CN1918160A - 用作趋化因子受体活性调节剂的新颖三环螺环衍生物 - Google Patents

用作趋化因子受体活性调节剂的新颖三环螺环衍生物 Download PDF

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Publication number
CN1918160A
CN1918160A CNA200480042013XA CN200480042013A CN1918160A CN 1918160 A CN1918160 A CN 1918160A CN A200480042013X A CNA200480042013X A CN A200480042013XA CN 200480042013 A CN200480042013 A CN 200480042013A CN 1918160 A CN1918160 A CN 1918160A
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amino
alkyl
group
compound
formula
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English (en)
Chinese (zh)
Inventor
纳菲扎尔·霍塞恩
斯维特拉纳·伊凡诺瓦
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AstraZeneca AB
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AstraZeneca AB
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Publication of CN1918160A publication Critical patent/CN1918160A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P37/08—Antiallergic agents
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNA200480042013XA 2003-12-22 2004-12-20 用作趋化因子受体活性调节剂的新颖三环螺环衍生物 Pending CN1918160A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0303541A SE0303541D0 (sv) 2003-12-22 2003-12-22 New compounds
SE03035417 2003-12-22

Publications (1)

Publication Number Publication Date
CN1918160A true CN1918160A (zh) 2007-02-21

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ID=30768856

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CNA200480042013XA Pending CN1918160A (zh) 2003-12-22 2004-12-20 用作趋化因子受体活性调节剂的新颖三环螺环衍生物

Country Status (17)

Country Link
US (2) US7524856B2 (https=)
EP (1) EP1699791A1 (https=)
JP (1) JP2007515476A (https=)
KR (1) KR20060117343A (https=)
CN (1) CN1918160A (https=)
AR (1) AR046992A1 (https=)
AU (1) AU2004303735B2 (https=)
BR (1) BRPI0417036A (https=)
CA (1) CA2548494A1 (https=)
IL (1) IL175958A0 (https=)
MX (1) MXPA06007025A (https=)
NO (1) NO20063355L (https=)
SE (1) SE0303541D0 (https=)
TW (1) TW200604197A (https=)
UY (1) UY28694A1 (https=)
WO (1) WO2005061499A1 (https=)
ZA (1) ZA200605082B (https=)

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CA2657639A1 (en) * 2006-07-19 2008-01-24 Astrazeneca Ab Novel tricyclic spiropiperidine compounds, their synthesis and their uses as modulators of chemokine receptor activity
WO2008103126A1 (en) * 2007-02-23 2008-08-28 Astrazeneca Ab Novel combination of compounds to be used in the treatment of airway diseases, especially chronic obstructive pulmonary disease (copd) and asthma
WO2009011654A1 (en) * 2007-07-17 2009-01-22 Astrazeneca Ab Process for the preparation of cyclic spiropiperidines
WO2009011655A1 (en) * 2007-07-17 2009-01-22 Astrazeneca Ab Splropiperidine compounds, a process of their preparation, pharmaceutical compositions containing them, and their use in the treatment of airway diseases, inflammatory diseases, copd or asthma
WO2009061881A1 (en) * 2007-11-07 2009-05-14 Glaxo Group Limited Spirodihydrobenzofurans as modulators of chemokine receptors
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US10752588B2 (en) 2014-12-19 2020-08-25 The Broad Institute, Inc. Dopamine D2 receptor ligands
JP7311048B2 (ja) 2021-02-08 2023-07-19 日本精工株式会社 逆入力遮断クラッチ

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SE0303090D0 (sv) 2003-11-20 2003-11-20 Astrazeneca Ab Novel compounds
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Publication number Publication date
BRPI0417036A (pt) 2007-02-06
SE0303541D0 (sv) 2003-12-22
NO20063355L (no) 2006-09-22
MXPA06007025A (es) 2006-08-31
TW200604197A (en) 2006-02-01
CA2548494A1 (en) 2005-07-07
US20090298861A1 (en) 2009-12-03
IL175958A0 (en) 2006-10-05
AU2004303735A1 (en) 2005-07-07
WO2005061499A1 (en) 2005-07-07
JP2007515476A (ja) 2007-06-14
US20070099945A1 (en) 2007-05-03
EP1699791A1 (en) 2006-09-13
ZA200605082B (en) 2007-11-28
KR20060117343A (ko) 2006-11-16
AR046992A1 (es) 2006-01-04
UY28694A1 (es) 2005-07-29
US7524856B2 (en) 2009-04-28
AU2004303735B2 (en) 2007-09-20

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