CN202582945U - Sampling device for dissolution tester with deaerating function - Google Patents
Sampling device for dissolution tester with deaerating function Download PDFInfo
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- CN202582945U CN202582945U CN 201220211168 CN201220211168U CN202582945U CN 202582945 U CN202582945 U CN 202582945U CN 201220211168 CN201220211168 CN 201220211168 CN 201220211168 U CN201220211168 U CN 201220211168U CN 202582945 U CN202582945 U CN 202582945U
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- dissolution
- stripping rotor
- cup
- sampling
- bull stick
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Abstract
The utility model discloses a sampling device for a dissolution tester with a deaerating function. The sampling device for the dissolution tester with the deaerating function comprises a dissolution cup and a sample cup, wherein the dissolution cup is connected with the sample cup through a sampling catheter; a sampling pump is arranged on the sampling catheter; a stirrer is arranged in the dissolution cup; the stirrer comprises a rotating rod arranged along the position of the axis of the dissolution cup and a stirring head connected with the rotating rod; the rotating rod is connected with a motor arranged outside the dissolution cup; a helium supply device is arranged outside the dissolution cup; and the helium supply device is communicated with the dissolution cup through a pipeline. The sampling device for the dissolution tester with the deaerating function is provided with a hollow cavity; double functions of deaerating and driving the stirring head to stir are realized at the same time; the design is very ingenious; and the detection accuracy is improved. The sampling device for the dissolution tester with the deaerating function is suitable for testing the dissolution rate of scientific research departments such as various universities and middle schools, medical treatment, epidemic prevention, environmental monitoring and pharmaceutical industry.
Description
Technical field
The utility model belongs to the checkout equipment of pharmaceutical industry, particularly relates to the sampler of the digestion instrument with deoxygenation function.
Background technology
Dissolution rate (Dissolution rate) also claim dissolution rate, is meant under specified solvent and condition the speed and the degree of medicine stripping from solid pharmaceutical preparations such as tablet, capsule, granule.The process of measuring the solid pharmaceutical preparation dissolution rate is called dissolution rate test (Dissolution test), and it is a kind of disintegration of oral solid formulation in intestines and stomach and in vitro test method of stripping simulated.The drug dissolution inspection is a kind of effective means of estimating preparation quality and technological level; The difference that can reflect crystal formation, granularity, prescription composition, auxiliary material kind and character, the production technology etc. of main ingredient to a certain extent; It also is a kind of effective standard of estimating preparation active component bioavilability and preparation uniformity coefficient; Can effectively distinguish the difference of same kind of drug bioavailability, therefore be one of drug quality control essential items for inspection.
It is generally acknowledged; Slightly solubility (referring generally to slightly soluble or insoluble in water) medicine; Because of the medicine (comprising soluble drug) that preparation prescription and production technology cause unsettled medicine of clinical efficacy and therapeutic dose and dosis toxica to be close, must set the dissolution test item in its oral solid formulation quality standard.In addition, in the prescription screening of solid pharmaceutical preparation and the technological process of production formulation process, also need the dissolution rate of exploitation formulation is done comprehensive investigation.Feasible dissolution rate test method(s) should be all must reach test findings at different time, place to the dissolution determination of same preparation or the mensuration between the different operation person to have good reappearance.Therefore, the digestion instrument that is used for the dissolution rate test is had very high requirement, all good design should be arranged each small details.During the digestion instrument test, in whipping process, oxygen can produce bubble, influences the dissolution rate of solid pharmaceutical preparation, therefore, must get rid of the oxygen in the medium.The common structure of existing degas method is complicated, and cost is higher; And do not reach desirable deaerating effect usually.
The utility model content
The utility model technical matters to be solved provides the sampler of the digestion instrument with deoxygenation function, and this device combines stirrer and deaerating plant together, and can be applied to existing digestion instrument support equipment; Not only simple in structure, and easy to use, improve the accuracy of taking a sample.
The utility model solves the problems of the technologies described above the technical scheme that is adopted: have the sampler of the digestion instrument of deoxygenation function, comprise stripping rotor and sample cup, said stripping rotor is connected through sampling catheter with sample cup, and said sampling catheter is provided with sampling pump; The inside of said stripping rotor is provided with stirrer, and said stirrer comprises along the bull stick of stripping rotor shaft core position setting, the stirring-head that is connected with bull stick; The said bull stick motor outer with being arranged on stripping rotor is connected, and the outside of said stripping rotor is provided with the helium feeding mechanism, and said helium feeding mechanism is communicated with stripping rotor through pipeline.
In the technique scheme, the dissolution medium (being generally deionized water) of in stripping rotor, packing into.When needs remove oxygen, stripping rotor is heated under 37 ℃, agitator speed 100rpm condition, the cavity of helium feeding mechanism through pipeline promptly can reach the desirable oxygen effect of removing behind the inner helium that feeds certain hour of stripping rotor.This structure can be used considerably less helium, reaches the desirable oxygen effect of removing, and therefore, cost is also lower.When needs were taken a sample from stripping rotor, the sampling pump on the sampling catheter was drawn sample in sample cup from stripping rotor.
The rim of a cup of said stripping rotor is provided with bowl cover, and said bowl cover is provided with several through holes; The through hole that said bull stick passes the bowl cover center is connected with the outer motor of stripping rotor; Said sampling catheter passes the through hole that departs from the bowl cover center, extend into the inside of stripping rotor; Said pipeline is connected with the outside helium feeding mechanism of stripping rotor after passing another through hole that departs from the bowl cover center.
Said sample cup connects the dissolution rate pick-up unit.
In the technique scheme, bowl cover is set, can prevents and reduce the volatilization of the dissolution medium in the stripping rotor at the rim of a cup of stripping rotor.
Said bull stick and stirring-head are through being threaded.
In the technique scheme, stirring-head can dismantled and change to bull stick and stirring-head easily through being threaded.
In sum, the utility model compared with prior art has following advantage:
(1), the utility model is provided with simple in structurely, manufacturing cost is lower.
(2), the stirrer that the utlity model has cavity has been realized removing oxygen and driving the double-deck function that stirring-head stirs simultaneously; Design very ingenious; Improved the accuracy of sampling, be applicable to of the test of scientific research departments such as each big-and-middle universities and colleges, medical treatment, health and epidemic prevention, environmental monitoring, pharmaceutical industry dissolution rate.
Description of drawings
Fig. 1 is the structural representation of the utility model embodiment 1.
The corresponding name of each parts is called among the figure: the 1-stripping rotor, and the 2-stirrer,, 3-bull stick, 4-stirring-head, 5-helium feeding mechanism, 6-sampling catheter, 7-sample cup, 8-bowl cover, 9-through hole, 10-sampling pump, 11-motor, 12-pipeline.
Embodiment
Below in conjunction with embodiment and accompanying drawing, the utility model is done further to specify, but the embodiment of the utility model is not limited thereto.
Embodiment 1:
As shown in Figure 1, have the sampler of the digestion instrument of deoxygenation function, comprise stripping rotor 1 and sample cup 7, said stripping rotor 1 is connected through sampling catheter 6 with sample cup 7, and said sampling catheter 6 is provided with sampling pump 10; The inside of said stripping rotor 1 is provided with stirrer 2, and said stirrer 2 comprises along the bull stick 3 of stripping rotor 1 shaft core position setting, the stirring-head 4 that is connected with bull stick 3; Said bull stick 3 motor 11 outer with being arranged on stripping rotor 1 is connected, and the outside of said stripping rotor 1 is provided with helium feeding mechanism 5, and said helium feeding mechanism 5 passes through pipeline 12 and is communicated with stripping rotor 1.The dissolution medium (being generally deionized water) of in stripping rotor, packing into.When needs remove oxygen, stripping rotor is heated under 37 ℃, agitator speed 100rpm condition, the cavity of helium feeding mechanism through pipeline promptly can reach the desirable oxygen effect of removing behind the inner helium that feeds certain hour of stripping rotor.This structure can be used considerably less helium, reaches the desirable oxygen effect of removing, and therefore, cost is also lower.When needs were taken a sample from stripping rotor, the sampling pump on the sampling catheter was drawn sample in sample cup from stripping rotor.
The rim of a cup of said stripping rotor 1 is provided with bowl cover 8, and said bowl cover 8 is provided with several through holes 9; The through hole 9 that said bull stick 3 passes bowl cover 8 centers is connected with stripping rotor 1 outer motor 11; Said sampling catheter 6 passes the through hole 9 that departs from bowl cover 8 centers, extend into the inside of stripping rotor 1; Said pipeline 12 passes another through hole that departs from bowl cover 8 centers 9 backs and is connected with stripping rotor 1 outside helium feeding mechanism 5.
Said sample cup 7 connects the dissolution rate pick-up unit.After sampling finishes, use the dissolution rate pick-up unit that the dissolution rate of the sample in the sample cup 7 is detected.
Said bull stick 3 and stirring-head 4 are through being threaded.
As stated, just can realize the utility model preferably.
Claims (4)
1. the sampler that has the digestion instrument of deoxygenation function comprises stripping rotor (1) and sample cup (7), and said stripping rotor (1) is connected through sampling catheter (6) with sample cup (7), and said sampling catheter (6) is provided with sampling pump (10); The inside of said stripping rotor (1) is provided with stirrer (2), and said stirrer (2) comprises along the bull stick (3) of stripping rotor (1) shaft core position setting, the stirring-head (4) that is connected with bull stick (3); Said bull stick (3) motor (11) outer with being arranged on stripping rotor (1) is connected; It is characterized in that: the outside of said stripping rotor (1) is provided with helium feeding mechanism (5), and said helium feeding mechanism (5) is communicated with stripping rotor (1) through pipeline (12).
2. the sampler with digestion instrument of deoxygenation function according to claim 1 is characterized in that: the rim of a cup of said stripping rotor (1) is provided with bowl cover (8), and said bowl cover (8) is provided with several through holes (9); The through hole (9) that said bull stick (3) passes bowl cover (8) center is connected with the outer motor (11) of stripping rotor (1); Said sampling catheter (6) passes the through hole (9) that departs from bowl cover (8) center, extend into the inside of stripping rotor (1); Said pipeline (12) passes another through hole (9) that departs from bowl cover (8) center back and is connected with the outside helium feeding mechanism (5) of stripping rotor (1).
3. the sampler with digestion instrument of deoxygenation function according to claim 1 is characterized in that: said sample cup (7) connects the dissolution rate pick-up unit.
4. according to any described sampler with digestion instrument of deoxygenation function in the claim 1 to 3, it is characterized in that: said bull stick (3) and stirring-head (4) are through being threaded.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220211168 CN202582945U (en) | 2012-05-11 | 2012-05-11 | Sampling device for dissolution tester with deaerating function |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220211168 CN202582945U (en) | 2012-05-11 | 2012-05-11 | Sampling device for dissolution tester with deaerating function |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202582945U true CN202582945U (en) | 2012-12-05 |
Family
ID=47252346
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201220211168 Expired - Fee Related CN202582945U (en) | 2012-05-11 | 2012-05-11 | Sampling device for dissolution tester with deaerating function |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202582945U (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103048167A (en) * | 2011-10-15 | 2013-04-17 | 四川汇利实业有限公司 | Sampling device of dissolution tester with deoxygenization function |
| CN108918740A (en) * | 2018-10-11 | 2018-11-30 | 重庆市计量质量检测研究院 | Disable the automation preprocessing system of harmful aromatic amine dyestuff detection |
| CN112326903A (en) * | 2020-11-02 | 2021-02-05 | 苏州安默医药科技有限公司 | Multi-dimensional bionic drug dissolution detection device and detection method |
| CN116448503A (en) * | 2023-04-21 | 2023-07-18 | 北京市永康药业有限公司 | Sampling device convenient to use and use method thereof |
-
2012
- 2012-05-11 CN CN 201220211168 patent/CN202582945U/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103048167A (en) * | 2011-10-15 | 2013-04-17 | 四川汇利实业有限公司 | Sampling device of dissolution tester with deoxygenization function |
| CN108918740A (en) * | 2018-10-11 | 2018-11-30 | 重庆市计量质量检测研究院 | Disable the automation preprocessing system of harmful aromatic amine dyestuff detection |
| CN112326903A (en) * | 2020-11-02 | 2021-02-05 | 苏州安默医药科技有限公司 | Multi-dimensional bionic drug dissolution detection device and detection method |
| CN116448503A (en) * | 2023-04-21 | 2023-07-18 | 北京市永康药业有限公司 | Sampling device convenient to use and use method thereof |
| CN116448503B (en) * | 2023-04-21 | 2023-12-12 | 北京市永康药业有限公司 | Sampling device convenient to use and use method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20121205 Termination date: 20130511 |