CN105168784B - Five osmanthus temperature are through piece and preparation method - Google Patents

Abstract

The invention discloses a kind of five osmanthus temperature through piece and preparation method, it is related to technical field of Chinese medicine, its effective component is made of the raw material of following parts by weight: excrementum pteropi 175-180g, charred POLLEN TYPHAE 175-180g, Resina Draconis 95-100g, aspongopus 130-135g, Radix Paeoniae Alba 175-180g, hawthorn 85-90g, ramulus cinnamomi 85-90 g, radix aucklandiae 40-50g, tangerine seed 130-135g, Radix Glycyrrhizae 85-90g.The present invention can solve the problem of diseases such as dysmenorrhes, menstrual discomfort.

Description

Five osmanthus temperature are through piece and preparation method

Technical field

It is especially a kind of for treating the medicine of the diseases such as dysmenorrhes, menstrual discomfort the present invention relates to technical field of Chinese medicine Piece and preparation method thereof.

Background technique

Dysmenorrhea is one of common gynecological disease, is more common in Unmarried women especially, can be divided into primary dysmenorrhea and secondary pain Through, refer to women positive value menstrual period or front and back of passing through, periodical underbelly pain occur, or pain draws waist sacrum, when serious with nausea, vomit It spits, limb cold, very then severe pain is fainted, and Chinese medicine is called " dysmenorrhea ", it is believed that before and after gynecologic menstrual or menstrual period, the sea of blood is by being completely full of And let out excessive, qi and blood variation is hurried, and at this moment pathogenic factor such as feelings will is hurt, and daily life is careless or the six external factors which cause diseases causes harm etc. to seize the opportunity to worm one's way into, Causing punching to appoint stasis blocking or cold accumulating in meridian, keeps QI-blood circulation unsmooth, the circulation of uterus menses is obstructed, so that not general rule pain, or punching Uterus is appointed to lose in supporting, not Rong Ze pain.Dysmenorrhea is in periodical attack with menstruation, brings great pain, shadow to numerous women Normal working and learning are rung, the quality of life is reduced.

The medicament categories of clinical treatment dysmenorrhea are various at present, there is Western medicine, Chinese medicine；Western medicine anodyne or amcinonide Object, effect is obvious in the short time, but long-term efficacy is poor, easy to recur, and side effect is big, and Western medicine is taken mostly, can make to body At the symptoms such as cold body, physically weak；Chinese medicine Small side effects, and temporary solution and the equilibrium between yin and yang of conditioning whole body can be reached into the mesh to effect a permanent cure 's；Although there are many Chinese medicine for treating such disease at present, curative effect is all not satisfactory, and effect is not significant, is much unable to satisfy trouble Person needs.

Summary of the invention

The technical problem to be solved by the present invention is in order to make up for the deficiencies of the prior art, provide a kind of good effect, see Effect is fast, the drug of the simple treatment dysmenorrhea of preparation.

To achieve the goals above, the technical solution that the present invention uses is: this five osmanthus temperature through piece it is effective at Divide and be made of the raw material of following parts by weight: excrementum pteropi 175-180g, charred POLLEN TYPHAE 175-180 g, Resina Draconis 95-100g, aspongopus 130-135g, Radix Paeoniae Alba 175-180g, hawthorn 85-90g, ramulus cinnamomi 85-90g, radix aucklandiae 40-50g, tangerine seed 130-135g, Radix Glycyrrhizae 85- 90g。

In above-mentioned technical proposal, more specifically scheme may is that its effective component by the raw material group of following parts by weight At: excrementum pteropi 178g, charred POLLEN TYPHAE 178g, Resina Draconis 98g, aspongopus 133g, Radix Paeoniae Alba 178g, hawthorn 89g, ramulus cinnamomi 89g, radix aucklandiae 44g, tangerine seed 133g, Radix Glycyrrhizae 89g.

Prepare five above-mentioned osmanthus temperature is through the method for piece:

Using the raw material of following parts by weight:

Excrementum pteropi 175-180g, charred POLLEN TYPHAE 175-180g, Resina Draconis 95-100g, aspongopus 130-135 g, Radix Paeoniae Alba 175- 180g, hawthorn 85-90g, ramulus cinnamomi 85-90g, radix aucklandiae 40-50g, tangerine seed 130-135g, Radix Glycyrrhizae 85-90g；

Its preparation step is as follows:

The above ten tastes medicine, takes charred POLLEN TYPHAE 40-50 g, Resina Draconis to be respectively crushed into fine powder；Ramulus cinnamomi, radix aucklandiae extract volatilization respectively Oil, the another device of aqueous solution after distillation are collected；The dregs of a decoction and remaining charred POLLEN TYPHAE and other seven tastes add water to cook three times, add water for the first time 4.5 times of amounts decoct 2 hours, and 4.5 times of amounts of second and third time plus water decoct 1 hour, collecting decoction, filtration, filtrate and above-mentioned aqueous solution Merge, be condensed into 1.35~1.40(85 DEG C of relative density) clear cream, above-mentioned fine powder is added, mix, set 60~65 DEG C of dryings, powder Broken, sieving adds starch 48-52g, particle is made, dry, sprays into ramulus cinnamomi, volatile oil of Radix Aucklandiae, mixes, be pressed into 1000 tablets of tablets, Sugar coating to get.

The characteristic of each medicinal material of the present invention is as follows:

Excrementum pteropi: for flying squirrel section animal trogopterus xanthipes Milne-Edwards Trogopterus Xanthipes Milne-Edwards or flying squirrel The drying excrement of the small flying squirrel Pteromys volans L. of section animal；Nature and flavor are salty, sweet, warm.Return liver warp.It is pierced for chest side of body, stomach duct and abdomen Bitterly, dysmenorrhea, menostasis, postpartum blood stasis pain, tumbling and swelling, snakebite and bugbite.

Charred POLLEN TYPHAE: cattail pollen is turbid cattail Typha angustifolia L. of Typhaceae vegetation water, typha orientalis Typha The dry pollen of orientalis Presl or congener.Summer harvests the yellow male inflorescence on cattail's spike top, dries rear rolloff, Sieve takes pollen.Net cattail pollen is charred POLLEN TYPHAE according to frying charcoal method and frying to sepia.Nature and flavor sweet and neutral.Return liver, pericardium channel.Hemostasis, stagnation resolvation, It is treating stranguria.For spitting blood, bleeding from five sense organs or subcutaneous tissue, hemoptysis, metrorrhagia and metrostaxis, traumatic hemorrhage, amenorrhea and algomenorrhea, stomach duct and abdomen shouting pain, tumbling and swelling, blood strangury and dry pain.

Resina Draconis: for liliaceous plant swordleaf dragon tree Dranaena cochinchinensis (Lour.) S.C.Chen The extracted obtained resin of material containing tallow wood.Nature and flavor are sweet, pungent, salty, temperature.Return lung, spleen, kidney channel.Promoting blood circulation to remove blood stasis, analgesic therapy hemostasis, shank Creation flesh.It for traumatic injury, bathes in blood and has a pain, women's qi and blood stagnation, traumatic hemorrhage, ulcer on the shank do not close up long.

Aspongopus: for the hirudo leech of Pentatomidae Insects aspongopus Aspongopus chinensis Dallas.Nature and flavor are salty, Temperature.Liver,spleen,kidney is returned to pass through.Regulating qi-flowing for relieving pain, middle benefit gas are supporing yang.For stomach cold distending pain, stomachache due to emotional depression and the hyperactive liver-qi attacking the stomach, impotence due to deficiency of the kidney, soreness of waist and knee joint.

Radix Paeoniae Alba: for the dry root of ranunculaceae plant Chinese herbaceous peony Paeonia lactiflora Pall..Bitter in taste, acid is micro- It is cold.Return liver, the spleen channel.Nourishing blood for regulating menstruation, sword yin hidroschesis, soft liver analgesic, suppressing liver-YANG.For blood deficiency chlorosis, irregular menstruation, spontaneous perspiration, Night sweat, hypochondriac pain, abdominal pain, four limbs contraction pain, headache and dizziness.

Hawthorn: for rosaceous plant large-fruited Chinese hawthorn Crataegus pinnatifida Bge.var.major N.E.Br. or The dry mature fruit of hawthorn Crataegus pinnatifida Bge..Nature and flavor are sour, sweet, tepor.Returns spleen, stomach, Liver Channel.It helps digestion Stomach invigorating, scattered stasis change turbid lipid-loweringing.For meat stagnation, gastral cavilty turgor, diarrhea dysentery abdominal pain, blood stasis closed, postpartum stasis, trusted subordinate Shouting pain, hernia pain；Hyperlipidemia.Charred FRUCTUS CRATAEGI promoting digestion effect enhancing.For meat stagnation, dysentery is not well.

Ramulus cinnamomi: for the dry twig of lauraceae plant cortex cinnamomi Cinnamomum cassia Presl.Nature and flavor acrid, sweet, warm.Enter Bladder, the heart, lung channel.Effect: sweating expelling pathogenic factors from muscles and skin, warming meridians and promoting circulation of qi, help yang gas, flat and gas.For anemofrigid cold, coldness and pain in the epigastrium, Pain, phlegm retention, oedema, palpitaition, renal mass are closed in blood trembles with fear Amenorrhea, joint.

Radix aucklandiae: for the dry root of compositae plant radix aucklandiae Aucklandia lappa Decne..It is pungent, bitter, temperature.Returns spleen, Stomach, large intestine, three burnt, gallbladder channels.Promoting qi circulation and relieving pain, reinforcing spleen to promote digestion.For chest side of body, abdominal distention, weight after rush down dysentery, dyspepsia do not think Diet.Roasted RADIX AUCKLANDIAE reality intestines antidiarrheal.For stomachache of having loose bowels.

Tangerine seed: for rutaceae orange Citrus reticulata Blanco and its drying and ripening kind of variety Son.It is bitter in taste, it puts down.Return liver and kidney channel.Qi-regulating, dissipating bind, analgesic.For herria, testiclar gall, acute mastitis swelling and pain.

Radix Glycyrrhizae: for glycyrrhizic legume Glycyrrhiza uralensis Fisch., swollen fruit Radix Glycyrrhiza The dry root of inflata Bat. or glycyrrhiza glabra Glycyrrhiza glabra L..Nature and flavor sweet and neutral.Return heart, lung, spleen, Stomach meridian.It invigorates the spleen and benefits qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, mediation property of medicine.For weakness of the spleen and the stomach, fatigue and weakness, palpitaition Shortness of breath, coughing with a lot of sputum, stomach duct and abdomen, four limbs contraction, carbuncle sore tumefacting virus alleviate drug toxicity, strong.

Due to the adoption of the above technical scheme, the invention has the following beneficial effects:

The present invention use pure Chinese medicine formula, suit the remedy to the case, there is dispersing stagnated hepatoqi, activating microcirculation and removing stasis medicinal, Wen Jing activates yang, regulating qi-flowing for relieving pain it Effect, for diseases such as dysmenorrhea, menstrual discomforts, therapeutic effect is good, can effectively treat dysmenorrhea, and have no toxic side effect, convenient to take, It is cheap, according to clinical 120 patient views statistics, using one course for the treatment of total effective rate 86.7% of drug of the present invention, two Course for the treatment of total effective rate 99%.

Specific embodiment

Below with reference to embodiment, the present invention is further described:

Embodiment one: five osmanthus temperature are made through piece using the raw material of following parts by weight:

175 grams of excrementum pteropi, 175 grams of charred POLLEN TYPHAE, 95 grams of Resina Draconis, 130 grams of aspongopus, 175 grams of Radix Paeoniae Alba, 85 grams of hawthorn, osmanthus Branch 85 grams, 40 grams of radix aucklandiae, 130 grams of tangerine seed, 85 grams of Radix Glycyrrhizae.

The above ten tastes medicine takes 40 grams of charred POLLEN TYPHAE, Resina Draconis to be respectively crushed into fine powder；Ramulus cinnamomi, radix aucklandiae extract volatile oil respectively, The another device of aqueous solution after distillation is collected；The dregs of a decoction and remaining charred POLLEN TYPHAE and other seven tastes add water to cook three times, add 4.5 times of water for the first time Amount decocts 2 hours, and 4.5 times of amounts of second and third time plus water decoct 1 hour, collecting decoction, filtration, and filtrate merges with above-mentioned aqueous solution, Be condensed into 1.35~1.40(85 DEG C of relative density) clear cream, above-mentioned fine powder is added, mix, setting 60~65 DEG C dry, pulverize, mistake Sieve, adds 48 grams of starch, particle is made, dry, sprays into ramulus cinnamomi, volatile oil of Radix Aucklandiae, mixes, and is pressed into 1000 tablets of tablets, sugar coating, To obtain the final product.

Embodiment two: five osmanthus temperature are made through piece using the raw material of following parts by weight:

178 grams of excrementum pteropi, 178 grams of charred POLLEN TYPHAE, 98 grams of Resina Draconis, 133 grams of aspongopus, 178 grams of Radix Paeoniae Alba, 89 grams of hawthorn, osmanthus Branch 89 grams, 44 grams of radix aucklandiae, 133 grams of tangerine seed, 89 grams of Radix Glycyrrhizae.

The above ten tastes medicine takes 44.5 grams of charred POLLEN TYPHAE, Resina Draconis to be respectively crushed into fine powder；Ramulus cinnamomi, radix aucklandiae extract volatilization respectively Oil, the another device of aqueous solution after distillation are collected；The dregs of a decoction and remaining charred POLLEN TYPHAE and other seven tastes add water to cook three times, add water for the first time 4.5 times of amounts decoct 2 hours, and 4.5 times of amounts of second and third time plus water decoct 1 hour, collecting decoction, filtration, filtrate and above-mentioned aqueous solution Merge, be condensed into 1.35~1.40(85 DEG C of relative density) clear cream, above-mentioned fine powder is added, mix, set 60~65 DEG C of dryings, powder Broken, sieving adds 50 grams of starch, particle is made, dry, sprays into ramulus cinnamomi, volatile oil of Radix Aucklandiae, mixes, be pressed into 1000 tablets of tablets, wraps Sugar-coat to get.

Embodiment three: five osmanthus temperature are made through piece using the raw material of following parts by weight:

180 grams of excrementum pteropi, 180 grams of charred POLLEN TYPHAE, 100 grams of Resina Draconis, 135 grams of aspongopus, 180 grams of Radix Paeoniae Alba, 90 grams of hawthorn, osmanthus Branch 90 grams, 50 grams of radix aucklandiae, 135 grams of tangerine seed, 90 grams of Radix Glycyrrhizae；

The above ten tastes medicine takes 50 grams of charred POLLEN TYPHAE, Resina Draconis to be respectively crushed into fine powder；Ramulus cinnamomi, radix aucklandiae extract volatile oil respectively, The another device of aqueous solution after distillation is collected；The dregs of a decoction and remaining charred POLLEN TYPHAE and other seven tastes add water to cook three times, add 4.5 times of water for the first time Amount decocts 2 hours, and 4.5 times of amounts of second and third time plus water decoct 1 hour, collecting decoction, filtration, and filtrate merges with above-mentioned aqueous solution, Be condensed into 1.35~1.40(85 DEG C of relative density) clear cream, above-mentioned fine powder is added, mix, setting 60~65 DEG C dry, pulverize, mistake Sieve, adds 52 grams of starch, particle is made, dry, sprays into ramulus cinnamomi, volatile oil of Radix Aucklandiae, mixes, and is pressed into 1000 tablets of tablets, sugar coating, To obtain the final product.

Five osmanthus temperature have activating microcirculation and removing stasis medicinal through piece, and Wen Jing activates yang, the function of regulating qi-flowing for relieving pain.Cure mainly the diseases such as dysmenorrhea, menstrual discomfort. Its usage and dosage is: it is oral, one time 3~4,3 times a day.One after each meal, 7 days as one therapeutic course.

Drug of the invention can also use the conventional fabrication process of Chinese materia medica preparation, can be made into institute in any pharmacy The dosage form said, such as pill, powder, capsule, granule, syrup, oral solution, such as these bulk pharmaceutical chemicals can be ground into powder Last shape is uniformly mixed and powder is made takes after mixing it with water；Decocting can be used, is filtered to get filtrate, preservative is added, oral solution is made；When necessary Decoction can also directly be taken.

Clinical test part:

One, five Gui Wenjing piece performances detect

[character] this product is sugar coated tablet, shows sepia after removing sugar-coat；It is mildly bitter flavor, pungent.

[identification] (1) takes this product 2, removes sugar-coat, finely ground, adds ethyl acetate 10ml, is ultrasonically treated 30 minutes, filtration, Filtrate is as test solution.Resina Draconis control medicinal material 0.2g separately is taken, is made in the same way of control medicinal material solution.Lourerin B pair is taken again According to product, add chloroform that solution of every 1ml containing 1mg is made, as reference substance solution.According to thin-layered chromatography (Chinese Pharmacopoeia 2010 One VI B of annex of year version) test, above-mentioned each 2 μ l of three kinds of solution is drawn, it is viscous for putting respectively in same with sodium carboxymethylcellulose It is exhibition with petroleum ether (60~90 DEG C)-chloroform-acetate-methanol (3: 5: 1: 0.5) on the silica gel g thin-layer plate of mixture Agent is opened, is unfolded, is taken out, is dried, set and inspected under ultraviolet lamp (365nm).In sample chromatogram, corresponding to reference medicine chromatography Position on, show same color fluorescence spot；Set in iodine vapor smoke inspect after twenty minutes, with control medicinal material and reference substance color It composes on corresponding position, shows the spot of same color.

(2) this product 20 are taken, sugar-coat is removed, it is finely ground, add ethyl alcohol 20ml, be heated to reflux 30 minutes, filters, filtrate is evaporated, Residue adds water 20ml to make to dissolve, filtration, and filtrate adds water saturated n-butanol 20ml, and shaking is extracted, and is divided and is taken n-butanol extracting liquid, steams Dry, residue adds ethyl alcohol 0.5ml to make to dissolve, as test solution.Paeoniflorin reference substance separately is taken, adds ethyl alcohol that every 1ml is made containing 2mg Solution, as reference substance solution.It is tested according to thin-layered chromatography (one VI B of annex of Chinese Pharmacopoeia version in 2010), draws above-mentioned two Kind each 4 μ l of solution, puts on the silica gel g thin-layer plate in same using sodium carboxymethylcellulose as adhesive, respectively with chloroform-second Acetoacetic ester-methyl alcohol-formic acid (40: 5: 10: 0.2) is solvent, is unfolded, and takes out, dries, and spray is with 5% vanillin-sulfuric acid solution, heat Wind is clear to spot development.In sample chromatogram, at the position corresponding to the chromatogram of the reference substance, the spot of same color is shown.

(3) this product 20 are taken, sugar-coat is removed, finely ground, add diethyl ether 30 ml, is ultrasonically treated 30 minutes, and filtration, filtrate volatilizes, Residue adds methanol 1ml to make to dissolve, as test solution.Radix aucklandiae control medicinal material 0.5g separately is taken, is made in the same way of control medicinal material solution. According to thin-layered chromatography (one VI B of annex of Chinese Pharmacopoeia version in 2010) test, draw each 5 μ l of above two solution, put respectively in It is same using sodium carboxymethylcellulose as on the silica gel g thin-layer plate of adhesive, with thiacyclohexane-acetone (10: 3) for solvent, expansion, It takes out, dries, spray with 5% vanillin-sulfuric acid solution, it is clear that hot wind is blown to spot development.In sample chromatogram, with control medicinal material On the corresponding position of chromatography, the spot of same color is shown.

[inspection]

(1) it disintegration time limited: should be all disintegrated in 60 minutes

(2) microbial limit: bacterial population must not cross 10000cfu/g, and yeast and mold number must not cross 100cfu/g, often 1g must not detect escherichia coli, coliform should be less than 100/g；Every 10g must not detect detection of Salmonella；Mite living must not be detected.

[assay] is measured according to high performance liquid chromatography (one annex VI D of Chinese Pharmacopoeia version in 2010).

Chromatographic condition and system suitability are filler with octadecylsilane chemically bonded silica；Methanol- 0.05mol/L potassium dihydrogen phosphate-acetic acid-isopropanol (67: 173: 4: 4) is mobile phase；Detection wavelength is 230nm.Reason 5000 should be not less than by calculating by plate number by Paeoniflorin peak.

The preparation precision of reference substance solution weighs dry 36 hours in phosphorus pentoxide vacuum drying apparatus Paeoniflorins pair It is appropriate according to product, add methanol be made every 1ml contain 50 μ g solution, shake up to get.

The preparation of test solution takes this product 20, removes sugar-coat, accurately weighed, finely ground, takes about 1.5g, accurately weighed, Methanol 20ml is added in precision, and weighed weight impregnates 4 hours, is ultrasonically treated 30 minutes, takes out, lets cool, weighed weight uses methanol The weight for supplying less loss, shakes up, filtration to get.

Measuring method difference is accurate to draw reference substance solution and each 10 μ l of test solution, injects liquid chromatograph, measures, To obtain the final product.

This product every (C23H28O11) containing Paeoniflorin must not be less than 0.15mg.

Two, Clinic Case: example 1: Lee, female, 25 years old, the firmly road Nanning City Jian Zheng 5.Because of prolonged and repeated lower abdomen and It is lumbosacral region distending pain 3 years, well medical May 23 nineteen ninety-five.Each menstrual onset is played before telling 3 years, if can all cause lower abdomen because suffering from cold And lumbosacral region distending pain, tenderness, for about 6 days, pain very when from taking somedon pain relief, but pain is again multiple later makees, and influences work, With blockage of menstruation, color it is purple it is black have a block, chest distress and irritability, when have nausea.Deny thering is pelvic inflammatory disease, endometriosis, uterus Myomata medical history.Physical examination: face dolorosa, cardiopulmonary are normal, and abdomen is soft, lower abdomen tenderness, no rebound tenderness, and gurgling sound is normal.Tongue is purple dark, arteries and veins It is heavy.Tcm diagnosis: dysmenorrhea (syndrome of qi stagnation and blood stasis).Doctor trained in Western medicine diagnosis: primary dysmenorrhea.Five osmanthus temperature are given through piece, 4 tablets once, and daily 3 It is secondary, it is taken from premenstrual 7 days, even served 7 days.Abdominal pain disappears after 10 days, and chest distress and irritability is also substantially reduced.All symptoms disappear after 12 days, extensive It returns to work work.Efficacy evaluation: effective.

Example 2: Zhao, female, 21 years old, the firmly Guangxi District petrochemical industry Room.Because of menstrual period pain 3 years repeatedly, May 25 nineteen ninety-five It is medical.Private prosecution is in a very depressed state over nearly 3 years, and each menstrual period lower abdomen distending pain occur unbearably, tenderness, and pain lasts 6 days or so.Companion Hypomenorrhea, color purple secretly have clot, reprieve bitterly under block, and premenstrual swollen breasts, chest distress and irritability influences work.Deny there is pelvic cavity Inflammation, endometriosis, fibroid medical history.Physical examination: face dolorosa, cardiopulmonary are normal, and abdomen is soft, lower abdomen tenderness, no knock-on Bitterly, gurgling sound is normal.Tongue is purple dark, while have petechia, veins string.Tcm diagnosis: dysmenorrhea (syndrome of qi stagnation and blood stasis).Doctor trained in Western medicine diagnosis: primary Dysmenorrhea.Five osmanthus temperature are given through piece, 4 tablets once, 3 times a day, takes from premenstrual 7 days, even served 7 days.Abdominal pain is substantially reduced after 10 days, cream Room distending pain and chest distress and irritability disappear.It disappears to the 11st day pain, restores to work normally.Efficacy evaluation: effective.

Claims (3)

1. a kind of five osmanthus temperature are through piece, which is characterized in that its effective component is made of the raw material of following weight proportion:

Excrementum pteropi 175-180 g, charred POLLEN TYPHAE 175-180 g, Resina Draconis 95-100 g, aspongopus 130-135 g, Radix Paeoniae Alba 175- 180 g, hawthorn 85-90 g, ramulus cinnamomi 85-90 g, radix aucklandiae 40-50 g, tangerine seed 130-135 g, Radix Glycyrrhizae 85-90 g.

2. the five osmanthus temperature are characterized in that through piece according to claim 1: its effective component by following weight proportion original Material is made: excrementum pteropi 178g, charred POLLEN TYPHAE 178g, Resina Draconis 98g, 133 g of aspongopus, Radix Paeoniae Alba 178g, hawthorn 89g, ramulus cinnamomi 89g, Radix aucklandiae 44g, tangerine seed 133g, Radix Glycyrrhizae 89g.

3. a kind of five preparation methods of the osmanthus temperature through piece, are characterized in that:

Using the raw material of following weight:

Excrementum pteropi 175-180g, charred POLLEN TYPHAE 175-180g, Resina Draconis 95-100g, aspongopus 130-135 g, Radix Paeoniae Alba 175-180g, Hawthorn 85-90g, ramulus cinnamomi 85-90g, radix aucklandiae 40-50g, tangerine seed 130-135 g, Radix Glycyrrhizae 85-90g；

Its preparation step is as follows:

The above ten tastes medicine, takes charred POLLEN TYPHAE 40-50g, Resina Draconis to be respectively crushed into fine powder；Ramulus cinnamomi, radix aucklandiae extract volatile oil respectively, steam The another device of aqueous solution after evaporating is collected；The dregs of a decoction and remaining charred POLLEN TYPHAE and other Six-elements add water to cook three times, and for the first time plus 4.5 times of water are measured It decocts 2 hours, 4.5 times of amounts of second and third time plus water decoct 1 hour, collecting decoction, filtration, and filtrate and above-mentioned aqueous solution close And it is condensed into the clear cream of the relative density 1.35~1.40 at 85 DEG C, above-mentioned fine powder is added, mixes, sets 60~65 DEG C of dryings, powder Broken, sieving adds starch 48-52g, particle is made, dry, sprays into ramulus cinnamomi, volatile oil of Radix Aucklandiae, mixes, be pressed into 1000 tablets of medicines Piece, sugar coating to get.