CN113663041A - Green compress ointment and preparation method thereof - Google Patents

Green compress ointment and preparation method thereof Download PDF

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Publication number
CN113663041A
CN113663041A CN202110898927.1A CN202110898927A CN113663041A CN 113663041 A CN113663041 A CN 113663041A CN 202110898927 A CN202110898927 A CN 202110898927A CN 113663041 A CN113663041 A CN 113663041A
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parts
radix
green
indigo naturalis
green plaster
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邱建华
欧昌坤
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Individual
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A—HUMAN NECESSITIES
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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Abstract

The invention discloses a green plaster and a preparation method thereof, wherein the green plaster comprises the following raw materials: indigo naturalis, radix angelicae, red paeony root, trichosanthes root, bletilla striata, golden cypress, turmeric, rhubarb and liquorice, wherein the raw materials comprise the following components in parts by weight: 10-20 parts of indigo naturalis, 10-20 parts of radix angelicae, 10-20 parts of radix paeoniae rubra, 10-20 parts of radix trichosanthis, 10-20 parts of bletilla striata, 6-15 parts of cortex phellodendri, 10-20 parts of turmeric, 10-20 parts of rheum officinale and 4-12 parts of liquorice; the preparation method of the green plaster comprises the following steps: putting indigo naturalis, radix Angelicae Dahuricae, radix Paeoniae Rubra, Trichosanthis radix, rhizoma Bletillae, cortex Phellodendri, Curcuma rhizome, radix et rhizoma Rhei and Glycyrrhrizae radix into a pulverizer, pulverizing, and sieving with 200 mesh sieve to obtain fine powder; adding 18-20 parts of raw powder and 5-9 parts of excipient into the crushed fine materials, and uniformly mixing to obtain a formed paste; uniformly coating the formed paste on far infrared functional cloth, and then sterilizing to obtain green paste; the green plaster prepared by the invention can effectively treat and prevent phlebitis.

Description

Green compress ointment and preparation method thereof
Technical Field
The invention relates to the field of traditional Chinese medicines, in particular to a green plaster and a preparation method thereof.
Background
Phlebitis is caused by damage to the intima of blood vessels due to hypertonic drugs, spasm of smooth muscles, hyperplasia of the intima of blood vessels, narrowing of the lumen, and slow blood flow. Clinically, phlebitis reactions of different degrees, such as streak-like red swelling and pain, induration and the like, occur in local veins caused by mechanical property and long-time infusion of high-concentration and strong-stimulation liquid medicine caused by using a small infusion steel needle, a shallow vein indwelling needle and a deep vein indwelling needle. This is related to the material of the catheter, the vascular condition of the patient, the puncture technique of the nurse, the nature of the medication used, the choice of the puncture site, the activity of the affected limb during the indwelling period, etc.; however, the drugs have high toxicity and strong irritation, and the phlebitis is easily caused by drug extravasation, and a plurality of methods for treating the phlebitis are reported, but the treatment effect and the prevention effect are not good.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a green plaster and a preparation method thereof, so as to at least achieve the aim of effectively treating and preventing phlebitis.
The purpose of the invention is realized by the following technical scheme: the green plaster comprises the following raw materials: indigo naturalis, radix angelicae, red paeony root, trichosanthes root, bletilla striata, golden cypress, turmeric, rhubarb and liquorice, wherein the raw materials comprise the following components in parts by weight: 10-20 parts of indigo naturalis, 10-20 parts of radix angelicae, 10-20 parts of radix paeoniae rubra, 10-20 parts of radix trichosanthis, 10-20 parts of bletilla striata, 6-15 parts of cortex phellodendri, 10-20 parts of turmeric, 10-20 parts of rheum officinale and 4-12 parts of liquorice.
Further, the weight parts of indigo naturalis, radix angelicae, radix paeoniae rubra, radix trichosanthis, bletilla striata, cortex phellodendri, rhizoma curcumae longae, rheum officinale and liquorice are 14-17 parts, 9-12 parts, 14-17 parts and 7-9 parts in sequence.
Furthermore, the weight parts of the indigo naturalis, the angelica dahurica, the red peony root, the trichosanthes root, the bletilla striata, the phellodendron, the turmeric, the rhubarb and the liquorice are 15 parts, 10 parts, 15 parts and 8 parts in sequence.
A preparation method of a green plaster comprises the following steps:
s1: putting 10-20 parts of indigo naturalis, 10-20 parts of radix angelicae, 10-20 parts of radix paeoniae rubra, 10-20 parts of radix trichosanthis, 10-20 parts of bletilla striata, 6-15 parts of cortex phellodendri, 10-20 parts of curcuma longa, 10-20 parts of rheum officinale and 4-12 parts of liquorice into a pulverizer to be pulverized, and sieving the pulverized materials by a 200-mesh sieve to obtain pulverized fine materials;
s2: adding 18-20 parts of raw powder and 5-9 parts of excipient into the crushed fine materials, and uniformly mixing to obtain a formed paste;
s3: and uniformly coating the formed paste on far infrared functional cloth, and sterilizing to obtain the green plaster, wherein the coating thickness of the formed paste is 0.13 mm.
Further, the far infrared functional cloth is obtained through the following steps:
s31: weighing 15-20 parts of alumina, 30-40 parts of selenium dioxide, 10-15 parts of titanium dioxide, 20-30 parts of silicon dioxide, 15-19 parts of ferroferric oxide, 2-5 parts of calcium oxide and 40-50 parts of loess stone, crushing and sieving by a 2000-mesh sieve to obtain a crushed raw material;
s32: adding 0.8-1.9 parts of polyvinyl alcohol, 0.4-1.2 parts of acrylic ester, 0.6-1.3 parts of amino modified organic acid milk and 110 parts of 100-organic water into the crushed raw materials, and stirring at the temperature of 150-170 ℃ and the pressure of 0.3MPa at the stirring speed of 80r/min for 30min to obtain a ceramic working solution;
s33: and uniformly spraying the ceramic working solution on medical cotton cloth, and then pre-drying, dehydrating, baking and shaping to obtain the far infrared functional cloth.
The ceramic working solution forms a biological ceramic layer on medical cotton cloth, the biological ceramic layer takes alumina and selenium dioxide as basic raw materials of the biological ceramic layer, titanium dioxide is added to improve the far infrared performance of the far biological ceramic layer, the emissivity of far infrared rays is improved, far infrared rays emitted by the selenium dioxide are beneficial to a human body, the far infrared emissivity of the whole biological ceramic layer is up to 98.4%, and the far infrared emissivity is easy to adhere to medical cotton after being treated by polyvinyl alcohol, acrylic ester and amino modified organic silicon acid milk, and simultaneously the hardness of the far infrared emissivity is reduced, so that discomfort can not be brought to a patient who uses the green dressing cream.
Further, the excipient is vaseline and lanolin, and the weight ratio of the added vaseline to the added lanolin is 5: 1.
Further, the processing temperature of the pre-drying dehydration is 105 ℃, and the time is 6-8 min; the processing temperature of baking and shaping is 200 ℃, and the time is 3-4 mim.
The formula of the green compress ointment related by the invention is as follows:
indigo naturalis: clearing away heat and toxic materials, relieving swelling, cooling blood, stopping bleeding, dredging meridians, and relieving pain;
radix angelicae: removing disease and dampness, promoting pus discharge and granulation, promoting blood circulation and relieving pain;
red peony root: clearing heat and cooling blood, promoting blood circulation and removing blood stasis;
trichosanthes root: clearing heat and purging fire, promoting fluid production to quench thirst, and relieving swelling and expelling pus;
bletilla striata: can be used for treating traumatic hemorrhage, pyocutaneous disease, toxic swelling, and chapped skin;
phellodendron bark: clearing heat and eliminating dampness, purging fire and removing steam, and removing toxic substance and treating sore;
turmeric: can promote qi circulation, remove blood stasis, dredge channels, relieve pain, and treat traumatic injury;
rhubarb: has effects in clearing away heat and dampness, purging pathogenic fire, cooling blood, removing blood stasis, and removing toxic materials;
licorice root: it can not only detoxify, but also clear heat, and harmonize radix Paeoniae Rubra to produce curative effect.
Phlebitis is caused by puncture injury in the injection process, and local vein blood circulation is unsmooth, blood stasis and stagnation cause pain; obstructed qi and blood, obstructed distribution of body fluids and swelling; blood stasis is accumulated in the body, and if the blood stasis is transformed into heat for a long time, local fever occurs; the generation mechanism is that qi stagnation and blood stasis, toxin and stagnation are in blood vessels, so that qi and blood circulation of local veins is not smooth, the veins are damaged, and blood overflows skin or blood heat is accumulated in the skin to cause local redness; if the medicine has high toxicity and strong irritation, phlebitis is more likely to be caused, and suppuration can be caused in serious cases; therefore, the prevention and treatment of phlebitis mainly comprises clearing heat, removing blood stasis, resolving masses, relieving swelling, detoxifying and cooling blood, and the detoxification is carried out by taking indigo naturalis as the main material and taking cortex phellodendri, rheum officinale and liquorice as the auxiliary materials; meanwhile, the liquorice regulates the red paeony root to clear heat and cool blood, activate blood and dissipate blood stasis; the angelica dahurica and the radix trichosanthis are used for cooperatively expelling pus, and the turmeric is used for promoting the circulation of qi, removing blood stasis, stimulating the menstrual flow and relieving pain; purging pathogenic fire, cooling blood and removing blood stasis with radix et rhizoma Rhei; healing wounds by bletilla striata; when the green dressing paste is used, a ceramic layer formed by ceramic working solution sprayed on the far infrared functional cloth can emit infrared rays with vibration frequency close to that of human cell molecules, the infrared rays penetrate into the body of a patient, resonance of atoms and molecules of the human cells can be caused, through resonance absorption, friction heat generation between molecules forms a thermal reaction, the temperature of a subcutaneous deep layer is promoted to rise, micro-blood vessels are expanded, blood circulation is accelerated, the accumulated matters of blood vessels and harmful substances in the body are favorably cleared, the obstacle hindering metabolism is cleared, tissues are revived again, enzyme generation is promoted, and the functions of activating blood, promoting tissue cells, preventing aging and strengthening an immune system are achieved; meanwhile, the far infrared functional cloth enables the green plaster to keep the physiological temperature of a human body about 37 ℃, does not cause secondary damage to the skin, blood vessels and tissues with pathological changes, is beneficial to medicine permeation and absorption, and enables the green plaster to keep certain humidity, thereby better exerting the curative effect.
The invention has the beneficial effects that: the green application paste provided by the invention has the advantages that the raw materials are easily available, no toxic or side effect is caused, the green application paste has the effects of detoxifying, clearing heat, removing blood stasis, resolving masses, diminishing swelling, cooling blood, removing pus and the like, phlebitis can be effectively treated and prevented, the vein of a patient is obviously protected, and the incidence rate of phlebitis in the treatment process is reduced; meanwhile, the far infrared functional cloth on the green plaster finished product can promote blood circulation, is beneficial to a patient to absorb medicine components, further eliminates toxic substances in blood, and further improves the treatment effect of the green plaster on phlebitis.
Detailed Description
The technical solutions of the present invention are described in further detail below, but the scope of the present invention is not limited to the following.
Example 1
The green plaster comprises the following raw materials in parts by weight: 10 parts of indigo naturalis, 10 parts of angelica dahurica, 10 parts of red peony root, 10 parts of trichosanthes root, 10 parts of bletilla striata, 6 parts of phellodendron, 10 parts of turmeric, 10 parts of rhubarb and 4 parts of liquorice.
Example 2
The green plaster comprises the following raw materials in parts by weight: 20 parts of indigo naturalis, 20 parts of angelica dahurica, 20 parts of red peony root, 20 parts of trichosanthes root, 20 parts of bletilla striata, 15 parts of phellodendron, 20 parts of turmeric, 20 parts of rhubarb and 12 parts of liquorice.
Example 3
The green plaster comprises the following raw materials in parts by weight: 14 parts of indigo naturalis, 14 parts of angelica dahurica, 14 parts of red peony root, 14 parts of trichosanthes root, 14 parts of bletilla striata, 9 parts of phellodendron, 14 parts of turmeric, 14 parts of rhubarb and 7 parts of liquorice.
Example 4
The green plaster comprises the following raw materials in parts by weight: 17 parts of indigo naturalis, 17 parts of angelica dahurica, 17 parts of red peony root, 17 parts of trichosanthes root, 17 parts of bletilla striata, 12 parts of phellodendron, 17 parts of turmeric, 17 parts of rhubarb and 9 parts of liquorice.
Example 5
The green plaster comprises the following raw materials in parts by weight: 15 parts of indigo naturalis, 15 parts of angelica dahurica, 15 parts of red peony root, 15 parts of trichosanthes root, 15 parts of bletilla striata, 10 parts of phellodendron, 15 parts of turmeric, 15 parts of rhubarb and 8 parts of liquorice.
A preparation method of a green plaster comprises the following steps:
s1: respectively putting the raw materials of the weight parts of the green compress cream described in the embodiment 1-the embodiment 5 into a pulverizer to be pulverized, and then sieving the pulverized materials by a 200-mesh sieve to obtain pulverized fine materials;
s2: adding raw powder and an excipient into the crushed fine materials according to the preparation data in the table 1, and uniformly mixing to obtain a formed paste, wherein the excipient is vaseline and lanolin, and the weight ratio of the added vaseline to the added lanolin is 5: 1;
s31: weighing aluminum oxide, selenium dioxide, titanium dioxide, silicon dioxide, ferroferric oxide, calcium oxide and loess stones according to the preparation data in the table 1, crushing and sieving with a 2000-mesh sieve to obtain crushed raw materials;
s32: adding polyvinyl alcohol, acrylic ester, amino modified organic acid milk and water into the crushed raw materials according to the preparation data in the table 1, stirring at a certain temperature and pressure intensity at a stirring speed of 80r/min for 30min to obtain a ceramic working solution, wherein the stirring is carried out in a Hastelloy high-pressure stirring kettle;
s33: uniformly spraying the ceramic working solution on medical cotton cloth, and then pre-drying, dehydrating, baking and shaping by the preparation data in the table 1 to obtain far infrared functional cloth;
s34: and (3) uniformly coating the formed paste on far infrared functional cloth, sterilizing to obtain green plaster, and performing an orthogonal test according to the preparation data in the table 1.
Table 1: data for preparing green plaster
Figure BDA0003195000760000041
Application examples: the green plaster raw materials of the examples 1 to 5 are prepared into corresponding green plasters according to the preparation method, the prepared corresponding green plasters are subjected to clinical tests, each green plaster corresponds to two groups of patients, one group is suffered from phlebitis, the other group is not suffered from phlebitis, each group is 20 patients, the disease severity, the disease course, the age and other basic data of each group of patients are compared, the difference has no statistical significance (P is more than 0.05), and the green plasters have comparability; the using method comprises the following steps: the green plaster is applied to the 3-4cm position of the two sides of the puncture vein, and is replaced every day for 4 days continuously.
Table 2: administration example data statistics
Figure BDA0003195000760000051
The effect is as follows: among patients with phlebitis, the cure rate of the group with the lowest cure rate is 93.4%, the cure rate of the group with the highest cure rate is 95.7%, and the effective rate is 100%; the incidence of phlebitis in the lowest group among patients without phlebitis was 3.7%, and the incidence of phlebitis in the highest group among patients without phlebitis was 6.1%; the green plaster of the group with the highest cure rate was the green plaster prepared according to the data of group 2 in example 5, and the green plaster of the group with the lowest disease rate was the green plaster prepared according to the data of group 1 in example 4.
The foregoing is illustrative of the preferred embodiments of this invention, and it is to be understood that the invention is not limited to the precise form disclosed herein and that various other combinations, modifications, and environments may be resorted to, falling within the scope of the concept as disclosed herein, either as described above or as apparent to those skilled in the relevant art. And that modifications and variations may be effected by those skilled in the art without departing from the spirit and scope of the invention as defined by the appended claims.

Claims (8)

1. The green plaster is characterized by comprising the following raw materials: indigo naturalis, radix Angelicae Dahuricae, radix Paeoniae Rubra, Trichosanthis radix, rhizoma Bletillae, cortex Phellodendri, Curcuma rhizome, radix et rhizoma Rhei and Glycyrrhrizae radix.
2. The green plaster of claim 1, wherein the raw materials comprise the following components in parts by weight: 10-20 parts of indigo naturalis, 10-20 parts of radix angelicae, 10-20 parts of radix paeoniae rubra, 10-20 parts of radix trichosanthis, 10-20 parts of bletilla striata, 6-15 parts of cortex phellodendri, 10-20 parts of turmeric, 10-20 parts of rheum officinale and 4-12 parts of liquorice.
3. The green plaster according to claim 1, wherein: the weight parts of the indigo naturalis, the angelica dahurica, the red paeony root, the Mongolian snakegourd root, the bletilla striata, the amur corktree bark, the turmeric, the rhubarb and the liquoric root are 14-17 parts, 9-12 parts, 14-17 parts and 7-9 parts in sequence.
4. The green plaster according to claim 1, wherein: the weight parts of the indigo naturalis, the angelica dahurica, the red paeony root, the Mongolian snakegourd root, the bletilla striata, the amur corktree bark, the turmeric, the rhubarb and the liquoric root are 15 parts, 10 parts, 15 parts and 8 parts in sequence.
5. The preparation method of the green plaster is characterized by comprising the following steps:
s1: putting 10-20 parts of indigo naturalis, 10-20 parts of radix angelicae, 10-20 parts of radix paeoniae rubra, 10-20 parts of radix trichosanthis, 10-20 parts of bletilla striata, 6-15 parts of cortex phellodendri, 10-20 parts of curcuma longa, 10-20 parts of rheum officinale and 4-12 parts of liquorice into a pulverizer to be pulverized, and sieving the pulverized materials by a 200-mesh sieve to obtain pulverized fine materials;
s2: adding 18-20 parts of raw powder and 5-9 parts of excipient into the crushed fine materials, and uniformly mixing to obtain a formed paste;
s3: and uniformly coating the formed paste on far infrared functional cloth, and sterilizing to obtain the green plaster, wherein the coating thickness of the formed paste is 0.13 mm.
6. The preparation method of the green plaster according to claim 5, wherein the far infrared functional cloth is obtained by the following steps:
s31: weighing 15-20 parts of alumina, 30-40 parts of selenium dioxide, 10-15 parts of titanium dioxide, 20-30 parts of silicon dioxide, 15-19 parts of ferroferric oxide, 2-5 parts of calcium oxide and 40-50 parts of loess stone, crushing and sieving by a 2000-mesh sieve to obtain a crushed raw material;
s32: adding 0.8-1.9 parts of polyvinyl alcohol, 0.4-1.2 parts of acrylic ester, 0.6-1.3 parts of amino modified organic acid milk and 110 parts of 100-organic water into the crushed raw materials, and stirring at the temperature of 150-170 ℃ and the pressure of 0.3MPa at the stirring speed of 80r/min for 30min to obtain a ceramic working solution;
s33: and uniformly spraying the ceramic working solution on medical cotton cloth, and then pre-drying, dehydrating, baking and shaping to obtain the far infrared functional cloth.
7. The method for preparing a green plaster according to claim 6, wherein the method comprises the following steps: the processing temperature of the pre-drying dehydration is 105 ℃, and the time is 6-8 min; the processing temperature of baking and shaping is 200 ℃, and the time is 3-4 mim.
8. The method for preparing a green plaster according to claim 5, wherein the method comprises the following steps: the excipient is vaseline and lanolin, and the weight ratio of the added vaseline to the added lanolin is 5: 1.
CN202110898927.1A 2021-08-03 2021-08-03 Green compress ointment and preparation method thereof Pending CN113663041A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107158575A (en) * 2017-06-12 2017-09-15 江西宜信堂医疗科技有限公司 A kind of quick patch of infrared nose and preparation method thereof

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Publication number Priority date Publication date Assignee Title
CN107158575A (en) * 2017-06-12 2017-09-15 江西宜信堂医疗科技有限公司 A kind of quick patch of infrared nose and preparation method thereof

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Application publication date: 20211119