CN109865123A - A kind of pharmaceutical composition and its preparation method and application for treating recurrent oral ulceration - Google Patents
A kind of pharmaceutical composition and its preparation method and application for treating recurrent oral ulceration Download PDFInfo
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- CN109865123A CN109865123A CN201910315118.6A CN201910315118A CN109865123A CN 109865123 A CN109865123 A CN 109865123A CN 201910315118 A CN201910315118 A CN 201910315118A CN 109865123 A CN109865123 A CN 109865123A
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Abstract
The present invention provides a kind of pharmaceutical compositions for treating recurrent oral ulceration, it includes the bulk pharmaceutical chemicals of following weight proportion: astragalus root 28-32g, radix glycyrrhizae preparata 18-22g, Radix Codonopsis 13-17g, bletilla striata 8-12g, jujube 13-17g, rhizoma zingiberis 13-17g, rhizoma pinellinae praeparata 13-17g, radix scutellariae 13-17g, coptis 3-7g.The results show, pharmaceutical composition composition formula provided by the invention is precise and appropriate, can significantly alleviate the clinical symptoms of Blood of Patients with Recurrent Oral, effectively treatment recurrent oral ulceration, and present composition safety is good, has no toxic side effect, it is easy to use, a kind of new medicament selection is provided for clinic.
Description
Technical field
The present invention is field of Chinese medicinal composition, and in particular to a kind of pharmaceutical composition for treating recurrent oral ulceration and its
Preparation method and purposes.
Background technique
Recurrent oral ulceration refers to the mucous membrane of mouth limitation ulcer damage of period recurrence, clinically to send out repeatedly
Make, it is touching it is refractory with the characteristics of, any season, oral mucosa any position can be betided, single-shot or multiple is gone out with oral mucosa
Existing round or ellipse, shallow-layer aphtha are main pathological manifestations, and burning property pain is cardinal symptom, hot to the cold, stimulation object
Afterwards, feeling of pain is obviously aggravated.Recurrent oral ulceration is the common disease in the department of stomatology, it is now recognized that the disease and virus infection,
Body's immunity such as is lacked of proper care, is deficient in vitamin at the correlations.Doctor trained in Western medicine is in the treatment without specificity method, the mainly life of supplement dimension at present
Element and anti symptom treatment, it is intended that prevent from continuing infection, mitigate pain, promote self-healing.But still there is some patientss symptom to be unable to get
Effectively control, it is the normal recurrent exerbation of canker sore, touching refractory, it cannot eradicate.
Recurrent oral ulceration is belonged to " aphtha, mouth ulcer " scope by traditional Chinese medicine, and main pathogenesis is that patient's spleen deficiency causes to tremble with fear
Heat is mixed in middle coke.The mouth is the body opening or window of the spleen, closes meat in body, and spleen deficiency is then unable to qi-supplementing, blood-engendering myogenic, dispute dystrophy and send out and burst for oral cavity
Ulcer, ulcer surface are not easy to heal.Cold-heat jumble leads to middle burnt disorder of qi, mediates not normal in middle coke, then temper cannot will be on qi and blood
Up to ulcer surface；Stomach Qi does not drop, strongly fragrant and generate heat, and follows through upper criminal, stifling dispute and aggravate canker sore, with halitosis or micro- tired.Chinese medicine
Chinese medicine has long history and experience abundant to the treatment of recurrent oral, has unique advantage, is by too many levels, more
The compound of target spot plays effect.However, there is presently no clinically can significantly alleviate Blood of Patients with Recurrent Oral symptom
Chinese medicine composition.
Summary of the invention
In order to solve the above-mentioned technical problem, the object of the present invention is to provide a kind of medicine groups for treating recurrent oral ulceration
Close object.
The present invention provides a kind of pharmaceutical compositions for treating recurrent oral ulceration, it includes the original of following weight proportion
Expect medicine:
Astragalus root 28-32g, radix glycyrrhizae preparata 18-22g, Radix Codonopsis 13-17g, bletilla striata 8-12g, jujube 13-17g, rhizoma zingiberis 13-17g,
Rhizoma pinellinae praeparata 13-17g, radix scutellariae 13-17g, coptis 3-7g.
Further, it includes the bulk pharmaceutical chemicals of following weight proportion:
Astragalus root 30g, radix glycyrrhizae preparata 20g, Radix Codonopsis 15g, bletilla striata 10g, jujube 15g, rhizoma zingiberis 15g, rhizoma pinellinae praeparata 15g, radix scutellariae
15g, coptis 5g.
Further, the rhizoma zingiberis is dried ginger.
Further, the Radix Codonopsis is the dry root of Campanulaceae radix codonpsis tangshen.
Further, the bulk pharmaceutical chemicals are selected from the organic molten of the powder of bulk pharmaceutical chemicals, the water extract of bulk pharmaceutical chemicals or bulk pharmaceutical chemicals
Agent extract.
The present invention provides a kind of preparations for treating recurrent oral ulceration, it is with above-mentioned pharmaceutical composition for activity
Ingredient, in addition the preparation that pharmaceutically acceptable auxiliary material is prepared.
Further, the preparation is oral preparation.
Further, the oral preparation is decoction, oral solution, granule, capsule, tablet or powder.
The present invention provides a kind of methods for preparing aforementioned pharmaceutical compositions, it includes the following steps:
(1) each bulk pharmaceutical chemicals are weighed by weight ratio；
(2) each bulk pharmaceutical chemicals are directly beaten into powder, obtains powder；Or each bulk pharmaceutical chemicals are impregnated and/or decocted into the water, it obtains
Water extract；Or each bulk pharmaceutical chemicals are put into organic solvent and impregnates and/or decocts, obtain extractive with organic solvent.
The present invention also provides purposes of the above-mentioned pharmaceutical composition on the drug of preparation treatment canker sore, preferably
Ground, the canker sore are recurrent oral ulceration.
The results show, pharmaceutical composition composition formula provided by the invention is precise and appropriate, can significantly alleviate recurrent oral ulceration
The clinical symptoms of patient, effectively treatment recurrent oral ulceration, and present composition safety is good, has no toxic side effect, and makes
With conveniently, a kind of new medicament selection is provided for clinic.
" radix codonpsis tangshen " Classification system of the present invention is Codonopsis tangshen Oliv..
Obviously, above content according to the present invention is not being departed from according to the ordinary technical knowledge and customary means of this field
Under the premise of the above-mentioned basic fundamental thought of the present invention, the modification, replacement or change of other diversified forms can also be made.
The specific embodiment of form by the following examples remakes further specifically above content of the invention
It is bright.But the range that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to example below.It is all to be based on above content of the present invention
The technology realized all belongs to the scope of the present invention.
Specific embodiment
Material source: the raw materials used in the present invention medicine, reagent, instrument are known product, as obtained by purchase commercial product.
The preparation of embodiment 1, pharmaceutical composition of the present invention
Prescription: astragalus root 30g, radix glycyrrhizae preparata 20g, Radix Codonopsis 15g, bletilla striata 10g, jujube 15g, rhizoma zingiberis 15g, rhizoma pinellinae praeparata 15g are yellow
A kind of reed mentioned in ancient books 15g, coptis 5g.
Preparation method: each bulk pharmaceutical chemicals are weighed by above-mentioned prescription proportion, first each bulk pharmaceutical chemicals are put into casserole, 2000ml is added
Water impregnate 0.5 hour.Then it is first boiled with intense fire (high fire), then surplus 150-200ml is boiled with mild fire (small fire), it will be well-done
Medical fluid, which is poured out, to be placed in clean container.1500ml is added water into the above-mentioned remaining dregs of a decoction, is first boiled by intense fire, then mild fire (small fire)
Surplus 150-200ml is boiled, well-done medical fluid is taken out, therewith the preposition medical fluid mixing in clean container, front and back mixes twice
For 300-400ml.
The preparation of embodiment 2, pharmaceutical composition of the present invention
Prescription: astragalus root 28g, radix glycyrrhizae preparata 18g, Radix Codonopsis 13g, bletilla striata 8g, jujube 13g, rhizoma zingiberis 13g, rhizoma pinellinae praeparata 13g are yellow
A kind of reed mentioned in ancient books 13g, coptis 3g.
Preparation method: with embodiment 1.
The preparation of embodiment 3, pharmaceutical composition of the present invention
Prescription: astragalus root 32g, radix glycyrrhizae preparata 22g, Radix Codonopsis 17g, bletilla striata 12g, jujube 17g, rhizoma zingiberis 17g, rhizoma pinellinae praeparata 17g are yellow
A kind of reed mentioned in ancient books 17g, coptis 7g.
Preparation method: with embodiment 1.
Illustrate beneficial effects of the present invention below by way of test example.
The research of test example 1, medicine composite for curing recurrent oral ulceration of the present invention
1. case-data
Test group: totally 17 patients, wherein male 8, women 9, average age (38.8 ± 9.31) year；
Control group: totally 18 patients, wherein male 9, women 9, average age (36.9 ± 10.06) year.
2. diagnostic criteria
Referring to the diagnostic criteria of " recurrent oral ulceration " in " combination of Chinese tradiational and Western medicine oral mucosal disease ": with recurrent,
Periodically, self limiting feature, clarifies a diagnosis in conjunction with medical history, clinical symptoms and sign, and at least three moon is not used before patient assessment
It crosses corticoid drug and influences immune drug.
3. exclusion criteria
1. do not meet Western medicine diagnostic criteria among the above, be traumatic ulcer, herpetiform ulceration, infectious stomatitis, Behcet's disease,
Other ulcers such as cancerous ulcer；2. merge the patient of the serious organic disease of important organs such as heart and brain kidney, mental patient,
Communicable disease and malignant tumor patient etc.；3. used in three months corticosteroid, immunomodulator, interferon or other
Chinese medicine person used antibiotic person in one month；4. the gestational period or breast feeding women；5. merging other autoimmune diseases trouble
Person.
4. treatment method
After clarifying a diagnosis, the drug of 17 patients received oral's embodiments 1 of test group preparation, 100~150ml/ times, 3 times/
It, the course for the treatment of is 28 days.18 patients of control group are all made of Kangfuxin Liquid (the good doctor Pan Xi pharmaceutcal corporation, Ltd in Sichuan, 50ml) spray
In affected part, 3 times a day, the course for the treatment of is 28 days.Patient further consultation or Effect of follow-up visit by telephone in 8,12,16,20,24 weeks are advised, each rank is recorded
The state of an illness of section patient.
5. efficacy determination
" the recurrent oral ulceration therapeutic evaluation examination formulated according to Chinese dentistry meeting oral mucosal disease Professional Committee
Rower is quasi- " it is foundation, with the progress of IN staging.
Index of assessment of curative effect and classification: total intermittent time (interval, I): the evaluation period is without ulcer temporal summation.It is total to burst
Ulcer number (number, N): evaluation period ulcer recurrence number summation.
I1: total intermittent time extends (t is examined, P < 0.05)；I0: total intermittent time is without change (t is examined, P > 0.05)；N1:
Total ulcer number reduces (t is examined, P < 0.05)；N0: total ulcer number is without change (t is examined, P > 0.05).
It is effective: I1 N1；It is effective: I1N0Or I0N1；It is invalid: I0N0。
6. statistical method
Using SPSS19.0 statistical analysis software, P < 0.05 is that difference is statistically significant.
7. treatment results
As can be seen from Table 1, compared with comparison medicine Kangfuxin Liquid, pharmaceutical composition prepared by the present invention is to recurrent
The ratio for having therapeutic effect (effective+effective) of canker sore is higher；In addition, pharmaceutical composition prepared by the present invention is to recurrent
The ratio for having significant therapeutic effect (effective) of canker sore is also higher.It is further accurately examined through Fisher, P < 0.05, institute
With the curative effect of pharmaceutical composition (experimental group) prepared by the present invention is substantially better than comparison medicine Kangfuxin Liquid (control group).
1: two group of overall treatment effect of table compares [n (%)]
| Group | Number of cases | It is effective | Effectively | In vain |
| Test group | 17 | 11 (62.7%) | 5 (29.4%) | 1 (5.9%) |
| Control group | 18 | 8 (44.4%) | 7 (38.9%) | 3 (16.7%) |
8. adverse reaction
Two groups are showed no serious adverse reaction.
To sum up, pharmaceutical composition composition formula provided by the invention is precise and appropriate, can significantly extend the ulcer intermittent time, reduce total ulcer
Number, effectively treatment recurrent oral ulceration, and present composition safety is good, has no toxic side effect, it is easy to use, to face
Bed provides a kind of new medicament selection.
Claims (10)
1. a kind of pharmaceutical composition for treating recurrent oral ulceration, it is characterised in that: it includes the raw material of following weight proportion
Medicine:
Astragalus root 28-32g, radix glycyrrhizae preparata 18-22g, Radix Codonopsis 13-17g, bletilla striata 8-12g, jujube 13-17g, rhizoma zingiberis 13-17g, method half
Summer 13-17g, radix scutellariae 13-17g, coptis 3-7g.
2. pharmaceutical composition according to claim 1, it is characterised in that: it includes the bulk pharmaceutical chemicals of following weight proportion:
Astragalus root 30g, radix glycyrrhizae preparata 20g, Radix Codonopsis 15g, bletilla striata 10g, jujube 15g, rhizoma zingiberis 15g, rhizoma pinellinae praeparata 15g, radix scutellariae 15g are yellow
Even 5g.
3. pharmaceutical composition according to claim 1 or 2, it is characterised in that: the rhizoma zingiberis is dried ginger.
4. pharmaceutical composition according to claim 1 or 2, it is characterised in that: the Radix Codonopsis is Campanulaceae radix codonpsis tangshen
Dry root.
5. pharmaceutical composition according to claim 1 or 2, it is characterised in that: the bulk pharmaceutical chemicals be selected from bulk pharmaceutical chemicals powder,
The water extract of bulk pharmaceutical chemicals or the extractive with organic solvent of bulk pharmaceutical chemicals.
6. a kind of preparation for treating recurrent oral ulceration, it is characterised in that: it is with the described in any item medicines of claim 1-5
Compositions are active constituent, in addition the preparation that pharmaceutically acceptable auxiliary material is prepared.
7. preparation according to claim 6, it is characterised in that: the preparation is oral preparation.
8. preparation according to claim 7, it is characterised in that: the oral preparation is decoction, oral solution, granule, glue
Wafer, tablet or powder.
9. a kind of method for preparing any one of Claims 1 to 5 described pharmaceutical composition, it is characterised in that: it includes following step
It is rapid:
(1) each bulk pharmaceutical chemicals are weighed by weight ratio；
(2) each bulk pharmaceutical chemicals are directly beaten into powder, obtains powder；
Or, each bulk pharmaceutical chemicals are impregnated and/or decocted into the water, water extract is obtained；
It impregnates and/or decocts or, each bulk pharmaceutical chemicals are put into organic solvent, obtain extractive with organic solvent.
10. purposes of the described in any item pharmaceutical compositions of Claims 1 to 5 on the drug of preparation treatment canker sore, excellent
Selection of land, the canker sore are recurrent oral ulceration.
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| CN201910315118.6A CN109865123A (en) | 2019-04-18 | 2019-04-18 | A kind of pharmaceutical composition and its preparation method and application for treating recurrent oral ulceration |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111956758A (en) * | 2020-09-08 | 2020-11-20 | 张红娟 | Pharmaceutical composition and preparation for treating recurrent oral ulcer and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101049488A (en) * | 2006-12-30 | 2007-10-10 | 张丰强 | Chinese traditional medicine of grain sweetness and bitterness in type of takinge medicine with water, and preparation method |
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2019
- 2019-04-18 CN CN201910315118.6A patent/CN109865123A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101049488A (en) * | 2006-12-30 | 2007-10-10 | 张丰强 | Chinese traditional medicine of grain sweetness and bitterness in type of takinge medicine with water, and preparation method |
Non-Patent Citations (4)
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| 刘峰，等: "白芨在口腔溃疡治疗中的应用", 《中医临床研究》 * |
| 曹静玲等: "黄芪治疗复发性口腔溃疡临床疗效观察 ", 《医学理论与实践》 * |
| 潘忠堤等: "中西医结合治疗复发性口腔溃疡288例临床疗效分析", 《临床口腔医学杂志》 * |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111956758A (en) * | 2020-09-08 | 2020-11-20 | 张红娟 | Pharmaceutical composition and preparation for treating recurrent oral ulcer and preparation method thereof |
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