CN207571117U - A kind of dissolution rate test device - Google Patents
A kind of dissolution rate test device Download PDFInfo
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- CN207571117U CN207571117U CN201721432346.4U CN201721432346U CN207571117U CN 207571117 U CN207571117 U CN 207571117U CN 201721432346 U CN201721432346 U CN 201721432346U CN 207571117 U CN207571117 U CN 207571117U
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- China
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- stripping rotor
- bull stick
- dissolution rate
- cup lid
- test device
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Abstract
The utility model is related to a kind of dissolution rate test devices, head box including bull stick can be installed, the stripping rotor positioned at the water bath of head lower box part and in water bath, stripping rotor is equipped with cup lid, bull stick passes through cup lid, bull stick lower end is equipped with stirrer paddle, sedimentation basket is equipped in stripping rotor, sedimentation basket is connected to fixed link lower end, fixed link upper end is mounted on cup lid, stripping rotor is additionally provided with sampling mechanism, sampling mechanism includes stretching into the probe tube in stripping rotor, and probe tube passes through the sampler outside hose connection.Compared with prior art, the utility model is fixed at the specific position of stripping rotor by basket is settled, and avoids in continuous mode, due to the factors such as tablet floats, sedimentation basket direction is inconsistent, experiment process is impacted, causes test inaccurate；Probe tube is equipped in stripping rotor, can be sampled in time, sample is taken to carrying out test analysis in corresponding analysis container, it is ensured that promptness, the validity of test.
Description
Technical field
The utility model is related to pharmaceutical field testing equipments, and in particular to a kind of dissolution rate test device.
Background technology
Dissolution rate is also referred to as dissolution rate, refer to defined solvent and under the conditions of, drug is from tablet, capsule, granule
Wait the speed and degree dissolved out in solid pharmaceutical preparations.The process for measuring solid pharmaceutical preparation dissolution rate is known as Dissolution Rate Testing, it is a kind of
Simulate the in vitro test method of oral solid formulation disintegration in the gastrointestinal tract and dissolution.Drug dissolution inspection is evaluation preparation
A kind of effective means of quality and technological level can reflect the crystal form of main ingredient, granularity, composition, auxiliary to a certain extent
The difference and evaluation agent activity ingredients Biogenic availability of item kind and property, production technology etc. and the one of the preparation uniformity
Kind effective standard, can effectively distinguish the difference of same drug bioavailability, thus be drug quality control essential items for inspection it
One.
Infiltration rate is usually determined drug by the speed dissolved in vivo, the drug in solid pharmaceutical preparation before being absorbed,
It has to pass through disintegration and dissolving then turns to the process of solution, if drug is not easy to release from preparation or the dissolving of drug
Speed is extremely slow, then the infiltration rate of drug or degree are possible to there are problem in said preparation, on the other hand, certain pharmacology
Effect is violent, and safety index is small, if it is too fast to absorb rapid drug dissolution rate, it is possible to create apparent adverse reaction, dimension
Holding the time of drug effect will also shorten, and in this case, the dissolution rate of preparation of traditional Chinese medicine should give control, therefore, in drug
Production and R＆D process in, to take orally class solid chemicals dissolution rate test be a very crucial link.One feasible
Dissolution Rate Testing method should be survey in different time, place between the dissolution determination of same preparation or different operators
Result of the test must be reached with good reproducibility by establishing a capital.
At present, the test generally use dissolution rate test instrument of dissolution rate carries out, and including rack, above rack and connects
There is a head box of several bull sticks, horizontal positioned water bath in rack is equipped with several stripping rotors in water bath and is inserted into stripping rotor
Turn basket.Tablet is put into during use and turns basket, bull stick is rotated with turn basket in the physiological saline of stripping rotor, tablet dissolving,
Stipulated time sampling detects drug-eluting speed and time, and the water for keeping certain temperature is filled in water bath.Existing dissolution rate
There are problems to have for test device：(1) turn basket to connect with bull stick, be moved by bull stick band turn basket, continuous mode, sometimes because of piece
Phenomena such as agent is floated has an impact detection, in addition, sedimentation basket direction is inconsistent, easily causes shadow to medicine dissolving out experimental process
It rings, turns basket and easily come off from bull stick so that turn test sample in basket and flow out, the especially small test sample of density can float on table
Face so as to be had an impact to detection, makes the accuracy of dissolution rate investigation result and poor repeatability mutation big；(2) it is carried out in experiment
In, digestion instrument lacks mating sampler, and it is inconvenient that the liquid being dissolved in stripping rotor takes out, and inconvenience is to the liquid in stripping rotor
Body in time, effectively analyze.
Utility model content
The purpose of this utility model is exactly to solve the above-mentioned problems and provides a kind of dissolution rate test device.
The purpose of this utility model is achieved through the following technical solutions：
A kind of dissolution rate test device, including can install bull stick head box, positioned at head lower box part water bath and
Stripping rotor in water bath, the stripping rotor are equipped with cup lid, and the bull stick passes through cup lid, and bull stick lower end is equipped with agitating paddle
Leaf, the stripping rotor is interior to be equipped with sedimentation basket, and the sedimentation basket is connected to fixed link lower end, and fixed link upper end is mounted on cup lid,
The stripping rotor is additionally provided with sampling mechanism, and the sampling mechanism includes stretching into the probe tube in stripping rotor, and the probe tube passes through
Sampler outside hose connection.The sedimentation basket for holding test sample is fixed on specific position in stripping rotor by the technical program,
The factor due to sedimentation basket movement is avoided to cause error to test, stirrer paddle is driven to rotate by bull stick, to liquid in stripping rotor
Body is stirred, and the sample settled in basket is dissolved, can test dissolution rate after a certain period of time, meanwhile, it is additionally provided in stripping rotor
Probe tube can be sampled in time, and sample is taken to test analysis is carried out in corresponding analysis container, ensures the promptness of test,
Operation is also more convenient.
Preferably, the sampler is injection-tube, can be taken out the test fluid in stripping rotor by way of extraction.
Preferably, the bull stick passes through the motor connection in the through-hole and head box of cup lid center, by electronic
The mixing speed of the controllable pawl of machine.
Preferably, the bull stick is adjustable in length bull stick, can adjust the length of bull stick as needed, so as to more have
Effect is stirred liquid in stripping rotor.
Preferably, the water bath uses micro pump circulating water flow, PT1000 sensors built in water bath, temperature control essence
Really.
Preferably, the probe tube passes through the through-hole for deviateing cup lid center, extend into inside stripping rotor.
Preferably, the head box is equipped with the control panel of control device operation, including temperature control panel, speed control
Panel processed, time control panel and control keyboard by the operation to control panel, can facilitate and carry out setting for each program
It is fixed.
Compared with prior art, the utility model has the following advantages：
The 1st, sedimentation basket is fixed to the specific position of stripping rotor, avoided in continuous mode, because tablet floats, sedimentation
The factors such as basket direction is inconsistent, impact medicine dissolving out experimental process, and can avoid turning basket coming off from bull stick, make to turn basket
Interior test sample outflow, so as to ensure the accuracy of test, particularly with the sample easily to float.
2nd, probe tube is equipped in stripping rotor, can be sampled in time, sample is taken to surveying in corresponding analysis container
Examination analysis, so as to ensure the promptness of test, validity.
Description of the drawings
Fig. 1 is the structure diagram of the utility model device；
Fig. 2 is the structure diagram of the utility model stripping rotor；
In figure：Head box 1；Control panel 2；Bull stick 3；Stripping rotor 4；Water bath 5；Cup lid 6；Fixed link 7；Settle basket 8；
Probe tube 9；Hose 10；Sampler 11；
Specific embodiment
The utility model is described in detail in the following with reference to the drawings and specific embodiments.
Embodiment 1
A kind of dissolution rate test device, as shown in Figure 1, including the head box 1 of bull stick 3 can be installed, positioned at 1 lower part of head box
Water bath 5 and the stripping rotor 4 in water bath 5, as shown in Fig. 2, stripping rotor 4 be equipped with cup lid 6, bull stick 3 pass through cup lid
6,3 lower end of bull stick is equipped with stirrer paddle, and sedimentation basket 8 is equipped in stripping rotor 4, and sedimentation basket 8 is the caged with grid, and use is stainless
Steel material is made, and can be fixed on sample in sedimentation basket, avoid floating, and sedimentation basket 8 is connected to 7 lower end of fixed link, fixed link 7
Upper end is mounted on cup lid 6 and is fixed, and can remove fixed link 7 from cup lid 6, after carrying out being put into and test of sample
The operations such as cleaning.Stripping rotor 4 is additionally provided with sampling mechanism, and sampling mechanism includes stretching into the probe tube 9 in stripping rotor 4, probe tube 9
External sampler 11 is connected by hose 10, sampler 11 preferably using injection-tube, can carry out the extraction of test liquid.Turn
Bar 3 passes through the through-hole of 6 center of cup lid to be connect with the motor in head box 1, and bull stick 3 is adjustable in length bull stick, can be with
It can be adjusted as needed.Water bath 5 uses micro pump circulating water flow, PT1000 sensors built in water bath 5, with PID
Shaping modes, quick heating, precision are high.Probe tube 9 passes through the through-hole for deviateing 6 center of cup lid, extend into inside stripping rotor 4,
A diameter of 2-4mm of probe tube 9, head box 1 is equipped with the control panel 2 of control device operation, including temperature control panel, speed
Control panel, time control panel and control keyboard by the operation to control panel, can facilitate and carry out setting for each program
It is fixed, host work parameter can preset and automatic storage, booting next time need not repeat to set, and rotating speed control is using subdivision power drives
Stepper motor mode, rotating speed is accurate, operates steadily, and low energy consumption.
When specifically used, starter adjusts bath temperature, the liquid of simulate the gastric juice is put into stripping rotor, excessively centainly
After time, after liquid is consistent with bath temperature in stripping rotor, sample to be tested is put into sedimentation basket, then sedimentation basket sinks
Enter in the liquid in stripping rotor, while open stirring, set mixing speed, the measure of dissolution rate, examination are carried out in specific time
Certain liquid is extracted during testing by probe tube, in time, effectively detect.
Claims (7)
1. a kind of dissolution rate test device, the head box (1) including bull stick (3) can be installed, the water-bath positioned at head box (1) lower part
Slot (5) and the stripping rotor (4) in water bath (5), which is characterized in that the stripping rotor (4) is equipped with cup lid (6), institute
Bull stick (3) is stated across cup lid (6), bull stick (3) lower end is equipped with stirrer paddle, and sedimentation basket (8), institute are equipped in the stripping rotor (4)
It states sedimentation basket (8) and is connected to fixed link (7) lower end, fixed link (7) upper end is mounted on cup lid (6), and the stripping rotor (4) also sets
There is sampling mechanism, the sampling mechanism includes stretching into the probe tube (9) in stripping rotor (4), and the probe tube (9) passes through hose
(10) sampler (11) outside connection.
2. a kind of dissolution rate test device according to claim 1, which is characterized in that the sampler (11) is injection
Pipe.
3. a kind of dissolution rate test device according to claim 1, which is characterized in that the bull stick (3) is across cup lid (6)
The through-hole of center is connect with the motor in head box (1).
4. a kind of dissolution rate test device according to claim 1, which is characterized in that the bull stick (3) can for length
Adjust bull stick.
5. a kind of dissolution rate test device according to claim 1, which is characterized in that the water bath (5) is using micro-
Type water pump circulating water flow, PT1000 sensors built in water bath (5).
6. a kind of dissolution rate test device according to claim 1, which is characterized in that the probe tube (9) is across deviation
It is internal to extend into stripping rotor (4) for the through-hole of cup lid (6) center.
7. a kind of dissolution rate test device according to claim 1, which is characterized in that the head box (1) is equipped with control
The control panel (2) of device operation processed, including temperature control panel, speed control panel, time control panel and control key
Disk.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721432346.4U CN207571117U (en) | 2017-10-31 | 2017-10-31 | A kind of dissolution rate test device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721432346.4U CN207571117U (en) | 2017-10-31 | 2017-10-31 | A kind of dissolution rate test device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207571117U true CN207571117U (en) | 2018-07-03 |
Family
ID=62692791
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201721432346.4U Active CN207571117U (en) | 2017-10-31 | 2017-10-31 | A kind of dissolution rate test device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN207571117U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109142775A (en) * | 2018-08-23 | 2019-01-04 | 沈阳奥吉娜药业有限公司 | Pick and place spline structure |
| CN111551680A (en) * | 2020-05-21 | 2020-08-18 | 宁波第二激素厂 | Device and method for detecting release of progesterone vaginal sustained release agent |
-
2017
- 2017-10-31 CN CN201721432346.4U patent/CN207571117U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109142775A (en) * | 2018-08-23 | 2019-01-04 | 沈阳奥吉娜药业有限公司 | Pick and place spline structure |
| CN111551680A (en) * | 2020-05-21 | 2020-08-18 | 宁波第二激素厂 | Device and method for detecting release of progesterone vaginal sustained release agent |
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