CN102944534A - Automatic medicine disintegration tester - Google Patents
Automatic medicine disintegration tester Download PDFInfo
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- CN102944534A CN102944534A CN2012104373242A CN201210437324A CN102944534A CN 102944534 A CN102944534 A CN 102944534A CN 2012104373242 A CN2012104373242 A CN 2012104373242A CN 201210437324 A CN201210437324 A CN 201210437324A CN 102944534 A CN102944534 A CN 102944534A
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- infrared
- suspension rod
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- hanging basket
- medicine
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Abstract
The invention discloses an automatic medicine disintegration tester. The structure of the automatic medicine disintegration tester is as follows: a camera is erected, and an infrared filter, an infrared source and a suspender are sequentially arranged on the same axial line under the camera. The suspender is of a hollow structure, a glass post is inserted in the suspender, a hanging basket is fixed on the suspender, and the infrared source and the suspender are connected with a suspender-driving mechanism. Infrared light irradiates the surface of medicine to be tested in a beaker through the glass post, the acquired infrared test data in the hanging basket are computed by a singlechip, the camera, the infrared filter, the infrared source and the suspender are formed into an infrared test system, N test systems are arranged over N hanging baskets in the automatic medicine disintegration testers, and the hanging basket is arranged in the beaker. The tester can automatically test the process of medicine disintegration, moreover, the testing process is stable, and the result is accurate. Since infrared light is invisible light, the affection of medicine color on shooting can be eliminated. The singlechip can automatically carry out parameter computation and provide experimental curves.
Description
Technical field
The invention belongs to the drug test instrument, be specifically related to a kind of instrument for detection of solid pharmaceutical preparation disintegration times such as tablet, capsule, dripping pills.
Background technology
Disintegration (time) test is one of important content in the drug test, is widely used in medicine and makes the field.Used intelligent its principle of disintegration detector is Hall element method, photoelectric detection method and electrode detection method etc. substantially at present, but these three kinds of methods all can cause error in the judgement to the disintegration concluding time, and major defect is:
(1) the Hall element method is that Hall element is installed on beaker bottom and the block, and when the medicine disintegration finished, block can fall with the sensor of beaker bottom and contact, and finishes thereby judge the medicine disintegration.But in the middle of actual experiment, when the medicine disintegration finished, block can because various factors can not fall, cause sensor can not accurately measure the concluding time of disintegration.
(2) photoelectric detecting method is to block (light beam) by the medicine that dissolves to shine on the sensor, judges thus the time that disintegration finishes.But when the medicine disintegration will finish, can produce pollutant in the solution, and pollutant can obstruct the light also, makes sensor can't in time receive light signal, even not receive light signal, therefore also just can't measure accurately the time that disintegration finishes.
(3) the electrode detection method is by detecting element the wire netting of beaker bottom to be divided into two-layerly, and the space is reserved in the centre, and two wire nettings that separate connect respectively electrode, and the block in the hanging basket (loading detected medicine) is metallic.Derby fell two wire netting contacts when disintegration finished, and measured the medicine disintegration time.But when problem was medicine disintegration end, block also can because various factors can not fall, cause sensor can not accurately measure the concluding time of disintegration.
Summary of the invention
General character defective for existing detector, the objective of the invention is, the automatic disintegration detector of medicine of a kind of CCD of utilization and infrared imaging test philosophy is provided, can not only accurately judge the time that the medicine disintegration finishes, can also show, observe in terminal whole experimentation, and automatically carry out calculation of parameter and describe curve.
The technical scheme that the automatic disintegration detector of medicine adopts is: instrument has camera, infrared fileter, infrared light supply, hollow suspension rod, computing machine, hanging basket and beaker etc.Its technical scheme is: camera stands up, and the below of camera is positioned at same axis and is provided with successively infrared fileter, infrared light supply and suspension rod.Suspension rod is interior hollow-core construction, is inlaid with the glass cylinder in the suspension rod, and suspension rod and hanging basket are fixed.Infrared light supply and suspension rod are connected with the suspension rod driving mechanism, and the suspension rod driving mechanism drives the hanging basket operation.The light of infrared light supply shines the surface of medicine to be checked in the beaker through the glass cylinder, single-chip microcomputer is to the suspension rod driving mechanisms control, and infrared detection data in the hanging basket that collects are calculated, form infrared detection system by camera, infrared fileter, infrared light supply, suspension rod, N detection system places the top of N hanging basket of drug test instrument, and hanging basket places beaker.
Its principle of work is: camera or camera carry the CCD chip and consist of the ccd image recognition system, be provided with infrared fileter before the cam lens, the upper infrared light supply that adopts of hanging basket (suspension rod), Infrared by incrusted glass cylinder in the hollow suspension rod with the medicine of Infrared irradiation in the hanging basket.Power by its reflection ray in the observation medicine disintegrating procedue changes, and judges the time that disintegration finishes.
Characteristics of the present invention and beneficial effect are that the automatically disintegrating procedue of test experience medicine, and testing process is stable, the result is accurate.Because the infrared light supply that instrument adopts is invisible light, so can get rid of the impact of medicine color on taking.Instrument can show experimentation so that observe by synchronization signal acquisition system at terminal display screen, and computing machine can automatically carry out calculation of parameter and provide empirical curve.
Description of drawings
Shown in accompanying drawing be structural principle synoptic diagram of the present invention.
Embodiment
Below in conjunction with accompanying drawing and by example structural principle of the present invention is described further.The automatic disintegration detector of medicine, its structure is: camera 1 stands up, and the below of camera is positioned at same axis and is provided with successively infrared fileter 2, infrared light supply 3 and suspension rod 4, and suspension rod is interior hollow-core construction.Be inlaid with glass cylinder 5 in the suspension rod, suspension rod and hanging basket 6 are fixing, and infrared light supply and suspension rod are connected with suspension rod driving mechanism 8, and the suspension rod driving mechanism drives hanging basket operation, the surface of the light of infrared light supply medicine to be checked in the glass cylinder shines hanging basket (beaker).7 pairs of suspension rod driving mechanisms control of single-chip microcomputer, and medicine infrared detection data in the hanging basket that collects are calculated, form infrared detection system by camera, infrared fileter, infrared light supply, suspension rod, N detection system places the top of N hanging basket of drug test instrument, and hanging basket places beaker.The lower top of glass cylinder is that indent is conical, and perhaps descending the top is tack, if when the lower top of glass cylinder was tack, the length that its length is slightly less than suspension rod got final product, be convenient to light in medicine to be measured to multidirectional scattering.Camera is equipped with the ccd image recognition system; Camera also can be the camera that the ccd image identification chip is housed.Infrared light supply is the infrared light diode, or can send other light source of infrared light.
The suspension rod driving mechanism promotes suspension rod by the motor-driven cam, and is identical with the medicine disintegration tester suspension rod shifting principle of present use.The suspension rod driving mechanism is equipped with sensor, and sensor sends position signalling to single-chip microcomputer, by single-chip microcomputer infrared detection system is controlled, and the data that gather are calculated.Present embodiment adopts industrial camera, and the ccd image recognition system is housed, and 2 detection systems place the top of 2 hanging baskets of drug test instrument, and the wavelength of used infrared fileter is 850nm.The regulation of the structure of hanging basket and size conforms Chinese Pharmacopoeia.Glass cylinder lower end is the indent conical structure.
During work, medicine is put into hanging basket, single-chip microcomputer set in advance the relevant parameters that disintegration experiment needs (such as: limit value etc. is judged in slaking test timing, disintegration), then start instrument, by the suspension rod driving mechanism hanging basket is entered in the beaker and move up and down, medicine begins disintegration.Infrared light supply is surperficial to tablet with infrared light scattering by (inlaying in the suspension rod) glass cylinder, and tablet can be with light reflection, and the light of reflection enters in the camera through infrared fileter, and camera is taken synchronously.Along with the medicine disintegration, the area of medicine (sheet) product diminishes gradually, the light of reflection also more and more a little less than, when the moment that medicine dissolves fully, its reflection ray is zero, instrument can judge that the medicine disintegration finishes.Single-chip microcomputer is enabled image analysis program synchronously according to signal, and image identifies the size of medicine by analysis afterwards, and drawing image (tablet) size variation curve.When the complete disintegration end of medicine, hanging basket lifts, and data are also calculated end simultaneously.
Claims (4)
1. the automatic disintegration detector of medicine, comprise camera, infrared fileter, infrared light supply, suspension rod, the glass cylinder, hanging basket, single-chip microcomputer and suspension rod driving mechanism, it is characterized in that: camera (1) stands up, the below of camera is positioned at same axis and is provided with successively infrared fileter (2), infrared light supply (3) and suspension rod (4), suspension rod is interior hollow-core construction, be inlaid with glass cylinder (5) in the suspension rod, suspension rod and hanging basket (6) are fixing, infrared light supply and suspension rod are connected with suspension rod driving mechanism (8), the suspension rod driving mechanism drives the hanging basket operation, the light of infrared light supply shines the surface of medicine to be checked in the hanging basket through the glass cylinder, single-chip microcomputer (7) is to the suspension rod driving mechanisms control, and medicine infrared detection data in the hanging basket that collects are calculated, by camera, infrared fileter, infrared light supply, suspension rod forms infrared detection system, N detection system places the top of N hanging basket of drug test instrument, and hanging basket places beaker.
2. the automatic disintegration detector of medicine according to claim 1, the lower top that it is characterized in that described glass cylinder (5) are that indent is conical, and perhaps descending the top is tack.
3. the automatic disintegration detector of medicine according to claim 1 is characterized in that described camera (1) is equipped with the ccd image recognition system; Camera can be the camera that the ccd image identification chip is housed.
4. the automatic disintegration detector of medicine according to claim 1 is characterized in that described infrared light supply (3) is the infrared light diode, or can send the light source of infrared light.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012104373242A CN102944534A (en) | 2012-11-06 | 2012-11-06 | Automatic medicine disintegration tester |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012104373242A CN102944534A (en) | 2012-11-06 | 2012-11-06 | Automatic medicine disintegration tester |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102944534A true CN102944534A (en) | 2013-02-27 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012104373242A Pending CN102944534A (en) | 2012-11-06 | 2012-11-06 | Automatic medicine disintegration tester |
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| CN (1) | CN102944534A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106970202A (en) * | 2017-04-28 | 2017-07-21 | 兰州大学 | A kind of disintegration test comprehensive analysis device and its verification method |
| CN110487991A (en) * | 2019-09-11 | 2019-11-22 | 西南交通大学 | A kind of soil agreegate water droplet impingement slaking test device and test method |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050003550A1 (en) * | 2001-10-11 | 2005-01-06 | Oliver Kyne | Apparatus and method for concurrently monitoring active release and physical appearance of solid dosage form pharmaceuticals |
| WO2008086542A2 (en) * | 2007-01-10 | 2008-07-17 | Varian, Inc. | Automated microsampling dissolution test system |
| CN202093014U (en) * | 2011-05-10 | 2011-12-28 | 金色年华药业有限公司 | Disintegration tester |
| CN202256307U (en) * | 2011-09-28 | 2012-05-30 | 苏州瑞纳生化技术有限公司 | Dissolution tester |
| CN202281772U (en) * | 2011-10-27 | 2012-06-20 | 成都恒瑞制药有限公司 | Disintegration tester |
-
2012
- 2012-11-06 CN CN2012104373242A patent/CN102944534A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050003550A1 (en) * | 2001-10-11 | 2005-01-06 | Oliver Kyne | Apparatus and method for concurrently monitoring active release and physical appearance of solid dosage form pharmaceuticals |
| WO2008086542A2 (en) * | 2007-01-10 | 2008-07-17 | Varian, Inc. | Automated microsampling dissolution test system |
| CN202093014U (en) * | 2011-05-10 | 2011-12-28 | 金色年华药业有限公司 | Disintegration tester |
| CN202256307U (en) * | 2011-09-28 | 2012-05-30 | 苏州瑞纳生化技术有限公司 | Dissolution tester |
| CN202281772U (en) * | 2011-10-27 | 2012-06-20 | 成都恒瑞制药有限公司 | Disintegration tester |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106970202A (en) * | 2017-04-28 | 2017-07-21 | 兰州大学 | A kind of disintegration test comprehensive analysis device and its verification method |
| CN110487991A (en) * | 2019-09-11 | 2019-11-22 | 西南交通大学 | A kind of soil agreegate water droplet impingement slaking test device and test method |
| CN110487991B (en) * | 2019-09-11 | 2023-08-15 | 西南交通大学 | Soil aggregate water drop impact disintegration test device and test method |
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Application publication date: 20130227 |