CN101049485A - Mulberry - ginger soft capsule for treating common cold, and preparation method - Google Patents
Mulberry - ginger soft capsule for treating common cold, and preparation method Download PDFInfo
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- CN101049485A CN101049485A CN 200610020639 CN200610020639A CN101049485A CN 101049485 A CN101049485 A CN 101049485A CN 200610020639 CN200610020639 CN 200610020639 CN 200610020639 A CN200610020639 A CN 200610020639A CN 101049485 A CN101049485 A CN 101049485A
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Abstract
A Chinese medicine in the form of softgel for treating cold, cough, headache and sore throat is prepared from 6 Chinese-medicinal materials including mulberry leaf, chrysanthemeem flower, forsythia fruit, dried ginger, etc. Its preparing process is also disclosed.
Description
Technical field:
The present invention relates to a kind of mulberry leaf-ginger common cold soft capsule and preparation method thereof, belong to technical field of Chinese medicine.
Background technology:
Flu is a kind of commonly encountered diseases, frequently-occurring disease, its cardinal symptom is headache, fever, cough, nasal obstruction, laryngopharynx swelling and pain etc., allow the people not feel well, though flu is a kind of commonly encountered diseases, but it gives the influence of people's work and life is very big, and the patient who has causes life danger in case flu also can cause complication.Motherland's medical science is divided into wind and cold and anemopyretic cold with flu, because the difference of flu type is also very exquisite aspect medication.When suffering from anemofrigid cold, need hot temperature medicine treatment with dispersing wind-cold; And during anemopyretic cold, need with disperse wind heat hot medicine of a cold nature treatment.So the Chinese patent medicine of the treatment of selling on the market flu is mostly only at wind and cold or a kind of disease type of anemopyretic cold.But human body is an organic whole, and in the ill process of human body, cold and heat can transform in human body mutually, if when wind-chill cold is converted into anemopyretic, the medicine of obeying dispersing wind-cold again is just improper, and vice versa.Here it is, and why some people catches a cold that just to begin to take certain medicine effective, along with the continuity of the flu course of disease, obeys the very poor on the contrary reason of this drug effect fruit again.The mulberry leaf-ginger common cold sheet is to be guidance with motherland's traditional Chinese medicine theory, select for use Folium Mori, Flos Chrysanthemi, Fructus Forsythiae, Semen Armeniacae Amarum, Rhizoma Zingiberis, Folium Perillae Six-element Chinese medicine to be prescription, pure Chinese medicinal preparation, safe and efficient, being primarily aimed at symptoms such as the back headache that occurs of flu, aversion to cold, general pain, heating, throat pain, is the present unique medicine that can treat the wind and cold anemopyretic cold simultaneously.But the mulberry leaf-ginger common cold sheet is in blocks by pressed powder that contains medicine or granule compacting, and coating forms, and exists the common problem of tablet, and dust-producing amount is big during coating; Sliver, variable color, quality instability in the storage life; Disintegrate, absorb slowly, bioavailability is not high, and curative effect is affected; Simultaneously, the mouthfeel of Chinese crude drug is heavier in the tablet, normally uses so also influence the patient; And coated tablet is unfavorable for that also diabetics takes.Though it is slow that the mulberry leaf-ginger common cold injection can solve the absorption of tablet, problem such as bioavailability is not high.But existing mulberry leaf-ginger common cold injection is the same with the mulberry leaf-ginger common cold sheet, in preparation technology, because long-time the decoction, all do not keep the central volatile oil of flavour of a drug, and volatile oil is very important for the treatment flu, by the vitro antibacterial activity of in-vitro antibacterial test discussion traditional medicine volatile oil and filtrate thereof, the result shows that traditional medicine volatile oil all has certain antibacterial action and certain antivirus action is arranged 6 kinds of bacterium such as staphylococcus aureus, escherichia coli, bacillus subtilis, yeast, Aspergillus flavus and Trichoderma virides.According to the literature, a large amount of aromatic series, sterols and two terpene compounds in Folium Mori volatile oil, have been found, may be relevant with its metabolic centre of production hormonal substance and end-product, found 3 ' in addition, 4 ' 5 ', 7-Tetramethoxyflavone flavonoid material, this and Folium Mori have physiological actions such as expelling wind and clearing away heat, cooling blood for improving eyesight, diuresis and have and directly get in touch, Flavonoid substances in the Folium Mori can suppress lipid oxidation, the prevention of arterial sclerosis, phytosterol also can suppress the absorption of intestinal to cholesterol effectively; Flos Chrysanthemi Indici volatile oil has heat-clearing and toxic substances removing, bacteriostasis; Forsythia volatile oil has certain antiinflammatory action, and the release of antiinflammatory mechanism and inflammation-inhibiting medium PGE2 and histamine, five amine tryptamines is relevant; Rhizoma Zingiberis volatile oil has Xin Xiang walks to scurry, the blood stasis dispelling of having one's ideas straightened out, and the effect of recuperating depleted YANG coronary circulation-promoting pain-relieving, energy strong inhibition platelet aggregation, the master contains zingiberol, zingiberene, effective ingredient such as the peppery enol of Rhizoma Zingiberis Recens; Amygdalin is the flat main component of coughing of Semen Armeniacae Amarum antitussive, oral after digestive tract absorbs and resolves into hydrocyanic acid and prove effective, because former technology decocting time is long, amygdalin in the Semen Armeniacae Amarum is easily become hydrocyanic acid and volatilization loss by the emulsin enzymolysis, and hydrocyanic acid is the effective ingredient of treatment exogenous cough, acute/chronic bronchitis, for guaranteeing the said preparation curative effect, should increase the volatile ingredient extraction process at the method for making item; As from the foregoing, keep the volatile ingredient of each flavour of a drug in the prescription, preparation technology is more reasonable, thereby improves the therapeutic effect to flu
Summary of the invention:
The objective of the invention is to: avoid having now the weak point that exists in dosage form and the technology, a kind of mulberry leaf-ginger common cold soft capsule and preparation technology thereof are provided, preparation process by the advanced person, on the basis that keeps good drug effect, original technology and preparation are improved, make the mulberry leaf-ginger common cold soft capsule, further to improve the quality of products and technology content.The mulberry leaf-ginger common cold soft capsule can overcome the shortcoming of existing dosage form, constant product quality, carry taking convenience, the effective ingredient stripping is fast, the bioavailability height satisfies the standard of such dosage form aspect outward appearance, disintegration, content and physicochemical property, its steady quality, easy to use effective.The preparation method that provides around pharmaceutical production is fairly simple in addition, is suitable for common pharmacy corporation production, does not have special technology, equipment requirements; Low production cost; Medicine of the present invention is made up of the Chinese medicine (weight portion) of following proportioning:
Folium Mori 150～450g Flos Chrysanthemi 60～240g Folium Perillae 80～320g
Fructus Forsythiae 80～320g Semen Armeniacae Amarum 80～320g Rhizoma Zingiberis 50～150g
The best proportioning following (weight portion) of medicine of the present invention
Folium Mori 300g, Flos Chrysanthemi 120g, Folium Perillae 160g, Fructus Forsythiae 160g, Semen Armeniacae Amarum 160g, Rhizoma Zingiberis 100g
The side separates: this product is made up of Folium Mori, Flos Chrysanthemi, Folium Perillae, Fructus Forsythiae, Semen Armeniacae Amarum, Rhizoma Zingiberis etc.Folium Mori, the cold and cool sweetness and bitterness of the Flos Chrysanthemi property of medicine in the side, quality is gently clear, directly goes into lung meridian, always is the key medicine of dispelling wind and heat pathogens, clear lung qi dispersing gas; Folium Perillae is warm in nature, and acrid in the mouth has relieving the exterior syndrome by diaphoresis, the function of promoting the circulation of QI to alleviate the stagnation in middle-JIAO; Fructus Forsythiae is cold in nature goes into lung, heat-clearing and toxic substances removing, a surname expelling pathogenic factors from the exterior that looses; Almond cough-relieving is relievingd asthma; Rhizoma Zingiberis acrid in the mouth hot in nature, warming spleen and stomach for dispelling cold is specially controlled the card of lung cold phlegm retention.Dispelling wind and heat pathogens, clear lung qi dispersing gas but all medicines match, but relieving the exterior syndrome by diaphoresis, relieving cough and resolving phlegm again have heat clearing away, detoxifcation, antiviral, effect such as antibiotic.This medicine is brought down a fever soon, and clinical efficacy is good, for wind and cold, the common cold due to wind heat of Chinese medical discrimination curative effect is preferably arranged all.
Mulberry leaf-ginger common cold soft capsule of the present invention is made up of content in softgel shell and the softgel shell, and its technical scheme is as follows:
1. according to given ratio, above Six-element is got Folium Mori 150g and is ground into fine powder, to remain the five tastes such as Folium Mori and all the other Flos Chrysanthemis and decoct with water three times, 1.5 hours for the first time, second and third time each 1 hour, collecting decoction filters, and filtrate is condensed into thick paste and adds the Folium Mori fine powder, mixing, drying is ground into fine powder, adds an amount of pharmaceutic adjuvant, mixing is made soft capsule.
2. according to given ratio, above Six-element is got Folium Mori 150g and is ground into fine powder, will remain the five tastes such as Folium Mori and all the other Flos Chrysanthemis and extract volatile oil, and the aqueous solution after distillation device is in addition collected; Medicinal residues decoct with water three times, and 1.5 hours for the first time, second and third time each 1 hour, collecting decoction filters, and filtrate and above-mentioned aqueous solution merge.Amalgamation liquid is condensed into thick paste, adds the Folium Mori fine powder, mixing, and drying is ground into fine powder, adds above-mentioned volatile oil and an amount of pharmaceutic adjuvant, and mixing is made soft capsule in parcel and the soft capsule shell.
3. according to given ratio, above-mentioned Six-element medicine extracts volatile oil, and the aqueous solution after distillation device is in addition collected; Residual medicine dreg is decocted with water three times, 3 hours for the first time, second and third time each 2 hours, collecting decoction filters, and filtrate and above-mentioned aqueous solution merge.Amalgamation liquid is condensed into thick paste, and drying is ground into fine powder, adds above-mentioned volatile oil and an amount of pharmaceutic adjuvant, and mixing is made soft capsule in parcel and the soft capsule shell.
Adjuvant can be diluent, suspending agent, surfactant, antiseptic, one or more in antioxidant and the additives.Wherein diluent is one or more in polyethylene glycols, isopropyl alcohol, tween, span, glycerol, propylene glycol, water, mineral oil and the vegetable oil; Suspending agent is one or more in oily wax mixture, Cera Flava, ethylhydroxyethylcellulose, agar, hydroxypropyl emthylcellulose, xanthan gum, aluminum monostearate, the ethyl cellulose; Antioxidant is one or more in ethylenediaminetetraacetic acid, disodium EDTA, dibenzylatiooluene, glycine, inositol, ascorbic acid, sodium ascorbate, soft phospholipid, malic acid, hydrogen a kind of jade, citric acid, succinic acid, the burnt inferior sour sodium; Antiseptic is one or more in sorbic acid, sorbic acid methyl ester, methyl parahydroxybenzoate, ethylparaben, propyl p-hydroxybenzoate, butyl p-hydroxybenzoate, P-hydroxybenzoic acid phenyl ester, benzyl p-hydroxybenzoate class, Sodium Methyl Hydroxybenzoate, benzoic acid, benzyl alcohol, propylene glycol, the glycerol; Described additives are one or more in antiseptic, antioxidant, the coloring agent.
(wherein gelatin, glycerol proportioning are difficult to grasp mulberry leaf-ginger common cold soft capsule of the present invention to the prescription of various conditions (as temperature, humidity etc.), softgel shell in the kind of soft capsule adjuvant and principal agent and proportioning dosage, the preparation process on the basis of conventional soft capsule preparation method.The amount of glycerol is too many, and softgel shell is softer,, than being easier to extrusion; The amount of glycerol very little, softgel shell is harder, crisp, influences the quality stability and the disintegration time of soft capsule.) preferred through test of many times research and long-term investigation, obtained proportioning preferably at last.Has the advantage that reasonable mixture ratio, technology are simple, be easy to control.
The best proportioning of medicine and adjuvant is 1: 0.5-1: 1.5.The best prescription proportioning is:
| Form | Content (percentage by weight) |
| Pharmaceutical diluents suspending agent other (as antioxidant, antiseptic) | 30％-70％ 30％-70％ 0％-5％ 0％-5％ |
The best proportioning of gelatin and glycerol is 2 in the softgel shell: 1-4: 1.
Compared with the prior art, beneficial effect of the present invention is embodied in:
The present invention is wrapped in medicine and adjuvant mixture to make soft capsule in the soft capsule shell.On the basis that keeps the good drug effect of tablet, original technology and dosage form are improved, increase the extraction of volatile oil, make ingredient more comprehensively, preparation process is more reasonable, and curative effect is better.Soft capsule soft or hard appropriateness after the improvement is imbued with flexibility and toughness, has improved content of effective in the dry extract, and Determination on content and qualitative easy operating make the quality standard of this medicine that new raising arranged.Constant product quality, disintegrate is fast, bioavailability is high, it is fast to play the school.Simultaneously, overcome the shortcoming of existing dosage form, reduced the dust-producing amount of producing, shortened the production cycle, improved the hygiology standard, overcome tablet defective such as sliver, variable color in the storage life.
Pharmacological research:
1, refrigeration function
Get 40 rabbit and survey the anus temperature, survey 1 time, survey altogether 4 times every 1h 17 ℃ of room temperatures, choose 4 times the equal 38.4-39.6 of body temperature ℃, and every 4 temperature difference are no more than 0.4 ℃ and are qualified rabbit.The test before measurement rabbit temperature difference is available at 0.2 ℃, it is divided into 5 groups at random: the high, medium and low dosage group of mulberry leaf-ginger common cold soft capsule (6,4,2g crude drug/kg), aspirin (0.2g/kg), matched group (normal saline 10ml/kg), every group 8, behind every animal injection typhoid fever, the paratyphoid fever first and second triple vaccine 10ml/kg, gastric infusion immediately.After the vaccinate 1-5 hour as a result, administration treated animal body temperature and matched group relatively, there were significant differences.
2, antiinflammatory action
Get 40 of rat, male and female half and half are divided into 4 groups at random by the body weight sex: the high and low dose group (6,4,2g crude drug/kg), aspirin (0.2g/kg), matched group (normal saline 10ml/kg), 10 every group.Continuous gastric infusion 7d, 0.5h only injects metapedes sole of the foot portion with 10% egg white solution 0.1ml/ after administration in the 7th day,, respectively at 1,2,3h is with the thickness of vernier caliper measurement foot sole of the foot portion, calculates the swelling degree.The result shows that the height of mulberry leaf-ginger common cold soft capsule, middle dosage are all similar to the aspirin antiinflammatory action, and the sufficient sole of the foot that can significantly suppress due to the Ovum Gallus domesticus album is swollen.
3, to Immune Effects
Get 40 of NIH kind mices, be divided into 4 groups at random: high dose group (6 crude drug g/kg), low dose group (2 crude drug g/kg), levamisole group (10mg/kg), matched group by the body weight sex.Successive administration 10d injects 10% india ink 0.2ml/20g body weight in last administration 1h posterior vein, in injection back 2min, respectively gets blood 20ul in 0.1%Na
2CO
32.5ml in, A value is read in normal mice blood zeroing, puts to death mice then, gets thymus, spleen, liver and weighs calculating κ value and a value.The result shows that levamisole and this medicine high and low dose group can obviously improve normal mouse
To the removing speed of colloid carbon granules in the blood, strengthen the activity that the mice reticuloendothelial cell is engulfed carbon granules.
The present invention is pure compound Chinese medicinal preparation, and acute experiment and long term toxicity test through to mice have no drug resistance and toxic and side effects.Effects such as that this product has is analgesic, analgesia, antiviral, antibacterial, cough-relieving.
The specific embodiment:
The present invention will be further described below in conjunction with example, and following each example only is used to illustrate the present invention, but the protection authority of the present patent application is not limited in this.
Embodiment 1:
Softgel shell prescription: gelatin 100g glycerol 45g water 100g titanium dioxide 1g
Preparation of soft capsule: get Folium Mori 150g and be ground into fine powder, will remain the five tastes such as Folium Mori and all the other Flos Chrysanthemis and extract volatile oil, standby; Residual medicine dreg is decocted with water three times, 1.5 hours for the first time, second and third time each 1 hour, collecting decoction filters, filtrate is condensed into thick paste and adds the Folium Mori fine powder, mixing, and drying is ground into fine powder, it is an amount of that adding contains mellisic soybean oil, and mixing is pressed into 1000 of soft capsules, promptly.
| Form | Umber (by weight) |
| Medicine (by the total medicated powder amount of last gained) soybean oil Cera Flava | 5 parts 5.7 parts 0.3 part |
Embodiment 2:
| Form | Umber (by weight) |
| Medicine (by the total medicated powder amount of last gained) Polyethylene Glycol-400 glycerol citric acid tween 80 Cera Flava | 5 parts 5.34 parts 0.3 part 0.05 part 0.12 part 0.05 part |
The preparation of substrate: taking polyethylene glycol-400 430.38g, add glycerol 24.2g, citric acid 4.05g, tween 80 9.67g, Cera Flava 4.03g, mix homogeneously gets soft capsule matrix 472.35g altogether.
Preparation of soft capsule: get Folium Mori 150g and be ground into fine powder, will remain the five tastes such as Folium Mori and all the other Flos Chrysanthemis and extract volatile oil, standby; Residual medicine dreg is decocted with water three times, 1.5 hours for the first time, second and third time each 1 hour, collecting decoction, filter, filtrate is condensed into thick paste and adds Folium Mori fine powder, mixing, drying, be ground into fine powder, in the soft capsule matrix that adds above-mentioned volatile oil and make according to above-mentioned prescription in right amount, mixing is made soft capsule.
Embodiment 3:
| Form | Umber (by weight) |
| Medicine (by the total medicated powder amount of last gained) Polyethylene Glycol-400 glycerol span sorbic acid methyl ester dibenzylatiooluene | 5 parts 3.2 parts 0.35 part 0.15 part 0.16 part 0.14 part |
The preparation of substrate: taking polyethylene glycol-400 256g, add glycerol 38g, span 12g, sorbic acid methyl ester 12.8g, dibenzylatiooluene 5.2g, mix homogeneously gets soft capsule matrix 321g.
Preparation of soft capsule: above-mentioned Six-element medicine extracts volatile oil, and is standby; Residual medicine dreg is decocted with water three times, 3 hours for the first time, second and third time each 2 hours, collecting decoction, filtration, filtrate are condensed into thick paste, and drying is ground into fine powder, in the soft capsule matrix that adds above-mentioned volatile oil and make according to above-mentioned prescription in right amount, mixing adds antiseptic again, makes soft capsule.
Embodiment 4:
The soft capsule that makes according to the foregoing description method is appointed and is got wherein qualified six and measure disintegration, all disintegrates in 15 minutes, and than tablet, disintegration time obviously shortens.The stripping time-limit test is measured its stripping active substance percentage rate in 45 minutes and is significantly improved than tablet under the same terms.
| Inspection item | The mulberry leaf-ginger common cold soft capsule | The mulberry leaf-ginger common cold tablet |
| Average disintegration (minute) | 14 | 27 |
Embodiment 5:
Because the difference of soft capsule content character cause the proportioning of its softgel shell also different, so we has carried out detailed experiments research to gelatin, the glycerol proportioning of softgel shell:
| Inspection item | Gelatin and glycerol proportioning | |||||
| The outward appearance of softgel shell and physical property | 5∶1 | 4.5∶1 | 4∶1 | 3∶1 | 2∶1 | 1.5∶1 |
| Too firmly, easily crisp | Too firmly, more crisp | More suitable | Suitable | More suitable | Too soft, the moisture absorption | |
Overcome by the mulberry leaf-ginger common cold soft capsule of as above specifically implementing the example gained that the tablet dust was big in the past, the tabletting condition is difficult for shortcomings such as grasp, and soft capsule dosage form has relative high bioavailability, and has proved technology simple possible of the present invention, product safety is effective, and is stable and controllable for quality.
Claims (10)
1, a kind of mulberry leaf-ginger common cold soft capsule is characterized in that: calculate according to weight proportion, it mainly is prepared from by Folium Mori 150～450g, Flos Chrysanthemi 20～240g, Folium Perillae 80～320g, Fructus Forsythiae 80～320g, Semen Armeniacae Amarum 80～320g, Rhizoma Zingiberis 50～150g.
2, according to the described mulberry leaf-ginger common cold soft capsule of claim 1, it is characterized in that: it mainly by: Six-elements such as Folium Mori 300g, Flos Chrysanthemi 120g, Folium Perillae 160g, Fructus Forsythiae 160g, Semen Armeniacae Amarum 160g, Rhizoma Zingiberis 100g are made.
3, this mulberry leaf-ginger common cold preparation of soft capsule method as claimed in claim 1 or 2 is characterized in that: above Six-element, and get Folium Mori 150g and be ground into fine powder, to remain the five tastes such as Folium Mori and all the other Flos Chrysanthemis and decoct with water three times, 1.5 hours for the first time, second and third time each 1 hour, collecting decoction filters, and filtrate is condensed into thick paste and adds the Folium Mori fine powder, mixing, drying is ground into fine powder, adds an amount of pharmaceutic adjuvant, mixing is made soft capsule.
4, this mulberry leaf-ginger common cold preparation of soft capsule method as claimed in claim 1 or 2 is characterized in that: above Six-element, and get Folium Mori 150g and be ground into fine powder, will remain the five tastes such as Folium Mori and all the other Flos Chrysanthemis and extract volatile oil, the aqueous solution after distillation device is in addition collected; Medicinal residues decoct with water three times, and 1-3 hour for the first time, each 0.5-2 of second and third time hour, collecting decoction filtered, and filtrate and above-mentioned aqueous solution merge.Amalgamation liquid is condensed into thick paste, adds the Folium Mori fine powder, mixing, and drying is ground into fine powder, adds above-mentioned volatile oil and an amount of pharmaceutic adjuvant, and mixing is made soft capsule.
5, this mulberry leaf-ginger common cold preparation of soft capsule method as claimed in claim 3 is characterized in that: above Six-element, and get Folium Mori 150g and be ground into fine powder, will remain the five tastes such as Folium Mori and all the other Flos Chrysanthemis and extract volatile oil, the aqueous solution after distillation device is in addition collected; Medicinal residues decoct with water three times, and 1.5 hours for the first time, second and third time each 1 hour, collecting decoction filters, and filtrate and above-mentioned aqueous solution merge.Amalgamation liquid is condensed into thick paste, adds the Folium Mori fine powder, mixing, and drying is ground into fine powder, adds above-mentioned volatile oil and an amount of pharmaceutic adjuvant, and mixing is made soft capsule.
6, this mulberry leaf-ginger common cold preparation of soft capsule method as claimed in claim 1 or 2 is characterized in that: above-mentioned Six-element medicine extracts volatile oil, and the aqueous solution after distillation device is in addition collected; Residual medicine dreg is decocted with water three times, and 1-3 hour for the first time, each 0.5-2 of second and third time hour, collecting decoction filtered, and filtrate and above-mentioned aqueous solution merge.Amalgamation liquid is condensed into thick paste, and drying is ground into fine powder, adds above-mentioned volatile oil and an amount of pharmaceutic adjuvant, and mixing is made soft capsule.
7, this mulberry leaf-ginger common cold preparation of soft capsule method as claimed in claim 5 is characterized in that: above-mentioned Six-element medicine extracts volatile oil, and the aqueous solution after distillation device is in addition collected; Residual medicine dreg is decocted with water three times, 3 hours for the first time, second and third time each 2 hours, collecting decoction filters, and filtrate and above-mentioned aqueous solution merge.Amalgamation liquid is condensed into thick paste, and drying is ground into fine powder, adds above-mentioned volatile oil and an amount of pharmaceutic adjuvant, and mixing is made soft capsule.
8, it is characterized in that as claim 3,4,5,6 described mulberry leaf-ginger common cold soft capsules: content accounts for 30%-70%, and adjuvant accounts for 70%-30%.Its best ratio range is 1: 0.5-1: 1.5.The best ratio range of gelatin and glycerol is 2 in the softgel shell: 1-4: 1.
9, it is characterized in that as claim 3,4,5,6,7 described mulberry leaf-ginger common cold soft capsules: adjuvant can be diluent, suspending agent, surfactant, antiseptic, one or more in antioxidant and the additives.
10, mulberry leaf-ginger common cold soft capsule as claimed in claim 8 is characterized in that: described diluent is one or more in polyethylene glycols, isopropyl alcohol, tween, span, glycerol, propylene glycol, water, mineral oil and the vegetable oil; Suspending agent is one or more in oily wax mixture, Cera Flava, ethylhydroxyethylcellulose, agar, hydroxypropyl emthylcellulose, xanthan gum, aluminum monostearate, the ethyl cellulose; Antioxidant is one or more in ethylenediaminetetraacetic acid, disodium EDTA, dibenzylatiooluene, glycine, inositol, ascorbic acid, sodium ascorbate, soft phospholipid, malic acid, hydrogen a kind of jade, citric acid, succinic acid, the burnt inferior sour sodium; Antiseptic is one or more in sorbic acid, sorbic acid methyl ester, methyl parahydroxybenzoate, ethylparaben, propyl p-hydroxybenzoate, butyl p-hydroxybenzoate, P-hydroxybenzoic acid phenyl ester, benzyl p-hydroxybenzoate class, Sodium Methyl Hydroxybenzoate, benzoic acid, benzyl alcohol, propylene glycol, the glycerol; Described additives are one or more in antiseptic, antioxidant, the coloring agent.
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| CN 200610020639 CN101049485A (en) | 2006-04-03 | 2006-04-03 | Mulberry - ginger soft capsule for treating common cold, and preparation method |
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| CN 200610020639 CN101049485A (en) | 2006-04-03 | 2006-04-03 | Mulberry - ginger soft capsule for treating common cold, and preparation method |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101912112A (en) * | 2010-07-23 | 2010-12-15 | 江苏老蚕坊蚕桑生物科技开发有限公司 | Method for manufacturing compound mulberry leaf throat moistening and cleaning tablet |
| CN102145091B (en) * | 2010-02-04 | 2012-10-17 | 天津中新药业集团股份有限公司达仁堂制药厂 | Traditional Chinese medicinal composition for eliminating wind and relieving heat and preparation method thereof |
| CN104645287A (en) * | 2014-06-26 | 2015-05-27 | 黄心诚 | Cold liquid medicine and preparation method thereof |
| CN104771713A (en) * | 2014-01-14 | 2015-07-15 | 四川好医生药业集团有限公司 | Mulberry-ginger extract, and preparation process and application thereof |
| CN105168784A (en) * | 2015-10-08 | 2015-12-23 | 广西新龙制药有限责任公司 | Wugui channel warming tablets and preparation method |
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2006
- 2006-04-03 CN CN 200610020639 patent/CN101049485A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102145091B (en) * | 2010-02-04 | 2012-10-17 | 天津中新药业集团股份有限公司达仁堂制药厂 | Traditional Chinese medicinal composition for eliminating wind and relieving heat and preparation method thereof |
| CN101912112A (en) * | 2010-07-23 | 2010-12-15 | 江苏老蚕坊蚕桑生物科技开发有限公司 | Method for manufacturing compound mulberry leaf throat moistening and cleaning tablet |
| CN104771713A (en) * | 2014-01-14 | 2015-07-15 | 四川好医生药业集团有限公司 | Mulberry-ginger extract, and preparation process and application thereof |
| CN104771713B (en) * | 2014-01-14 | 2018-03-06 | 四川好医生药业集团有限公司 | A kind of mulberry ginger medicinal extract and its preparation technology and application |
| CN104645287A (en) * | 2014-06-26 | 2015-05-27 | 黄心诚 | Cold liquid medicine and preparation method thereof |
| CN105168784A (en) * | 2015-10-08 | 2015-12-23 | 广西新龙制药有限责任公司 | Wugui channel warming tablets and preparation method |
| CN105168784B (en) * | 2015-10-08 | 2019-04-05 | 广西新龙制药有限责任公司 | Five osmanthus temperature are through piece and preparation method |
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