CN106177364A

CN106177364A - A kind of heat clearing away granulation promoting burn cream and preparation method thereof

Info

Publication number: CN106177364A
Application number: CN201610781749.3A
Authority: CN
Inventors: 唐维礼; 周德勇
Original assignee: Chongqing Knight Hospital
Current assignee: Chongqing Knight Hospital
Priority date: 2016-08-29
Filing date: 2016-08-29
Publication date: 2016-12-07

Abstract

The invention discloses a kind of heat clearing away granulation promoting burn cream, be made up of following raw material: Radix Rehmanniae 55 65g, Fructus Gardeniae 55 65g, Fructus Forsythiae 55 65g, Cortex Phellodendri 65 75g, Rhizoma Coptidis 55 65g, Rhizoma Smilacis Glabrae 75 85g, Radix Scutellariae 55 65g, Herba Schizonepetae 55 65g, the Radix Angelicae Dahuricae 55 65g, Caulis Akebiae 55 65g, Gypsum Fibrosum 75 85g, Nidus Vespae 10 15g, Radix Et Rhizoma Rhei 35 45g, Periostracum Serpentis 8 12g, Olibanum 35 45g, Borneolum Syntheticum 65 75g, Resina Draconis 0.8 1.2g, Myrrha 35 45g, Rhizoma Polygoni Cuspidati 25 35g.The invention also discloses the preparation method of described heat clearing away granulation promoting burn cream.Heat clearing away granulation promoting burn cream of the present invention has heat-clearing and toxic substances removing, promoting diuresis to eliminate damp pathogen, reducing swelling and alleviating pain, puies forward effect of pus and growing muscle, it is adaptable to burns, scald, burn and skin ulceration, and cost is relatively low, is more easy to be accepted by extensive patients.

Description

A kind of heat clearing away granulation promoting burn cream and preparation method thereof

Technical field

The present invention relates to the field of Chinese medicines, specifically a kind of heat clearing away granulation promoting burn cream and preparation method thereof.

Background technology

In the market for the Chinese medicinal ointment of burn and scald, mainly have following several: 1) external curing that uses clinically Dressing, such as silver dressing, medical tomography Corii Sus domestica, allograft skin etc., these external curing dressing curative effects still can, but expense is costly, general Logical patient is difficult to undertake medical expense, therefore is difficult to clinically promote the use of on a large scale；2) spread in folk therapy burn and scald Secret recipe, the uncertain therapeutic efficacy of these secret recipes is cut, and is lacked necessary scientific appraisal, easily causes the state of an illness and is delayed, even results in and disable And the generation of the serious adverse consequences such as death.The Chinese patent medicine that traditional Chinese medical science aspect is used, its curative effect is inconspicuous and the course for the treatment of is longer, not only Add the misery of patient, and add the financial burden of patient home；3) traditional Chinese medicine plaster, its drug loading is few, uses if taking Method is not to causing medicated powder to stick in location for paste, it addition, poor air permeability, medicated powder is uneven at coated face, and making material glue can Can induce human body and produce allergy.For above-mentioned deficiency, in recent years, for treatment burn and scald, Chinese medicine is the most increasingly focused on The development and application of unguentum.

Summary of the invention

It is an object of the invention to provide a kind of heat clearing away granulation promoting burn cream and preparation method thereof, to solve above-mentioned background technology The problem of middle proposition.

For achieving the above object, the present invention provides following technical scheme:

A kind of heat clearing away granulation promoting burn cream, is made up of following raw material: Radix Rehmanniae 55-65g, Fructus Gardeniae 55-65g, Fructus Forsythiae 55-65g, Cortex Phellodendri 65-75g, Rhizoma Coptidis 55-65g, Rhizoma Smilacis Glabrae 75-85g, Radix Scutellariae 55-65g, Herba Schizonepetae 55-65g, Radix Angelicae Dahuricae 55-65g, Caulis Akebiae 55- 65g, Gypsum Fibrosum 75-85g, Nidus Vespae 10-15g, Radix Et Rhizoma Rhei 35-45g, Periostracum Serpentis 8-12g, Olibanum 35-45g, Borneolum Syntheticum 65-75g, Resina Draconis 0.8- 1.2g, Myrrha 35-45g, Rhizoma Polygoni Cuspidati 25-35g.

As the further scheme of the present invention: be made up of following raw material: Radix Rehmanniae 57-64g, Fructus Gardeniae 56-63g, Fructus Forsythiae 58- 63g, Cortex Phellodendri 67-72g, Rhizoma Coptidis 58-61g, Rhizoma Smilacis Glabrae 79-83g, Radix Scutellariae 56-64g, Herba Schizonepetae 58-62g, Radix Angelicae Dahuricae 57-63g, Caulis Akebiae 57-62g, Gypsum Fibrosum 78-81g, Nidus Vespae 11-14g, Radix Et Rhizoma Rhei 37-43g, Periostracum Serpentis 9-11g, Olibanum 38-42g, Borneolum Syntheticum 67-73g, Resina Draconis 0.9-1.1g, Myrrha 38-42g, Rhizoma Polygoni Cuspidati 27-32g.

As the present invention further scheme: be made up of following raw material: Radix Rehmanniae 60g, Fructus Gardeniae 60g, Fructus Forsythiae 60g, Huang Cypress 70g, Rhizoma Coptidis 60g, Rhizoma Smilacis Glabrae 80g, Radix Scutellariae 60g, Herba Schizonepetae 60g, Radix Angelicae Dahuricae 60g, Caulis Akebiae 60g, Gypsum Fibrosum 80g, Nidus Vespae 12g, Radix Et Rhizoma Rhei 40g, Periostracum Serpentis 10g, Olibanum 40g, Borneolum Syntheticum 70g, Resina Draconis 1g, Myrrha 40g, Rhizoma Polygoni Cuspidati 30g.

The preparation method of described heat clearing away granulation promoting burn cream, step is as follows:

1) clear paste is prepared；

1.1) weigh Gypsum Fibrosum, Gypsum Fibrosum is dried 4-7 hour at 55-65 DEG C, then pulverizes, cross 100 mesh sieves, it is thus achieved that Gypsum Fibrosum Powder；

1.2) in Gypsum Fibrosum powder, add appropriate water, make water lucky submergence Gypsum Fibrosum powder, soak 20-30 minute, it is thus achieved that Gypsum Fibrosum Immersion mixture；

1.3) add water in Gypsum Fibrosum immersion mixture, make water lucky submergence Gypsum Fibrosum powder, heated and boiled, and keep micro-boiling 1 little Time；

1.4) step 1.3 is repeated) three times, filter, stand, it is thus achieved that Gypsum Fibrosum leachate；

1.5) Radix Rehmanniae, Fructus Gardeniae, Fructus Forsythiae, Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, Herba Schizonepetae, the Radix Angelicae Dahuricae, Caulis Akebiae, Nidus Vespae, Radix Et Rhizoma Rhei, Olibanum are weighed And Myrrha, after mixing, add appropriate water, make water lucky submergence medical material, soak 2-3 days, it is thus achieved that medical material immersion mixture；

1.6) add water in medical material immersion mixture, make water lucky submergence medical material, heated and boiled, and keep micro-boiling 1 hour；

1.7) step 1.6 is repeated) three times, filter, stand, it is thus achieved that medical material leachate；

1.8) being mixed with medical material leachate by Gypsum Fibrosum leachate, filter, concentrating the filtrate to relative density at 60 DEG C is 1.08-1.15 clear paste；

2) in clear paste, the fine powder of remaining component is added, it is thus achieved that clear paste mixture；

2.1) weigh Rhizoma Smilacis Glabrae, Periostracum Serpentis, Borneolum Syntheticum, Resina Draconis and Rhizoma Polygoni Cuspidati, be dried 4-7 hour at 55-65 DEG C respectively, and respectively Pulverize, cross 100 mesh sieves, it is thus achieved that fine powder；

2.2) by step 2.1) fine powder that obtained carries out sterilization treatment by microwave bacteria degermer respectively；

2.3) by step 2.2) each fine powder after sterilizing, it is sequentially added into step 1.8) in the clear paste that obtained, and stir mixed Close uniformly, it is thus achieved that clear paste mixture；

3) preparation；

3.1) Oleum sesami is taken, heating, and maintain the temperature at 72-78 DEG C, as oil phase, standby；

3.2) qinghuo reagent mixture, is heated to 75 DEG C, adds sorbic acid and azone, after stirring and dissolving, as aqueous phase, standby With；

3.3) under agitation, gradually aqueous phase is added to oil phase, add appropriate water and carry out emulsifying, continue stirring extremely Mixture presents solid-state, stops stirring, samples quality inspection；

4) fill；

5) packaging；

6) finished product warehouse-in.

Described heat clearing away granulation promoting burn cream can be used in preparation treatment and burns, scalds, burns and the medicine of skin ulceration.

Compared with prior art, the invention has the beneficial effects as follows:

1, the crude drug heat-clearing and toxic substances removing of heat clearing away granulation promoting burn cream of the present invention, the effect of promoting diuresis to eliminate damp pathogen can allow burn surface locally Occur red, swollen, hot, bitterly well improved, while also can allow the quick granulation promoting of burn surface, incrustation, preventing from scar after recovery, There is heat-clearing and toxic substances removing, promoting diuresis to eliminate damp pathogen, reducing swelling and alleviating pain, put forward effect of pus and growing muscle, it is adaptable to burn, scald, burn and skin is burst Rotten；

2, the preparation method of heat clearing away granulation promoting burn cream of the present invention, uses water extraction to extract Chinese medicine, makes the active ingredient of Chinese medicine Easily overflowing, water this ratio of deducting a percentage is relatively low simultaneously.Using oil-in-water to make unguentum, water is dispersion phase, and skin and the affinity of water Height, skin can preferably be received.It addition, the preservative sorbic acid adding highly effective and safe makes unguentum effect duration be guaranteed, add Enter cosolvent azone and can allow the effective ingredient dissolution of medical material, improve the utilization rate of medical material.

3, the operation strategies of heat clearing away granulation promoting burn cream of the present invention is wide, the most only for burn, to scalding, burn, skin Good curative effect can also be played for the patient of skin ulcer, and cost is relatively low, be more easy to be accepted by extensive patients.

Detailed description of the invention

Below in conjunction with detailed description of the invention, technical scheme is described in more detail.

Embodiment 1

A kind of heat clearing away granulation promoting burn cream, is made up of following raw material: Radix Rehmanniae 60g, Fructus Gardeniae 60g, Fructus Forsythiae 60g, Cortex Phellodendri 70g, Rhizoma Coptidis 60g, Rhizoma Smilacis Glabrae 80g, Radix Scutellariae 60g, Herba Schizonepetae 60g, Radix Angelicae Dahuricae 60g, Caulis Akebiae 60g, Gypsum Fibrosum 80g, Nidus Vespae 12g, Radix Et Rhizoma Rhei 40g, Serpentis Slough off 10g, Olibanum 40g, Borneolum Syntheticum 70g, Resina Draconis 1g, Myrrha 40g, Rhizoma Polygoni Cuspidati 30g.

In the present embodiment, the preparation method of described heat clearing away granulation promoting burn cream, step is as follows:

1) clear paste is prepared；

1.1) weigh Gypsum Fibrosum, Gypsum Fibrosum is dried 5 hours at 60 DEG C, then pulverizes, cross 100 mesh sieves, it is thus achieved that Gypsum Fibrosum powder；

1.2) in Gypsum Fibrosum powder, add appropriate water, make water lucky submergence Gypsum Fibrosum powder, soak 25 minutes, it is thus achieved that Gypsum Fibrosum soaks Mixture；

1.5) Radix Rehmanniae, Fructus Gardeniae, Fructus Forsythiae, Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, Herba Schizonepetae, the Radix Angelicae Dahuricae, Caulis Akebiae, Nidus Vespae, Radix Et Rhizoma Rhei, Olibanum are weighed And Myrrha, after mixing, add appropriate water, make water lucky submergence medical material, soak 2.5 days, it is thus achieved that medical material immersion mixture；

1.8) being mixed with medical material leachate by Gypsum Fibrosum leachate, filter, concentrating the filtrate to relative density at 60 DEG C is 1.12 clear paste；

2.1) weigh Rhizoma Smilacis Glabrae, Periostracum Serpentis, Borneolum Syntheticum, Resina Draconis and Rhizoma Polygoni Cuspidati, be dried 5 hours at 60 DEG C respectively, and pulverize respectively, Cross 100 mesh sieves, it is thus achieved that fine powder；

3) preparation；

3.1) Oleum sesami is taken, heating, and maintain the temperature at 75 DEG C, as oil phase, standby；

4) fill；

5) packaging；

6) finished product warehouse-in.

Embodiment 2

A kind of heat clearing away granulation promoting burn cream, is made up of following raw material: Radix Rehmanniae 55g, Fructus Gardeniae 55g, Fructus Forsythiae 55g, Cortex Phellodendri 65, Huang Even 55g, Rhizoma Smilacis Glabrae 75g, Radix Scutellariae 55g, Herba Schizonepetae 55g, Radix Angelicae Dahuricae 55g, Caulis Akebiae 55g, Gypsum Fibrosum 75g, Nidus Vespae 10g, Radix Et Rhizoma Rhei 35g, Periostracum Serpentis 8g, Olibanum 35g, Borneolum Syntheticum 65g, Resina Draconis 0.8g, Myrrha 35g, Rhizoma Polygoni Cuspidati 25g.

1) clear paste is prepared；

1.1) weigh Gypsum Fibrosum, Gypsum Fibrosum is dried 4 hours at 55 DEG C, then pulverizes, cross 100 mesh sieves, it is thus achieved that Gypsum Fibrosum powder；

1.2) in Gypsum Fibrosum powder, add appropriate water, make water lucky submergence Gypsum Fibrosum powder, soak 20 minutes, it is thus achieved that Gypsum Fibrosum soaks Mixture；

1.5) Radix Rehmanniae, Fructus Gardeniae, Fructus Forsythiae, Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, Herba Schizonepetae, the Radix Angelicae Dahuricae, Caulis Akebiae, Nidus Vespae, Radix Et Rhizoma Rhei, Olibanum are weighed And Myrrha, after mixing, add appropriate water, make water lucky submergence medical material, soak 2 days, it is thus achieved that medical material immersion mixture；

1.8) being mixed with medical material leachate by Gypsum Fibrosum leachate, filter, concentrating the filtrate to relative density at 60 DEG C is 1.08 clear paste；

2.1) weigh Rhizoma Smilacis Glabrae, Periostracum Serpentis, Borneolum Syntheticum, Resina Draconis and Rhizoma Polygoni Cuspidati, be dried 4 hours at 55 DEG C respectively, and pulverize respectively, Cross 100 mesh sieves, it is thus achieved that fine powder；

3) preparation；

3.1) Oleum sesami is taken, heating, and maintain the temperature at 72 DEG C, as oil phase, standby；

4) fill；

5) packaging；

6) finished product warehouse-in.

Embodiment 3

A kind of heat clearing away granulation promoting burn cream, is made up of following raw material: Radix Rehmanniae 58g, Fructus Gardeniae 57g, Fructus Forsythiae 60g, Cortex Phellodendri 69g, Rhizoma Coptidis 61g, Rhizoma Smilacis Glabrae 77g, Radix Scutellariae 58g, Herba Schizonepetae 56g, Radix Angelicae Dahuricae 55g, Caulis Akebiae 62g, Gypsum Fibrosum 78g, Nidus Vespae 12g, Radix Et Rhizoma Rhei 39g, Serpentis Slough off 11g, Olibanum 37g, Borneolum Syntheticum 68g, Resina Draconis 0.9g, Myrrha 38g, Rhizoma Polygoni Cuspidati 27g.

1) clear paste is prepared；

1.1) weigh Gypsum Fibrosum, Gypsum Fibrosum is dried 5 hours at 58 DEG C, then pulverizes, cross 100 mesh sieves, it is thus achieved that Gypsum Fibrosum powder；

1.2) in Gypsum Fibrosum powder, add appropriate water, make water lucky submergence Gypsum Fibrosum powder, soak 23 minutes, it is thus achieved that Gypsum Fibrosum soaks Mixture；

1.8) being mixed with medical material leachate by Gypsum Fibrosum leachate, filter, concentrating the filtrate to relative density at 60 DEG C is 1.10 clear paste；

2.1) weigh Rhizoma Smilacis Glabrae, Periostracum Serpentis, Borneolum Syntheticum, Resina Draconis and Rhizoma Polygoni Cuspidati, be dried 5 hours at 56 DEG C respectively, and pulverize respectively, Cross 100 mesh sieves, it is thus achieved that fine powder；

3) preparation；

3.1) Oleum sesami is taken, heating, and maintain the temperature at 74 DEG C, as oil phase, standby；

4) fill；

5) packaging；

6) finished product warehouse-in.

Embodiment 4

A kind of heat clearing away granulation promoting burn cream, is made up of following raw material: Radix Rehmanniae 62g, Fructus Gardeniae 59g, Fructus Forsythiae 63g, Cortex Phellodendri 68g, Rhizoma Coptidis 56g, Rhizoma Smilacis Glabrae 84g, Radix Scutellariae 61g, Herba Schizonepetae 60g, Radix Angelicae Dahuricae 57g, Caulis Akebiae 59g, Gypsum Fibrosum 83g, Nidus Vespae 14g, Radix Et Rhizoma Rhei 39g, Serpentis Slough off 9g, Olibanum 36g, Borneolum Syntheticum 72g, Resina Draconis 1.1g, Myrrha 36g, Rhizoma Polygoni Cuspidati 29g.

1) clear paste is prepared；

1.1) weigh Gypsum Fibrosum, Gypsum Fibrosum is dried 6 hours at 62 DEG C, then pulverizes, cross 100 mesh sieves, it is thus achieved that Gypsum Fibrosum powder；

1.2) in Gypsum Fibrosum powder, add appropriate water, make water lucky submergence Gypsum Fibrosum powder, soak 28 minutes, it is thus achieved that Gypsum Fibrosum soaks Mixture；

1.5) Radix Rehmanniae, Fructus Gardeniae, Fructus Forsythiae, Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, Herba Schizonepetae, the Radix Angelicae Dahuricae, Caulis Akebiae, Nidus Vespae, Radix Et Rhizoma Rhei, Olibanum are weighed And Myrrha, after mixing, add appropriate water, make water lucky submergence medical material, soak 3 days, it is thus achieved that medical material immersion mixture；

1.8) being mixed with medical material leachate by Gypsum Fibrosum leachate, filter, concentrating the filtrate to relative density at 60 DEG C is 1.13 clear paste；

2.1) weigh Rhizoma Smilacis Glabrae, Periostracum Serpentis, Borneolum Syntheticum, Resina Draconis and Rhizoma Polygoni Cuspidati, be dried 5 hours at 63 DEG C respectively, and pulverize respectively, Cross 100 mesh sieves, it is thus achieved that fine powder；

3) preparation；

3.1) Oleum sesami is taken, heating, and maintain the temperature at 76 DEG C, as oil phase, standby；

4) fill；

5) packaging；

6) finished product warehouse-in.

Embodiment 5

A kind of heat clearing away granulation promoting burn cream, is made up of following raw material: Radix Rehmanniae 65g, Fructus Gardeniae 65g, Fructus Forsythiae 65g, Cortex Phellodendri 75g, Rhizoma Coptidis 65g, Rhizoma Smilacis Glabrae 85g, Radix Scutellariae 65g, Herba Schizonepetae 65g, Radix Angelicae Dahuricae 65g, Caulis Akebiae 65g, Gypsum Fibrosum 85g, Nidus Vespae 15g, Radix Et Rhizoma Rhei 45g, Serpentis Slough off 12g, Olibanum 45g, Borneolum Syntheticum 75g, Resina Draconis 1.2g, Myrrha 45g, Rhizoma Polygoni Cuspidati 35g.

1) clear paste is prepared；

1.1) weigh Gypsum Fibrosum, Gypsum Fibrosum is dried 7 hours at 65 DEG C, then pulverizes, cross 100 mesh sieves, it is thus achieved that Gypsum Fibrosum powder；

1.2) in Gypsum Fibrosum powder, add appropriate water, make water lucky submergence Gypsum Fibrosum powder, soak 30 minutes, it is thus achieved that Gypsum Fibrosum soaks Mixture；

1.8) being mixed with medical material leachate by Gypsum Fibrosum leachate, filter, concentrating the filtrate to relative density at 60 DEG C is 1.15 clear paste；

2.1) weigh Rhizoma Smilacis Glabrae, Periostracum Serpentis, Borneolum Syntheticum, Resina Draconis and Rhizoma Polygoni Cuspidati, be dried 7 hours at 65 DEG C respectively, and pulverize respectively, Cross 100 mesh sieves, it is thus achieved that fine powder；

3) preparation；

3.1) Oleum sesami is taken, heating, and maintain the temperature at 78 DEG C, as oil phase, standby；

4) fill；

5) packaging；

6) finished product warehouse-in.

In the present invention, effect of each medical material is as follows:

Radix Rehmanniae: the heart-yin is induced sweat, heat-clearing and toxic substances removing Fructus Gardeniae: removing heat from blood, reducing swelling and alleviating pain Fructus Forsythiae: solve the heat of wind and cold, dissipating blood stasis for subsidence of swelling Huang Cypress: heat clearing away Rhizoma Coptidis: clearing away heat-fire Rhizoma Smilacis Glabrae: removing toxic substances Radix Scutellariae: carry pus and growing muscle, heat-clearing and toxic substances removing Herba Schizonepetae: induce sweat, stop blooding the Radix Angelicae Dahuricae: detumescence Caulis Akebiae: infiltration, the meridian dredging Nidus Vespae: pain relieving Radix Et Rhizoma Rhei: pain relieving Periostracum Serpentis: detumescence Olibanum: detumescence Borneolum Syntheticum: recover granulation promoting Resina Draconis: antiinflammatory, only Blood granulation promoting, eliminating stasis to stop pain Myrrha: dissipating blood stasis analgesic therapy, detumescence and promoting granulation Rhizoma Polygoni Cuspidati: heat-clearing and toxic substances removing, eliminating stasis to stop pain.

The effect that in the present invention, each Chinese crude drug and adjuvant play in burn is as follows: for fire victim, burn Position there will be red, swollen, hot, the symptom of pain；Radix Rehmanniae, Fructus Forsythiae, Cortex Phellodendri, Gypsum Fibrosum have the effect of heat clearing away, and several persons are combined The effect of good heat clearing away can be played.Fructus Gardeniae, the Radix Angelicae Dahuricae, Periostracum Serpentis, Olibanum have effect of detumescence, and four share and can allow detumescence Double.Nidus Vespae, Radix Scutellariae, Rhizoma Polygoni Cuspidati, Rhizoma Smilacis Glabrae heat-clearing and toxic substances removing, Myrrha detumescence and promoting granulation, Radix Scutellariae carry pus and growing muscle, Borneolum Syntheticum recovers granulation promoting, blood Scorpion hemostasia and promoting granulation makes burned part be dried rapidly, easily forms a scab.Radix Et Rhizoma Rhei, Nidus Vespae pain relieving, Rhizoma Polygoni Cuspidati, Resina Draconis, Myrrha all have dissipating blood stasis Effect of pain relieving, can make fire victim injury reduce pain, and dissipating blood stasis promotes that burn surface recovers.Sorbic acid, for preservative, Expiration date of drug is made to be guaranteed.Azone, for penetrating agent, promotes the burned part absorption to each Chinese crude drug, thus preferably reaches To detumescence, heat clearing away, the effect of pain relieving.

The crude drug heat-clearing and toxic substances removing of heat clearing away granulation promoting burn cream of the present invention, the effect of promoting diuresis to eliminate damp pathogen can allow burn surface local go out Existing red, swollen, hot, pain is well improved, and also can allow the quick granulation promoting of burn surface, incrustation simultaneously, preventing from scar after recovery, tool There are heat-clearing and toxic substances removing, promoting diuresis to eliminate damp pathogen, reducing swelling and alleviating pain, put forward effect of pus and growing muscle, it is adaptable to burn, scald, burn and skin ulceration； The preparation method of heat clearing away granulation promoting burn cream of the present invention, uses water extraction to extract Chinese medicine, makes the active ingredient of Chinese medicine easily overflow, with Time water this ratio of deducting a percentage relatively low.Using oil-in-water to make unguentum, water is dispersion phase, and the affinity of skin and water is high, allows the skin can Preferably to receive.It addition, the preservative sorbic acid adding highly effective and safe makes unguentum effect duration be guaranteed, add cosolvent azone Can allow the effective ingredient dissolution of medical material, improve the utilization rate of medical material.The operation strategies of heat clearing away granulation promoting burn cream of the present invention is wide, no The most only for burn, good curative effect can also be played to scalding, burn, for the patient of skin ulcer, and cost is relatively Low, it is more easy to be accepted by extensive patients.

Assay

1) Rhizoma Smilacis Glabrae extract astilbin

Assay method: high performance liquid chromatography

Chromatographic condition is tested with system suitability: with octadecylsilane chemically bonded silica as filler；With methanol-0.1% Glacial acetic acid solution (39:61) is flowing phase；Detection wavelength is 291nm.Number of theoretical plate is calculated should be not less than by astilbin peak 5000。

Prepared by reference substance solution: take astilbin reference substance appropriate, accurately weighed, adds 60% methanol and makes every 1ml and contain The solution of 0.2mg, to obtain final product.

The preparation of need testing solution: the Indian Bread that fetches earth (crossing No. two sieves) about 0.8g, accurately weighed.Put in round-bottomed flask, Accurate addition 60% methanol 100ml, weighed weight, it is heated to reflux 1 hour, lets cool, more weighed weight, supply with 60% methanol and subtract Weight loss, shakes up；Filter, take subsequent filtrate, to obtain final product.

Algoscopy: precision draws reference substance solution and each 10ul of need testing solution respectively, injects chromatograph of liquid, measures, Obtain.

This product is pressed dry product and is calculated, must not be less than 0.45% containing astilbin (C21H22O11).

2) Fructus Forsythiae extract phillyrin

Assay method: high performance liquid chromatography

Chromatographic condition and system suitability: be filler with octadecylsilane chemically bonded silica；Acetonitrile-water (25: 75) for flowing phase；Detection wavelength is that 277nm. number of theoretical plate should be not less than 3000 by the calculating of phillyrin peak.

The preparation of reference substance solution: it is appropriate that precision weighs phillyrin reference substance, adds methanol and makes molten containing 0.2mg of every 1ml Liquid, to obtain final product.

The preparation of need testing solution: take this product powder about 1g, accurately weighed, to put in tool plug conical flask, precision adds methanol 15ml, close plug, weighed weight, steeped overnight, supersound process 25 minutes, let cool, close plug, more weighed weight, supply with methanol and subtract The weight lost, shakes up, and filters, and precision measures subsequent filtrate 5ml, steams near dry, adds neutral alumina 0.5g and mix thoroughly, be added on neutral oxygen Change on aluminum post (100～120 mesh, 1g, internal diameter 1～1.5cm), with 70% ethanol 80ml eluting, collect eluent, be concentrated to dryness, Residue is transferred in 5ml measuring bottle after dissolving with 50% methanol, and is diluted to scale, shakes up, and filters with microporous filter membrane (0.45 μm), Obtain.

Algoscopy: precision draws reference substance solution and each 10 μ l of need testing solution respectively, injects chromatograph of liquid, measures, Obtain.

This product is pressed dry product and is calculated, containing phillyrin (C29H36O11)) must not be less than 0.15%.

Raw material differentiates

1) Fructus Forsythiae

Algoscopy: thin layer chromatography.

Take Weeping Forsythia Capsule 1g, add petroleum ether (30-60 DEG C) 20ml, close plug, supersound process 15 minutes, filter, discard oil Ether liquid, residue volatilizes petroleum ether, adds methanol 20ml, close plug, supersound process 20 minutes, filters, and filtrate is evaporated, and residue adds methanol 5ml makes dissolving, as need testing solution.Separately take Fructus Forsythiae control medicinal material 1g, be made in the same way of control medicinal material solution.Take phillyrin pair again According to product, add methanol and make every 1ml solution containing 0.25mg, as reference substance solution, test according to thin layer chromatography, draw above-mentioned three Plant solution lattice 3ul, put respectively on same silica gel g thin-layer plate, with chloroform-methanol (8:1) as developing solvent, launch, take out, Drying, spray, with 10% ethanol solution of sulfuric acid, is heated to spot development at 105 DEG C clear.In test sample chromatograph, with reference substance medicine On material and the corresponding position of reference substance chromatograph, the speckle of aobvious same color.

Check impurity: green grass or young crops must not stick up 3%, always must not stick up 9%

Moisture: 10.0% must not be crossed

Total ash: 4.0% must not be crossed

Extractum: measuring according to the cold-maceration under ethanol-soluble extractives algoscopy item, make solvent with 65% ethanol, green grass or young crops must not stick up Less than 30.0%；Always must not stick up less than 13.0%.

2) Rhizoma Smilacis Glabrae

Measure and send out: thin layer chromatography.

Take this product powder 1g, add methanol 20ml, supersound process 30 minutes, filter, take filtrate as need testing solution, separately take Astilbin is reference substance, adds methanol and makes every 1ml solution containing 0.1mg, as reference substance solution.Try according to thin layer chromatography Test, draw each 10ul of above two solution, put respectively on same silica gel g thin-layer plate, with toluene-ethyl ester acetic acid-formic acid (13: 32:9) being developing solvent, launch, take out, dry, spray, with aluminum chloride test solution, after imitated 5 minutes, is put under ultra-violet lamp (365nm) Inspect.In test sample chromatograph, on position corresponding with reference substance chromatograph, the fluorescence speckle of aobvious same color.

Check: moisture must not cross 15.0%

Total ash: 5.0% must not be crossed

Extractum: measure according to the hot dipping under ethanol-soluble extractives algoscopy item, make solvent with Diluted Alcohol, must not be less than 15.0%.

Above the better embodiment of the present invention is explained in detail, but the present invention is not limited to above-mentioned embodiment party Formula, in the ken that one skilled in the relevant art is possessed, it is also possible on the premise of without departing from present inventive concept Various changes can be made.

Claims

1. a heat clearing away granulation promoting burn cream, it is characterised in that be made up of following raw material: Radix Rehmanniae 55-65g, Fructus Gardeniae 55-65g, company Stick up 55-65g, Cortex Phellodendri 65-75g, Rhizoma Coptidis 55-65g, Rhizoma Smilacis Glabrae 75-85g, Radix Scutellariae 55-65g, Herba Schizonepetae 55-65g, Radix Angelicae Dahuricae 55-65g, Caulis Akebiae 55-65g, Gypsum Fibrosum 75-85g, Nidus Vespae 10-15g, Radix Et Rhizoma Rhei 35-45g, Periostracum Serpentis 8-12g, Olibanum 35-45g, Borneolum Syntheticum 65-75g, Resina Draconis 0.8-1.2g, Myrrha 35-45g, Rhizoma Polygoni Cuspidati 25-35g.

Heat clearing away granulation promoting burn cream the most according to claim 1, it is characterised in that be made up of following raw material: Radix Rehmanniae 57- 64g, Fructus Gardeniae 56-63g, Fructus Forsythiae 58-63g, Cortex Phellodendri 67-72g, Rhizoma Coptidis 58-61g, Rhizoma Smilacis Glabrae 79-83g, Radix Scutellariae 56-64g, Herba Schizonepetae 58-62g, Radix Angelicae Dahuricae 57-63g, Caulis Akebiae 57-62g, Gypsum Fibrosum 78-81g, Nidus Vespae 11-14g, Radix Et Rhizoma Rhei 37-43g, Periostracum Serpentis 9-11g, Olibanum 38-42g, Borneolum Syntheticum 67-73g, Resina Draconis 0.9-1.1g, Myrrha 38-42g, Rhizoma Polygoni Cuspidati 27-32g.

Heat clearing away granulation promoting burn cream the most according to claim 2, it is characterised in that be made up of following raw material: Radix Rehmanniae 60g, Fructus Gardeniae 60g, Fructus Forsythiae 60g, Cortex Phellodendri 70g, Rhizoma Coptidis 60g, Rhizoma Smilacis Glabrae 80g, Radix Scutellariae 60g, Herba Schizonepetae 60g, Radix Angelicae Dahuricae 60g, Caulis Akebiae 60g, stone Cream 80g, Nidus Vespae 12g, Radix Et Rhizoma Rhei 40g, Periostracum Serpentis 10g, Olibanum 40g, Borneolum Syntheticum 70g, Resina Draconis 1g, Myrrha 40g, Rhizoma Polygoni Cuspidati 30g.

4. the heat clearing away granulation promoting burn cream as described in claim 1-3 is arbitrary burn in preparation treatment, scalds, is burnt and skin is routed Purposes in rotten medicine.

5. the preparation method of the heat clearing away granulation promoting burn cream as described in claim 1-3 is arbitrary, it is characterised in that step is such as Under:

1) clear paste is prepared；

1.2) in Gypsum Fibrosum powder, add appropriate water, make water lucky submergence Gypsum Fibrosum powder, soak 20-30 minute, it is thus achieved that Gypsum Fibrosum soaks Mixture；

1.3) add water in Gypsum Fibrosum immersion mixture, make water lucky submergence Gypsum Fibrosum powder, heated and boiled, and keep micro-boiling 1 hour；

1.5) weigh Radix Rehmanniae, Fructus Gardeniae, Fructus Forsythiae, Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, Herba Schizonepetae, the Radix Angelicae Dahuricae, Caulis Akebiae, Nidus Vespae, Radix Et Rhizoma Rhei, Olibanum and do not have Medicine, after mixing, adds appropriate water, makes water lucky submergence medical material, soaks 2-3 days, it is thus achieved that medical material immersion mixture；

1.8) being mixed with medical material leachate by Gypsum Fibrosum leachate, filter, concentrating the filtrate to relative density at 60 DEG C is 1.08- 1.15 clear paste；

2.1) weigh Rhizoma Smilacis Glabrae, Periostracum Serpentis, Borneolum Syntheticum, Resina Draconis and Rhizoma Polygoni Cuspidati, be dried 4-7 hour at 55-65 DEG C respectively, and powder respectively Broken, cross 100 mesh sieves, it is thus achieved that fine powder；

2.3) by step 2.2) each fine powder after sterilizing, it is sequentially added into step 1.8) in the clear paste that obtained, and stir mixing all Even, it is thus achieved that clear paste mixture；

3) preparation；

3.2) qinghuo reagent mixture, is heated to 75 DEG C, adds sorbic acid and azone, after stirring and dissolving, as aqueous phase, standby；

3.3) under agitation, gradually aqueous phase is added to oil phase, add appropriate water and carry out emulsifying, continue stirring to mixing Thing presents solid-state, stops stirring, samples quality inspection；

4) fill；

5) packaging；

6) finished product warehouse-in.