CN219084901U

CN219084901U - Dissolution instrument

Info

Publication number: CN219084901U
Application number: CN202223557762.0U
Authority: CN
Inventors: 秦杰子; 施辉昊
Original assignee: Zezheng Shanghai Biotechnology Co ltd
Current assignee: Zezheng Shanghai Biotechnology Co ltd
Priority date: 2022-12-30
Filing date: 2022-12-30
Publication date: 2023-05-26
Anticipated expiration: 2032-12-30

Abstract

The utility model discloses a dissolution instrument, and relates to the technical field of dissolution instruments. The utility model provides a dissolve out appearance, includes the water bath, fixedly connected with heater strip in the water bath, be provided with a plurality of dissolving out cups in the water bath, still include: the reciprocating screw rod is rotatably connected to one side of the water bath box, and the guide rod is fixedly connected to the other side of the water bath box; an upper cover; according to the utility model, the motor drives the reciprocating screw rod to rotate, so that the upper cover drives the stirring rod to lift in a reciprocating manner, and drives the stirring rod and the turbine to rotate, so that liquid and solid preparations in the dissolution cup are stirred, and the dynamic environment of the solid preparation in a human body after the solid preparation is taken by a simulation real person and the slow release characteristic of the solid preparation in the human body are further improved for the medicine preparation which easily floats to the upper layer of the liquid in the dissolution cup.

Description

Dissolution instrument

Technical Field

The utility model belongs to the technical field of dissolution instruments, and particularly relates to a dissolution instrument.

Background

The dissolution rate of a solid preparation is also referred to as dissolution rate, and refers to the rate and extent of dissolution of a drug from a solid preparation such as a tablet, capsule, or granule under a predetermined solvent and condition.

The process of measuring the dissolution rate of a solid preparation is called a dissolution rate test, which is an in vitro test method for simulating the disintegration and dissolution of an oral solid preparation in the gastrointestinal tract; dissolution tests are commonly used to guide the development of pharmaceutical formulations, evaluate consistency of mass from batch to batch within a formulation batch, evaluate consistency of mass and efficacy before and after a drug prescription process change, and the like.

In the prior art, patent CN209117448U (date of grant: 2019.07.16) discloses a dissolution instrument, which comprises a frame, a moving table, a stirring device, a sample throwing device, a power piece for driving the moving table to move, dissolution cups, a sampling device and a heating device, wherein the dissolution cups are arranged in a plurality and are positioned on the same horizontal line, the sample throwing device comprises a plurality of turnover cup covers which are respectively and rotatably connected with the inner walls of the upper ends of the dissolution cups, a limiting component which is fixed at one end of each turnover cup cover close to the moving table and is used for limiting the moving path of a target preparation on the turnover cup cover, a rotating shaft which penetrates through the plurality of turnover cup covers along the horizontal direction, and a first driving piece which is arranged on the frame and is used for driving the rotating shaft to rotate, the side wall of each dissolution cup is symmetrically provided with a mounting groove which is rotatably connected with the rotating shaft, and the opening of the upper end of the mounting groove is positioned on the same plane with the cup opening of the dissolution cup, so that the dissolution instrument has the advantage of small experimental error; although the experimental error can be reduced, when the dissolution cup is stirred, the stirring paddle can only rotate at a fixed position relative to the dissolution cup, in the actual dissolution process, the pharmaceutical preparation is not necessarily quiet and stays at the bottom of the dissolution cup, and possibly floats to the middle upper layer of the dissolution cup liquid, and at this time, the stirring and dissolving effects of the fixed stirring paddle on the target preparation and the dissolving liquid are poor, so that the dynamic simulation of the intestinal dynamic environment after the target solid preparation enters the human body is not facilitated.

Disclosure of Invention

The technical problem to be solved by the present utility model is to overcome the disadvantages of the prior art and to provide a dissolution instrument which overcomes or at least partially solves the above-mentioned problems.

In order to solve the technical problems, the utility model adopts the basic conception of the technical scheme that: the utility model provides a dissolve out appearance, includes the water bath, fixedly connected with heater strip in the water bath, be provided with a plurality of dissolving out cups in the water bath, still include: the reciprocating screw rod is rotatably connected to one side of the water bath box, and the guide rod is fixedly connected to the other side of the water bath box; the upper cover is connected with one side of the reciprocating screw rod in a threaded manner, the other side of the upper cover is connected with the guide rod in a sliding manner, the upper cover is rotatably connected with a plurality of stirring rods corresponding to the dissolution cups, and one end of each stirring rod is fixedly connected with a gear; the eccentric wheel is connected to the reciprocating screw rod in a sliding way through a sliding hole, the eccentric wheel is rotationally connected to the upper cover, an annular connecting groove is formed in the circumference of the outer diameter of the eccentric wheel, a sliding groove is formed in the outer diameter of the reciprocating screw rod, a limiting block is fixedly connected to the inner wall of the sliding hole of the eccentric wheel, and the limiting block is connected to the sliding groove in a sliding way; the rack is connected to the upper cover in a sliding manner, the rack is meshed with the gear, and one end of the rack is connected to the annular connecting groove in a sliding manner.

In order to facilitate the placement of the dissolution cup in the water bath, preferably, a supporting plate is fixedly connected in the water bath, a placing groove is formed in the supporting plate, and one side of the placing groove penetrates through the supporting plate.

In order to be convenient for fix the dissolution cup, further, fixedly connected with magnetism on the dissolution cup open end outer wall is inhaled the piece, magnetism is inhaled the piece and is adsorbed in the backup pad, the backup pad is iron material.

Preferably, the stirring rod end is fixedly connected with a turbine.

In order to facilitate driving the reciprocating screw rod to rotate, preferably, the water bath box is fixedly connected with a motor, and the output end of the motor is connected with the reciprocating screw rod through a synchronous belt.

In order to facilitate the sliding of the rack, preferably, the upper cover is fixedly connected with a sliding rail, one side of the rack is fixedly connected with a sliding seat, and the sliding seat is in sliding connection with the sliding rail.

After the technical scheme is adopted, compared with the prior art, the utility model has the following beneficial effects: according to the utility model, the motor drives the reciprocating screw rod to rotate, so that the upper cover drives the stirring rod to lift up and down in a reciprocating manner, and drives the stirring rod and the turbine to rotate, so that liquid and solid preparations in the dissolving cup are stirred, and the dynamic environment of a simulated real person taking the solid preparation in a body and the slow release characteristic of the simulated solid preparation in the body are facilitated to be further improved, and meanwhile, the solution speed of the solid preparation is improved, and the measurement speed is further improved; compared with the stirring paddles in the comparison document, the dynamic environment of the solid preparation after entering the human body can be further truly simulated, and the measurement speed is improved.

The following describes the embodiments of the present utility model in further detail with reference to the accompanying drawings.

Drawings

In the drawings:

FIG. 1 is a schematic diagram of a front view of a dissolution apparatus according to the present utility model;

fig. 2 is a schematic top view of an upper cover of a dissolution apparatus according to the present utility model;

FIG. 3 is a schematic view of the structure of a support plate and a placement tank of a dissolution apparatus according to the present utility model;

FIG. 4 is a schematic diagram of the eccentric wheel, chute and stopper of the dissolution instrument according to the present utility model;

fig. 5 is a schematic structural diagram of a turbine of a dissolution apparatus according to the present utility model.

In the figure: 1. a water bath tank; 10. a guide rod; 11. a heating wire; 12. a support plate; 121. a placement groove; 13. a dissolution cup; 14. a magnetic suction block; 15. a motor; 16. a reciprocating screw rod; 161. a chute; 17. an eccentric wheel; 171. a limiting block; 172. an annular connecting groove; 2. a stirring rod; 21. a turbine; 22. a gear; 23. a rack; 24. a slide rail; 241. a slide; 3. and (5) an upper cover.

It should be noted that these drawings and the written description are not intended to limit the scope of the inventive concept in any way, but to illustrate the inventive concept to those skilled in the art by referring to the specific embodiments.

Detailed Description

For the purpose of making the objects, technical solutions and advantages of the embodiments of the present utility model more apparent, the technical solutions in the embodiments will be clearly and completely described with reference to the accompanying drawings in the embodiments of the present utility model, and the following embodiments are used to illustrate the present utility model, but are not intended to limit the scope of the present utility model.

Example 1:

referring to fig. 1-5, a dissolution apparatus includes a water bath tank 1, a heating wire 11 fixedly connected with the water bath tank 1, four dissolution cups 13 arranged in the water bath tank 1, and further includes: the reciprocating screw rod 16 is rotatably connected to one side of the water bath box 1, and the guide rod 10 is fixedly connected to the other side of the water bath box 1; the upper cover 3, one side of the upper cover 3 is connected to the reciprocating screw rod 16 in a threaded manner, the other side of the upper cover 3 is connected to the guide rod 10 in a sliding manner, four stirring rods 2 corresponding to the dissolution cups 13 respectively are connected to the upper cover 3 in a rotating manner, and one end of each stirring rod 2 is fixedly connected with a gear 22; the eccentric wheel 17 is connected to the reciprocating screw rod 16 in a sliding way through a sliding hole, the eccentric wheel 17 is connected to the upper cover 3 in a rotating way, an annular connecting groove 172 is formed in the circumference of the outer diameter of the eccentric wheel 17, a sliding groove 161 is formed in the outer diameter of the reciprocating screw rod 16, a limiting block 171 is fixedly connected to the inner wall of the sliding hole of the eccentric wheel 17, and the limiting block 171 is connected in the sliding groove 161 in a sliding way; a rack 23 slidably connected to the upper cover 3, the rack 23 being engaged with the gear 22, one end of the rack 23 being slidably connected to the annular connecting groove 172; a supporting plate 12 is fixedly connected in the water bath tank 1, a placing groove 121 is formed in the supporting plate 12, and one side of the placing groove 121 penetrates through the supporting plate 12; the outer wall of the opening end of the dissolution cup 13 is fixedly connected with a magnetic suction block 14, the magnetic suction block 14 is adsorbed on a supporting plate 12, and the supporting plate 12 is made of iron material; the tail end of the stirring rod 2 is fixedly connected with a turbine 21; the water bath box 1 is fixedly connected with a motor 15, and the output end of the motor 15 is connected with a reciprocating screw rod 16 through a synchronous belt; the upper cover 3 is fixedly connected with a slide rail 24, one side of the rack 23 is fixedly connected with a slide seat 241, and the slide seat 241 is in sliding connection with the slide rail 24;

placing a solid preparation to be measured in a dissolution cup 13, pouring warm water into the dissolution cup 13, wherein the temperature of the warm water is about 30 DEG+/-3 DEG, then extending the dissolution cup 13 into a water bath 1, placing a cup body of the dissolution cup 13 into a placing groove 121, enabling a magnetic suction block 14 to be adsorbed on the upper surface of a supporting plate 12, and placing the dissolution cup 13 to move; after the dissolution cup 13 is placed on the supporting plate 12, pouring water into the water bath box 1, starting the heating wire 11, wherein the heating wire 11 is electrically connected with an external power supply, the heating wire 11 heats the water in the water bath box 1 to 37 degrees, and maintains a constant temperature of 37 degrees so as to simulate the temperature of a human body;

starting a motor 15, the motor 15 drives a reciprocating screw rod 16 to rotate through a synchronous belt, the reciprocating screw rod 16 drives an upper cover 3 to reciprocate on the reciprocating screw rod 16, the upper cover 3 drives a stirring rod 2 to reciprocate in a dissolution cup 13 when in reciprocating lifting, an eccentric wheel 17 is driven to rotate on the upper cover 3 through the reciprocating screw rod 16 to rotate, a rack 23 is pulled back and forth when the eccentric wheel 17 rotates, the rack 23 is meshed with a gear 22, the gear 22 is driven to rotate forward and backward, the gear 22 is fixed on the stirring rod 2, the stirring rod 2 is driven to rotate forward and backward, the stirring rod 2 rotates in the dissolution cup 13 and then lifts, and meanwhile, a turbine 21 is driven to rotate, so that liquid and solid preparation in the dissolution cup 13 are fully stirred, and the dynamic environment in a body and the slow release characteristic of the solid preparation in a human body after the solid preparation is simulated by a real person are conveniently further improved, and the measuring speed is further improved; compared with the stirring paddles in the comparison file, the dynamic environment of the solid preparation after entering the human body can be further truly simulated, and the measurement speed is improved;

it should be understood that when the upper cover 3 is lifted and lowered reciprocally, the eccentric wheel 17 slides on the reciprocating screw 16 and slides in the chute 161 through the limiting block 171, so that the reciprocating screw 16 can drive the eccentric wheel 17 to rotate when rotating.

After a certain stirring time is set, the motor 15 is stopped when the upper cover 3 moves to the top end of the reciprocating screw rod 16 after the time is reached, the dissolving cup 13 is taken down from the supporting plate 12, the dissolving cup 13 is taken out from the water bath 1, the mixed and dissolved solution is taken out by using a tool, and the medicine content in the solution is measured to obtain simulation data.

According to the utility model, the motor 15 drives the reciprocating screw rod 16 to rotate, so that the upper cover 3 drives the stirring rod 2 to reciprocate and drive the stirring rod 2 and the turbine 21 to rotate, and the liquid and the solid preparation in the dissolution cup 13 are stirred, so that the dynamic environment of the solid preparation in a human body after a simulation person takes the solid preparation and the slow release characteristic of the solid preparation in the human body are further improved, and meanwhile, the solution speed of the solid preparation is improved, and the measurement speed is further improved; compared with the stirring paddles in the comparison document, the dynamic environment of the solid preparation after entering the human body can be further truly simulated, and the measurement speed is improved.

In the description provided herein, numerous specific details are set forth. However, it is understood that embodiments of the utility model may be practiced without these specific details. In some instances, well-known methods, structures and techniques have not been shown in detail in order not to obscure an understanding of this description.

The foregoing description is only illustrative of the preferred embodiment of the present utility model, and is not to be construed as limiting the utility model, but is to be construed as limiting the utility model to any and all simple modifications, equivalent variations and adaptations of the embodiments described above, which are within the scope of the utility model, may be made by those skilled in the art without departing from the scope of the utility model.

Claims

1. The utility model provides a dissolve out appearance, includes water bath (1), fixedly connected with heater strip (11) in water bath (1), its characterized in that is provided with a plurality of dissolving out cup (13) in water bath (1), still includes:

the reciprocating screw rod (16) is rotatably connected to one side of the water bath box (1), and the guide rod (10) is fixedly connected to the other side of the water bath box (1);

the upper cover (3), one side of the upper cover (3) is connected to the reciprocating screw rod (16) in a threaded manner, the other side of the upper cover (3) is connected to the guide rod (10) in a sliding manner, the upper cover (3) is connected with a plurality of stirring rods (2) corresponding to the dissolution cup (13) in a rotating manner, and one end of each stirring rod (2) is fixedly connected with a gear (22);

an eccentric wheel (17) which is connected to the reciprocating screw rod (16) in a sliding way through a sliding hole, wherein the eccentric wheel (17) is rotationally connected to the upper cover (3), an annular connecting groove (172) is formed in the circumference of the outer diameter of the eccentric wheel (17), a sliding groove (161) is formed in the outer diameter of the reciprocating screw rod (16), a limiting block (171) is fixedly connected to the inner wall of the sliding hole of the eccentric wheel (17), and the limiting block (171) is connected in the sliding groove (161) in a sliding way;

the rack (23) is connected to the upper cover (3) in a sliding mode, the rack (23) is meshed with the gear (22), and one end of the rack (23) is connected to the annular connecting groove (172) in a sliding mode.

2. A dissolution apparatus according to claim 1, wherein: the water bath box is characterized in that a supporting plate (12) is fixedly connected in the water bath box (1), a placing groove (121) is formed in the supporting plate (12), and one side of the placing groove (121) penetrates through the supporting plate (12).

3. A dissolution apparatus according to claim 1, wherein: the magnetic suction block (14) is fixedly connected to the outer wall of the opening end of the dissolution cup (13), the magnetic suction block (14) is adsorbed on the supporting plate (12), and the supporting plate (12) is made of iron materials.

4. A dissolution apparatus according to claim 1, wherein: the tail end of the stirring rod (2) is fixedly connected with a turbine (21).

5. A dissolution apparatus according to claim 1, wherein: the water bath box (1) is fixedly connected with a motor (15), and the output end of the motor (15) is connected with the reciprocating screw rod (16) through a synchronous belt.

6. A dissolution apparatus according to claim 1, wherein: the upper cover (3) is fixedly connected with a sliding rail (24), one side of the rack (23) is fixedly connected with a sliding seat (241), and the sliding seat (241) is slidably connected in the sliding rail (24).