CN1934078B - 维生素d类似物的立体选择性合成 - Google Patents

维生素d类似物的立体选择性合成 Download PDF

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Publication number
CN1934078B
CN1934078B CN2005800086209A CN200580008620A CN1934078B CN 1934078 B CN1934078 B CN 1934078B CN 2005800086209 A CN2005800086209 A CN 2005800086209A CN 200580008620 A CN200580008620 A CN 200580008620A CN 1934078 B CN1934078 B CN 1934078B
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CN
China
Prior art keywords
compound
formula
mixture
hydrogen
calcipotriol
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Expired - Fee Related
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CN2005800086209A
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English (en)
Chinese (zh)
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CN1934078A (zh
Inventor
T·P·萨布勒
M·J·卡尔弗利
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Leo Pharma AS
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Leo Pharma AS
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Publication of CN1934078A publication Critical patent/CN1934078A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dermatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2005800086209A 2004-03-18 2005-03-10 维生素d类似物的立体选择性合成 Expired - Fee Related CN1934078B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US55396204P 2004-03-18 2004-03-18
US60/553,962 2004-03-18
DKPA200400454 2004-03-22
DKPA200400454 2004-03-22
PCT/DK2005/000161 WO2005087719A1 (en) 2004-03-18 2005-03-10 Stereoselective synthesis of vitamin d analogues

Publications (2)

Publication Number Publication Date
CN1934078A CN1934078A (zh) 2007-03-21
CN1934078B true CN1934078B (zh) 2011-07-06

Family

ID=34961016

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2005800086209A Expired - Fee Related CN1934078B (zh) 2004-03-18 2005-03-10 维生素d类似物的立体选择性合成

Country Status (17)

Country Link
EP (1) EP1730108B1 (enExample)
JP (1) JP4667450B2 (enExample)
KR (1) KR100859277B1 (enExample)
CN (1) CN1934078B (enExample)
AR (1) AR048274A1 (enExample)
AT (1) ATE390411T1 (enExample)
BR (1) BRPI0507318A (enExample)
CA (1) CA2555260C (enExample)
CY (1) CY1108156T1 (enExample)
DE (2) DE05706821T1 (enExample)
ES (1) ES2304686T3 (enExample)
IL (1) IL176718A (enExample)
PL (1) PL1730108T3 (enExample)
RU (1) RU2380359C2 (enExample)
SI (1) SI1730108T1 (enExample)
TW (1) TWI324063B (enExample)
WO (1) WO2005087719A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2378252C2 (ru) * 2004-04-02 2010-01-10 Лео Фарма А/С Новый способ получения промежуточных соединений, применяемых для синтеза аналогов витамина d
EP1844010B1 (en) 2006-03-17 2013-02-13 Leo Pharma A/S Isomerisation of pharmaceutical intermediates
US8013189B2 (en) * 2007-09-21 2011-09-06 Basf Se Accelerated amide and ester reductions with amine boranes and additives
EP2299809B1 (en) * 2008-06-17 2018-10-17 Ben Gurion University Of The Negev R&D Authority Substituted cyclohexylidene-ethylidene-octahydro-indene compounds
CN103265528B (zh) * 2013-05-10 2015-05-06 湖南千金湘江药业股份有限公司 埃索美拉唑镁的制备方法
CN106908524B (zh) * 2015-12-23 2021-05-04 重庆华邦胜凯制药有限公司 卡泊三醇中间体l及其潜在基因毒性杂质的分离与测定方法
CN107643354B (zh) * 2016-07-22 2022-02-01 重庆华邦胜凯制药有限公司 卡泊三醇起始原料a及相关杂质的分离与测定方法
ES2945426B2 (es) * 2021-12-30 2024-01-22 Laboratorios Vinas S A Procedimiento para obtener epímeros 24S a partir de derivados de vitaminas D y procedimiento de obtención de vitaminas D relacionado

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1099385A (zh) * 1993-06-04 1995-03-01 杜法尔国际研究公司 维生素d化合物和这些化合物的制备方法
CN1189151A (zh) * 1995-12-05 1998-07-29 里奥药物制品有限公司 维生素d类似物
US6531460B1 (en) * 1998-10-23 2003-03-11 Teijin Limited Vitamin D, derivatives and remedies for inflammatory respiratory diseases containing the same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4866048A (en) * 1985-08-02 1989-09-12 Leo Pharmaceutical Products Ltd. Novel vitamin D analogues
JPH075542B2 (ja) * 1988-09-14 1995-01-25 呉羽化学工業株式会社 ビタミンｄ▲下３▼誘導体及びその製造方法
US5247104A (en) * 1992-11-04 1993-09-21 Wisconsin Alumni Research Foundation Preparation of 1α, 24-dihydroxyvitamin D analogs
GB9300763D0 (en) * 1993-01-15 1993-03-03 Leo Pharm Prod Ltd Chemical compound
GB9622590D0 (en) * 1996-10-30 1997-01-08 Leo Pharm Prod Ltd Chemical compounds
US6262283B1 (en) * 1996-12-06 2001-07-17 Magainin Pharmaceuticals Inc. Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1099385A (zh) * 1993-06-04 1995-03-01 杜法尔国际研究公司 维生素d化合物和这些化合物的制备方法
CN1189151A (zh) * 1995-12-05 1998-07-29 里奥药物制品有限公司 维生素d类似物
US6531460B1 (en) * 1998-10-23 2003-03-11 Teijin Limited Vitamin D, derivatives and remedies for inflammatory respiratory diseases containing the same

Also Published As

Publication number Publication date
TW200539866A (en) 2005-12-16
PL1730108T3 (pl) 2008-09-30
EP1730108A1 (en) 2006-12-13
DE602005005645T2 (de) 2009-06-18
CN1934078A (zh) 2007-03-21
RU2006129922A (ru) 2008-02-27
KR100859277B1 (ko) 2008-09-19
ATE390411T1 (de) 2008-04-15
TWI324063B (en) 2010-05-01
DE05706821T1 (de) 2008-02-07
JP2007529433A (ja) 2007-10-25
JP4667450B2 (ja) 2011-04-13
AR048274A1 (es) 2006-04-12
CA2555260A1 (en) 2005-09-22
DE602005005645D1 (de) 2008-05-08
EP1730108B1 (en) 2008-03-26
IL176718A (en) 2007-07-04
ES2304686T3 (es) 2008-10-16
KR20060134045A (ko) 2006-12-27
RU2380359C2 (ru) 2010-01-27
SI1730108T1 (sl) 2008-08-31
BRPI0507318A (pt) 2007-06-26
CA2555260C (en) 2011-12-06
CY1108156T1 (el) 2014-02-12
WO2005087719A1 (en) 2005-09-22
HK1098122A1 (en) 2007-07-13

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