CN202582963U - Oxygen removal device capable of quickly testing dissolution rate - Google Patents
Oxygen removal device capable of quickly testing dissolution rate Download PDFInfo
- Publication number
- CN202582963U CN202582963U CN 201220211161 CN201220211161U CN202582963U CN 202582963 U CN202582963 U CN 202582963U CN 201220211161 CN201220211161 CN 201220211161 CN 201220211161 U CN201220211161 U CN 201220211161U CN 202582963 U CN202582963 U CN 202582963U
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- China
- Prior art keywords
- valve
- removes
- sample cup
- stripping rotor
- carry out
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- Expired - Fee Related
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Abstract
The utility model discloses an oxygen removal device capable of quickly testing a dissolution rate. The oxygen removal device comprises a dissolution cup, a sample cup and a helium supply device. A sampling tube is arranged in the dissolution cup, and is connected with a three-way valve arranged outside the dissolution cup. The three-way valve is connected with the helium supply device and the sample cup respectively. A water pump is arranged between the sample cup and the three-way valve. The helium supply device is used for removing oxygen from a dissolution medium, so that the oxygen removal device is high in oxygen removal speed, and has a good oxygen removal effect, and control over a sampling process is facilitated.
Description
Technical field
The utility model belongs to the checkout equipment of pharmaceutical industry, particularly relates to the oxygen unit that removes that can carry out the solubleness test fast.
Background technology
Dissolution rate (Dissolution rate) also claim dissolution rate, is meant under specified solvent and condition the speed and the degree of medicine stripping from solid pharmaceutical preparations such as tablet, capsule, granule.The process of measuring the solid pharmaceutical preparation dissolution rate is called dissolution rate test (Dissolution test), and it is a kind of disintegration of oral solid formulation in intestines and stomach and in vitro test method of stripping simulated.The drug dissolution inspection is a kind of effective means of estimating preparation quality and technological level; The difference that can reflect crystal formation, granularity, prescription composition, auxiliary material kind and character, the production technology etc. of main ingredient to a certain extent; It also is a kind of effective standard of estimating preparation active component bioavilability and preparation uniformity coefficient; Can effectively distinguish the difference of same kind of drug bioavailability, therefore be one of drug quality control essential items for inspection.
It is generally acknowledged; Slightly solubility (referring generally to slightly soluble or insoluble in water) medicine; Because of the medicine (comprising soluble drug) that preparation prescription and production technology cause unsettled medicine of clinical efficacy and therapeutic dose and dosis toxica to be close, must set the dissolution test item in its oral solid formulation quality standard.In addition, in the prescription screening of solid pharmaceutical preparation and the technological process of production formulation process, also need the dissolution rate of exploitation formulation is done comprehensive investigation.Feasible dissolution rate test method(s) should be all must reach test findings at different time, place to the dissolution determination of same preparation or the mensuration between the different operation person to have good reappearance.
During the digestion instrument test, in whipping process, oxygen can produce bubble, influences the dissolution rate of solid pharmaceutical preparation, therefore, must get rid of the oxygen in the medium.The common structure of existing degas method is complicated, and cost is higher; And do not reach desirable deaerating effect usually.
Therefore, the digestion instrument that is used for the dissolution rate test is had very high requirement, all good design should be arranged each small details.
The utility model content
The utility model technical matters to be solved provides the oxygen unit that removes that can carry out the solubleness test fast, and this oxygen unit that removes can be applied to existing digestion instrument support equipment; Not only simple in structure, and easy to use.
The utility model solves the problems of the technologies described above the technical scheme that is adopted: the oxygen unit that removes that can carry out the solubleness test fast; Comprise stripping rotor, sample cup and helium feeding mechanism; The inside of said stripping rotor is provided with stopple coupon; The said stopple coupon T-valve outer with being arranged on stripping rotor is connected, and said T-valve is connected with helium feeding mechanism and sample cup respectively, is provided with water pump between said sample cup and the T-valve.
Said stopple coupon is connected with first interface of T-valve; Second interface of said T-valve is connected with the helium feeding mechanism, and the 3rd interface of said T-valve is connected with sample cup through water pump.
The axial location of said stripping rotor is provided with stirrer, and said stirrer comprises along the bull stick of the axis setting of stripping rotor, the stirring-head that is connected with bull stick.
Said bull stick is connected through engage thread with stirring-head.
The rim of a cup of said stripping rotor is provided with bowl cover, and the center of said bowl cover is provided with first through hole, and the off-centered position of said bowl cover is provided with second through hole.
Said bull stick passes first through hole and is connected with the motor of bowl cover top; Said stopple coupon passes second through hole and is connected with first interface of T-valve.
Said sample cup connects the dissolution rate pick-up unit.
In sum, the utility model compared with prior art has following advantage:
(1), the utility model is provided with simple in structurely, manufacturing cost is lower, is applicable to the test of scientific research departments such as each big-and-middle universities and colleges, medical treatment, health and epidemic prevention, environmental monitoring, pharmaceutical industry to dissolution rate.
(2), the utility model utilizes the helium feeding mechanism that dissolution medium is removed oxygen, deoxygenation is quick and effect is very good, is convenient to the control to sampling process.
Description of drawings
Fig. 1 is the structural representation of the utility model embodiment 1.
The corresponding name of each parts is called among the figure: 1-stripping rotor, 2-stirrer, 3-bull stick, 4-stirring-head, 5-T-valve, 6-helium feeding mechanism, 7-sample cup, 8-bowl cover, 91-first through hole, 92-second through hole, 10-stopple coupon, 11-motor, 12-water pump.
Embodiment
Below in conjunction with embodiment and accompanying drawing, the utility model is done further to specify, but the embodiment of the utility model is not limited thereto.
Embodiment
:
As shown in Figure 1; Can carry out the oxygen unit that removes of solubleness test fast; Comprise stripping rotor 1, sample cup 7 and helium feeding mechanism 6, the inside of said stripping rotor 1 is provided with stopple coupon 10, and said stopple coupon 10 T-valve 5 outer with being arranged on stripping rotor 1 is connected; Said T-valve 5 is connected with helium feeding mechanism 6 and sample cup 7 respectively, is provided with water pump 12 between said sample cup 7 and the T-valve 5.Water pump 12 can be quickly and easily be drawn into the liquid of 1 li of stripping rotor in the sample cup 7.
Said stopple coupon 10 is connected with first interface of T-valve 5; Second interface of said T-valve 5 is connected with helium feeding mechanism 6, and the 3rd interface of said T-valve 5 is connected with sample cup 7 through water pump 12.
At 1 li dissolution medium of packing into of stripping rotor (being generally deionized water).When needs remove oxygen; Stripping rotor 1 is heated under 37 ℃, rotating speed of agitator 100rpm condition; Swivel tee valve 5; Second interface that connects helium feeding mechanisms 6 in the T-valve 5 is connected with the bull sticks 3 in the stripping rotor 1, and the cavity through bull stick 3 promptly can reach desirable except that the oxygen effect after stripping rotor 1 feeds certain hour.This structure can be used considerably less helium, reaches the desirable oxygen effect of removing, and therefore, cost is also lower.When needs were taken a sample from stripping rotor 1, swivel tee valve 5 was connected the 3rd interface and the bull stick in the stripping rotor 13 that connect sample cup 7 in the T-valve 5, starts water pump 12 then, from stripping rotor 1, draws sample in sample cup through the cavity of bull stick 3.Therefore, this stirrer with cavity has been realized removing oxygen, stopple coupon and driving three kinds of functions that stirring-head stirs simultaneously, designs very ingenious.
The axial location of said stripping rotor 1 is provided with stirrer 2, and said stirrer 2 comprises along the bull stick 3 of the axis setting of stripping rotor 1, the stirring-head 4 that is connected with bull stick 3.
Said bull stick 3 and stirring-head 4 are connected through engage thread.
The rim of a cup of said stripping rotor 1 is provided with bowl cover 8, and the center of said bowl cover 8 is provided with first through hole 91, and said bowl cover 8 off-centered positions are provided with second through hole 92.
Said bull stick 3 passes first through hole 91 and is connected with the motor 11 of bowl cover 8 tops; Said stopple coupon 10 passes second through hole 92 and is connected with first interface of T-valve 5.
Said sample cup 7 connects the dissolution rate pick-up unit.
As stated, just can realize the utility model preferably.
Claims (7)
1. can carry out the oxygen unit that removes of solubleness test fast; Comprise stripping rotor (1), sample cup (7) and helium feeding mechanism (6); The inside of said stripping rotor (1) is provided with stopple coupon (10); Said stopple coupon (10) T-valve (5) outer with being arranged on stripping rotor (1) is connected, and said T-valve (5) is connected with helium feeding mechanism (6) and sample cup (7) respectively, it is characterized in that: be provided with water pump (12) between said sample cup (7) and the T-valve (5).
2. the oxygen unit that removes that can carry out the solubleness test fast according to claim 1, it is characterized in that: said stopple coupon (10) is connected with first interface of T-valve (5); Second interface of said T-valve (5) is connected with helium feeding mechanism (6), and the 3rd interface of said T-valve (5) is connected with sample cup (7) through water pump (12).
3. the oxygen unit that removes that can carry out the solubleness test fast according to claim 1; It is characterized in that: the axial location of said stripping rotor (1) is provided with stirrer (2), and said stirrer (2) comprises along the bull stick (3) of the axis setting of stripping rotor (1), the stirring-head (4) that is connected with bull stick (3).
4. the oxygen unit that removes that can carry out the solubleness test fast according to claim 3, it is characterized in that: said bull stick (3) is connected through engage thread with stirring-head (4).
5. the oxygen unit that removes that can carry out the solubleness test fast according to claim 3; It is characterized in that: the rim of a cup of said stripping rotor (1) is provided with bowl cover (8); And the center of said bowl cover (8) is provided with first through hole (91), and the off-centered position of said bowl cover (8) is provided with second through hole (92).
6. the oxygen unit that removes that can carry out the solubleness test fast according to claim 5 is characterized in that: said bull stick (3) passes first through hole (91) and is connected with the motor (11) of bowl cover (8) top; Said stopple coupon (10) passes second through hole (92) and is connected with first interface of T-valve (5).
7. according to each described oxygen unit that removes that can carry out the solubleness test fast of claim 1-6, it is characterized in that: said sample cup (7) connects the dissolution rate pick-up unit.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220211161 CN202582963U (en) | 2012-05-11 | 2012-05-11 | Oxygen removal device capable of quickly testing dissolution rate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220211161 CN202582963U (en) | 2012-05-11 | 2012-05-11 | Oxygen removal device capable of quickly testing dissolution rate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202582963U true CN202582963U (en) | 2012-12-05 |
Family
ID=47252364
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201220211161 Expired - Fee Related CN202582963U (en) | 2012-05-11 | 2012-05-11 | Oxygen removal device capable of quickly testing dissolution rate |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202582963U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103048182A (en) * | 2011-10-15 | 2013-04-17 | 四川汇利实业有限公司 | Deoxidizing device capable of rapidly testing solubility |
-
2012
- 2012-05-11 CN CN 201220211161 patent/CN202582963U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103048182A (en) * | 2011-10-15 | 2013-04-17 | 四川汇利实业有限公司 | Deoxidizing device capable of rapidly testing solubility |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20121205 Termination date: 20130511 |