for placing an electrode assembly, the second measurement assembly comprises a plurality of conductive members disposed on the mounting seat, the plurality of conductive members correspond to the plurality of electrodes, and each electrode of the electrode assembly is electrically connected to the respective corresponding conductive member.

8. The biochemical analyzer of claim 7, wherein the mounting base comprises a movable adjusting member, two abutting members arranged opposite to each other in a horizontal direction, and a mounting platform, the plurality of electrodes of the electrode assembly are arranged on the mounting platform, the plurality of electrodes are fixed between the two abutting members, and at least one of the two abutting members can move horizontally according to the movement of the adjusting member to adjust the distance between the two abutting members to mount the plurality of electrodes.

9. The biochemical analyzer according to claim 7, wherein the plurality of conductive members are disposed at intervals in a first direction on the mounting base, the plurality of electrodes include a reference electrode and at least one detection electrode, the reference electrode and the at least one detection electrode are disposed in an aligned manner in the first direction, the reference electrode is disposed on one side of the corresponding conductive member in a second direction, the second direction is different from the first direction, the reference electrode has a first accommodating cavity for accommodating a first internal reference solution to form a reference potential, and orthographic projections of the first accommodating cavity and at least two conductive members in the second direction at least partially coincide.

10. The biochemical analyzer according to claim 7, wherein the plurality of conductive members are disposed at intervals in the mounting seat along a first direction, the plurality of electrodes include a reference electrode and at least one detection electrode, the reference electrode and the at least one detection electrode are disposed in an aligned manner along the first direction, the detection electrode has a second accommodating cavity for accommodating a second internal reference solution to form a membrane potential, the reference electrode has a first accommodating cavity for accommodating a first internal reference solution to form a reference potential, and a width of the first accommodating cavity in the first direction is twice or more than twice a width of the second accommodating cavity in the first direction.

11. The biochemical analyzer of claim 7, wherein said conductive member includes an end surface for abutting said electrodes, at least one of said conductive member having a convex surface.

12. The biochemical analyzer of claim 1, wherein the plurality of electrodes comprises a K ion electrode, a Cl ion electrode, and a Na ion electrode, wherein the sensitive film color of the Cl ion electrode is: the R has a value in the range of [ 50, 99 ], and the G has a value in the range of [ 10, 100 ].

13. The biochemical analyzer of claim 1, wherein said electrolyte measurement module further comprises a calibration fluid module comprising a calibration fluid reservoir for holding a calibration fluid reservoir, a calibration fluid line, and a calibration fluid power device coupled to said calibration fluid line for providing power, an inlet end of said calibration fluid line being in communication with said calibration fluid reservoir, an outlet end of said calibration fluid line being in communication with said sample reservoir or said sample flow path for delivering said calibration fluid to said sample flow path, said second measurement assembly further being configured for calibrating said electrical signal generated by said electrode assembly based on said calibration fluid flowing through said sample flow path.

14. The biochemical analyzer of claim 13, wherein said calibration fluid cartridge is configured to removably mount a calibration fluid pack, said calibration fluid pack comprising said calibration fluid container and a chip assembly for recording at least calibration fluid information; and an information reading assembly for reading the calibration liquid information recorded in the chip assembly is further arranged in the calibration liquid bin.

15. The biochemical analyzer of claim 14, wherein an inlet end of said calibration fluid line is disposed within said calibration fluid reservoir; the calibration liquid bin further comprises an on-site detection component, and the on-site detection component generates state change when the connection state of the calibration liquid container and the inlet end of the calibration liquid pipeline is switched between disconnection and connection.

16. The biochemical analyzer of claim 15, further comprising an indicator light that switches from on to off or from off to on when the presence detection assembly generates a change in state.

17. The biochemical analyzer of claim 14, wherein the calibration fluid container comprises a first calibration fluid container carrying a first calibration fluid and a second calibration fluid container carrying a second calibration fluid, the calibration fluid lines comprising a first calibration fluid line having an inlet end in communication with the first calibration fluid container and a second calibration fluid line having an inlet end in communication with the second calibration fluid container, the sample container having a first calibration fluid inlet in communication with the outlet end of the first calibration fluid line and a second calibration fluid inlet in communication with the outlet end of the second calibration fluid line, the first calibration fluid inlet being positioned below the second calibration fluid inlet in a height direction of the sample container; the frequency of use of the first calibration liquid is higher than that of the second calibration liquid.

18. The biochemical analyzer according to any one of claims 13 to 17, wherein the calibration fluid container includes a first calibration fluid container carrying a first calibration fluid and a second calibration fluid container carrying a second calibration fluid, the calibration fluid lines including a first calibration fluid line having an inlet end in communication with the first calibration fluid container and a second calibration fluid line having an inlet end in communication with the second calibration fluid container, an outlet end of the first calibration fluid line in communication with the sample container or the sample flow channel for delivering the first calibration fluid to the sample flow channel, and an outlet end of the second calibration fluid line in communication with the sample container or the sample flow channel for delivering the second calibration fluid to the sample flow channel; the electrolyte measuring module further comprises a sample hydrodynamic device communicated with the sample flow passage, and the sample hydrodynamic device is used for providing power for the second sample to be measured, the first calibration liquid and the second calibration liquid flowing through the sample flow passage.

19. The biochemical analyzer of claim 18, further comprising a frame, said electrolyte measurement module further comprising a first mounting bracket, a second mounting bracket, and a third mounting bracket mounted on said frame, respectively; the sample container, electrode assembly and second measurement assembly are mounted on the first mounting bracket; the first power device, the second power device and the sample hydrodynamic device are arranged on the second mounting bracket; the calibration liquid bin is mounted on the third mounting bracket.

20. The biochemical analyzer according to claim 13, wherein the first measuring unit comprises a light source for emitting light to irradiate the reaction liquid and a light detection module for receiving the light irradiated from the light source to obtain a result of a light detection item, the calibration liquid module and the light source are disposed on opposite corners or both sides of the biochemical analyzer, respectively,

and/or the sample container and the light source are respectively arranged on the opposite angles or two sides of the biochemical analyzer.

21. The biochemical analyzer of claim 1, wherein said second sample dispensing assembly includes a second sampling needle for injecting said second sample to be measured into said sample container, said sample container having an opening at a top thereof for said sampling needle to inject said second sample to be measured into said sample container, a bottom thereof having a detection outlet in communication with said sample flow channel for said second sample to be measured to flow out, and a projection of a liquid discharge axis of said second sampling needle when injecting said second sample to said sample container at the bottom thereof being misaligned with a center of said sample container bottom detection outlet.

22. The biochemical analyzer of claim 1, further comprising a waste fluid tank for containing waste fluid from at least one of the sample dispensing assembly, the reagent dispensing assembly, and a reaction cup carrying a reaction fluid; the top of the sample container is provided with an opening for the second sample dispensing component to inject the second sample to be tested into the sample container, the sample container is also provided with an overflow port penetrating through the side wall of the sample container and an overflow groove for collecting liquid overflowing from the overflow port, and the overflow groove is connected to the waste liquid tank through an overflow pipeline.