CN104257638A - Traditional Chinese medicine cataplasm for treating wind-cold arthralgia pain and preparation method - Google Patents
Traditional Chinese medicine cataplasm for treating wind-cold arthralgia pain and preparation method Download PDFInfo
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Abstract
The invention belongs to the technical field of medicines, and particularly relates to traditional Chinese medicine compound cataplasm which is used for treating wind-cold arthralgia and has certain anti-inflammatory and analgesic effects and a preparation method. The traditional Chinese medicine cataplasm for treating the periarticular pain caused by the wind-cold arthralgia consists of three parts, namely, a back lining layer, a paste layer and a cover lining layer, wherein the paste layer of the cataplasm is formed by mixing of a medicine part and a substance part; the medicine part of the paste layer of the cataplasm consists of largeleaf gentian root extract clear paste and prepared common monkshood daughter root extract clear paste in the weight ratio of 5:1, and every gram of the extract clear paste contains 6-12 g of crude medicines; each patch of cataplasm contains 0.3-1.2 g of traditional Chinese medicine compound extracts. The cataplasm has the advantages as follows: 1, the cataplasm belongs to an externally applied patch and is convenient to use, low in price, good in compliance and suitable for long-term medication; 2, the cataplasm is highly-targeted, can directly act on an affected part to play a medicine curative effect to the maximum extent and is high in safety performance and small in side effect, and the toxicity is reduced; 3, the cataplasm is good in moisture retention and air permeability and small in skin irritation.
Description
Technical field
The invention belongs to medical art, is specifically a kind of for the treatment of wind and cold arthromyodynia, Chinese medicine compound cataplasma and the preparation method with certain anti-inflammatory and analgesic effect.
Background technology
China's Chinese medicine and pharmacy is early recognized percutaneous dosing, as far back as 2nd century of Christian era one's own views China doctor's allusion quotation " interior through Plain Questions ", in the Song dynasty " formulary of peaceful benevolent dispensary ", have the plaster that may be used for topical therapeutic or Transdermal absorption, wherein is mostly black plasters, but prolonged application all has impact to human body and environment due to the existence of lead.Cataplasma is a kind of external use plaster, is with water-soluble high-molecular compound or hydroaropic substance for substrate, the external preparation be mixed with Chinese medicine extract.Cataplasma adopts water-soluble high-molecular material to be substrate, has good affinity, can strengthen the hydration of skin, thus be beneficial to the Transdermal absorption of medicine with skin.Cataplasma is larger than traditional black plaster, rubber paste drug loading, good permeability, rapid-action, zest is little, also avoid the plumbous harm of existence to human body and the pollution of environment; The pollution to medicated clothing can be avoided compared with ointment; Have compared with oral drugs rapid-action, blood drug level is constant, the feature of few side effects.Also can add suitable adjuvant in prescription, have in medicine release and penetrate, play the effects such as quick-acting and long-acting, be particularly suitable for the modern production of Chinese medicine." Chinese Pharmacopoeia 2005 version and version in 2010 have all recorded the rules of preparations requirement of Babu cream, and its research is applied in China and also starts gradually, but mostly are and change conventional plaster and rubber-emplastrum into cataplasma, and the cataplasma report of novel composing prescription is less.Therefore research and development technique advanced person, determined curative effect, Babu cream preparation easy to use will have higher learning value and application prospect to adapt to clinical needs.
Rheumatism, rheumatoid arthritis are a kind of common rheumatism, and its etiology and pathogenesis there is no final conclusion both at home and abroad, and majority thinks that its morbidity is relevant with the factor such as autoimmune, heredity, infection virus, endocrine, environmental factors, gonadal hormone and psychoneural state.Sickness rate has the trend increased year by year in recent years, causes great impact to family and social development.Also there is no gratifying Therapeutic Method at present.Conventional western medical treatment method comprises Drug therapy, surgical treatment, stem cell transplantation, immunologic purging treatment and gene therapy etc.Drug therapy mainly comprises NSAID (non-steroidal anti-inflammatory drug), because it needs long term administration, GI irritation is its main adverse reaction always, it is the principal element affecting patient medication compliance, oneself causes attracting attention of common people to the treatment of this disease for Chinese medicine and therapy thereof in recent years, actively develop the research of Chinese medicine rheumatism, there is boundless prospect and realistic meaning.
Chinese medicine thinks that rheumatism, rheumatoid arthritis belong to " arthromyodynia " category.Treatment have accumulated rich experience, and define secret recipe and the proved recipe of a large amount of determined curative effects.Its method for the treatment of has internal treatment, external treatment, interior external treatment.But external treatment with Chinese medicine medicine ubiquity dosage form falls behind phenomenon at present, mostly rest on diachylon, rubber plaster and ointment level, mainly there is method for making not science, spice effective ingredient destroys by pyrolytic, substrate better can not mix with Chinese medicine water extract, alcohol extract, the drawbacks such as the drug loading of preparation is little, and often exist large, airtight, the easy pollution clothes of flavour of a drug, onset slow, easily skin produced stimulate and the shortcoming such as allergy.Especially test and proved long-time use containing a large amount of diachylon preparations, patient's blood lead, lead in urine are all significantly higher than normal level, produce harm to people's physical ability, and the production of diachylon and all produce larger pollution to environment after using.So exploitation curative effect is remarkable lastingly, safe external Modern preparations easy to use just becomes an important topic of the modernization of Chinese medicine.
This cataplasma former side be loaded in " wushu sportsmen ", and in side, Radix Gentianae Macrophyllae cold expelling dredging collateral, the large heat of Radix Aconiti Lateralis Preparata great Xin are with dispersing wind and cold, and it is supporing yang that benefit fire played altogether by two medicines, the merit of dispersing cold for relieving pain, and be the key medicine for the treatment of wind and cold arthralgia pain, compatibility is precise and appropriate, and flavour of a drug are few, and power is specially grand.We are used for the treatment of rheumatism, rheumatoid arthritis, and curative effect is determined.But have this toxic traditional Chinese medicine of Radix Aconiti Lateralis Preparata in side, and consumption is comparatively large again, easily causes poisoning, so do not declare clothes of a specified duration.External then can reduce toxicity, and medicine can be directly to and reaches lesions position without stomach, intestinal, liver and play curative effect.There is no this medicine clinical report at present and pharmacological experiment research is reported, also without the exploitation of large-scale production and new medicine.Be necessary to research and develop novel form, make it give play to better curative effect.Therefore, prepare this cataplasma Transdermal absorption novel form and there is fine development prospect and higher learning value.
Summary of the invention
The present invention aim to provide a kind of easy to use, cheap, safe and effective, side effect is little, reproducible, stability is high, the herbal mixture external use plaster that compliance is good.The preparation method of its substrate can be widely used in the cataplasma preparation of various Chinese medicine.
Cataplasma of the present invention former side be loaded in " wushu sportsmen ", and letter 81 is said: " control numbness brothers Yong Zhongfang Qin recover five pay separately all two thing smeltings of son one point close and half tool for weighing medicine in ancient China one first Bu meal beverage day three with more for spending." Radix Gentianae Macrophyllae cold expelling dredging collateral, the large heat of Radix Aconiti Lateralis Preparata great Xin are with dispersing wind and cold in side, two medicines play that to mend fire supporing yang altogether, and dispersing cold for relieving pain, be the key medicine for the treatment of wind and cold arthralgia pain, compatibility is precise and appropriate, and flavour of a drug are few, and power is specially grand.
A kind of wind and cold arthromyodynia for the treatment of of the present invention causes the Chinese medicine patcher of periarticular pain to be made up of backing layer, paste layer, lid lining three part; Wherein cataplasma paste layer is made up of drug moiety and base portion mixing; Described cataplasma paste layer drug moiety by weight ratio be the Radix Gentianae Macrophyllae of 5 ﹕ 1, Radix Aconiti Lateralis Preparata extract clear paste forms, every g extract clear paste is containing crude drug 6 ~ 12g; Every note cataplasma is containing Chinese medicinal compound extract 0.3-1.2g.
Treat the Chinese medicine patcher preparation method that wind and cold arthromyodynia causes periarticular pain, described cataplasma paste layer drug extract obtains by the following method:
Added water by Radix Aconiti Lateralis Preparata at the adjustable electric furnace of electronics fire decoction above 60min, decoction liquor is filtered, and add water the decoction three times that uses the same method in medicinal residues, and the filtrate of three times mixing, the ethanol adding 75% leaves standstill 24 hours, and filtered and recycled ethanol, obtains water extract; The Radix Gentianae Macrophyllae powder soak with ethanol 72 hours of 80%, reclaims ethanol with Rotary Evaporators, obtains ethanol extract; The mixing of said extracted thing is condensed into clear paste.
The present invention is a kind of treats the Chinese medicine patcher of wind and cold arthralgia-syndrome pain and preparation method has following beneficial effect compared with prior art: cataplasma of the present invention, according to the consumption of two taste Chinese medicines in compound recipe, design every note in production containing Chinese medicinal compound extract (clear paste) 0.3-1.2g, every day one pastes.
Cataplasma of the present invention, with the uniformity of mastic, can stretchability, degree of oozing out and to the tracing ability of skin for inspection target, orthogonal experiment research is carried out to mixing time, refining and temperature, the preparation process condition of cataplasma is optimized.After experimental result shows cataplasma sticker and excipient mix in preparation process, be that 200r/min stirs 30 minutes with rotating speed, refining and temperature are 50 DEG C.By this technique repetitive operation, gained sample result is satisfied.
Cataplasma of the present invention, measure the quality standard such as adhesion, plastic property all meet the requirements according to the Pharmacopoeia of the People's Republic of China (2010 editions) annex Ⅻ, annex I, skin irritation test and skin hypersensitivity experiment show application on human skin nonirritant and sensitization.
Cataplasma of the present invention, adopt human body skin Subtraction method to measure its transdermal efficiency, 12h medicine main component gentiopicrin release rate reaches 69%, shows that Radix Gentianae Macrophyllae pain-relieving Babu agent release is fast, good effect.
Cataplasma of the present invention, every lO0cm
2paste containing amount is 9.5 ± 0.4g.
The present invention has the following advantages:
1. cataplasma of the present invention belongs to external use plaster, easy to use, cheap, compliance is good, is applicable to long-term prescription.
2. targeting is strong, can direct effect and affected part, maximum performance curative effect of medication.Medicine can be directly to and reaches lesions position without stomach, intestinal, liver and play curative effect, avoid the first pass effect of gastrointestinal tract degraded and liver, because containing this toxic traditional Chinese medicine of Radix Aconiti Lateralis Preparata in we, large usage quantity, easily cause poisoning, so do not declare clothes of a specified duration, external then can reduce toxicity, and security performance is high, side effect is little.
3. moisture retention and good permeability, little to skin irritation.
The cataplasma pharmacodynamics test of preparation of the present invention is as follows:
1. Dichlorodiphenyl Acetate brings out the impact of mouse writhing reaction:
Result shows, cataplasma each dosage group writhing number of times is all low than matched group, all has significant difference (p ﹤ 0.01) between the two, illustrates that this cataplasma has good analgesic activity.
2. the impact of rat paw edema caused by Carrageenan:
Result shows, each dosage group of cataplasma is in causing scorching latter 1,2,3,5 hour, and its swelling, all lower than blank group, has significant difference (p ﹤ 0.01) between the two.Rat paw pathological section, visible muscular tissue fracture under model arrangement of mirrors, a large amount of inflammatory cell diffuse infiltrating, tissue edema, illustrate the rat acute inflammation modeling success with carrageenin induction.Positive control drug aspirin and each dosage group of cataplasma are all significantly improved inflammatory cell infiltration, muscular tissue fracture, tissue edema.Illustrate that this cataplasma has stronger antiinflammatory action.
3. couple rat blood serum IL-1 β and PGE
2impact:
Adopt Freund's complete adjuvant to prepare rheumatoid arthritis in rats animal model (AA), detect IL-1 β and PGE in rat blood serum with ELISA
2changes of contents, result show: compared with blank group, model group IL-1, PGE
2significantly increase (P<0.001); Each treatment group IL-1, PGE
2significantly lower than model group (P<0.01 or P<0.05).Illustrate that this cataplasma has good antiinflammatory action, the mechanism of its treatment of arthritis may with its T suppression cell factor LI-1 'beta ' activity and inflammatory mediator PGE
2produce relevant.
Detailed description of the invention
Below in conjunction with embodiment to the present invention a kind of treat wind and cold arthralgia-syndrome pain Chinese medicine patcher and preparation method technical scheme be further described.
The present invention be directed to rheumatism, a kind of new medicine external use plaster---cataplasma that rheumatoid arthritis causes periarticular pain symptom to develop, its Chinese medicine treats the common medicine of wind and cold arthralgia pain for raw material with Radix Aconiti Lateralis Preparata, Radix Gentianae Macrophyllae two taste, through effective component extracting, it is formulated through a series of preparation technology to add cataplasma adjuvant.
Cataplasma of the present invention is made up of backing layer, paste layer, lid lining three part.Core paste layer is made up of substrate and drug moiety, and namely Radix Aconiti Lateralis Preparata, Radix Gentianae Macrophyllae extract and cataplasma excipient (binding agent, cross-linking agent, filler, wetting agent, transdermal enhancer) form, and backing layer selects non-woven fabrics, cotton, paper one wherein; Lid lining selects plastic sheeting, separate paper, aluminium foil-polyethylene composite film, hard gauze one wherein.
A kind of wind and cold arthromyodynia for the treatment of causes the Chinese medicine patcher of periarticular pain to be made up of backing layer, paste layer, lid lining three part; Wherein cataplasma paste layer is made up of drug moiety and base portion mixing; Described cataplasma paste layer drug moiety by weight ratio be the Radix Gentianae Macrophyllae of 5 ﹕ 1, Radix Aconiti Lateralis Preparata extract clear paste forms, every g extract clear paste is containing crude drug 6 ~ 12g; Every note cataplasma is containing Chinese medicinal compound extract 0.3-1.2g.
A kind of wind and cold arthromyodynia for the treatment of causes cataplasma paste layer drug extract described in the Chinese medicine patcher preparation method of periarticular pain to obtain by the following method:
Added water by Radix Aconiti Lateralis Preparata at the adjustable electric furnace of electronics fire decoction above 60min, decoction liquor is filtered, and add water the decoction three times that uses the same method in medicinal residues, and the filtrate of three times mixing, the ethanol adding 75% leaves standstill 24 hours, and filtered and recycled ethanol, obtains water extract; The Radix Gentianae Macrophyllae powder soak with ethanol 72 hours of 80%, reclaims ethanol with Rotary Evaporators, obtains ethanol extract; The mixing of said extracted thing is condensed into clear paste.
Substrate is made up of binding agent, cross-linking agent, filler, wetting agent, transdermal enhancer, and described cataplasma paste layer base portion comprises the component of following weight percentage
Binding agent 5%-30%
Cross-linking agent 0%-5%
Filler 5%-20%
Wetting agent 30%-50%
Transdermal enhancer 1%-10%.
Described paste layer is by the one in binding agent, cross-linking agent, filler, wetting agent, transdermal enhancer in Chinese medicine extract and substrate and severally form; Backing layer selects non-woven fabrics, cotton, paper one wherein; Lid lining selects plastic sheeting, separate paper, aluminium foil-polyethylene composite film, hard gauze one wherein.
The present invention be directed to rheumatism, a kind of new medicine external use plaster---cataplasma that rheumatoid arthritis causes periarticular pain symptom to develop, its Chinese medicine treats the common medicine of wind and cold arthralgia pain for raw material with Radix Aconiti Lateralis Preparata, Radix Gentianae Macrophyllae two taste, through effective component extracting, it is formulated through some row preparation technology to add cataplasma adjuvant.
Cataplasma of the present invention is made up of backing layer, paste layer, lid lining three part.Core paste layer is made up of substrate and drug moiety, and namely Radix Aconiti Lateralis Preparata, Radix Gentianae Macrophyllae extract and cataplasma excipient (binding agent, cross-linking agent, filler, wetting agent, transdermal enhancer) form, and backing layer selects non-woven fabrics, cotton, paper one wherein; Lid lining selects plastic sheeting, separate paper, aluminium foil-polyethylene composite film, hard gauze one wherein.
Cataplasma paste layer base portion of the present invention, binding agent can be one or more in the copolymer of gelatin, starch, agar, mannan, alginic acid, polyacrylic acid, polyacrylate, dextrin, methylcellulose, sodium carboxymethylcellulose pyce, carboxymethyl cellulose, sodium carboxymethyl cellulose, polyvinyl alcohol, polyvinylpyrrolidone, methyl vinyl ether and maleic anhydride, Radix Acaciae senegalis, tragakanta, karaya, tracasol; Cross-linking agent can be one or more in the higher valence metal oxide such as aluminum chloride, aluminum glycinate, zinc oxide; Filler can be one or more in zinc oxide, Kaolin, micropowder silica gel, calcium carbonate, kaolin, titanium dioxide; Wetting agent can be one or more in ethylene glycol, diethylene glycol, Polyethylene Glycol, glycerol, sorbitol, propylene glycol, 1,3 butylene glycol; Transdermal enhancer can be menthol, Borneolum Syntheticum, eucalyptus oil, azone, Oleum Terebinthinae, salicylic acid, one or more in oleic acid, lauryl alcohol.
The each component of catablasm base material of the present invention is made up of following proportioning:
Binding agent 5%-30%
Cross-linking agent 0%-5%
Filler 5%-20%
Wetting agent 30%-50%
Transdermal enhancer 1%-10%
Cataplasma of the present invention, according to the consumption of two taste Chinese medicines in compound recipe, design every note in production containing Chinese medicinal compound extract (clear paste) 0.3-1.2g, every day one pastes.
Cataplasma of the present invention, with the uniformity of mastic, can stretchability, degree of oozing out and to the tracing ability of skin for inspection target, orthogonal experiment research is carried out to mixing time, refining and temperature, the preparation process condition of cataplasma is optimized.After experimental result shows cataplasma sticker and excipient mix in preparation process, be that 200r/min stirs 30 minutes with rotating speed, refining and temperature are 50 DEG C.By this technique repetitive operation, gained sample result is satisfied.
Cataplasma of the present invention, measure the quality standard such as adhesion, plastic property all meet the requirements according to the Pharmacopoeia of the People's Republic of China (2010 editions) annex Ⅻ, annex I, skin irritation test and skin hypersensitivity experiment show application on human skin nonirritant and sensitization.
Cataplasma of the present invention, adopt human body skin Subtraction method to measure its transdermal efficiency, 12h medicine main component gentiopicrin release rate reaches 69%, shows that Radix Gentianae Macrophyllae pain-relieving Babu agent release is fast, good effect.
Cataplasma of the present invention, every lO0cm
2paste containing amount is 9.5 ± 0.4g.
Embodiment 1:
Backing layer: non-woven fabrics
Lid lining: transparent polypropylene film
Ointment-containing body layer is by following weight proportion:
Compound Chinese medicine extract: 0.5g
Binding agent: gelatin 1g
Sodium polyacrylate 0.6g
Sodium carboxymethyl cellulose 0.8g
Cross-linking agent: aluminum chloride 0.2g
Filler: Kaolin 1g
Wetting agent: glycerol 5g
Transdermal enhancer: azone 0.2g
Borneolum Syntheticum 0.05g
Water: 7g
Preparation method is:
Added water by required Radix Aconiti Lateralis Preparata at the adjustable electric furnace of electronics fire decoction above 60min, decoction liquor is filtered, and add water the decoction three times that uses the same method in medicinal residues, and the filtrate of three times mixing, the ethanol adding 75% leaves standstill 24 hours, and filtered and recycled ethanol, obtains water extract; The required Radix Gentianae Macrophyllae powder soak with ethanol 72 hours of 80%, reclaims ethanol with Rotary Evaporators, obtains ethanol extract.The extract finally obtained is condensed into extractum.Take recipe quantity gelatin distilled water swelling after A; Separately get recipe quantity sodium carboxymethyl cellulose, sodium polyacrylate, Kaolin, glycerol dissolve miscible B; Drug extract, aluminum chloride, azone, Borneolum Syntheticum are dispersed in B, add suitable quantity of water and mix to obtain C.Finally be blended in C by A, 50 DEG C is that 200r/min stirs and obtains homogeneous mastic in 30 minutes with rotating speed, is then evenly applied on non-woven fabrics by cataplasma coating machine, compressing, covers transparent polypropylene film.
Embodiment 2:
Backing layer: non-woven fabrics
Lid lining: transparent polypropylene film
Ointment-containing body layer is by following weight proportion:
Compound Chinese medicine extract: 0.8g
Binding agent: gelatin 1.5g
Sodium polyacrylate 0.8g
Sodium carboxymethyl cellulose 1.2g
Cross-linking agent: aluminum chloride 0.5g
Filler: Kaolin 1g
Wetting agent: glycerol 5g
Transdermal enhancer: azone 0.3g
Borneolum Syntheticum 0.1g
Water: 9g
Preparation method is with example 1.
Embodiment 3:
Backing layer: non-woven fabrics
Lid lining: transparent polypropylene film
Ointment-containing body layer is by following weight proportion:
Compound Chinese medicine extract: 1g
Binding agent: gelatin 2g
Sodium polyacrylate 1g
Sodium carboxymethyl cellulose 1.6g
Cross-linking agent: aluminum chloride 1g
Filler: Kaolin 1.5g
Wetting agent: glycerol 6g
Transdermal enhancer: azone 1g
Borneolum Syntheticum 0.05g
Water: 11g
Preparation method is with example 1.
Embodiment 4:
Backing layer: cotton
Lid lining: separate paper
Ointment-containing body layer is by following weight proportion:
Compound Chinese medicine extract: 1g
Binding agent: Radix Acaciae senegalis 1.5g
Sodium polyacrylate 0.8g
Sodium carboxymethyl cellulose 0.8g
Cross-linking agent: aluminum chloride 0.8g
Filler: Kaolin 1g
Wetting agent: glycerol 5g
Transdermal enhancer: azone 1g
Borneolum Syntheticum 0.15g
Water: 8g
Preparation method is:
Drug extract extracting method is with example 1.Take recipe quantity Radix Acaciae senegalis distilled water swelling after A; Separately get recipe quantity sodium carboxymethyl cellulose, sodium polyacrylate, Kaolin, glycerol dissolve miscible B; Drug extract, aluminum chloride, azone, Borneolum Syntheticum are dispersed in B, add suitable quantity of water and mix to obtain C.Finally be blended in C by A, 50 DEG C is that 200r/min stirs and obtains homogeneous mastic in 30 minutes with rotating speed, is then evenly applied on non-woven fabrics by cataplasma coating machine, compressing, covers separate paper.
Claims (4)
1. treat the Chinese medicine patcher that wind and cold arthromyodynia causes periarticular pain, it is characterized in that: cataplasma is made up of backing layer, paste layer, lid lining three part; Wherein cataplasma paste layer is made up of drug moiety and base portion mixing; Described cataplasma paste layer drug moiety by weight ratio be the Radix Gentianae Macrophyllae of 5 ﹕ 1, Radix Aconiti Lateralis Preparata extract clear paste forms, every g extract clear paste is containing crude drug 6 ~ 12g; Every note cataplasma is containing Chinese medicinal compound extract 0.3-1.2g.
2. according to claim 1ly a kind ofly treat the Chinese medicine patcher preparation method that wind and cold arthromyodynia causes periarticular pain, it is characterized in that, described cataplasma paste layer drug extract obtains by the following method:
Added water by Radix Aconiti Lateralis Preparata at the adjustable electric furnace of electronics fire decoction above 60min, decoction liquor is filtered, and add water the decoction three times that uses the same method in medicinal residues, and the filtrate of three times mixing, the ethanol adding 75% leaves standstill 24 hours, and filtered and recycled ethanol, obtains water extract; The Radix Gentianae Macrophyllae powder soak with ethanol 72 hours of 80%, reclaims ethanol with Rotary Evaporators, obtains ethanol extract; The mixing of said extracted thing is condensed into clear paste.
3. treatment wind and cold arthromyodynia according to claim 1 and 2 causes the Chinese medicine patcher of periarticular pain, it is characterized in that, substrate is made up of binding agent, cross-linking agent, filler, wetting agent, transdermal enhancer, and described cataplasma paste layer base portion comprises the component of following weight percentage
Binding agent 5%-30%
Cross-linking agent 0%-5%
Filler 5%-20%
Wetting agent 30%-50%
Transdermal enhancer 1%-10%.
4. treatment wind and cold arthromyodynia according to claim 1 causes the Chinese medicine patcher of periarticular pain, it is characterized in that: described paste layer is by the one in binding agent, cross-linking agent, filler, wetting agent, transdermal enhancer in Chinese medicine extract and substrate and severally form; Backing layer selects non-woven fabrics, cotton, paper one wherein; Lid lining selects plastic sheeting, separate paper, aluminium foil-polyethylene composite film, hard gauze one wherein.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410540870.8A CN104257638A (en) | 2014-10-14 | 2014-10-14 | Traditional Chinese medicine cataplasm for treating wind-cold arthralgia pain and preparation method |
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| CN201410540870.8A CN104257638A (en) | 2014-10-14 | 2014-10-14 | Traditional Chinese medicine cataplasm for treating wind-cold arthralgia pain and preparation method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105944015A (en) * | 2016-06-06 | 2016-09-21 | 邹金樑 | External patch for treating gout and preparing method thereof |
| CN110680892A (en) * | 2018-07-04 | 2020-01-14 | 黑龙江燎原科技有限公司 | Cataplasm hot patch for relieving pain of tumor |
| CN111466639A (en) * | 2020-05-06 | 2020-07-31 | 佳木斯大学 | Sustained-release medicine antiviral mask patch and preparation method thereof |
| CN112717116A (en) * | 2021-02-04 | 2021-04-30 | 贾刘杰 | A topical patch for treating arthromyodynia due to rheumatism and cold, and its preparation method |
-
2014
- 2014-10-14 CN CN201410540870.8A patent/CN104257638A/en active Pending
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105944015A (en) * | 2016-06-06 | 2016-09-21 | 邹金樑 | External patch for treating gout and preparing method thereof |
| CN110680892A (en) * | 2018-07-04 | 2020-01-14 | 黑龙江燎原科技有限公司 | Cataplasm hot patch for relieving pain of tumor |
| CN111466639A (en) * | 2020-05-06 | 2020-07-31 | 佳木斯大学 | Sustained-release medicine antiviral mask patch and preparation method thereof |
| CN112717116A (en) * | 2021-02-04 | 2021-04-30 | 贾刘杰 | A topical patch for treating arthromyodynia due to rheumatism and cold, and its preparation method |
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Application publication date: 20150107 |
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