CN1985791B - Preparing process of skin care silk protein gel cream - Google Patents

Preparing process of skin care silk protein gel cream Download PDF

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CN1985791B
CN1985791B CN200610155515A CN200610155515A CN1985791B CN 1985791 B CN1985791 B CN 1985791B CN 200610155515 A CN200610155515 A CN 200610155515A CN 200610155515 A CN200610155515 A CN 200610155515A CN 1985791 B CN1985791 B CN 1985791B
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gel
silk
solution
antiseptic
fibroin
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CN1985791A (en
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闵思佳
吴迪
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HANGZHOU WENSLI SILK CULTURE Co Ltd
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Zhejiang University ZJU
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Abstract

The present invention discloses preparation process of skin care silk protein gel cream. The preparation process includes the following steps: adding water soluble sericin or water soluble sericin and silk peptide as gel promoter into water solution of fimbrin through homogeneous mixing; stilling the solution at 0-90deg.c for gelatinizing the solution into translucent silk protein gel with water content of 70-98 %; and homogenizing and emulsifying to form silk protein gel cream. Into the silk protein gel cream, other cosmetics matrix component and supplementary material component may be added as required. The silk protein gel cream has the functions as nutrient additive, humectant and matrix, and may be used in producing high quality natural skin care cosmetics.

Description

The preparation method of skin care silk protein gel cream
Technical field
The present invention relates to a kind of preparation method that is used for beauty and skin care, repairs the fibroin albumen gel cream of skin.
Background technology
Along with growth in the living standard, people more and more pay attention to beauty and skin care, and are also more and more higher to the quality requirements of cosmetics and skincare product.Contain the cosmetics and skincare product of the active skull cap components that extracts in the biologies such as collagen protein, fibroin albumen, seaweed extract thing, Radix Ginseng leaching liquid, not only protect skin, also have the function of conditioning skin, promotion skin metabolism, enjoy favor.Silkworm silk and human body skin have good affinity, and ventilative suction is described as the fiber queen since ancient times.Fibroin albumen is to extract the native protein that obtains from silkworm silk, is made up of 18 seed amino acids.Studies show that fibroin albumen has the biological activity that promotes growth to most mammal cells such as fibroblast, epidermis cell, epithelial cell, chondrocytes, so fibroin albumen is applied in the medical materials such as various cosmetics and skincare products and artificial skin.
Usually fibroin albumen only plays the effect of nourishing additive agent, and does not bring into play moisture-keeping functions in cosmetics and skincare product, does not also have the function of substrate, that is to say that the effect of fibroin albumen is not fully exerted.Its reason is because fibroin albumen is the form adding with silk fibroin protein solution, silk peptide solution, water solublity silk peptide powder, so it only can bring into play the effect of nourishing additive agent.
Summary of the invention
The objective of the invention is to develop a kind of preparation method of skin care silk protein protein gel cream.
The technical problem to be solved in the present invention be existing fibroin albumen in cosmetics and skincare product, fibroin albumen can only use as nourishing additive agent, preserves moisture and problem that the substrate effect is not fully exerted.
Among the present invention, fibroin albumen is made the silk extract gel of high-moisture percentage after, make beauty and skin care goods, the skin repair goods of cream form again.Silk extract gel existing nourishing additive agent effect in these goods, again have the effect of preserving moisture, also play the effect of substrate, given full play to the multiple efficacies of fibroin albumen, can reduce the use of other synthesis materials, obtain high-quality natural beauty and skin care goods.
Main Ingredients and Appearance silk extract gel among the present invention has such characteristic: the silk extract gel that 1 gram fibroin albumen is made can contain up to the moisture about 90 grams, and very high water-retaining property is arranged.Contain high-molecular weight fibroin albumen in the silk extract gel, also can dissociate low-molecular-weight fibroin albumen polypeptide and aminoacid can also increase low-molecular-weight fibroin albumen polypeptide and amino acid whose content as required in preparation process.Low molecular fibroin albumen polypeptide, aminoacid and moisture can directly infiltrate skin, nourishes rough skin cell.High molecular fibroin albumen and skin have good affinity, can form the microenvironment of skin care at skin surface.Fibroin albumen promptly has hydrophilic, and lipotropy is also arranged.Hydrophilic makes the fibroin albumen gel can contain large quantity of moisture, for skin keeps the skin wet.Lipotropy makes the fibroin albumen gel also have the soft facial unnecessary greasy effect of removing except nourishes rough skin.
Aspects such as cream shape skin repair health product after these characteristics of silk extract gel make it can be applied in beautifying face minor operations such as face mask cream, skin cream, speckle dispelling play good effect.For example: be applied on the face with skim when the silk extract gel face mask cream uses, and keeping certain moistening time on the face, play the effect of skin nutrition and additional moisture of skin during beginning, back gel when silk extract gel moisture progressively evaporates shrinks, and plays the effect of Firm and the little wrinkle of elimination.The silk extract gel face mask cream that does not add the fat added material is very easy to water and cleans, and cleans the bright and clean delicacy of rear face skin, cleaning is smooth.The silk extract gel face mask cream is to be applied on the face with skim in addition, and is easy to use, do not influence activity again, so very suitable emphasis skin care lacks the working clan of time again.Skin after the beautifying face minor operations such as speckle dispelling needs careful care, and the silk extract gel skin repair health care cream of natural quality is coated on the injured skin can take good care of skin well, promotes skin growth, makes the delicacy more naturally that becomes of skin after the recovery.
Technical scheme of the present invention has following four kinds
First kind of technical scheme may further comprise the steps:
(a) in the silk fibroin water solution of 10-200g/L, adding water-soluble silk glue albumen 0-30g/L, leaves standstill solution behind the uniform mixing as gel promoter under 0-90 ℃ of condition, changes into to solution gel to be translucent silk extract gel;
(b) by adjusting the concentration of silk fibroin water solution, the moisture content of fibroin albumen gel is controlled in the 98%-70% scope; Or air-dry at normal temperatures or the above-mentioned translucent silk extract gel that is prepared at 40-80 ℃ of following transpiring moisture, reduce moisture content to the 98%-70% scope;
(c) the even matter of the fibroin albumen gel of making is emulsified into the cream shape, in this process, can adds amount of water, to adjust the denseness of cream;
(d) can when the preparation silk extract gel, add an amount of antiseptic as required.
Second kind of technical scheme may further comprise the steps:
(a) in the silk fibroin water solution of 10-200g/L, add silk polypeplide 0-50g/L (molecular weight is below 2000), add water-soluble silk glue albumen 0-30g/L as gel promoter, behind the uniform mixing solution is left standstill under 0-90 ℃ of condition, change into translucent gel to solution gel;
(b) concentration of adjustment silk fibroin water solution is controlled in the 98%-70% scope moisture content of fibroin albumen gel; Or air-dry at normal temperatures or the above-mentioned translucent silk extract gel that is prepared at 40-80 ℃ of following transpiring moisture, reduce moisture content to the 98%-70% scope;
(c) the even matter of the fibroin albumen gel of making is emulsified into the cream shape.In this process, can add amount of water, to adjust the denseness of cream;
(d) can when the preparation silk extract gel, add an amount of antiseptic as required.
The third technical scheme may further comprise the steps:
(a) in the silk fibroin water solution of 10-200g/L, add silk polypeplide 0-50g/L (molecular weight is below 2000), after adding other cosmetic base composition and auxiliary element in right amount, add water-soluble silk glue albumen 0-30g/L as gel promoter, behind the uniform mixing solution is left standstill under 0-90 ℃ of condition, change into to solution gel and be translucent gel;
(b) concentration of adjustment silk fibroin water solution is controlled in the 98%-70% scope moisture content of fibroin albumen gel; Or air-dry at normal temperatures or the above-mentioned translucent silk extract gel that is prepared at 40-80 ℃ of following transpiring moisture, reduce moisture content to the 98%-70% scope;
(c) the even matter of the fibroin albumen gel of making is emulsified into the cream shape.In this process, can add amount of water, to adjust the denseness of cream;
(d) can when the preparation silk extract gel, add an amount of antiseptic as required.
The 4th kind of technical scheme may further comprise the steps:
(a) in the gel that fibroin albumen that fibroin albumen gel that first kind of technical scheme obtains and second kind of technical scheme obtain and silk polypeplide form, add other cosmetic base composition and auxiliary element after, even matter is emulsified into the white paste of certain denseness.
The specific embodiment
The invention will be further described below in conjunction with embodiment, but the present invention is not confined to given embodiment.
Embodiment one: the silk extract gel face mask cream
Family's Bombyx bombycis is through shelling cocoon, going pupa to obtain cocoon layer.Use 5g/L Na 2CO 3The concise cocoon layer of aqueous solution 2 times, each 30 minutes kinds, 98 ℃ of concise temperature, bath raio 1: 100.Concise back is fully clean with distilled water, and natural drying obtains fibroin fiber.Use 1000g/L CaCl 2Aqueous solution dissolving fibroin fiber, 98 ℃ of solution temperatures, bath raio 1: 25,10 minutes time.The solution that obtains after the dissolving is poured in the cellulose dialyzer (molecular components 12,000～14,000), and dialysis is 3 in flowing water.Solution after the dialysis is air-dry concentrated, obtain silk fibroin water solution.In the silk fibroin water solution of 50g/L, add water-soluble silk glue albumen 5g/L, leave standstill under 60 ℃ of conditions, become translucent gel to solution, perhaps the even matter of gel is emulsified into the cream shape.Can when the preparation silk extract gel, add an amount of antiseptic as required.
This prescription is simple, but what obtain is high-quality natural silk fibroin face mask cream, can give full play to distinctive nourishing effect of fibroin albumen and moisture-keeping efficacy, to skin of face have that tangible benefit is wet, the effect of skin care, reduce wrinkle, cleaning.
Embodiment two |, silk extract gel anti-ageing face mask cream
Family's Bombyx bombycis is through shelling cocoon, going pupa to obtain cocoon layer.Use 5g/L Na 2CO 3The concise cocoon layer of aqueous solution 2 times, each 30 minutes kinds, 98 ℃ of concise temperature, bath raio 1: 100.Concise back is fully clean with distilled water, and natural drying obtains fibroin fiber.With mol ratio is 1: 8: 2 calcium chloride, water, dissolve with ethanol solution fibroin fiber, 70 ℃ of solution temperatures, bath raio 1: 25,10 minutes time.The solution that obtains after the dissolving is poured in the cellulose dialyzer (molecular components 12,000～14,000), and dialysis is 3 in flowing water.Solution after the dialysis is air-dry concentrated, obtain silk fibroin water solution.In the 60g/L silk fibroin water solution, add water-soluble silk glue protein 10 g/L, add the silk polypeplide 10g/L of molecular weight below 2000, leave standstill under 70 ℃ of conditions, become translucent gel to solution.Gel with other cosmetics auxiliary element glycerol, vitamin E acetic acid fat, foreign Citrus essential oil, essence and antiseptic, even matter emulsifying, is made into anti-ageing face mask cream.
Concrete proportioning is:
Constituent mass mark/%
Silk extract gel 60.0
Glycerol 2.0
Vitamin E acetic acid fat 0.5
Ocean Citrus essential oil 1.0
Antiseptic is an amount of
Essence is an amount of
Deionized water adds to 100.0
Antiseptic can be benzoic acid, sorbic acid, Salicylate of acids antiseptic etc., the parabens of antiseptic phenols (first, second, third, butyl ester), nipalgin, parachlorometaxylenol etc., 2 of amide-type, 4,4 '-three chloros-carbanilide, the alkyl trimethyl ammonium chloride of quaternary ammonium salt, alkyl bromination quinoline, hexadecylpyridinium chloride, the ethanol of alcohols antiseptic etc., the methyl dibromo glutaronitrile of composite anti-corrosion agent and phenoxyethanol, two imidazolidinyl urea (GERMALL II) and iodine can be selected wherein one or more for use.
Embodiment three: silk extract gel nourishes facial cream
Family's Bombyx bombycis is through shelling cocoon, going pupa to obtain cocoon layer.With the concise cocoon layer of 0.4% neutral soap solution 2 times, each 1 hour, 98 ℃ of concise temperature, bath raio 1: 100.Concise back is fully clean with distilled water, and natural drying obtains fibroin fiber.With lithium bromide, ethanol, water with the composite 3 yuan of solvents of 45: 53: 2 weight ratio, heating for dissolving fibroin fiber under 70-100 ℃ of temperature.Bath raio 1: 50.The solution that obtains after the dissolving is poured in the cellulose dialyzer (molecular components 12,000～14,000), and dialysis is 3 in flowing water.Solution after the dialysis is air-dry concentrated, obtain silk fibroin water solution.In the silk fibroin water solution of 80g/L, add propylene glycol 30g/L, leave standstill under 50 ℃ of conditions, become translucent gel to solution.With gel with other cosmetic base composition stearic acid, Cera Flava, squalane,, hexadecanol, Vinlub 73, auxiliary element lanolin derivative, essence and the even matter emulsifying of antiseptic, be made into the nourishing facial cream.Concrete proportioning is:
Constituent mass mark/%
Silk extract gel 51.0
Stearic acid 5.0
Cera Flava 2.0
Hexadecanol 6.0
Squalane 5.0
Vinlub 73 3.0
Lanolin derivative 2.0
Essence is an amount of
Antiseptic is an amount of
Deionized water adds to 100.0
It is identical with embodiment one that antiseptic is selected for use.
Embodiment four: silk extract gel skin repair health-care cream
Obtain silk fibroin water solution with the method among the embodiment one to three.In the silk fibroin water solution of 40g/L, add ethanol 30g/L then, leave standstill under 60 ℃ of conditions, become the translucent gels of moisture content about 90% to solution.Gel with the even matter emulsifying of other cosmetic base composition vaseline, auxiliary element ethylene glycol, basic fibroblast growth factor (BFGF), vitamin E acetic acid fat and antiseptic, is made into the skin repair health-care cream.Concrete proportioning is:
Constituent mass mark/%
Silk extract gel 86.4
Vaseline 8.0
Ethylene glycol 5.0
Basic fibroblast growth factor (BFGF) 0.1
Vitamin E acetic acid fat 0.5
Antiseptic is an amount of
It is identical with embodiment one that antiseptic is selected for use.
Embodiment five: the silk extract gel nutritional emulsions
Obtain silk fibroin water solution with embodiment one or embodiment two or embodiment three methods.Then in the 100g/L silk fibroin water solution, add silk polypeplide 10g/L (molecular weight is below 2000), add water-soluble silk glue protein 10 g/L as gel promoter, behind the uniform mixing solution is left standstill under 60 ℃ of conditions, change into translucent gel to solution gel.Gel with the even matter emulsifying of other cosmetic base composition hexadecanol, white oil, fatty alcohol-polyoxyethylene ether, glyceryl monostearate, sodium lauryl sulphate, auxiliary element glycerol, ginsenoside, essence and antiseptic, is made into the nourishing facial cream.Concrete proportioning is:
Constituent mass mark/%
Silk extract gel 20.0
Hexadecanol 2.0
White oil 8.5
Fatty alcohol-polyoxyethylene ether 0.6
Glyceryl monostearate 3.0
Sodium lauryl sulphate 0.6
The ginsenoside 0.1
Glycerol 5.0
Essence is an amount of
Antiseptic is an amount of
Deionized water adds to 100.0
It is identical with embodiment one that antiseptic is selected for use.
Embodiment six: the silk extract gel nourishing pack
Obtain silk fibroin water solution with embodiment one or embodiment two or embodiment three methods.Then in the 50g/L silk fibroin water solution, add silk polypeplide 10g/L (molecular weight is below 2000), add auxiliary element sodium alginate 5g/L, propylene glycol 20g/L, antiseptic is an amount of, behind the uniform mixing solution is left standstill under 20 ℃ of conditions, change into to solution gel to be translucent gel.Also the even matter of gel can be emulsified into the cream shape, add deionized water in right amount and regulate denseness.
It is identical with embodiment one that antiseptic is selected for use.
Water-soluble silk glue albumen among the present invention can replace with water-soluble chitosan as gel promoter; Also can be with the water soluble organic substance ethanol that can be used for cosmetics that skin is not had the destructive stimulus effect, trimethylammonium second inner salt, Polyethylene Glycol, ethylene glycol, propylene glycol, butanediol, polyvinyl pyrrolidone, and one or more replacements in the derivant, the use amount of gel promoter is 0-100g/L.
Matrix components of the present invention can also be palmitic acid, cardanol, oleyl alcohol, silicone oil and derivant thereof.
Auxiliary element of the present invention can also be that surfactant, lecithin, soap, pigment, Oleum menthae, Oleum lavandula angustifolia, Oleum Rosae Rugosae, Michelia leap oil, lactic acid and lactic acid are received, pyrrolidone sodium carboxylate, basic fibroblast growth factor (BFGF), fruit acid, enzyme (SOD) vitamin (A, B1, B2, B3, B6, C, D, F).

Claims (7)

1. the preparation method of a skin care silk protein gel cream is characterized in that it may further comprise the steps:
(a) in the 10-200g/L silk fibroin water solution, adding water-soluble silk glue albumen 5-30g/L, leaves standstill solution behind the uniform mixing as gel promoter under 0-90 ℃ of condition, changes into to solution gel to be translucent silk extract gel; The molecular weight of fibroin albumen is 10,000-350,000;
(b) by adjusting the concentration of silk fibroin water solution, the moisture content of fibroin albumen gel is controlled in the 98%-70% scope; Or air-dry at normal temperatures or the above-mentioned translucent silk extract gel that is prepared at 40-80 ℃ of following transpiring moisture, reduce moisture content to the 98%-70% scope;
(c) the even matter of the fibroin albumen gel of making is emulsified into the cream shape, in this process, can adds amount of water, to adjust the denseness of cream;
(d) when the preparation silk extract gel, add an amount of antiseptic; Described antiseptic is that the acids antiseptic comprises benzoic acid, sorbic acid, Salicylate; Antiseptic phenols comprises parabens, nipalgin, parachlorometaxylenol; The amide-type antiseptic comprises 2,4,4 '-three chloros-carbanilide; The quaternary ammonium salt antiseptic comprises alkyl trimethyl ammonium chloride, alkyl bromination quinoline, hexadecylpyridinium chloride; The ethanol of alcohols antiseptic; The composite anti-corrosion agent comprises methyl dibromo glutaronitrile and phenoxyethanol, two imidazolidinyl urea and iodine; Add wherein one or more.
2. the preparation method of skin care silk protein gel cream according to claim 1 is characterized in that at the fibroin albumen gel, add cosmetic base composition and auxiliary element again after, even matter is emulsified into the white paste of certain denseness.
3. the preparation method of a skin care silk protein gel cream is characterized in that it may further comprise the steps:
(a) in the 10-200g/L silk fibroin water solution, add silk polypeplide 0-50g/L, the molecular weight of silk polypeplide is below 2000, adds water-soluble silk glue protein 10-30g/L as gel promoter, behind the uniform mixing solution is left standstill under 0-90 ℃ of condition, change into translucent gel to solution gel; The molecular weight of fibroin albumen is 10,000-350,000;
(b) concentration of adjustment silk fibroin water solution is controlled in the 98%-70% scope moisture content of fibroin albumen gel; Or air-dry at normal temperatures or the above-mentioned translucent silk extract gel that is prepared at 40-80 ℃ of following transpiring moisture, reduce moisture content to the 98%-70% scope;
(c) the even matter of the fibroin albumen gel of making is emulsified into the cream shape; In this process, add amount of water, to adjust the denseness of cream;
(d) when the preparation silk extract gel, add an amount of antiseptic; Described antiseptic is that the acids antiseptic comprises benzoic acid, sorbic acid, Salicylate; Antiseptic phenols comprises parabens, nipalgin, parachlorometaxylenol; The amide-type antiseptic comprises 2,4,4 '-three chloros-carbanilide; The quaternary ammonium salt antiseptic comprises alkyl trimethyl ammonium chloride, alkyl bromination quinoline, hexadecylpyridinium chloride; The ethanol of alcohols antiseptic; The composite anti-corrosion agent comprises methyl dibromo glutaronitrile and phenoxyethanol, two imidazolidinyl urea and iodine; Add wherein one or more.
4. the preparation method of skin care silk protein gel cream according to claim 3 is characterized in that in the gel that fibroin albumen and silk polypeplide form, add cosmetic base composition and auxiliary element again after, even matter is emulsified into the white paste of certain denseness.
5. according to the preparation method of claim 2 or 4 described skin care silk protein gel creams, it is characterized in that the matrix components that adds comprises stearic acid, palmitic acid, cardanol, oleyl alcohol, Cera Flava, squalane, lanoline and derivant thereof, hexadecanol, Vinlub 73, sodium alginate, vaseline, white oil, fatty alcohol-polyoxyethylene ether, glyceryl monostearate, sodium lauryl sulphate, silicone oil and derivant thereof, propylene glycol, auxiliary element comprises lecithin, soap, essence, pigment, Oleum menthae, Oleum lavandula angustifolia, Oleum Rosae Rugosae, Michelia leap oil, glycerol, propylene glycol, 1, the 3-butanediol, Polyethylene Glycol, lactic acid, vitamin E acetic acid fat, the ocean Citrus essential oil, ethylene glycol, basic fibroblast growth factor, fruit acid, enzyme, the ginsenoside, Sargassum extract, vitamin A, B1, B2, B3, B6, C, D, F.
6. according to the preparation method of claim 1 or 3 described skin care silk protein gel creams, the manufacture method that it is characterized in that silk fibroin protein solution is: add the method dissolving fibroin that water adds alcoholic acid mixed solution with calcium chloride solution, lithium-bromide solution or calcium chloride commonly used, then through dialysis and concentrated obtaining.
7. according to the preparation method of claim 1 or 3 described skin care silk protein gel creams, it is characterized in that water-soluble silk glue albumen also is the protein that extracts in a kind of silkworm silk.
CN200610155515A 2006-12-27 2006-12-27 Preparing process of skin care silk protein gel cream Active CN1985791B (en)

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