CN202256308U - Oxygen removing device for testing solubility - Google Patents
Oxygen removing device for testing solubility Download PDFInfo
- Publication number
- CN202256308U CN202256308U CN2011203917921U CN201120391792U CN202256308U CN 202256308 U CN202256308 U CN 202256308U CN 2011203917921 U CN2011203917921 U CN 2011203917921U CN 201120391792 U CN201120391792 U CN 201120391792U CN 202256308 U CN202256308 U CN 202256308U
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- China
- Prior art keywords
- removes
- stripping rotor
- valve
- interface
- bull stick
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Abstract
The utility model discloses an oxygen removing device for testing solubility, comprising a dissolution cup (1), a sample cup (7) and a helium supply device (6), wherein the dissolution cup (1) is internally provided with a sampling tube (10); the sampling tube (10) is connected with a first connector of a three-way valve (5) which is arranged outside of the dissolution cup (1); a second connector of the three-way valve is connected with the helium supply device (6); and a third connector of the three-way valve is connected with the sample cup (7). The oxygen removing device for testing the solubility disclosed by the utility model has the advantages of capability of removing the oxygen of dissolution mediums by utilizing the helium supply device, high oxygen removing speed and very good effects.
Description
Technical field
The utility model belongs to the checkout equipment of pharmaceutical industry, particularly relates to the oxygen unit that removes that is used for the solubleness test.
Background technology
Dissolution rate (Dissolution rate) also claim dissolution rate, is meant under specified solvent and condition the speed and the degree of medicine stripping from solid pharmaceutical preparations such as tablet, capsule, granule.The process of measuring the solid pharmaceutical preparation dissolution rate is called dissolution rate test (Dissolution test), and it is a kind of disintegration of oral solid formulation in intestines and stomach and in vitro test method of stripping simulated.The drug dissolution inspection is a kind of effective means of estimating preparation quality and technological level; The difference that can reflect crystal formation, granularity, prescription composition, auxiliary material kind and character, the production technology etc. of main ingredient to a certain extent; It also is a kind of effective standard of estimating preparation active component bioavilability and preparation uniformity coefficient; Can effectively distinguish the difference of same kind of drug bioavailability, therefore be one of drug quality control essential items for inspection.It is generally acknowledged; Slightly solubility (referring generally to slightly soluble or insoluble in water) medicine; Because of the medicine (comprising soluble drug) that preparation prescription and production technology cause unsettled medicine of clinical efficacy and therapeutic dose and dosis toxica to be close, must set the dissolution test item in its oral solid formulation quality standard.In addition, in the prescription screening of solid pharmaceutical preparation and the technological process of production formulation process, also need the dissolution rate of exploitation formulation is done comprehensive investigation.Feasible dissolution rate test method(s) should be all must reach test findings at different time, place to the dissolution determination of same preparation or the mensuration between the different operation person to have good reappearance.
Therefore, the digestion instrument that is used for the dissolution rate test is had very high requirement, all good design should be arranged each small details.
During the digestion instrument test, in whipping process, oxygen can produce bubble, influences the dissolution rate of solid pharmaceutical preparation, therefore, must get rid of the oxygen in the medium.The common structure of existing degas method is complicated, and cost is higher; And do not reach desirable deaerating effect usually.
The utility model content
The utility model technical matters to be solved provides the oxygen unit that removes that is used for the solubleness test, and this oxygen unit that removes can be applied to existing digestion instrument support equipment; Not only simple in structure, and easy to use.
The utility model solves the problems of the technologies described above the technical scheme that is adopted: the oxygen unit that removes that is used for the solubleness test; Comprise stripping rotor, sample cup and helium feeding mechanism; The inside of said stripping rotor is provided with stopple coupon, and first interface of the T-valve that said stopple coupon is outer with being arranged on stripping rotor is connected; Second interface of said T-valve is connected with the helium feeding mechanism, and the 3rd interface of said T-valve is connected with sample cup.
The axial location of said stripping rotor is provided with stirrer.
Said stirrer comprises along the bull stick of the axis setting of stripping rotor, the stirring-head that is connected with bull stick.
Said bull stick is connected through engage thread with stirring-head.
The rim of a cup of said stripping rotor is provided with bowl cover, and the center of said bowl cover is provided with first through hole, and the off-centered position of said bowl cover is provided with second through hole; Said bull stick passes first through hole and is connected with the motor of bowl cover top; Said stopple coupon passes second through hole and is connected with first interface of T-valve.
Said sample cup connects the dissolution rate pick-up unit.
In sum, the utility model compared with prior art has following advantage:
(1), the utility model is provided with simple in structurely, manufacturing cost is lower.
(2), the utility model is applicable to the test of scientific research departments such as each big-and-middle universities and colleges, medical treatment, health and epidemic prevention, environmental monitoring, pharmaceutical industry to dissolution rate.
(4), the utility model utilizes the helium feeding mechanism that dissolution medium is removed oxygen, deoxygenation is quick and effect is very good.
Description of drawings
Fig. 1 is the structural representation of the utility model embodiment 1.
The corresponding name of each parts is called among the figure: 1 stripping rotor, 2 stirrers, 3 bull sticks, 4 stirring-heads, 5 T-valve, 6 helium feeding mechanisms, 7 sample cups, 8 bowl covers, 91 first through holes, 92 second through holes, 10 stopple coupons, 11 motor.
Embodiment
Below in conjunction with embodiment and accompanying drawing, the utility model is done further to specify, but the embodiment of the utility model is not limited thereto.
Embodiment 1:
As shown in Figure 1, be used for the oxygen unit that removes of solubleness test, comprise stripping rotor 1, sample cup 7 and helium feeding mechanism 6, the inside of said stripping rotor 1 is provided with stopple coupon 10, and said stopple coupon 10 is connected with first interface that is arranged on stripping rotor T-valve 5 outward; Second interface of said T-valve is connected with helium feeding mechanism 6, and the 3rd interface of said T-valve is connected with sample cup 7.
The axial location of said stripping rotor is provided with stirrer 2.Said stirrer comprises along the bull stick 3 of the axis setting of stripping rotor, the stirring-head 4 that is connected with bull stick.Said bull stick 3 and stirring-head 4 are connected through engage thread.
The rim of a cup of said stripping rotor is provided with bowl cover 8, and the center of said bowl cover is provided with first through hole 91, and the off-centered position of said bowl cover is provided with second through hole 92; Said bull stick passes first through hole 91 and is connected with the motor 11 of bowl cover top; Said stopple coupon passes second through hole and is connected with first interface of T-valve 5.
Said sample cup connects the dissolution rate pick-up unit.
As stated, just can realize the utility model preferably.
Claims (6)
1. the oxygen unit that removes that is used for the solubleness test; It is characterized in that; Comprise stripping rotor (1), sample cup (7) and helium feeding mechanism (6); The inside of said stripping rotor (1) is provided with stopple coupon (10), and first interface of the T-valve (5) that said stopple coupon (10) is outer with being arranged on stripping rotor is connected; Second interface of said T-valve is connected with helium feeding mechanism (6), and the 3rd interface of said T-valve is connected with sample cup (7).
2. the oxygen unit that removes that is used for the solubleness test according to claim 1 is characterized in that the axial location of said stripping rotor is provided with stirrer (2).
3. the oxygen unit that removes that is used for the solubleness test according to claim 2 is characterized in that said stirrer comprises along the bull stick (3) of the axis setting of stripping rotor, the stirring-head (4) that is connected with bull stick.
4. the oxygen unit that removes that is used for the solubleness test according to claim 3 is characterized in that said bull stick (3) is connected through engage thread with stirring-head (4).
5. the oxygen unit that removes that is used for the solubleness test according to claim 4; It is characterized in that; The rim of a cup of said stripping rotor is provided with bowl cover (8), and the center of said bowl cover is provided with first through hole (91), and the off-centered position of said bowl cover is provided with second through hole (92); Said bull stick passes first through hole (91) and is connected with the motor (11) of bowl cover top; Said stopple coupon passes second through hole and is connected with first interface of T-valve (5).
6. according to each described oxygen unit that removes that is used for the solubleness test of claim 1-5, it is characterized in that said sample cup connects the dissolution rate pick-up unit.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011203917921U CN202256308U (en) | 2011-10-15 | 2011-10-15 | Oxygen removing device for testing solubility |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011203917921U CN202256308U (en) | 2011-10-15 | 2011-10-15 | Oxygen removing device for testing solubility |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202256308U true CN202256308U (en) | 2012-05-30 |
Family
ID=46117529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011203917921U Expired - Fee Related CN202256308U (en) | 2011-10-15 | 2011-10-15 | Oxygen removing device for testing solubility |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202256308U (en) |
-
2011
- 2011-10-15 CN CN2011203917921U patent/CN202256308U/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120530 Termination date: 20121015 |