CN101822741B - Oral ulcer healing membrane with traditional Chinese medicine bioadhesive one-way medicine release - Google Patents
Oral ulcer healing membrane with traditional Chinese medicine bioadhesive one-way medicine release Download PDFInfo
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Abstract
The invention relates to an oral ulcer healing membrane with traditional Chinese medicine bioadhesive one-way medicine release, capable of effectively solving the problem of used medicines for treating the oral ulcer. The technical scheme for solving the problem is as follows: the ulcer healing membrane is prepared by the following materials: 10-13g of figwortflower picrorhiza rhizome, 10-13g of tree peony bark, 8-11g of natural indigo, 1.5-2.5g of borneol, 2-4g of Carbomer 934P, 2-4g of hydroxy propyl cellulose, 2.3-2.5g of sodium cyclamate, 10-14ml of glycerin and ethyecellulose and absolute ethyl alcohol. The invention has reasonable compatibility of components, advanced and unique method, convenient use and good treatment effect and is innovation for treating oral ulcer.
Description
One, technical field
The present invention relates to field of medicaments, particularly a kind of Chinese traditional medicine biology is sticked the oral ulcer healing membrane of unidirectional release.
Two, background technology
Recurrent oral ulceration is commonly encountered diseases, frequently-occurring disease, belongs to one of department of stomatology difficult miscellaneous diseases, and prevalence is up to 25%.Modern medicine thinks that its cause of disease and immunologic hypofunction, antibacterial and viral infection, endocrine disturbance, autonomic nervous function are relevant with the digestive tract function disorder.The traditional Chinese medical science thinks that this disease and taste excess-heat, flaming up of heart-fire, interior-heat caused by deficiency of YIN, retention of damp-heat in the interior, the deficiency of YIN damp and hotly are mingled with the nutrient blood that causes burning, the corrosion sarolemma is relevant, or stagnate with warm removing dampness accent due to deficiency of spleen-YANG and kidneyYANG, deficiency of spleen-QI and stomach-QI, the coldheat complex, body fluid, cold-damp is stranded in the oral cavity, sarolemma festers relevant.
The Chinese medicine exterior-applied formulation for the treatment of this disease clinically has powder, membrane, the usage of powder is to be that herbal sprinkling is in the affected part, but because the special physiological environment in oral cavity, medicine is very fast diluted, concentration descends rapidly, the treatment concentration of can not remaining valid in the part for a long time, even medicine is swallowed, active component is got rid of too early, thereby influenced curative effect.The middle medicine film of listing only has ice boron film and propolis oral cavity membrance at present, though the former is the bio-adhesive film, does not belong to unidirectional release film, and the latter is common membrane then, has to stick short shortcoming of time.The Western medicine exterior-applied formulation has oral cavity bio-adhesive tablet as " meaning can be pasted " and pelliculae pro cavo oris such as the listing of compound recipe chlorhexidine dexamethasone film, these medicines are hormone medicine, being used for recurrent oral ulceration repeatedly will have side effects to human body, especially not be suitable for the child.
Bio-adhesive preparation in oral cavity is at home and abroad studied and is got rapid development in recent years.The medium metronidazole oral cavity adhesion film of having developed of Yan Yan, this membrane haves three layers, and ground floor is the water-insoluble film, and the second layer is for connecting the intermediary layer of water soluble film layer and water-insoluble layer, and the 3rd layer for adhering to the release layer.Xiao Hua etc. have developed the double-deck oral film of compound Ofloxacin, are used for oral ulcer that multiple factor such as antibacterial, wound causes, tongue ulcer etc.Cao Xiuhong etc. with Preparation of Chitosan compound recipe levofloxacin KOUQIANG KUIYANG MO, can improve the clinical symptoms of oral ulcer rapidly, promote ulcer healing.But above-mentioned preparation more or less has certain limitation, belongs to antibacterials as metronidazole and ofloxacin, and for the recurrent oral ulceration patient, prolonged and repeated medication easily causes the oral cavity flora imbalance.Fu Zhijun etc. utilize PVA-1750: CMC-Na: CP (3: 6: 1) is developed into the mucosa adhesion release membranes with the routed peaceful side of compound recipe.The little equality of poplar
[9]With polyvinyl alcohol and glycerol is the tripterygium glycosides membrane that filmogen makes, and its technology is simple, and clinical research shows that the recurrent aphtha patient is had immunoregulation effect and definite curative effect.But these preparations are monolayer membrane, not the plurality of advantages of the double-deck membrane of tool.Therefore, though existing have multiple treatment oral ulcer membrane (oral ulcer healing membrane), for various reasons, it uses and is unsatisfactory.
Three, summary of the invention
At above-mentioned situation, for overcoming the prior art defective, the present invention's purpose just provides the oral ulcer healing membrane that a kind of Chinese traditional medicine biology is sticked unidirectional release, can effectively solve the medication problem of treatment oral ulcer, the technical scheme of its solution is, this ulcer healing membrane is by Rhizoma Picrorhizae 10～13g, Cortex Moutan 10～13g, Indigo Naturalis 8～11g, Borneolum Syntheticum 1.5～2.5g, carbomer 934 P 2～4g, hydroxypropyl cellulose 2～4g, cyclamate 2.3～2.5g, glycerol 10～14ml and ethyl cellulose, dehydrated alcohol is made, wherein, the mass concentration that Indigo Naturalis is added 10 times of weight of Indigo Naturalis at every turn is 80～90% alcohol reflux secondary, each 0.5～1h, filter, merging filtrate, reclaiming ethanol and being concentrated into relative density is 1.05 concentrated solution, standby;
The mass concentration that Rhizoma Picrorhizae is added at every turn 10 times of weight of Rhizoma Picrorhizae is 65～80% alcohol refluxs three times, and each 1～2h filters, and merging filtrate is standby;
Cortex Moutan extracts paeonol with vapor distillation, collect the aqueous solution after distilling, the water that adds 8 times of amounts of Cortex Moutan weight in the medicinal residues, decocted 30-45 minute, get decocting liquid, merge with the aqueous solution after the distillation, concentrate, 50 ℃ are surveyed relative densities is 1.03～1.05, adds ethanol, makes to contain the alcohol amount and reach 55～60%, placed 24-48 hour, get the merging of supernatant and Rhizoma Picrorhizae filtrate, reclaim ethanol and be condensed into Rhizoma Picrorhizae and the Cortex Moutan thick paste that relative density is 1.1-1.2 (being that relative density is about 1.15), standby;
Ethyl cellulose adds dehydrated alcohol and is swelling to fully dissolving and is transparence, paints the thick film of 0.25cm as backing layer, and is standby; Carbomer 934 P2～4g is with after hydroxypropyl cellulose 2～4g mixes with weight ratio at 1: 1, adding water, to be mixed with mass concentration be 3% clear solution, add Indigo Naturalis concentrated solution, Rhizoma Picrorhizae and Cortex Moutan thick paste, cyclamate 2.3-2.5g, after the limit edged stirs, again paeonol, Borneolum Syntheticum 1～2g, glycerol 10-14ml are ground well, slowly add, stir evenly, leave standstill and outgas into pastille film forming liquid, on the surface of ethyl cellulose, be coated with 2200ml/m
2Pastille film forming liquid, get final product, component compatibility of the present invention is reasonable, method advanced person, uniqueness are easy to use, good effect is the innovation of treatment on the oral ulcer.
Four, the specific embodiment
Below in conjunction with embodiment the specific embodiment of the present invention is elaborated.
Embodiment 1
The present invention in the specific implementation, can realize by following scheme: make by Rhizoma Picrorhizae 10g, Cortex Moutan 10g, Indigo Naturalis 8g, Borneolum Syntheticum 1g, carbomer 934 P 2g, hydroxypropyl cellulose 2g, cyclamate 2.3g, glycerol 10ml and ethyl cellulose, dehydrated alcohol, wherein, the mass concentration that Indigo Naturalis is added 10 times of weight of Indigo Naturalis at every turn is 80% alcohol reflux secondary, each 0.5h filters merging filtrate, reclaiming ethanol and being concentrated into relative density is 1.05 concentrated solution, standby;
The mass concentration that Rhizoma Picrorhizae is added at every turn 10 times of weight of Rhizoma Picrorhizae is 65% alcohol reflux three times, and each 1h filters, and merging filtrate is standby;
Cortex Moutan extracts paeonol with vapor distillation, collects the aqueous solution after distilling, and adds the water of 8 times of amounts of Cortex Moutan weight in the medicinal residues, decocted 30 minutes, and got decocting liquid, with the aqueous solution merging after the distillation, concentrate, 50 ℃ are surveyed relative densities is 1.03, adds ethanol, makes to contain the alcohol amount and reach 55%, placed 24 hours, get supernatant and Rhizoma Picrorhizae filtrate and merge, reclaiming ethanol and being condensed into relative density is 1.1 Rhizoma Picrorhizae and Cortex Moutan thick paste, standby;
Ethyl cellulose adds dehydrated alcohol and is swelling to fully dissolving and is transparence, paints the thick film of 0.25cm as backing layer, and is standby; Carbomer 934 P 2g is with after hydroxypropyl cellulose 2g mixes, adding water, to be mixed with mass concentration be 3% clear solution, add Indigo Naturalis concentrated solution, Rhizoma Picrorhizae and Cortex Moutan thick paste, cyclamate 2.3g, after the limit edged stirs, again paeonol, Borneolum Syntheticum 1g, glycerol 10ml are ground well, slowly add, stir evenly, leave standstill and outgas into pastille film forming liquid, on the surface of ethyl cellulose, be coated with 2200ml/m
2Pastille film forming liquid, get final product.
Embodiment 2
The present invention in the specific implementation, also realize: make by Rhizoma Picrorhizae 11g, Cortex Moutan 11g, Indigo Naturalis 9g, Borneolum Syntheticum 1.5g, carbomer 934 P 3g, hydroxypropyl cellulose 3g, cyclamate 2.4g, glycerol 12ml and ethyl cellulose, dehydrated alcohol by following scheme, wherein, the mass concentration that Indigo Naturalis is added 10 times of weight of Indigo Naturalis at every turn is 85% alcohol reflux secondary, each 0.7h filters merging filtrate, reclaiming ethanol and being concentrated into relative density is 1.05 concentrated solution, standby;
The mass concentration that Rhizoma Picrorhizae is added at every turn 10 times of weight of Rhizoma Picrorhizae is 70% alcohol reflux three times, and each 1.5h filters, and merging filtrate is standby;
Cortex Moutan extracts paeonol with vapor distillation, collects the aqueous solution after distilling, and adds the water of 8 times of amounts of Cortex Moutan weight in the medicinal residues, decocted 40 minutes, and got decocting liquid, with the aqueous solution merging after the distillation, concentrate, 50 ℃ are surveyed relative densities is 1.04, adds ethanol, makes to contain the alcohol amount and reach 58%, placed 30 hours, get supernatant and Rhizoma Picrorhizae filtrate and merge, reclaiming ethanol and being condensed into relative density is 1.15 Rhizoma Picrorhizae and Cortex Moutan thick paste, standby;
Ethyl cellulose adds dehydrated alcohol and is swelling to fully dissolving and is transparence, paints the thick film of 0.25cm as backing layer, and is standby; Carbomer 934 P 3g is with after hydroxypropyl cellulose 3g mixes, adding water, to be mixed with mass concentration be 3% clear solution, add Indigo Naturalis concentrated solution, Rhizoma Picrorhizae and Cortex Moutan thick paste, cyclamate 2.4g, after the limit edged stirs, again paeonol, Borneolum Syntheticum 1.5g, glycerol 12ml are ground well, slowly add, stir evenly, leave standstill and outgas into pastille film forming liquid, on the surface of ethyl cellulose, be coated with 2200ml/m
2Pastille film forming liquid, get final product.
Embodiment 3
The present invention is made by Rhizoma Picrorhizae 12g, Cortex Moutan 12g, Indigo Naturalis 10g, Borneolum Syntheticum 2g, carbomer 934 P 4g, hydroxypropyl cellulose 4g, cyclamate 2.5g, glycerol 14ml and ethyl cellulose, dehydrated alcohol, wherein, the mass concentration that Indigo Naturalis is added 10 times of weight of Indigo Naturalis at every turn is 90% alcohol reflux secondary, each 1h, filter, merging filtrate, reclaiming ethanol and being concentrated into relative density is 1.05 concentrated solution, standby;
The mass concentration that Rhizoma Picrorhizae is added at every turn 10 times of weight of Rhizoma Picrorhizae is 80% alcohol reflux three times, and each 2h filters, and merging filtrate is standby;
Cortex Moutan extracts paeonol with vapor distillation, collects the aqueous solution after distilling, and adds the water of 8 times of amounts of Cortex Moutan weight in the medicinal residues, decocted 45 minutes, and got decocting liquid, with the aqueous solution merging after the distillation, concentrate, 50 ℃ are surveyed relative densities is 1.05, adds ethanol, makes to contain the alcohol amount and reach 60%, placed 48 hours, get supernatant and Rhizoma Picrorhizae filtrate and merge, reclaiming ethanol and being condensed into relative density is 1.2 Rhizoma Picrorhizae and Cortex Moutan thick paste, standby;
Ethyl cellulose adds dehydrated alcohol and is swelling to fully dissolving and is transparence, paints the thick film of 0.25cm as backing layer, and is standby; Carbomer 934 P 4g is with after hydroxypropyl cellulose 4g mixes, adding water, to be mixed with mass concentration be 3% clear solution, add Indigo Naturalis concentrated solution, Rhizoma Picrorhizae and Cortex Moutan thick paste, cyclamate 2.5g, after the limit edged stirs, again paeonol, Borneolum Syntheticum 1～2g, glycerol 14ml are ground well, slowly add, stir evenly, leave standstill and outgas into pastille film forming liquid, on the surface of ethyl cellulose, be coated with 2200ml/m
2Pastille film forming liquid, get final product.
Rhizoma Picrorhizae of the present invention not only clearing away damp-heat but also clearind deficient heat are monarch drug; The Cortex Moutan clearing away heat and cooling blood, the Indigo Naturalis heat-clearing and toxic substances removing, removing heat from blood is ministerial drug altogether; The Borneolum Syntheticum clearing away heat to alleviate pain is adjuvant drug; All medicines share and play clearing away damp-heat, deficiency-heat altogether, detoxifcation, the merit of cooling blood and relieving pain; Cure mainly asthenic fire, excess-fire, the damp and hot oral ulcer that is mingled with of deficiency-heat.
Traditional oral mucosa drug-delivery preparation (as buccal tablet, powder etc.) holdup time in the oral cavity is short, and medicine often enters gastrointestinal tract by involuntary deglutition with saliva, causes drug loss.It is shorter that the pelliculae pro cavo oris of listing sticks the time at present, can not unidirectionally discharge.Ulcer healing membrane agent of the present invention is composited by the drug-loaded layer of tool bioadhesive and the backing layer of bioadhesive of not having, belong to bioadhesive one-way release membrane, has the powder incomparable advantage: the physiological characteristics that more meets the oral cavity, overcome the shortcoming of powder, no matter be that any position generation ulcer can both attach to site of action preferably in the oral cavity, be difficult for moving.Experimentation shows that the ethyl cellulose backing layer does not dissolve, and can stop medicine to see through in the oral cavity, medicine is only discharged to the inside, has increased Concentraton gradient, and has kept local higher concentration, has alleviated the uncomfortable taste of medicine simultaneously.Medicated layer adopts bio-adhesive material carbomer and hydroxypropyl cellulose, and its adhesive effect to mucosa is comparatively tight, has increased preparation in the intraoral time of staying.Experimental result shows that this membrane can reach 2～3 hours in the time of sticking in affected part, oral cavity, and the release in vitro of main chemical compositions meets the Higuch equation, belongs to sustained release film formulation.Said preparation has prolonged drug treating time, thereby improves curative effect greatly, shortens the course of treatment, reduces the medication number of times, improves patient's compliance.Membrane of the present invention is to the covering of ulcer surface and to stick the time longer, has the stimulation of blocking-up extraneous factor to ulcer surface, plays the effect of protection wound surface, to alleviate the patient suffering.
In sum, ulcer healing membrane agent characteristics of the present invention have three: the first, adopt pure Chinese medicine, any side effect is not seen in clinical observation; The second, have bioadhesive, stick the time in the oral cavity longer, belongs to slow releasing preparation; The 3rd, guarantee the unidirectional release of medicine, good effect, and proved fully that through clinical data its relevant clinical data is as follows:
1. physical data
1.1 case source: observe totally 50 examples, recurrent oral ulceration 30 examples wherein, simple property oral ulcer 20 examples, male's 28 examples, women's 22 examples from 2009.6～2009.12 oral ulcer patients.At 7～70 years old age, the course of disease 1 day was to discontinuity 3 years.
1.2 case is selected
1.3 diagnostic criteria: with reference to Ministry of Public Health " new Chinese medicine clinical research guideline " (2002 publish) and " People's Republic of China's Chinese medicine industry standard. TCM E.N.T. Dept. case diagnosis criterion of therapeutical effect " (enforcement on January 1 nineteen ninety-five).
2. diagnostic criteria
2.1 with the part aphtha appears, scorching hot pain is the oral mucosal disease of feature, comprises recurrent oral ulceration and simple property oral ulcer.
2.2 diagnosis basis
2.2.1 the ulcer of or several diameter 2～5mm single with the oral mucosa appearance, scorching hot pain is cardinal symptom.
2.2.2 it is very fast to play pain, recovery from illness in general about 7 days, if rise one after another, then the course of disease prolongs.The normal easily recurrence of healing.
2.2.3 examination of mouth: stomatocace is shown shallow, and is circular or oval.1～2 at least of quantity, individual surplus in the of 5 at most, surperficial faint yellow secretions adheres to, and is congested mostly around the ulcer.
2.2.4 should differentiate mutually with inflammation around behcet's syndrome (hu huo syndrome), the recurrent gangrenosum acne mucosa and herpetic stomatitis.
3. traditional Chinese medical science differential diagnosis of diseases standard
3.1 accumulation of heat in the heart and spleen card: pain in mouthful, thirsty, halitosis, short urination Huang, constipation.Aphtha quantity is many, on every side congested obviously, red tongue, yellow fur, rapid pulse.
3.2 syndrome of hyperactivity of fire due to deficiency of YIN: pain, xerostomia, feverish sensation in the palms and soles, weak in mouthful.1～2 or 2～3 of aphtha, slight on every side congested.Red tongue, few, the thready and rapid pulse of tongue.
3.3 deficiency of qi and blood: mouth is not thirsty, or accompanies fear of cold, loose stool.Aphtha quantity is few, and is fuzzy on every side not congested.Light red tongue, white and thin fur, thready and weak pulse.
4. case is included standard in
Meet the primary disease diagnostic criteria and the differential diagnosis in tcm person can include the test case in.Get rid of the case standard:
4.1 gestation or women breast-feeding their children, allergic constitution or to this medicine allergy sufferers.
4.2 used the other drug therapist.
4.3 be associated with serious constitutional disorder such as cardiovascular, lung, liver, kidney and hemopoietic system, psychotic.
4.4 allly do not meet the standard of including in, not medication in accordance with regulations, can't judge that curative effect or data are not congruent and affect the treatment and safety judgement person.
5. Therapeutic Method
Take out the medicine film, medicine film hair side is affixed on the affected part.Every day 3～4 times.
6. observation index
Curative effect determinate standard
Recovery from illness: medication 3 days is with interior oral cavity ulcer healing, local no sense of discomfort.
Take a turn for the better: medication 3 days is little or do not enlarge pain relief with the interior oral ulcer reduction of area of healing.
Invalid: medication 3 days enlarges with the interior oral ulcer face of healing, and pain increases the weight of.
7. statistical procedures
The ulcer healing membrane clinical observation result
Clinical observation result shows that this product is to recurrent oral ulceration effective percentage 93.3%, to simple property oral ulcer effective percentage 95.0%.
7.2 untoward reaction: do not see any untoward reaction.
7.3 find for initial stage ulcer surface diameter 1～2mm person that at viewing duration medication is more obvious to ulcer healing and pain symptom control effect, generally transference cure in 1～3 day.Ulcer surface diameter 2～4mm person, may command ulcer area after the medication, but prevent that it from enlarging and alleviating pain.The above person of ulcer surface diameter 4mm, the course of treatment, then effect was not good enough person more than 4 days.The early stage use of prompting this product is very important, and cure rate can reach 100% to the course of disease with interior person in 3 days.Of the present invention succeeding in developing is the innovation on the treatment stomatocace medicine, and economic and social benefit is huge.
Claims (4)
1. a Chinese traditional medicine biology is sticked the oral ulcer healing membrane of unidirectional release, it is characterized in that, make by Rhizoma Picrorhizae 10～13g, Cortex Moutan 10～13g, Indigo Naturalis 8～11g, Borneolum Syntheticum 1～2g, carbomer 934 P 2～4g, hydroxypropyl cellulose 2～4g, cyclamate 2.3～2.5g, glycerol 10～14ml and ethyl cellulose, dehydrated alcohol, wherein, the mass concentration that Indigo Naturalis is added 10 times of weight of Indigo Naturalis at every turn is 80～90% alcohol reflux secondary, each 0.5～1h, filter, merging filtrate, reclaiming ethanol and being concentrated into relative density is 1.05 concentrated solution, standby;
The mass concentration that Rhizoma Picrorhizae is added at every turn 10 times of weight of Rhizoma Picrorhizae is 65～80% alcohol refluxs three times, and each 1～2h filters, and merging filtrate is standby;
Cortex Moutan extracts paeonol with vapor distillation, collects the aqueous solution after distilling, and adds the water of 8 times of amounts of Cortex Moutan weight in the medicinal residues, decocted 30-45 minute, and got decocting liquid, with the aqueous solution merging after the distillation, concentrate, 50 ℃ are surveyed relative densities is 1.03～1.05, adds ethanol, makes to contain the alcohol amount and reach 55～60%, placed 24-48 hour, get the merging of supernatant and Rhizoma Picrorhizae filtrate, reclaim ethanol and be condensed into Rhizoma Picrorhizae and the Cortex Moutan thick paste that relative density is 1.1-1.2, standby;
Ethyl cellulose adds dehydrated alcohol and is swelling to fully dissolving and is transparence, paints the thick film of 0.25cm as backing layer, and is standby; Carbomer 934 P 2～4g is with after hydroxypropyl cellulose 2～4g mixes with weight ratio at 1: 1, adding water, to be mixed with mass concentration be 3% clear solution, add Indigo Naturalis concentrated solution, Rhizoma Picrorhizae and Cortex Moutan thick paste, cyclamate 2.3～2.5g, after the limit edged stirs, again paeonol, Borneolum Syntheticum 1～2g, glycerol 10-14ml are ground well, slowly add, stir evenly, leave standstill and outgas into pastille film forming liquid, on the surface of ethyl cellulose, be coated with 2200ml/m
2Pastille film forming liquid.
2. Chinese traditional medicine biology according to claim 1 is sticked the oral ulcer healing membrane of unidirectional release, it is characterized in that, make by Rhizoma Picrorhizae 10g, Cortex Moutan 10g, Indigo Naturalis 8g, Borneolum Syntheticum 1g, carbomer 934 P 2g, hydroxypropyl cellulose 2g, cyclamate 2.3g, glycerol 10ml and ethyl cellulose, dehydrated alcohol, wherein, the mass concentration that Indigo Naturalis is added 10 times of weight of Indigo Naturalis at every turn is 80% alcohol reflux secondary, each 0.5h, filter, merging filtrate, reclaiming ethanol and being concentrated into relative density is 1.05 concentrated solution, standby;
The mass concentration that Rhizoma Picrorhizae is added at every turn 10 times of weight of Rhizoma Picrorhizae is 65% alcohol reflux three times, and each 1h filters, and merging filtrate is standby;
Cortex Moutan extracts paeonol with vapor distillation, collects the aqueous solution after distilling, and adds the water of 8 times of amounts of Cortex Moutan weight in the medicinal residues, decocted 30 minutes, and got decocting liquid, with the aqueous solution merging after the distillation, concentrate, 50 ℃ are surveyed relative densities is 1.03, adds ethanol, makes to contain the alcohol amount and reach 55%, placed 24 hours, get supernatant and Rhizoma Picrorhizae filtrate and merge, reclaiming ethanol and being condensed into relative density is 1.1 Rhizoma Picrorhizae and Cortex Moutan thick paste, standby;
Ethyl cellulose adds dehydrated alcohol and is swelling to fully dissolving and is transparence, paints the thick film of 0.25cm as backing layer, and is standby; Carbomer 934 P 2g is with after hydroxypropyl cellulose 2g mixes, adding water, to be mixed with mass concentration be 3% clear solution, add Indigo Naturalis concentrated solution, Rhizoma Picrorhizae and Cortex Moutan thick paste, cyclamate 2.3g, after the limit edged stirs, again paeonol, Borneolum Syntheticum 1g, glycerol 10ml are ground well, slowly add, stir evenly, leave standstill and outgas into pastille film forming liquid, on the surface of ethyl cellulose, be coated with 2200ml/m
2Pastille film forming liquid.
3. Chinese traditional medicine biology according to claim 1 is sticked the oral ulcer healing membrane of unidirectional release, it is characterized in that, make by Rhizoma Picrorhizae 11g, Cortex Moutan 11g, Indigo Naturalis 9g, Borneolum Syntheticum 1.5g, carbomer 934 P 3g, hydroxypropyl cellulose 3g, cyclamate 2.4g, glycerol 12ml and ethyl cellulose, dehydrated alcohol, wherein, the mass concentration that Indigo Naturalis is added 10 times of weight of Indigo Naturalis at every turn is 85% alcohol reflux secondary, each 0.7h, filter, merging filtrate, reclaiming ethanol and being concentrated into relative density is 1.05 concentrated solution, standby;
The mass concentration that Rhizoma Picrorhizae is added at every turn 10 times of weight of Rhizoma Picrorhizae is 70% alcohol reflux three times, and each 1.5h filters, and merging filtrate is standby;
Cortex Moutan extracts paeonol with vapor distillation, collects the aqueous solution after distilling, and adds the water of 8 times of amounts of Cortex Moutan weight in the medicinal residues, decocted 40 minutes, and got decocting liquid, with the aqueous solution merging after the distillation, concentrate, 50 ℃ are surveyed relative densities is 1.04, adds ethanol, makes to contain the alcohol amount and reach 58%, placed 30 hours, get supernatant and Rhizoma Picrorhizae filtrate and merge, reclaiming ethanol and being condensed into relative density is 1.15 Rhizoma Picrorhizae and Cortex Moutan thick paste, standby;
Ethyl cellulose adds dehydrated alcohol and is swelling to fully dissolving and is transparence, paints the thick film of 0.25cm as backing layer, and is standby; Carbomer 934 P 3g is with after hydroxypropyl cellulose 3g mixes, adding water, to be mixed with mass concentration be 3% clear solution, add Indigo Naturalis concentrated solution, Rhizoma Picrorhizae and Cortex Moutan thick paste, cyclamate 2.4g, after the limit edged stirs, again paeonol, Borneolum Syntheticum 1.5g, glycerol 12ml are ground well, slowly add, stir evenly, leave standstill and outgas into pastille film forming liquid, on the surface of ethyl cellulose, be coated with 2200ml/m
2Pastille film forming liquid.
4. Chinese traditional medicine biology according to claim 1 is sticked the oral ulcer healing membrane of unidirectional release, it is characterized in that, make by Rhizoma Picrorhizae 12g, Cortex Moutan 12g, Indigo Naturalis 10g, Borneolum Syntheticum 2g, carbomer 934 P 4g, hydroxypropyl cellulose 4g, cyclamate 2.5g, glycerol 14ml and ethyl cellulose, dehydrated alcohol, wherein, the mass concentration that Indigo Naturalis is added 10 times of weight of Indigo Naturalis at every turn is 90% alcohol reflux secondary, each 1h, filter, merging filtrate, reclaiming ethanol and being concentrated into relative density is 1.05 concentrated solution, standby;
The mass concentration that Rhizoma Picrorhizae is added at every turn 10 times of weight of Rhizoma Picrorhizae is 80% alcohol reflux three times, and each 2h filters, and merging filtrate is standby;
Cortex Moutan extracts paeonol with vapor distillation, collects the aqueous solution after distilling, and adds the water of 8 times of amounts of Cortex Moutan weight in the medicinal residues, decocted 45 minutes, and got decocting liquid, with the aqueous solution merging after the distillation, concentrate, 50 ℃ are surveyed relative densities is 1.05, adds ethanol, makes to contain the alcohol amount and reach 60%, placed 48 hours, get supernatant and Rhizoma Picrorhizae filtrate and merge, reclaiming ethanol and being condensed into relative density is 1.2 Rhizoma Picrorhizae and Cortex Moutan thick paste, standby;
Ethyl cellulose adds dehydrated alcohol and is swelling to fully dissolving and is transparence, paints the thick film of 0.25cm as backing layer, and is standby; Carbomer 934 P 4g is with after hydroxypropyl cellulose 4g mixes, adding water, to be mixed with mass concentration be 3% clear solution, add Indigo Naturalis concentrated solution, Rhizoma Picrorhizae and Cortex Moutan thick paste, cyclamate 2.5g, after the limit edged stirs, again paeonol, Borneolum Syntheticum 1～2g, glycerol 14ml are ground well, slowly add, stir evenly, leave standstill and outgas into pastille film forming liquid, on the surface of ethyl cellulose, be coated with 2200ml/m
2Pastille film forming liquid.
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2010
- 2010-04-30 CN CN2010101606805A patent/CN101822741B/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| 谢仁明等.阿弗他口腔溃疡中医辨治进展.《山东中医药大学学报》.1998,第22卷(第6期), * |
| 高建荣等.治疗牙痛方药中医文献研究.《江苏中医药》.2003,第24卷(第10期), * |
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| CN101822741A (en) | 2010-09-08 |
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Inventor after: Duan Xiaoying Inventor after: Wang Xiaoxiao Inventor after: Duan Xiaopeng Inventor after: Gao Weifang Inventor after: Zhang Hui Inventor after: Wang Jiheng Inventor before: Duan Xiaoying Inventor before: Gao Weifang Inventor before: Wang Xiaoxiao |
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