CN1899441A - Chinese medicine paste for burn and its preparing method - Google Patents
Chinese medicine paste for burn and its preparing method Download PDFInfo
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- CN1899441A CN1899441A CN 200610036331 CN200610036331A CN1899441A CN 1899441 A CN1899441 A CN 1899441A CN 200610036331 CN200610036331 CN 200610036331 CN 200610036331 A CN200610036331 A CN 200610036331A CN 1899441 A CN1899441 A CN 1899441A
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Abstract
The present invention relates to Chinese medicine ointment for treating burns and its preparation process. The Chinese medicine ointment for treating burns is prepared with rehmannia root and other ten kinds of Chinese medicinal materials, and through heating to extract in sesame oil, filtering, adding vegetable oil thickener and other steps. The present invention features the added vegetable oil thickener to replace traditional beeswax matrix, and the Chinese medicine ointment for treating burns has high clinical application value, and transport, carrying and use convenience.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of skin burn, scalding usefulness, particularly relate to a kind of preparation method that is used for the treatment of the shallow II degree and the Chinese medicine burn cream of dark II burn, scald.
Background technology
Burn and scald is a kind of damage that causes owing to heating power, electric energy, chemical substance, lonizing radiation etc., is clinical a kind of commonly encountered diseases.The scar healing of the pain of empyrosis wound surface, the necrosis progrediens that infects empyema, burn and scald tissue and dark II degree and III degree wound surface is the international four problems of treatment burn and scald.In recent years, the Chinese medicine burn and scald has been obtained gratifying achievement, and especially the processing to empyrosis wound surface has more distinctive feature, really reaches the effect of pain relieving, infection, wound repairing three aspects.
The Chinese medicine burn cream has the effect of removing pathogenic heat from blood and toxic substance from the body, promoting blood circulation and stopping pain, removing the necrotic tissue and promoting granulation, clinical shallow II degree of treatment and the dark II burn and scald of being widely used in; But from clinical operating position for many years, it is substrate that traditional Chinese medicine burn cream adopts Oleum Sesami and Cera Flava more, make ointment, such ointment internal structure is loose, and when temperature raises or storage time when oversize, the mastic surface has oil and oozes out, influence product appearance, the oily oxidation of oozing out causes mastic spoiled etc., influences the product result of use; On the other hand in transportation or use, be subjected to external force extruding, collision, thinning, the deliquescing of mastic meeting, and seepage appears, pollute outer package, use inconvenience, so a lot of similar products are indicated printed words such as " this product are met heat, pushed possibility deliquescing, thinning ... " in description [points for attention], directly influence the use of product so to a certain extent, limited the use on a large scale of Chinese medicine burn cream.
Summary of the invention
At the problem of above existence, the invention provides a kind of new-type traditional Chinese burn cream, promptly replace traditional Cera Flava as substrate with vegetable oil thickener, solve the Chinese medicine burn cream and preserved oil impregnate, spoiled etc. problem for a long time.Concrete technical scheme is as follows:
A kind of Chinese medicine burn cream is characterized in that being equipped with raw material by following proportioning: Radix Rehmanniae 15-20 part, Radix Et Rhizoma Rhei 15-30 part, Cortex Phellodendri 15-20 part, Calcitum rubrum 15-20 part, Radix Sanguisorbae 15-20 part, Cortex Moutan 8-15 part, Radix Arnebiae (Radix Lithospermi) 3-4 part, Radix Angelicae Sinensis 15-20 part, Olibanum 15-20 part, Myrrha 15-20 part, Borneolum Syntheticum 5-8 part, Radix Angelicae Dahuricae 10-20 part, Oleum Sesami 800-1500 part, vegetable oil thickener 30-80 part.
Described Chinese medicine burn cream, used vegetable oil thickener has: aluminium-magnesium silicate, modified montmorillonite used, sucrose fatty acid ester, trihydroxy stearic acid triglyceride or dimetylsilyl silicon dioxide.Choose any one kind of them during preparation, join in the filtrate according to above-mentioned prescription ratio, stir evenly, cooling all can be made described Chinese medicine burn cream.
Described Chinese medicine burn cream prepares by following preparation method: earlier borneol and grinding is become fine powder; Again 11 flavor pulverizing medicinal materials such as Radix Rehmanniae, Radix Et Rhizoma Rhei, Cortex Phellodendri, Calcitum rubrum, Radix Sanguisorbae, Cortex Moutan, Radix Arnebiae (Radix Lithospermi), Radix Angelicae Sinensis, Olibanum, Myrrha, the Radix Angelicae Dahuricae are become coarse granule, reuse Oleum Sesami floods a couple of days, and the extraction of heating then filters; In filtrate, add vegetable oil thickener, stir evenly, cooling; Cold slightly back adds above-mentioned Borneolum Syntheticum fine powder, stirs evenly, and cooling promptly makes required Chinese medicine burn cream.
In the described preparation method, borneol and grinding becomes fine powder, crosses 100 mesh sieves.
In the described preparation method, 11 flavor pulverizing medicinal materials such as Radix Rehmanniae become coarse granule, cross 40 mesh sieves, so that the extraction of medical material in Oleum Sesami.
In the described preparation method, the time of flooding with Oleum Sesami is 6-8 days, and the temperature of extraction is 110-150 ℃, and the time of extraction is 30-60 minute; The temperature that adds vegetable oil thickener is 80-100 ℃; The temperature that adds the Borneolum Syntheticum fine powder is 40-60 ℃.
In the described preparation method, it is to realize by Universalpulverizer that 11 flavor pulverizing medicinal materials are become coarse granule.
The inventor finds the novel vegetable oil thickener of a class by groping test for many years.This thickening agent is added in the vegetable oil (as Oleum Sesami), through the high temperature heating for dissolving, after the cooling, can make vegetable oil become the moderate semi-solid state mastic of denseness, adjusting the thickening agent consumption can make the mastic of making have stretchability preferably, use is smeared gently, can evenly be applied in skin, this mastic internal structure is gluey compact texture, is not subjected to the influence of temperature and storage time, also can not push because of external force, the collision and thinning, it is comparatively convenient to transport, the inventor is applied to this type of vegetable oil thickener in the Chinese medicine burn cream for this reason, replaces the Cera Flava substrate that traditional burn cream is used, and prepares the new-type traditional Chinese burn cream, solve the Chinese medicine burn cream and preserved oil impregnate for a long time, the problem of spoiled grade, and be convenient to transportation, carry, use more conveniently, have high clinical value.
Radix Rehmanniae sweetness and bitterness cold in the product, heat clearing and blood cooling, YIN nourishing skin moistening; The Radix Et Rhizoma Rhei bitter cold, clearing away heat and cooling blood, detoxification and removing stasis, both can clearing away heat,cooling blood and removing toxin, mutual reinforcement between is for dispeling the cause of disease, again can skin moistening with the protection wound surface, blood stasis dispelling is with reducing swelling and alleviating pain, so monarch drug in Radix Rehmanniae and the Radix Et Rhizoma Rhei side of being all.The Cortex Phellodendri bitter cold, heat clearing and damp drying, eliminating fire and detoxication; The Mirabilitum crystallina suffering is salty-cold, clearing away heat-fire; The Radix Sanguisorbae picric acid is cold, and heat clearing and damp drying, removing pathogenic heat from blood and toxic substance from the body all can strengthen the clearing away heat-fire effect of monarch drug Radix Rehmanniae, Radix Et Rhizoma Rhei, again can dampness and reduce wound secretion, help protecting wound surface.Cortex Moutan is arduous cool, clearing away heat and cooling blood, promoting blood circulation to remove blood stasis; The Radix Arnebiae (Radix Lithospermi) bitter cold, the removing heat from blood and promoting blood circulation detoxifcation all can strengthen the effect of monarch drug heat clearing and blood cooling, and can improve the wound surface blood supply, promotes wound healing.More than five medicines: ministerial drug in Cortex Phellodendri, Mirabilitum crystallina, Radix Sanguisorbae, Cortex Moutan and the Radix Arnebiae (Radix Lithospermi) side of being all.Radix Angelicae Sinensis Gan Xinwen, promoting blood circulation and stopping pain, moist skin; The arduous temperature of Olibanum, Myrrha is bitter flat, the analgesic therapy of invigorating blood circulation, detumescence and promoting granulation; Borneolum Syntheticum is arduous cool, the heat radiation pain relieving, and wherein Radix Angelicae Sinensis, Olibanum, Myrrha all can strengthen the effect of invigorating blood circulation of ministerial drug Cortex Moutan, Radix Arnebiae (Radix Lithospermi), improve the wound surface blood supply; Four all have analgesic activity, can help the principal drug assistance Radix Et Rhizoma Rhei to alleviate the hardship of burn local pain; Olibanum, Myrrha are worked in coordination, can also detumescence and promoting granulation, promote wound healing; The skin moistening effect of Radix Angelicae Sinensis assistant principal drug assistance Radix Rehmanniae.More than adjuvant drug in the four medicine sides of being all.The hot temperature of the Radix Angelicae Dahuricae, pain relieving granulation promoting, moist skin, can " in reach limbs; all over logical skin ", be the guide of all medicines, make it act on burn wound, can help the pain relieving of principal drug assistance Radix Et Rhizoma Rhei, the skin moistening of Radix Rehmanniae again, assist the granulation promoting of adjuvant drug Olibanum, Myrrha, so the adjuvant in the side of being.All medicines cooperates, and the effect of playing removing pathogenic heat from blood and toxic substance from the body, promoting blood circulation and stopping pain, removing the necrotic tissue and promoting granulation altogether is applicable to the wound of burn and scald.
The specific embodiment
Embodiment 1
Get Radix Rehmanniae 15g, Radix Et Rhizoma Rhei 15g, Cortex Phellodendri 15g, Calcitum rubrum 15g, Radix Sanguisorbae 15g, Cortex Moutan 8g, Radix Arnebiae (Radix Lithospermi) 3g, Radix Angelicae Sinensis 15g, Olibanum 15g, Myrrha 15g, Borneolum Syntheticum 5g, Radix Angelicae Dahuricae 10g, Oleum Sesami 800ml, aluminium-magnesium silicate 30g.
Earlier borneol and grinding is become fine powder, cross 100 mesh sieves; Again 11 flavor pulverizing medicinal materials such as Radix Rehmanniae, Radix Et Rhizoma Rhei, Cortex Phellodendri, Calcitum rubrum, Radix Sanguisorbae, Cortex Moutan, Radix Arnebiae (Radix Lithospermi), Radix Angelicae Sinensis, Olibanum, Myrrha, the Radix Angelicae Dahuricae are become coarse granule, cross 40 mesh sieves; Flooded 6 days with Oleum Sesami, be heated to 110 ℃ of extractions then, 60 minutes time, filter; Add aluminium-magnesium silicate 30g again in filtrate, adding temperature is 80 ℃, stirs evenly, and is cooled to 45 ℃; Add above-mentioned Borneolum Syntheticum fine powder, stir evenly, cooling promptly makes required Chinese medicine burn cream.
Be equipped with raw material in above ratio during batch process.
Embodiment 2
Get Radix Rehmanniae 18g, Radix Et Rhizoma Rhei 20g, Cortex Phellodendri 18g, Calcitum rubrum 18g, Radix Sanguisorbae 18g, Cortex Moutan 10g, Radix Arnebiae (Radix Lithospermi) 3.5g, Radix Angelicae Sinensis 18g, Olibanum 18g, Myrrha 18g, Borneolum Syntheticum 6g, Radix Angelicae Dahuricae 15g, Oleum Sesami 1000ml, sucrose fatty acid ester 40g.
Earlier borneol and grinding is become fine powder, cross 100 mesh sieves; Again 11 flavor pulverizing medicinal materials such as Radix Rehmanniae, Radix Et Rhizoma Rhei, Cortex Phellodendri, Calcitum rubrum, Radix Sanguisorbae, Cortex Moutan, Radix Arnebiae (Radix Lithospermi), Radix Angelicae Sinensis, Olibanum, Myrrha, the Radix Angelicae Dahuricae are become coarse granule, cross 40 mesh sieves; Flooded 7 days with Oleum Sesami, be heated to 120 ℃ of extractions then, 40 minutes time, filter; Add sucrose fatty acid ester 40g again in filtrate, adding temperature is 90 ℃, stirs evenly, and is cooled to 50 ℃; Add above-mentioned Borneolum Syntheticum fine powder, stir evenly, cooling promptly makes required Chinese medicine burn cream.
Be equipped with raw material in above ratio during batch process.
Embodiment 3
Get Radix Rehmanniae 20g, Radix Et Rhizoma Rhei 30g, Cortex Phellodendri 20g, Calcitum rubrum 20g, Radix Sanguisorbae 20g, Cortex Moutan 15g, Radix Arnebiae (Radix Lithospermi) 3.7g, Radix Angelicae Sinensis 20g, Olibanum 18g, Myrrha 18g, Borneolum Syntheticum 7g, Radix Angelicae Dahuricae 20g, Oleum Sesami 1200ml, trihydroxy stearic acid triglyceride 60g.
Earlier borneol and grinding is become fine powder, cross 100 mesh sieves; Again 11 flavor pulverizing medicinal materials such as Radix Rehmanniae, Radix Et Rhizoma Rhei, Cortex Phellodendri, Calcitum rubrum, Radix Sanguisorbae, Cortex Moutan, Radix Arnebiae (Radix Lithospermi), Radix Angelicae Sinensis, Olibanum, Myrrha, the Radix Angelicae Dahuricae are become coarse granule, cross 40 mesh sieves; Flooded 7 days with Oleum Sesami, be heated to 150 ℃ of extractions then, 60 minutes time, filter; Add trihydroxy stearic acid triglyceride 60g again in filtrate, adding temperature is 100 ℃, stirs evenly, and is cooled to 60 ℃; Add above-mentioned Borneolum Syntheticum fine powder, stir evenly, cooling promptly makes required Chinese medicine burn cream.
Be equipped with raw material in above ratio during batch process.
Embodiment 4
Get Radix Rehmanniae 18g, Radix Et Rhizoma Rhei 30g, Cortex Phellodendri 20g, Calcitum rubrum 20g, Radix Sanguisorbae 20g, Cortex Moutan 15g, Radix Arnebiae (Radix Lithospermi) 4.0g, Radix Angelicae Sinensis 20g, Olibanum 18g, Myrrha 18g, Borneolum Syntheticum 8g, Radix Angelicae Dahuricae 18g, Oleum Sesami 1500ml, dimetylsilyl silicon dioxide 70g.
Earlier borneol and grinding is become fine powder, cross 100 mesh sieves; Again 11 flavor pulverizing medicinal materials such as Radix Rehmanniae, Radix Et Rhizoma Rhei, Cortex Phellodendri, Calcitum rubrum, Radix Sanguisorbae, Cortex Moutan, Radix Arnebiae (Radix Lithospermi), Radix Angelicae Sinensis, Olibanum, Myrrha, the Radix Angelicae Dahuricae are become coarse granule, cross 40 mesh sieves; Flooded 8 days with Oleum Sesami, be heated to 140 ℃ of extractions then, 60 minutes time, filter; Add dimetylsilyl silicon dioxide 70g again in filtrate, adding temperature is 90 ℃, stirs evenly, and is cooled to 60 ℃; Add above-mentioned Borneolum Syntheticum fine powder, stir evenly, cooling promptly makes required Chinese medicine burn cream.
Be equipped with raw material in above ratio during batch process.
Embodiment 5
Get Radix Rehmanniae 20g, Radix Et Rhizoma Rhei 30g, Cortex Phellodendri 20g, Calcitum rubrum 20g, Radix Sanguisorbae 20g, Cortex Moutan 15g, Radix Arnebiae (Radix Lithospermi) 4.0g, Radix Angelicae Sinensis 20g, Olibanum 20g, Myrrha 20g, Borneolum Syntheticum 8g, Radix Angelicae Dahuricae 20g, Oleum Sesami 1500ml, modified montmorillonite used 80g.
Earlier borneol and grinding is become fine powder, cross 100 mesh sieves; Again 11 flavor pulverizing medicinal materials such as Radix Rehmanniae, Radix Et Rhizoma Rhei, Cortex Phellodendri, Calcitum rubrum, Radix Sanguisorbae, Cortex Moutan, Radix Arnebiae (Radix Lithospermi), Radix Angelicae Sinensis, Olibanum, Myrrha, the Radix Angelicae Dahuricae are become coarse granule, cross 40 mesh sieves; Flooded 8 days with Oleum Sesami, be heated to 140 ℃ of extractions then, 60 minutes time, filter; Add modified montmorillonite used 80g again in filtrate, adding temperature is 100 ℃, stirs evenly, and is cooled to 60 ℃; Add above-mentioned Borneolum Syntheticum fine powder, stir evenly, cooling promptly makes required Chinese medicine burn cream.
Be equipped with raw material in above ratio during batch process.
The Chinese medicine burn cream that the present invention is prepared, investigate test through long-time stability, meet the requirement of medicine agent stability assessment, product is through how tame medical institutions clinical verifications such as Affiliated Hospital of Zhongshan Medical Univ., 304 hospitals of PLA, effect with removing pathogenic heat from blood and toxic substance from the body, promoting blood circulation and stopping pain, removing the necrotic tissue and promoting granulation, be used for the treatment of shallow II degree and dark II degree burn and scald, determined curative effect.
Claims (7)
1. a Chinese medicine burn cream is characterized in that being equipped with raw material by following proportioning: Radix Rehmanniae 15-20 part, Radix Et Rhizoma Rhei 15-30 part, Cortex Phellodendri 15-20 part, Calcitum rubrum 15-20 part, Radix Sanguisorbae 15-20 part, Cortex Moutan 8-15 part, Radix Arnebiae (Radix Lithospermi) 3-4 part, Radix Angelicae Sinensis 15-20 part, Olibanum 15-20 part, Myrrha 15-20 part, Borneolum Syntheticum 5-8 part, Radix Angelicae Dahuricae 10-20 part, Oleum Sesami 800-1500 part, vegetable oil thickener 30-80 part.
2, Chinese medicine burn cream according to claim 1 is characterized in that described vegetable oil thickener is selected from aluminium-magnesium silicate, modified montmorillonite used, sucrose fatty acid ester, trihydroxy stearic acid triglyceride or dimetylsilyl silicon dioxide.
3, Chinese medicine burn cream according to claim 1 is characterized in that by the preparation of following preparation method: earlier borneol and grinding is become fine powder; Again 11 flavor pulverizing medicinal materials such as Radix Rehmanniae, Radix Et Rhizoma Rhei, Cortex Phellodendri, Calcitum rubrum, Radix Sanguisorbae, Cortex Moutan, Radix Arnebiae (Radix Lithospermi), Radix Angelicae Sinensis, Olibanum, Myrrha, the Radix Angelicae Dahuricae are become coarse granule, reuse Oleum Sesami floods a couple of days, and the extraction of heating then filters; In filtrate, add vegetable oil thickener, stir evenly, cooling; Cold slightly back adds above-mentioned Borneolum Syntheticum fine powder, stirs evenly, and cooling promptly makes required Chinese medicine burn cream.
4. the preparation method of Chinese medicine burn cream according to claim 3 is characterized in that: borneol and grinding becomes fine powder, crosses 100 mesh sieves.
5. the preparation method of Chinese medicine burn cream according to claim 3 is characterized in that: 11 flavor pulverizing medicinal materials such as Radix Rehmanniae become coarse granule, cross 40 mesh sieves.
6. the preparation method of Chinese medicine burn cream according to claim 3 is characterized in that: the time with the Oleum Sesami dipping is 6-8 days, and the temperature of extraction is 110-150 ℃, and the time of extraction is 30-60 minute; The temperature that adds vegetable oil thickener is 80-100 ℃; The temperature that adds Borneolum Syntheticum fine powder and Radix Et Rhizoma Rhei, Cortex Phellodendri fine powder is 40-60 ℃.
7, the preparation method of Chinese medicine burn cream according to claim 5 is characterized in that: 11 flavor pulverizing medicinal materials such as Radix Rehmanniae become coarse granule to realize by Universalpulverizer.
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CN101904973A (en) * | 2010-06-28 | 2010-12-08 | 江苏沙钢集团淮钢特钢有限公司 | External ointment for treating fire burn and scald and preparation method thereof |
CN102048894A (en) * | 2010-12-22 | 2011-05-11 | 陈远征 | Traditional Chinese medicine composition for treating burn and preparation method thereof |
CN101249215B (en) * | 2008-04-07 | 2011-06-01 | 喻永强 | Medicine for curing burn dressing and method of preparing the same |
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CN102327478A (en) * | 2011-09-28 | 2012-01-25 | 韩树华 | Pharmaceutical composition for treating burns and scalds and preparation method thereof |
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CN106177307A (en) * | 2016-08-08 | 2016-12-07 | 太仓张根木生物科技有限公司 | A kind of burn and scald externally applied anti-inflammation cream |
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Family Cites Families (2)
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CN1055297A (en) * | 1991-03-28 | 1991-10-16 | 许聿祥 | A kind of autofrettage of skin-moistening burn and scald medicine |
CN1046203C (en) * | 1992-05-10 | 1999-11-10 | 株洲市财贸职工医院 | Method for preparing moistening wound and burn ointment |
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CN101745090B (en) * | 2010-01-19 | 2012-06-27 | 王孔永 | Medicinal oil for treating burns and scalds and preparation method thereof |
CN101904973A (en) * | 2010-06-28 | 2010-12-08 | 江苏沙钢集团淮钢特钢有限公司 | External ointment for treating fire burn and scald and preparation method thereof |
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CN102327478B (en) * | 2011-09-28 | 2013-03-27 | 蔡圳 | Pharmaceutical composition for treating burns and scalds and preparation method thereof |
CN102327478A (en) * | 2011-09-28 | 2012-01-25 | 韩树华 | Pharmaceutical composition for treating burns and scalds and preparation method thereof |
CN103181976A (en) * | 2011-12-31 | 2013-07-03 | 上海金皮宝制药有限公司 | Burn cream transdermal patch |
CN102895526A (en) * | 2012-10-31 | 2013-01-30 | 唐和斌 | Externally-applied skin-generating oil for treatment of burn and preparation method and application thereof |
CN102895526B (en) * | 2012-10-31 | 2014-06-04 | 唐和斌 | Externally-applied skin-generating oil for treatment of burn and preparation method and application thereof |
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CN103599291A (en) * | 2013-11-20 | 2014-02-26 | 于田 | Ointment for treating burns and scalds |
CN103599291B (en) * | 2013-11-20 | 2016-05-25 | 于田 | A kind of ointment for the treatment of burn and scald |
CN106177307A (en) * | 2016-08-08 | 2016-12-07 | 太仓张根木生物科技有限公司 | A kind of burn and scald externally applied anti-inflammation cream |
CN106236955A (en) * | 2016-08-22 | 2016-12-21 | 杨晓琼 | A kind of medicament for treating scald compositions and preparation method thereof |
CN106177312A (en) * | 2016-08-26 | 2016-12-07 | 汪学增 | A kind of burn cream and preparation method thereof |
CN106177364A (en) * | 2016-08-29 | 2016-12-07 | 重庆骑士医院 | A kind of heat clearing away granulation promoting burn cream and preparation method thereof |
CN114699455A (en) * | 2022-01-13 | 2022-07-05 | 赵治国 | Medicine for treating non-healing burn and scald and preparation method thereof |
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Owner name: GUANGDONG TAI ANTANG PHARMACEUTICAL CO., LTD. Free format text: FORMER NAME: GUANGDONG PIBAO PHARMACEUTICAL CO., LTD. |
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CP01 | Change in the name or title of a patent holder |
Address after: 515021 Guangdong city of Shantou province 11R2-2 Jinyuan Industrial Zone area first, second Patentee after: Guangdong Taiantang Pharmaceutical Co., Ltd. Address before: 515021 Guangdong city of Shantou province 11R2-2 Jinyuan Industrial Zone area first, second Patentee before: Pibao Pharmaceutical Co., Ltd., Guangdong |