CN1938034A - Ed-71制剂 - Google Patents
Ed-71制剂 Download PDFInfo
- Publication number
- CN1938034A CN1938034A CNA2005800098776A CN200580009877A CN1938034A CN 1938034 A CN1938034 A CN 1938034A CN A2005800098776 A CNA2005800098776 A CN A2005800098776A CN 200580009877 A CN200580009877 A CN 200580009877A CN 1938034 A CN1938034 A CN 1938034A
- Authority
- CN
- China
- Prior art keywords
- preparation
- secocholesta
- triolefins
- triol
- prescription
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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Abstract
Description
原料名 | 对照配方1 | 配方1 | 配方2 | 配方3 |
无添加 | 添加BHT | 添加生育酚 | 添加BHT+生育酚 | |
胶囊壳明胶(APB-H)甘油氧化钛纯化水 | 47.67mg16.68mg0.65mg | |||
小计 | 65.00mg | |||
芯液ED-71无水乙醇BHTd1-α-生育酚MCT(ODO-C) | 1μg1.30mg--98.70mg | 1μg1.30mg0.02mg-98.68mg | 1μg1.30mg-0.02mg98.68mg | 1μg1.30mg0.02mg0.02mg98.66mg |
小计 | 100.00mg | 100.00mg | 100.00mg | 100.00mg |
计 | 165.00mg | 165.00mg | 165.00mg | 165.00mg |
保存条件 | 保存时间(月) | 速固型的峰面积比 | |||
对照配方1无添加 | 处方BHT | 处方2生育酚 | 处方3BHT+生育酚 | ||
30℃/60%RH密封 | 0612 | N.D.1.311.85 | N.D.N.D.0.56 | N.D.N.D.N.D. | N.D.N.D.N.D. |
30℃/60%RH未密封 | 0612 | N.D.1.542.06 | N.D.N.D.0.63 | N.D.N.D.N.D. | N.D.N.D.N.D. |
保存条件 | 保存时间(月) | 反式型的峰面积比 | |||
对照配方1无添加 | 处方BHT | 处方2生育酚 | 处方3BHT+生育酚 | ||
30℃/60%RH密封 | 0612 | N.D.1.311.85 | N.D.N.D.0.56 | N.D.N.D.N.D. | N.D.N.D.N.D. |
30℃/60%RH未密封 | 0612 | N.D.1.542.06 | N.D.N.D.0.63 | N.D.N.D.N.D. | N.D.N.D.N.D. |
保存条件 | 保存时间(月) | ED-71的残留率 | |||
对照配方1无添加 | 处方BHT | 处方2生育酚 | 处方3BHT+生育酚 | ||
30℃/60%RH密封 | 612 | 96.793.0 | 99.998.3 | 100.598.3 | 100.098.6 |
30℃/60%RH未密封 | 612 | 93.688.1 | 98.093.7 | 97.695.0 | 97.995.5 |
原料名称 | 对照配方2 | 配方4 | 配方5 |
0% | 0.02% | 0.005% | |
胶囊壳明胶(APB-H)甘油氧化钛(纯化水) | 47.67mg16.68mg0.65mg(71.84mg) | ||
总计 | 65.00mg | ||
芯液ED-71无水乙醇d1-α-生育酚MCT(ODO-C) | 0.001mg1.300mg0.000mg98.700mg | 0.001mg1.300mg0.002mg98.697mg | 0.001mg1.300mg0.005mg98.694mg |
总计 | 100.000mg | 100.000mg | 100.000mg |
原料名称 | 对照配方6 | 配方7 | 配方8 |
001% | 0.02% | 0.04% | |
胶囊壳明胶(APB-H)甘油氧化钛(纯化水) | |||
总计 | |||
芯液ED-71无水乙醇d1-α-生育酚MCT(OD0-C) | 0.001mg1.300mg0.010mg98.689mg | 0.001mg1.300mg0.020mg98.679mg | 0.001mg1.300mg0.040mg98.659mg |
总计 | 100.000mg | 100.000mg | 100.000mg |
保存条件 | 保存时间(月) | 速甾醇型的峰面积比 | ||
配方2(0%) | 配方4(0.002%) | 配方5(0.005%) | ||
40℃密封 | 0123 | N.D.1.222.814.04 | N.D.0.460.901.34 | N.D.0.270.510.86 |
保存条件 | 保存时间(月) | 速甾醇型的峰面积比 | ||
配方6(0.01%) | 配方7(0.02%) | 配方8(0.04%) | ||
40℃密封 | 0123 | N.D.0.240.460.64 | N.D.N.D.0.280.42 | N.D.N.D.N.D.0.23 |
保存条件 | 保存时间(月) | 反式型的峰面积比 | ||
对照配方2(0%) | 配方4(0.002%) | 配方5(0.005%) | ||
40℃密封 | 0123 | N.D.0.872.183.33 | N.D.N.D.N.D.0.60 | N.D.N.D.N.D.0.14 |
保存条件 | 保存时间(月) | 反式型的峰面积比 | ||
配方6(0.01%) | 配方7(0.02%) | 配方8(0.04%) | ||
40℃密封 | 0123 | N.D.N.D.N.D.N.D. | N.D.N.D.N.D.N.D. | N.D.N.D.N.D.N.D. |
配方 | 抗氧化剂 | 峰面积比(%) | |
速甾醇型 | 反式型 | ||
对照配方3配方9配方10配方11配方12 | 未使用d1-α-生育酚二丁基羟基甲苯丁基羟基茴香醚没食子酸丙酯 | 0.76N.D.N.D.N.D.N.D.N.D. | 0.43N.D.N.D.N.D.N.D.N.D. |
原料名称 | 处方13 | 处方14 |
(0.02%) | (0.02%) | |
胶囊壳明胶(APB-H)山梨醇焦糖(2MC)(纯化水) | 54.71mg8.34mg1.95mg(82.33) | |
总计 | 65.00mg | |
芯液ED-71无水乙醇d1-α-生育酚MCT(ODO-C) | 0.0005mg1.300mg0.020mg98.6795mg | 0.001mg1.300mg0.020mg98.679mg |
总计 | 100.000mg | 100.000mg |
Claims (10)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004030702 | 2004-02-06 | ||
JP030702/2004 | 2004-02-06 | ||
PCT/JP2005/001749 WO2005074943A1 (ja) | 2004-02-06 | 2005-02-07 | Ed−71製剤 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2009102228115A Division CN101721708B (zh) | 2004-02-06 | 2005-02-07 | Ed-71制剂 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1938034A true CN1938034A (zh) | 2007-03-28 |
CN1938034B CN1938034B (zh) | 2010-12-08 |
Family
ID=34836013
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2009102228115A Ceased CN101721708B (zh) | 2004-02-06 | 2005-02-07 | Ed-71制剂 |
CN2005800098776A Ceased CN1938034B (zh) | 2004-02-06 | 2005-02-07 | Ed-71制剂 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2009102228115A Ceased CN101721708B (zh) | 2004-02-06 | 2005-02-07 | Ed-71制剂 |
Country Status (8)
Country | Link |
---|---|
US (1) | US20070129340A1 (zh) |
EP (1) | EP1714656B8 (zh) |
JP (2) | JP4921794B2 (zh) |
KR (1) | KR101166394B1 (zh) |
CN (2) | CN101721708B (zh) |
ES (1) | ES2638836T3 (zh) |
HK (2) | HK1101139A1 (zh) |
WO (1) | WO2005074943A1 (zh) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2008009652A (es) | 2006-01-24 | 2008-11-06 | R Tech Ueno Ltd | Composicion farmaceutica que comprende un compuesto biciclico y metodo para estabilizar el compuesto biciclico. |
BR102015024165A2 (pt) * | 2015-09-18 | 2017-03-28 | Prati Donaduzzi & Cia Ltda | composição farmacêutica oral compreendendo canabinóide, processo para sua preparação e seu uso |
KR101785319B1 (ko) * | 2016-05-04 | 2017-10-17 | 대한뉴팜(주) | 안정성이 향상된 콜레칼시페롤 조성물 및 이의 제조방법 |
WO2018124260A1 (ja) * | 2016-12-28 | 2018-07-05 | 中外製薬株式会社 | Ed-71の固体分散体および油分分散体を含む医薬組成物 |
JP2019014676A (ja) * | 2017-07-06 | 2019-01-31 | 東海カプセル株式会社 | カプセル剤 |
CN108420797B (zh) * | 2018-05-09 | 2022-05-03 | 南京海融制药有限公司 | 维生素d类似物制剂及其制备方法 |
CN112368000B (zh) | 2018-06-27 | 2024-08-27 | 中外制药株式会社 | 含有在油脂中包含ed-71及其环氧体的油分分散体的药物组合物 |
JP6628927B1 (ja) * | 2019-08-09 | 2020-01-15 | 日医工株式会社 | エルデカルシトール軟カプセル剤 |
JP6742487B1 (ja) * | 2019-08-09 | 2020-08-19 | 日医工株式会社 | エルデカルシトール含有医薬組成物 |
CN111272902A (zh) * | 2020-03-16 | 2020-06-12 | 温州海鹤药业有限公司 | 一种艾地骨化醇血药浓度的检测方法 |
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JPS5312414A (en) | 1976-07-21 | 1978-02-03 | Chugai Pharmaceut Co Ltd | Production of preparation containing stable 1alpha-hydroxyvitamines d |
US4666634A (en) * | 1984-12-05 | 1987-05-19 | Chugai Seiyaku Kabushiki Kaisha | vitamin D3 derivatives having a substituent at 2-position |
JPH0780773B2 (ja) * | 1986-06-05 | 1995-08-30 | 中外製薬株式会社 | 新規ビタミンd▲下3▼誘導体を有効成分とする医薬 |
JPS63267706A (ja) * | 1987-04-22 | 1988-11-04 | Dainippon Jiyochiyuugiku Kk | ベンジルアルコ−ルエステルを含有する燻焼用及び加熱蒸散用殺虫剤ならびにその製造法 |
JPH0768208B2 (ja) * | 1989-02-15 | 1995-07-26 | 大同ほくさん株式会社 | 22,23―セコ―1,7,8―トリヒドロキシビタミンdあるいはその誘導体とその製造方法 |
JPH054925A (ja) * | 1991-06-27 | 1993-01-14 | Teikoku Chem Ind Corp Ltd | アルフアカルシドール軟カプセル製剤 |
ATE188482T1 (de) * | 1992-02-27 | 2000-01-15 | Duphar Int Res | Verfahren zur herstellung 9-beta,10-alpha-5,7- dien-steroiden |
JPH0687750A (ja) * | 1992-09-08 | 1994-03-29 | Taiyo Yakuhin Kogyo Kk | 医薬組成物 |
WO1994020143A1 (en) * | 1993-03-03 | 1994-09-15 | Fujisawa Pharmaceutical Co., Ltd. | Optical isomerization inhibitor |
JP3429432B2 (ja) * | 1996-07-01 | 2003-07-22 | 中外製薬株式会社 | ビタミンd誘導体結晶およびその製造方法 |
TWI247001B (en) * | 1996-07-01 | 2006-01-11 | Chugai Pharmaceutical Co Ltd | The method for purifying vitamin d derivatives and its crystalline products |
AU743514B2 (en) * | 1997-05-16 | 2002-01-24 | Women & Infants Hospital | Cyclic ether vitamin D3 compounds, 1alpha (OH) 3-EPI-vitamin D3 compounds and uses thereof |
EA003741B1 (ru) * | 1998-06-01 | 2003-08-28 | Энтони Дж. Вербискар | Местное трансдермальное лечение |
US6267985B1 (en) * | 1999-06-30 | 2001-07-31 | Lipocine Inc. | Clear oil-containing pharmaceutical compositions |
TW561047B (en) * | 1999-08-31 | 2003-11-11 | Chugai Pharmaceutical Co Ltd | Soft capsule formulations |
WO2001090061A1 (fr) * | 2000-05-23 | 2001-11-29 | Chugai Seiyaku Kabushiki Kaisha | Derives de 5, 6-trans-2-alkylevitamine d |
US6660306B2 (en) * | 2000-10-12 | 2003-12-09 | Mickey L. Peshoff | Wound healing compound |
US7094431B2 (en) * | 2000-10-12 | 2006-08-22 | Mickey L. Peshoff | Method of healing skin wounds in mammals and a composition therefor |
AU2002363959B2 (en) | 2001-12-03 | 2007-12-13 | Novacea, Inc. | Pharmaceutical compositions comprising active vitamin D compounds |
US7632518B2 (en) * | 2002-01-15 | 2009-12-15 | Dsm Ip Assets B.V. | 25-hydroxy vitamin D3 compositions |
US8486374B2 (en) * | 2003-08-04 | 2013-07-16 | Foamix Ltd. | Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses |
-
2005
- 2005-02-07 CN CN2009102228115A patent/CN101721708B/zh not_active Ceased
- 2005-02-07 CN CN2005800098776A patent/CN1938034B/zh not_active Ceased
- 2005-02-07 JP JP2005517763A patent/JP4921794B2/ja active Active
- 2005-02-07 US US10/588,609 patent/US20070129340A1/en not_active Abandoned
- 2005-02-07 KR KR1020067017923A patent/KR101166394B1/ko active IP Right Grant
- 2005-02-07 ES ES05709801.4T patent/ES2638836T3/es active Active
- 2005-02-07 WO PCT/JP2005/001749 patent/WO2005074943A1/ja active Application Filing
- 2005-02-07 EP EP05709801.4A patent/EP1714656B8/en active Active
-
2007
- 2007-08-27 HK HK07109267.0A patent/HK1101139A1/xx unknown
-
2010
- 2010-10-25 HK HK10110017.6A patent/HK1144179A1/xx not_active IP Right Cessation
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2011
- 2011-11-24 JP JP2011256586A patent/JP5529104B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
CN1938034B (zh) | 2010-12-08 |
US20070129340A1 (en) | 2007-06-07 |
KR101166394B1 (ko) | 2012-07-23 |
EP1714656A1 (en) | 2006-10-25 |
HK1144179A1 (en) | 2011-02-02 |
EP1714656B8 (en) | 2017-09-20 |
WO2005074943A1 (ja) | 2005-08-18 |
JPWO2005074943A1 (ja) | 2007-10-11 |
KR20070003904A (ko) | 2007-01-05 |
CN101721708A (zh) | 2010-06-09 |
EP1714656A4 (en) | 2012-10-31 |
CN101721708B (zh) | 2013-09-04 |
JP2012072169A (ja) | 2012-04-12 |
HK1101139A1 (en) | 2007-10-12 |
ES2638836T8 (es) | 2017-11-28 |
JP5529104B2 (ja) | 2014-06-25 |
JP4921794B2 (ja) | 2012-04-25 |
EP1714656B1 (en) | 2017-08-16 |
ES2638836T3 (es) | 2017-10-24 |
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