CN114769233B - Cleaning equipment, cleaning method and sample analyzer - Google Patents
Cleaning equipment, cleaning method and sample analyzer Download PDFInfo
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- CN114769233B CN114769233B CN202210663273.9A CN202210663273A CN114769233B CN 114769233 B CN114769233 B CN 114769233B CN 202210663273 A CN202210663273 A CN 202210663273A CN 114769233 B CN114769233 B CN 114769233B
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/02—Cleaning pipes or tubes or systems of pipes or tubes
- B08B9/027—Cleaning the internal surfaces; Removal of blockages
- B08B9/032—Cleaning the internal surfaces; Removal of blockages by the mechanical action of a moving fluid, e.g. by flushing
- B08B9/0321—Cleaning the internal surfaces; Removal of blockages by the mechanical action of a moving fluid, e.g. by flushing using pressurised, pulsating or purging fluid
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17D—PIPE-LINE SYSTEMS; PIPE-LINES
- F17D1/00—Pipe-line systems
- F17D1/08—Pipe-line systems for liquids or viscous products
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17D—PIPE-LINE SYSTEMS; PIPE-LINES
- F17D3/00—Arrangements for supervising or controlling working operations
- F17D3/01—Arrangements for supervising or controlling working operations for controlling, signalling, or supervising the conveyance of a product
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
Abstract
The application discloses a cleaning device, a cleaning method and a sample analyzer. This cleaning equipment includes: the device comprises a power source, a temporary storage tank, a waste liquid tank and a sampling assembly, wherein the temporary storage tank is used for temporarily storing cleaning liquid; the first output end of the power source is connected with the temporary storage tank through a pipeline, the liquid outlet of the temporary storage tank is connected with the sampling assembly through a pipeline, the sampling assembly is connected with the liquid inlet end of the waste liquid tank through a pipeline, and the second output end of the power source is connected with the air inlet end of the waste liquid tank through a pipeline; the power source outputs positive pressure to the temporary storage tank through the first output end, and the cleaning liquid in the temporary storage tank is conveyed to the sampling assembly so as to clean the sampling assembly through the cleaning liquid; the same power supply outputs negative pressure to the waste liquid tank through the second output end, and waste liquid of the cleaning and sampling assembly is collected to the waste liquid tank. Through above-mentioned embodiment, utilize a power supply to realize the washing of sampling needle and the recovery of waste liquid, replace the scheme of a plurality of power supplies, can reduce the fault rate of product, reduce the instrument volume.
Description
Technical Field
The application relates to the technical field of medical detection and analysis, in particular to a cleaning device, a cleaning method and a sample analyzer.
Background
The immunoassay detection equipment goes through several different development stages of radioimmunoassay, fluorescence immunoassay, enzyme-labeled immunoassay, chemiluminescence immunoassay and the like, and the full-automatic chemiluminescence immunoassay is a new stage of the current immunoassay detection development, has the characteristics of environmental protection, rapidness and accuracy, and is gradually widely accepted by the market.
The full-automatic immunity analyzer utilizes the specific reaction of the mutual combination of the antigen and the antibody to carry out qualitative or quantitative diagnosis and analysis on a sample to be detected. The types of samples to be tested which can be supported by the full-automatic immunoassay analyzer comprise whole blood, serum, plasma samples and the like, when the samples are collected aiming at the samples, the sampling needles are required to be cleaned, otherwise, the instruments are carried and polluted, and the test result is falsely increased.
The waste liquid is taken out to the in-process to different parts of current washing sampling needle adopts different power supplies usually, but under the condition that the power supply among the sample analysis appearance is more, the possibility that sample analysis appearance broke down also can relatively increase, still can appear increasing whole sample analysis appearance's volume scheduling problem simultaneously.
Disclosure of Invention
The present application mainly aims to provide a cleaning device, a cleaning method and a sample analyzer, and aims to solve the above technical problems in the prior art.
In order to solve the above problem, the present application provides a cleaning apparatus, which is applied to a sample analyzer, and includes: the cleaning device comprises a power source, a temporary storage tank, a waste liquid tank and a sampling assembly, wherein the temporary storage tank is used for temporarily storing cleaning liquid; the first output end of the power source is connected with the temporary storage tank through a pipeline, a liquid outlet of the temporary storage tank is connected with the sampling assembly through a pipeline, the sampling assembly is connected with a liquid inlet end of the waste liquid tank through a pipeline, and the second output end of the power source is connected with a gas inlet end of the waste liquid tank through a pipeline; the power source outputs positive pressure to the temporary storage tank through the first output end, and the cleaning liquid in the temporary storage tank is conveyed to the sampling assembly so as to clean the sampling assembly through the cleaning liquid; and the same power source outputs negative pressure to the waste liquid tank through the second output end, and waste liquid for cleaning the sampling assembly is collected to the waste liquid tank.
For solving the above-mentioned problem, this application provides a sample analyzer, sample analyzer includes the controller, advances kind subassembly, determine module and foretell cleaning equipment, it is used for providing the sample that awaits measuring to advance kind subassembly, the controller is used for control the sample subassembly is followed advance and gather in the kind subassembly the sample that awaits measuring, the determine module is used for detecting the sample that awaits measuring, cleaning equipment is used for wasing the sample subassembly.
In order to solve the above problems, the present application provides a cleaning method, which is applied to a sample analyzer including the above cleaning apparatus, the method including: controlling the power source to output positive pressure to the temporary storage tank through the first output port; conveying the cleaning liquid in the temporary storage tank to the sampling assembly by utilizing the positive pressure output to the temporary storage tank; and cleaning the inner wall of the sampling needle of the sampling assembly and/or the outer wall of the sampling needle by using the cleaning liquid.
Compared with the prior art, the cleaning equipment of this application includes: the cleaning device comprises a power source, a temporary storage tank, a waste liquid tank and a sampling assembly, wherein the temporary storage tank is used for temporarily storing cleaning liquid; the first output end of the power source is connected with the temporary storage tank through a pipeline, the liquid outlet of the temporary storage tank is connected with the sampling assembly through a pipeline, the sampling assembly is connected with the liquid inlet end of the waste liquid tank through a pipeline, and the second output end of the power source is connected with the air inlet end of the waste liquid tank through a pipeline; the power source outputs positive pressure to the temporary storage tank through the first output end, and the cleaning liquid in the temporary storage tank is conveyed to the sampling assembly so as to clean the sampling assembly through the cleaning liquid; the same power supply outputs negative pressure to the waste liquid tank through the second output end, and waste liquid of the cleaning and sampling assembly is collected to the waste liquid tank. Through above-mentioned embodiment, the power supply can provide the malleation to the jar of keeping in, provides the negative pressure to the waste liquid jar simultaneously to utilize a power supply to realize the washing of sampling needle and the recovery of waste liquid, replace the scheme of a plurality of power supplies, can reduce the fault rate of product, reduce the instrument volume.
Drawings
In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings needed to be used in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings without creative efforts.
FIG. 1 is a schematic structural diagram of a first embodiment of a cleaning apparatus provided in the present application;
FIG. 2 is a schematic structural diagram of a second embodiment of the cleaning apparatus provided herein;
FIG. 3 is a schematic structural diagram of a third embodiment of the cleaning apparatus provided in the present application;
fig. 4 is a schematic flow chart of an embodiment of a cleaning method provided in the present application.
The reference numbers are: a cleaning device 10; a power source 100; a first output terminal 110; a second output 120; a first pressure regulating device 111; the second pressure adjusting device 121; a holding tank 210; a waste liquid tank 220; a cleaning solution tank 230; the anti-inversion tank 240; a waste liquid treatment device 250; a sampling assembly 300; a sampling needle 310; a wiping member 320; a first switching piece 410; a first three-way valve 411; a first controllable valve 412; a second controllable valve 413; a second switch 420; a second three-way valve 421; a third controllable valve 422; a fourth controllable valve 423; a first joint 510; a second joint 520; a third joint 530; a fourth joint 540; a syringe 600.
Detailed Description
The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. It is to be understood that the specific embodiments described herein are merely illustrative of the application and are not limiting of the application. It should be further noted that, for the convenience of description, only some of the structures related to the present application are shown in the drawings, not all of the structures. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
The terms "first", "second" and "third" in this application are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implying any indication of the number of technical features indicated. Thus, a feature defined as "first," "second," or "third" may explicitly or implicitly include at least one of the feature. In the description of the present application, "plurality" means at least two, e.g., two, three, etc., unless explicitly specifically limited otherwise. In the embodiment of the present application, all the directional indicators (such as upper, lower, left, right, front, and rear … …) are used only to explain the relative positional relationship between the components, the movement, and the like in a specific posture (as shown in the drawing), and if the specific posture is changed, the directional indicator is changed accordingly. Furthermore, the terms "include" and "have," as well as any variations thereof, are intended to cover non-exclusive inclusions. For example, a process, method, system, article, or apparatus that comprises a list of steps or elements is not limited to only those steps or elements listed, but may alternatively include other steps or elements not listed, or inherent to such process, method, article, or apparatus.
Reference herein to "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment can be included in at least one embodiment of the application. The appearances of the phrase in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. It is explicitly and implicitly understood by one skilled in the art that the embodiments described herein can be combined with other embodiments.
In order to solve the technical problems in the prior art, the application provides a sample analyzer, which is applied to the field of blood analysis or biochemical analysis and is used for detecting a sample, wherein a common sample analyzer can be a blood cell analyzer; the sample analyzer may also be other non-blood-ball clinical laboratory equipment.
The sample analyzer of the present application may be a blood cell analyzer for performing one or more of routine blood testing, specific protein testing, biochemical immunoassay, and coagulation testing. Among them, the conventional Blood test includes, but is not limited to, WBC (White Blood Cell) test, HGB (Hemoglobin) test, RBC (red Blood Cell) test, DIFF (diffferential, leukocyte quintet) test, or RET (reticulocyte) test. Specific proteins include, but are not limited to, the detection of SAA (serum amyloid A protein), CRP (C-reactive protein), TRF (tramsferrin, transferrin), hs-CRP (hypersensitive C-reactive protein), and D-Dimer (D-Dimer). Biochemical immunoassays include, but are not limited to. Immunoassays include, but are not limited to, detection assays for PCT (procalcitonin ) and IL-6 (interleukin-6). For example, the blood cell analyzer is a combined-examination machine for detecting blood routine, SAA and CRP. In other embodiments, the sample analyzer can also be used for specific protein detection and immunoassay detection, and the blood cell analyzer is a joint inspection integrated machine for detecting SAA, CRP, PCT and IL-6.
The sample analyzer comprises a controller, a sample feeding assembly, a detection assembly and a cleaning device, wherein the sample feeding assembly is used for providing a sample to be detected, the controller is used for controlling the sampling assembly to collect the sample to be detected from the sample feeding assembly, the detection assembly is used for detecting the sample to be detected, and the cleaning device is used for cleaning the sampling assembly. The controller can be used as an overall control module in the sample analyzer and used for controlling each module in the sample analyzer to realize corresponding functions.
In one embodiment, the detection assembly can include a fluorescence detection module, the sample analyzer of the present application can be used to perform fluorescence detection on a sample, and the sample introduction assembly can include a transport module, a reagent module, a reaction module, and a magnetic separation module. When the device is used, the original sample is transferred to the sampling assembly through the transportation module, the sampling assembly is used for sampling the original sample quantitatively, and the original sample is transferred to the reaction module to wait for reaction. The reagent module is used for accommodating and preparing reagents required by sample detection, the transportation module transports the reagents which are required to be added into the samples to the reagent station, and the reagent needles of the reagent module absorb the corresponding reagents and accurately and quantitatively add the reagents into the reaction disc of the reaction module, wherein the reagents comprise magnetic beads with specific antibodies. The sampling needle adds the original sample to the reaction disc, and in order to make the antigen in the original sample combine with the specific antibody in the reagent, the original sample needs to be incubated in the reaction disc for a period of time. After incubation, the magnetic separation module performs magnetic separation on the incubated sample mixture, cells which do not react with specific antibodies are separated in the magnetic separation module through an immunomagnetic bead separation technology, and magnetic bead compositions obtained through magnetic separation are cleaned, so that reagents which cannot be combined with magnetic beads in the reaction disc and other wastes are cleaned, and then a sample to be detected is obtained. The fluorescence detection module detects a sample to be detected and converts photoelectric data to obtain detection data.
In this embodiment, the detection assembly may include, but is not limited to, an impedance detection assembly, an optical detection assembly, a sheath flow technology detection assembly, an impedance sheath flow detection assembly.
Referring to fig. 1, fig. 1 is a schematic structural diagram of a first embodiment of a cleaning apparatus provided in the present application.
The cleaning apparatus 10 includes a power source 100, a buffer tank 210, a waste liquid tank 220, and a sampling assembly 300, wherein the buffer tank 210 is used for buffering cleaning liquid.
The first output end 110 of the power source 100 is connected with the temporary storage tank 210 through a pipeline, the liquid outlet of the temporary storage tank 210 is connected with the sampling assembly 300 through a pipeline, the sampling assembly 300 is connected with the liquid inlet end of the waste liquid tank 220 through a pipeline, and the second output end 120 of the power source 100 is connected with the air inlet end of the waste liquid tank 220 through a pipeline; wherein, the power source 100 outputs positive pressure to the temporary storage tank 210 through the first output end 110, and conveys the cleaning solution in the temporary storage tank 210 to the sampling assembly 300, so as to clean the sampling assembly 300 through the cleaning solution; the same power source 100 outputs negative pressure to the waste liquid tank 220 through the second output end 120, and collects the waste liquid from the cleaning and sampling assembly 300 to the waste liquid tank 220.
The cleaning solution may be a solution such as a buffer solution that can clean impurities attached to the sampling module 300. The power source 100 may be an air pressure source and the power source 100 may output a positive pressure using the first output 110 while outputting a negative pressure using the second output 120. In the process of cleaning the sampling assembly 300, a pipeline between the first output end 110 and the temporary storage tank 210, a pipeline between the temporary storage tank 210 and the sampling assembly 300, a pipeline between the sampling assembly 300 and the waste liquid tank 220, and a pipeline between the waste liquid tank 220 and the second output end 120 are firstly communicated, then negative pressure can be output in the communicated pipeline through the second output end 120, and then positive pressure is output in the communication through the first output end 110, so that the cleaning of the sampling assembly 300 and the collection of waste liquid generated after the cleaning can be simultaneously realized by using one power source 100; or the second output end 120 can be used to output negative pressure in the connected pipeline and the first output end 110 can be used to output positive pressure in the connected pipeline, so that the cleaning of the sampling assembly 300 and the collection of waste liquid generated after the cleaning can be realized by one power source 100.
Through the above embodiment, the power source 100 can provide positive pressure to the temporary storage tank 210 and negative pressure to the waste liquid tank 220, so that one power source 100 is used for cleaning the sampling needle 310 and recycling waste liquid, the scheme of replacing a plurality of power sources 100 can be replaced, the failure rate of products can be reduced, and the volume of the instrument can be reduced.
In one embodiment, the cleaning apparatus 10 further comprises a first connector 510, a first switch member 410, and a solution tank 230, the solution tank 230 being adapted to provide a cleaning solution. The first joint 510 may be a three-way joint. The first end of the first joint 510 is connected to the second output end 120, the second end of the first joint 510 is connected to the first switching element 410 through a pipeline, the second output end 120 outputs negative pressure to the waste liquid tank through the third end of the first joint 510, and the cleaning liquid tank 230 is connected to the temporary storage tank 210 through a pipeline. The buffer tank 210 is connected to the first output terminal 110 or the second output terminal 120 through the first switching member 410, and the power source 100 outputs negative pressure to the buffer tank 210 through the second output terminal 120, so that the cleaning liquid in the cleaning liquid tank 230 is delivered to the buffer tank 210.
The first switching member 410 is used for communicating the temporary storage tank 210 with the first output end 110 or the second output end 120, and when a cleaning process needs to be executed, the temporary storage tank 210 is communicated with the first output end 110 through the first switching member 410, so as to output positive pressure to the temporary storage tank 210 through the first output end 110; when the temporary storage tank 210 needs to be replenished with the cleaning solution, the temporary storage tank 210 is communicated with the second output end 120 through the first switching member 410, so as to output the negative pressure to the temporary storage tank 210 through the second output end 120, so that the temporary storage tank 210 sucks the cleaning solution from the cleaning solution tank 230.
In one embodiment, the first switch 410 may be a three-way valve, and the first switch 410 includes a first three-way valve 411, a first end of the first three-way valve 411 is connected to a second end of the first joint 510 through a pipeline, a second end of the first three-way valve 411 is connected to the first output end 110 through a pipeline, and a common end of the first three-way valve 411 is connected to the buffer tank 210 through a pipeline. Thus, the buffer tank 210 may be communicated with the first output terminal 110 or the second output terminal 120 by controlling the first three-way valve 411.
In one embodiment, the cleaning apparatus 10 further comprises a second joint 520, a second switch 420, and a waste liquid treatment device 250. A first end of the second joint 520 is connected with the first output end 110, a second end of the second joint 520 is connected with the second switching piece 420 through a pipeline, the first output end 110 outputs positive pressure to the temporary storage tank 210 through a third end of the second joint 520, the first output end 110 outputs positive pressure to the waste liquid tank 220 through a second end of the second joint 520, and the waste liquid tank 220 is connected with the waste liquid treatment device 250 through a pipeline; the waste liquid tank 220 is communicated with the first output end 110 or the second output end 120 through the second switching member 420, and the power source 100 outputs positive pressure to the waste liquid tank 220 through the first output end 110 so as to convey the waste liquid in the waste liquid tank 220 to the waste liquid treatment device 250.
The second switching member 420 is used to communicate the waste liquid tank 220 with the first output port 110 or with the second output port 120. When the cleaning process needs to be executed, the second switching element 420 may enable the waste liquid tank 220 to communicate with the second output end 120, so as to output negative pressure to the waste liquid tank 220 through the second output end 120, so that the waste liquid tank 220 absorbs the waste liquid flowing out from the sampling assembly 300; when the waste liquid in the waste liquid tank 220 needs to be discharged out of the waste liquid tank 220, the second switching member 420 can communicate the waste liquid tank 220 with the first output end 110, so as to output positive pressure to the waste liquid tank 220 through the first output end 110, and discharge the waste liquid in the waste liquid tank 220 to the waste liquid treatment device 250.
In an embodiment, the second switching member 420 may be a three-way valve, and the second switching member 420 includes a second three-way valve 421, a first end of the second three-way valve 421 is connected to the second end of the second joint 520 through a pipeline, a second end of the second three-way valve 421 is connected to the second output end 120 through a pipeline, and a common end of the second three-way valve 421 is connected to the waste liquid tank 220 through a pipeline. Thus, the waste liquid tank 220 can be communicated with the first output terminal 110 or the second output terminal 120 by controlling the second three-way valve 421.
Wherein, the first switching member 410 and the second switching member 420 can both be implemented by two-way valves, see fig. 2, and fig. 2 is a schematic structural diagram of a second embodiment of the cleaning apparatus provided in the present application.
As shown in fig. 2, the first switching member 410 includes a first controllable valve 412 and a second controllable valve 413, a first end of the first controllable valve 412 is connected to the second end of the first joint 510 through a pipeline, a second end of the first controllable valve 412 is connected to the buffer tank 210 through a pipeline, a first end of the second controllable valve 413 is connected to the first output end 110 through a pipeline, and a second end of the second controllable valve 413 is connected to the buffer tank 210 through a pipeline. Thus, the buffer tank 210 may be placed in communication with the first output 110 or the second output 120 by controlling the first controllable valve 412 and the second controllable valve 413.
The second switching member 420 includes a third controllable valve 422 and a fourth controllable valve 423, a first end of the third controllable valve 422 is connected to the second end of the second joint 520 through a pipeline, a second end of the third controllable valve 422 is connected to the waste liquid tank 220 through a pipeline, a first end of the fourth controllable valve 423 is connected to the second output end 120 through a pipeline, and a first end of the fourth controllable valve 423 is connected to the waste liquid tank 220 through a pipeline. Thus, the waste-liquid tank 220 can be put into communication with the first output 110 or with the second output 120 by controlling the third controllable valve 422 and the fourth controllable valve 423.
In other embodiments, the specific structure of the first switch 410 and the second switch 420 may be set according to actual conditions, for example, the first switch 410 includes a first three-way valve 411, and the second switch 420 includes a third controllable valve 422 and a fourth controllable valve 423; or the first switch 410 comprises a first controllable valve 412 and a second controllable valve 413 and the second switch 420 comprises a second three-way valve 421.
Referring to fig. 1 and 2, in one embodiment, the cleaning apparatus 10 further includes an anti-drainback tank 240, through which the second output 120 of the power source 100 is connected to the inlet of the waste tank 220. Set up in power source 100 and waste liquid tank 220 and prevent down jar 240, can avoid utilizing power source 100 to absorb the waste liquid to waste liquid tank 220 output negative pressure, can be because of the too big or waste liquid is more in the waste liquid tank 220 of negative pressure, lead to the waste liquid flow direction power source 100 in the waste liquid tank 220 to damage the possibility of power source 100.
In one embodiment, the cleaning apparatus 10 includes: a first pressure regulating device 111 and a second pressure regulating device 121, the first pressure regulating device 111 is used for regulating the positive pressure value output by the power source 100 through the first output end 110, and the second pressure regulating device 121 is used for regulating the negative pressure value output by the power source 100 through the second output end 120. The first pressure adjusting device 111 is located at the first output end 110, the second pressure adjusting device 121 is located at the second output end 120, and the first pressure adjusting device 111 and the second pressure adjusting device 121 are arranged to adjust a positive pressure value and a negative pressure value respectively, so that the situation that liquid leakage occurs to sampling components and other device parts and further instruments are damaged due to the fact that the pressure value is too large and the flow of cleaning liquid in a pipeline is large in the cleaning process can be avoided; or the pressure value is too small, so that the sampling assembly 300 cannot be cleaned smoothly, and the cleaning effect is poor.
In one embodiment, the sampling assembly 300 comprises a sampling needle 310, a wiping member 320 arranged on the outer wall of the sampling needle 310, and a third joint 530, wherein the liquid outlet of the temporary storage tank 210 is connected with the cleaning port of the wiping member 320 through a pipeline so as to clean the outer wall of the sampling needle 310 through the wiping member 320; the liquid inlet end of the waste liquid tank 220 is connected with the waste liquid port of the wiping component 320 through a pipeline. A first end of the third joint 530 is connected to the liquid outlet of the buffer tank 210 through a pipeline, a second end of the third joint 530 is connected to the cleaning port of the wiping unit 320 through a pipeline, and a third end of the third joint 530 is connected to the sampling needle 310 through a pipeline.
When the outer wall of the sampling needle 310 needs to be cleaned, a pipeline between the first output end 110 and the temporary storage tank 210, a pipeline between the temporary storage tank 210 and the wiping part 320, a pipeline between the wiping part 320 and the waste liquid tank 220, and a pipeline between the waste liquid tank 220 and the second output end 120 can be firstly conducted, then positive pressure is applied to the temporary storage tank 210 through the first output end 110, negative pressure is applied to the waste liquid tank 220 through the second output end 120, the cleaning of the outer wall of the sampling needle 310 is realized, and the recovery of waste liquid generated after the cleaning is realized.
When the inner wall of the sampling needle 310 needs to be cleaned, the pipeline between the first output end 110 and the temporary storage tank 210 and the pipeline between the temporary storage tank 210 and the sampling needle 310 may be firstly conducted, and then positive pressure is applied to the temporary storage tank 210 through the first output end 110, so as to clean the inner wall of the sampling needle 310.
In one embodiment, the cleaning apparatus 10 further comprises a syringe 600, the third end of the third connector 530 is connected to the inlet end of the syringe 600 through a pipeline, and the outlet of the syringe 600 is connected to the sampling needle 310 through a pipeline, so as to clean the interior of the sampling needle 310.
When the inner wall of the sampling needle 310 needs to be cleaned, the pipeline between the first output end 110 and the temporary storage tank 210, the pipeline between the temporary storage tank 210 and the injector 600, and the pipeline between the sampling needle 310 and the injector 600 may be firstly conducted, and then positive pressure is applied to the temporary storage tank 210 through the first output end 110, so that the cleaning of the inner wall of the sampling needle 310 is realized.
Referring to fig. 3, fig. 3 is a schematic structural diagram of a third embodiment of the cleaning apparatus provided in the present application.
The cleaning device 10 further comprises a fourth adapter 540, wherein a first end of the fourth adapter 540 is connected to a third end of the third adapter 530 through a pipeline, a second end of the fourth adapter 540 is connected to a liquid outlet of the syringe 600 through a pipeline, and a third end of the syringe 600 is connected to the sampling needle 310 through a pipeline.
When the inner wall of the sampling needle 310 needs to be cleaned, the pipeline between the first output end 110 and the temporary storage tank 210, the pipeline between the temporary storage tank 210 and the third joint 530, the pipeline between the third joint 530 and the fourth joint 540, and the pipeline between the fourth joint 540 and the sampling needle 310 may be firstly conducted, and then positive pressure is applied to the temporary storage tank 210 through the first output end 110, so that the inner wall of the sampling needle 310 is cleaned.
When a reagent or a sample needs to be collected by using the sampling needle 310, the pipeline between the syringe 600 and the sampling needle 310 may be conducted, and then the sample or the reagent may be collected by controlling the syringe 600.
Through the above embodiment, the power source 100 can provide positive pressure to the temporary storage tank 210 and negative pressure to the waste liquid tank 220, so that one power source 100 is used for cleaning the sampling needle 310 and recycling waste liquid, the scheme of replacing a plurality of power sources 100 can be replaced, the failure rate of products can be reduced, and the volume of the instrument can be reduced.
In one embodiment, the controller of the sample analyzer provided by the present application is configured to calculate a total sample extraction amount according to a sample amount required for each test item, wherein the test items include a diluted test item and a non-diluted test item; the controller is used for controlling the sampling assembly 300 to extract a sample to be detected from the sample injection assembly at one time according to the total sample extraction amount; the controller is used for controlling the sampling component 300 to distribute part of samples to be tested to the transfer positions according to the sample amount required by the dilution type test items; the controller is configured to control the sampling assembly 300 to allocate the remaining sample to be tested to the sampling position of each non-diluted test item according to the sample amount required by each non-diluted test item.
When the item of the dilution type test item is tested, the sample needs to be diluted by using the diluent, and then the diluted sample is added into a reaction cup of the reaction device, so that the sample reacts, and the reacted sample is tested. When testing the non-diluted test items, the sample is only required to be added into the reaction cup of the reaction device, the sample is reacted, and the reacted sample is tested. The total sample extraction amount can be obtained by calculating the sample amount required for each test item, for example, when the test items are seven blood coagulation tests (including plasma Prothrombin Time (PT), activated partial Prothrombin time (APTT), fibrinogen (FIB), thrombin Time (TT), D-Dimer (D-Dimer, D-D), antithrombin-III (AT-III), fibrin (ogen) degradation product (FDP)). Each test item is configured with its own required sample size, and then the total sample extraction amount can be calculated according to the sample sizes required by the five test items.
After the total sample extraction amount is determined, the sample to be detected can be extracted from the sample tube at one time. The sample to be measured can be sucked from the sample tube at one time through the sampling needle 310, and then the sucked sample is temporarily stored in the pipeline to which the sampling needle 310 is connected. Compared with the method of extracting the sample again in each test, the method of extracting the sample to be tested once can reduce the time consumed by absorbing the sample again in each test and improve the test speed of the instrument. Meanwhile, when the sampling needle 310 is used for puncturing the sample tube to extract a sample, the situation that the material in the cover enters the sample to pollute the sample after the same sample tube is punctured for multiple times can be reduced.
The transfer position can be stored with one or more reaction cups, and after the sample to be detected is extracted, a part of the sample to be detected is distributed to the transfer position for temporary storage. The sample size required for the dilution-type item may include the sample originally required for performing the dilution-type test, and in theory, a redundant sample that remains at the middle position may be required. Illustratively, when the test items are seven blood coagulation tests, three test items of plasma Prothrombin Time (PT), activated partial prothrombin time (APTT), and Thrombin Time (TT) are dilution-type test items. And the sample size required for detection in PT, APTT and TT is A, B and C, respectively, where the sample size of the to-be-detected sample allocated to the middle index can be a + B + C + X, and X is redundancy.
The remaining sample to be tested in the sample needle includes the total sample extraction amount minus the extraction amount of the sample to be tested distributed to the transfer position. And then distributing the rest samples to be tested to the sample adding positions according to the sample amount required by each non-diluted test item. And then the sample distributed to the sample adding position can be directly placed in a reaction device for testing. Illustratively, fibrinogen (FIB), D-dimer (D-D), antithrombin III (AT-III), and fibrin (ogen) degradation product (FDP) are non-dilution type test items when the test item is seven-item blood coagulation. The four detection items respectively have a sample size required by the four detection items, and the rest samples to be detected are distributed according to the sample size required by the four detection items. Because the requirement on the precision of the dosage required by the dilution type project is relatively high, in the embodiment, the sample to be detected required by the dilution type project is firstly distributed, and then the sample to be detected required by the non-dilution type project is distributed, so that the possibility that errors occur in the final detection result due to insufficient samples can be reduced.
The application also provides a cleaning method, and the cleaning method is applied to a sample analyzer, and the sample analyzer includes the cleaning device 10 of any embodiment described above, and referring to fig. 1 to 4, fig. 4 is a schematic flow chart of an embodiment of the cleaning method provided in the application. Specifically, the method includes the following steps S401 to S403.
Step S401: the power source 100 is controlled to output positive pressure to the buffer tank 210 through the first output port 110.
Step S402: the cleaning fluid in the staging tank 210 is delivered to the sampling assembly 300 using the positive pressure output to the staging tank 210.
Step S403: the cleaning fluid is used to clean the inner wall of sampling needle 310 and/or the outer wall of sampling needle 310 of sampling assembly 300.
With the above-described embodiments, the power source 100 may be utilized to provide positive pressure to the buffer tank 210, such that the power source 100 may be utilized to drive the cleaning fluid in the buffer tank 210 to clean the inner wall of the sampling needle 310 and/or the outer wall of the sampling needle 310.
In one embodiment, the cleaning method further comprises: controlling the power source 100 to output negative pressure to the waste liquid tank 220 through the second output end 120; the waste liquid generated by cleaning the sampling needle 310 is absorbed into the waste liquid tank 220 by outputting negative pressure to the waste liquid tank 220.
Through the above embodiment, the power source 100 can provide positive pressure to the temporary storage tank 210 and negative pressure to the waste liquid tank 220, so that one power source 100 is used for cleaning the sampling needle 310 and recycling waste liquid, the scheme of replacing a plurality of power sources 100 can be replaced, the failure rate of products can be reduced, and the volume of the instrument can be reduced.
In one embodiment, after the waste liquid generated by cleaning the sampling needle 310 is absorbed into the waste liquid tank 220 by outputting negative pressure to the waste liquid tank 220, the method includes: controlling power source 100 to provide positive pressure to waste tank 220; discharging the waste liquid in the waste liquid tank 220 by using the positive pressure supplied to the waste liquid tank 220; controlling the power source 100 to supply a negative pressure to the buffer tank 210 while discharging the waste liquid in the waste liquid tank 220; the cleaning liquid is sucked from the cleaning liquid tank 230 of the cleaning apparatus 10 to the buffer tank 210 by the negative pressure supplied to the buffer tank 210.
Through the above embodiment, the working state of the positive pressure and the negative pressure output by the power source 100 can be reasonably utilized, and in the process of providing the positive pressure to the waste liquid tank 220 by utilizing the first output end 110, the negative pressure is provided to the temporary storage tank 210 by utilizing the second output end 120, namely, the cleaning liquid is supplemented to the temporary storage tank 210 while the waste liquid of the waste liquid tank 220 is discharged, so that the efficiency of cleaning the sampling needle 310 by the sample analyzer is improved, and the working efficiency of detecting the sample by the sample analyzer is improved.
In one embodiment, the step of cleaning the inner wall of the sampling needle 310 and/or the outer wall of the sampling needle 310 of the sampling assembly 300 with the cleaning solution (step S403) includes: controlling the injector 600 of the washing apparatus 10 to dispense the sample to be measured; the outer wall of the sampling needle 310 is cleaned with the cleaning solution while the syringe 600 of the cleaning apparatus 10 is controlled to dispense the sample to be measured.
Because the waste liquid that the produced outer wall of washing sampling needle 310 can directly be drawn to waste liquid tank 220 through power source 100, can not influence the distribution of the sample that awaits measuring at the in-process of washing the outer wall of sampling needle 310 this moment equally, also utilize cleaning equipment 10 to wash the outer wall of sampling needle 310 to and utilize sampling needle 310 to distribute the sample that awaits measuring and can go on simultaneously, further improve the work efficiency that sample analysis appearance detected the sample.
In one embodiment, the step of delivering the cleaning solution in the buffer tank 210 to the sampling assembly 300 by using the positive pressure output to the buffer tank 210 (step S402) includes: an injector 600 for delivering the cleaning solution in the buffer tank 210 to the cleaning device 10 by using the positive pressure output to the buffer tank 210; the step of controlling the movement of the syringe 600 to increase the receiving space of the syringe 600 and cleaning the inner wall of the sampling needle 310 and/or the outer wall of the sampling needle 310 of the sampling assembly 300 with the wash liquid in the process of delivering the wash liquid to the syringe 600 of the washing apparatus 10 (step S403) includes: the inner wall of the sampling needle 310 is cleaned with the cleaning solution passing through the syringe 600.
Referring to fig. 1 and 2, in the pipeline between the temporary storage tank 210 and the sampling needle 310, in the process of cleaning the inner wall of the sampling needle 310, the pipeline between the first output end 110 and the temporary storage tank 210, the pipeline between the temporary storage tank 210 and the injector 600, and the pipeline between the sampling needle 310 and the injector 600 may be first conducted, and then positive pressure is applied to the temporary storage tank 210 through the first output end 110, so that in the process of delivering the cleaning solution to the injector 600, the injector 600 is controlled to move, so as to increase the accommodating space of the injector 600, thereby increasing the speed of the injector 600 acquiring the cleaning solution and improving the cleaning efficiency of cleaning the inner wall of the sampling needle 310.
The principle and the embodiment of the present application are explained by applying specific examples, and the above description of the embodiments is only used to help understand the method and the core idea of the present application; meanwhile, for a person skilled in the art, according to the idea of the present application, there may be variations in the specific embodiments and the application scope, and in summary, the content of the present specification should not be construed as a limitation to the present application.
Claims (15)
1. A cleaning apparatus for use with a sample analyzer, the cleaning apparatus comprising: the cleaning device comprises a power source, a temporary storage tank, a waste liquid tank and a sampling assembly, wherein the temporary storage tank is used for temporarily storing cleaning liquid;
the first output end of the power source is connected with the temporary storage tank through a pipeline, a liquid outlet of the temporary storage tank is connected with the sampling assembly through a pipeline, the sampling assembly is connected with a liquid inlet end of the waste liquid tank through a pipeline, and the second output end of the power source is connected with a gas inlet end of the waste liquid tank through a pipeline;
the power source outputs positive pressure to the temporary storage tank through the first output end, and the cleaning liquid in the temporary storage tank is conveyed to the sampling assembly so as to clean the sampling assembly through the cleaning liquid; the same power source outputs negative pressure to the waste liquid tank through the second output end, and waste liquid for cleaning the sampling assembly is collected to the waste liquid tank;
the cleaning equipment further comprises a first joint, a first switching piece and a cleaning liquid tank, wherein the cleaning liquid tank is used for providing cleaning liquid;
the first joint is a three-way joint, a first end of the first joint is connected with the second output end, a second end of the first joint is connected with the first switching piece through a pipeline, the second output end outputs negative pressure to the waste liquid tank through a third end of the first joint, and the cleaning liquid tank is connected with the temporary storage tank through a pipeline;
the temporary storage tank is communicated with the first output end or the second output end through the first switching piece, and the power source outputs negative pressure to the temporary storage tank through the second output end so that the cleaning liquid in the cleaning liquid tank is conveyed to the temporary storage tank;
the first switching piece is used for enabling the temporary storage tank to be communicated with the first output end or the second output end.
2. The cleaning apparatus according to claim 1,
the first switching piece comprises a first three-way valve, a first end of the first three-way valve is connected with a second end of the first joint through a pipeline, a second end of the first three-way valve is connected with the first output end through a pipeline, and a common end of the first three-way valve is connected with the temporary storage tank through a pipeline;
or, the first switching piece comprises a first controllable valve and a second controllable valve, the first end of the first controllable valve is connected with the second end of the first joint through a pipeline, the second end of the first controllable valve is connected with the temporary storage tank through a pipeline, the first end of the second controllable valve is connected with the first output end through a pipeline, and the second end of the second controllable valve is connected with the temporary storage tank through a pipeline.
3. The cleaning apparatus according to claim 1 or 2, characterized in that the cleaning apparatus further comprises a second joint, a second switching member, and a waste liquid treatment device;
the first end of the second joint is connected with the first output end, the second end of the second joint is connected with the second switching piece through a pipeline, the first output end outputs positive pressure to the temporary storage tank through the third end of the second joint, the first output end outputs positive pressure to the waste liquid tank through the second end of the second joint, and the waste liquid tank is connected with the waste liquid treatment device through a pipeline;
the waste liquid tank is communicated with the first output end or the second output end through the second switching piece, and the power source outputs positive pressure to the waste liquid tank through the first output end so as to convey waste liquid in the waste liquid tank to the waste liquid treatment device.
4. The cleaning apparatus according to claim 3,
the second switching piece comprises a second three-way valve, a first end of the second three-way valve is connected with a second end of the second joint through a pipeline, a second end of the second three-way valve is connected with the second output end through a pipeline, and a common end of the second three-way valve is connected with the waste liquid tank through a pipeline;
or the second switching piece comprises a third controllable valve and a fourth controllable valve, the first end of the third controllable valve is connected with the second end of the second joint through a pipeline, the second end of the third controllable valve is connected with the waste liquid tank through a pipeline, the first end of the fourth controllable valve is connected with the second output end through a pipeline, and the first end of the fourth controllable valve is connected with the waste liquid tank through a pipeline.
5. The cleaning apparatus defined in claim 1, further comprising an anti-drainback tank, the second output of the power source being connected to an air inlet of the waste liquid tank via the anti-drainback tank and a conduit.
6. The cleaning apparatus of claim 1, wherein the cleaning apparatus comprises: first pressure regulating device and second pressure regulating device, first pressure regulating device is used for adjusting the power supply passes through the positive pressure value of first output, second pressure regulating device is used for adjusting the power supply passes through the negative pressure value of second output.
7. The cleaning device according to claim 1, wherein the sampling assembly comprises a sampling needle, a wiping part arranged on the outer wall of the sampling needle and a third joint, and the liquid outlet of the temporary storage tank is connected with the cleaning port of the wiping part through a pipeline so as to clean the outer wall of the sampling needle through the wiping part; the liquid inlet end of the waste liquid tank is connected with the waste liquid port of the wiping part through a pipeline; the first end of the third joint is connected with the liquid outlet of the temporary storage tank through a pipeline, the second end of the third joint is connected with the cleaning port of the wiping part through a pipeline, and the third end of the third joint is connected with the sampling needle through a pipeline.
8. The cleaning apparatus defined in claim 7, further comprising a syringe;
the third end of the third joint is connected with the liquid inlet end of the injector through a pipeline, and the liquid outlet of the injector is connected with the sampling needle through a pipeline so as to clean the interior of the sampling needle; or the like, or, alternatively,
the cleaning equipment further comprises a fourth joint, wherein the first end of the fourth joint is connected with the third end of the third joint through a pipeline, the second end of the fourth joint is connected with the liquid outlet of the injector through a pipeline, and the third end of the injector is connected with the sampling needle through a pipeline.
9. A sample analyzer, comprising a controller, a sample feeding assembly, a detecting assembly and the cleaning device of any one of claims 1-8, wherein the sample feeding assembly is used for providing a sample to be tested, the controller is used for controlling the sampling assembly to collect the sample to be tested from the sample feeding assembly, the detecting assembly is used for detecting the sample to be tested, and the cleaning device is used for cleaning the sampling assembly.
10. The sample analyzer of claim 9,
the controller is used for calculating the total sample extraction amount according to the sample amount required by each test item, wherein the test items comprise diluted test items and non-diluted test items;
the controller is used for controlling the sampling assembly to extract the sample to be detected from the sampling assembly at one time according to the total sample extraction amount;
the controller is used for controlling the sampling assembly to distribute part of the samples to be tested to a transfer position according to the sample amount required by the dilution type test items;
the controller is used for controlling the sampling assembly according to the sample amount required by each non-diluted test item, and distributing the rest sample to be tested to the sample adding position of each non-diluted test item.
11. A method of cleaning, applied to a sample analyzer comprising the cleaning apparatus of any one of claims 1~8, the method comprising:
controlling the power source to output positive pressure to the temporary storage tank through the first output end;
conveying the cleaning liquid in the temporary storage tank to the sampling assembly by utilizing the positive pressure output to the temporary storage tank;
and cleaning the inner wall of the sampling needle of the sampling assembly and/or the outer wall of the sampling needle by using the cleaning liquid.
12. The cleaning method according to claim 11, wherein the method comprises:
controlling the power source to output negative pressure to the waste liquid tank through the second output end;
and absorbing the waste liquid generated by cleaning the sampling needle into the waste liquid tank by utilizing the negative pressure output to the waste liquid tank.
13. The cleaning method according to claim 12, wherein after absorbing the waste liquid generated by cleaning the sampling needle into the waste liquid tank by outputting negative pressure to the waste liquid tank, the method comprises:
controlling the power source to provide positive pressure to the waste liquid tank;
discharging the waste liquid in the waste liquid tank by using positive pressure supplied to the waste liquid tank;
controlling the power source to provide negative pressure to the temporary storage tank while discharging the waste liquid in the waste liquid tank;
and sucking the cleaning liquid from the cleaning liquid tank of the cleaning equipment to the temporary storage tank by using the negative pressure provided for the temporary storage tank.
14. The cleaning method of claim 11, wherein the cleaning the inner wall of the sampling needle and/or the outer wall of the sampling needle of the sampling assembly with the cleaning solution comprises:
controlling an injector of the cleaning equipment to distribute a sample to be detected;
and when the injector of the cleaning equipment is controlled to distribute a sample to be measured, the cleaning liquid is utilized to clean the outer wall of the sampling needle.
15. The method of cleaning according to claim 11, wherein said delivering cleaning fluid from the staging tank to the sampling assembly using positive pressure output to the staging tank comprises:
the injector is used for conveying the cleaning liquid in the temporary storage tank to the cleaning equipment by utilizing the positive pressure output to the temporary storage tank;
controlling the injector to move in the process of conveying the cleaning liquid to the injector of the cleaning equipment so as to increase the accommodating space of the injector;
utilize the washing liquid wash the inner wall of the sampling needle of sampling subassembly and/or the outer wall of sampling needle, include:
cleaning an inner wall of the sampling needle with the cleaning solution passing through the syringe.
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