CN102488808B - Traditional Chinese medicine capsule for treating ischemic cerebrovascular disease - Google Patents

Abstract

The invention belongs to the field of traditional Chinese medicine and especially discloses a traditional Chinese medicine capsule for treating ischemic cerebrovascular disease. The traditional Chinese medicine is prepared from active components of ramulus mori, cyathula root, fructus liquidambaris, buck grass, spatholobus stem, ligusticum wallichii, red sage root, safflower, scorpion, pawpaw, rhizoma pinelliae preparata, trichosanthes kirilowii maxim and phyllanthus ussuriensis, according to a certain weight part. The traditional Chinese medicine of the invention is special for treating ischemic cerebrovascular disease; a plurality of medicaments are cooperated properly to increase curative effect through mutual cooperation or opposing effects, so as to adapt to treatment requirements of complex conditions and reduce adverse reactions; the traditional Chinese medicine capsule has substantial curative effect, simple formula and convenience for gaining materials, is safe, reliable, economical, practical and easy for administration, can improve brain blood circulation of patients, reduce blood viscosity and resist platelet aggregation and lower recurrence rate of ischemic cerebrovascular disease and has good treatment effects on ischemic cerebrovascular disease.

Description

A kind of Chinese medicinal capsule for the treatment of ischemic cerebrovascular

(1) technical field

The invention belongs to the field of Chinese medicines, particularly a kind of Chinese medicinal capsule for the treatment of ischemic cerebrovascular.

(2) background technology

Ischemic cerebrovascular is a kind of commonly encountered diseases clinically, refers to cause the cerebrovascular function obstacle because the cerebrovascular that a variety of causes causes stops up, and causes related symptoms, such as hemiplegia, dysphonia, dizziness and tinnitus etc.At present, the treatment ischemic cerebrovascular except rational diet, suitably take exercise, discontinue the habit of smoking and drinking, form the good living habit, generally carry out Drug therapy, at present, it is more to treat this sick medicine, but the poor problem of ubiquity therapeutic effect, the medicine long-term taking that has, side effect is very large.

(3) summary of the invention

The present invention provides a kind of Chinese medicinal capsule for preparing treatment ischemic cerebrovascular simple, evident in efficacy in order to remedy the deficiencies in the prior art.

The present invention is achieved through the following technical solutions:

A kind of Chinese medicinal capsule for the treatment of ischemic cerebrovascular, its special character is: its active component is comprised of the raw material of following parts by weight:

Ramulus Mori 25-35 part, Radix Cyathulae 15-25 part, Fructus Liquidambaris 15-25 part

Herba Lycopodii 10-20 part, Caulis Spatholobi 10-20 part, Rhizoma Chuanxiong 10-20 part

Radix Salviae Miltiorrhizae 10-20 part, Flos Carthami 5-15 part, Scorpio 5-15 part

Fructus Chaenomelis 10-20 part, Rhizoma Pinelliae 15-25 part, Fructus Trichosanthis 10-15 part

Radix Glycyrrhizae 4-8 part.

The weight proportion of its preferred each active component is:

30 parts of Ramulus Moris, 20 parts of Radix Cyathulaes, 20 parts of Fructus Liquidambaris

15 parts of Herba Lycopodiis, 15 parts of Caulis Spatholobis, 15 parts of Rhizoma Chuanxiongs

15 parts of Radix Salviae Miltiorrhizaes, 10 parts on Flos Carthami, 10 parts of Scorpios

15 parts of Fructus Chaenomeliss, 20 parts of Rhizoma Pinelliae, 12 parts of Fructus Trichosanthiss

6 parts of Radix Glycyrrhizae.

Preparation method: with above Chinese medicine routinely preparation method make capsule.

Usage and dosage: warm water is taken after mixing it with water, and three times on the one, each 5.

All medicines share in the prescription, have the effect of blood circulation promoting and blood stasis dispelling, channels sootheing and network vessel quickening, are used for that distortion of commissure due to the ischemic cerebrovascular, aphasia, hemiplegia of limb, walking are unfavorable, hemianesthesia, pain etc.

Chinese medicine of the present invention is specifically designed to the treatment ischemic cerebrovascular, multi-medicament is suitably cooperated, utilize its mutual collaborative or resistant function, improve curative effect, to adapt to the treatment requirement of the complicated state of an illness, reduce untoward reaction, evident in efficacy, safe and reliable, prescription is simple, draws materials conveniently, and is economical and practical, take simple, can improve patient's cerebral blood circulation, reduce blood viscosity, the multiple actions such as antiplatelet aggregation, can reduce the relapse rate of ischemic cerebrovascular, ischemic cerebrovascular is had preferably therapeutic effect.

(4) specific embodiment

Embodiment 1:

Get Ramulus Mori 30 gram, Radix Cyathulae 20 grams, Fructus Liquidambaris 20 grams, Herba Lycopodii 15 grams, Caulis Spatholobi 15 grams, Rhizoma Chuanxiong 15 grams, Radix Salviae Miltiorrhizae 15 grams, Flos Carthami 10 grams, Scorpio 10 grams, Fructus Chaenomelis 15 grams, Rhizoma Pinelliae 20 grams, Fructus Trichosanthis 12 grams, Radix Glycyrrhizae 6 grams, with above Chinese medicine routinely preparation method make capsule.

Usage and dosage: warm water is taken after mixing it with water, and three times on the one, each 5.

Embodiment 2:

Get Ramulus Mori 25 gram, Radix Cyathulae 15 grams, Fructus Liquidambaris 15 grams, Herba Lycopodii 10 grams, Caulis Spatholobi 10 grams, Rhizoma Chuanxiong 10 grams, Radix Salviae Miltiorrhizae 10 grams, Flos Carthami 5 grams, Scorpio 5 grams, Fructus Chaenomelis 10 grams, Rhizoma Pinelliae 15 grams, Fructus Trichosanthis 10 grams, Radix Glycyrrhizae 4 grams, with above Chinese medicine routinely preparation method make capsule.

Usage and dosage: warm water is taken after mixing it with water, and three times on the one, each 5.

Embodiment 3:

Get Ramulus Mori 35 gram, Radix Cyathulae 25 grams, Fructus Liquidambaris 25 grams, Herba Lycopodii 20 grams, Caulis Spatholobi 20 grams, Rhizoma Chuanxiong 20 grams, Radix Salviae Miltiorrhizae 20 grams, Flos Carthami 15 grams, Scorpio 15 grams, Fructus Chaenomelis 20 grams, Rhizoma Pinelliae 25 grams, Fructus Trichosanthis 15 grams, Radix Glycyrrhizae 8 grams, with above Chinese medicine routinely preparation method make capsule.

Usage and dosage: warm water is taken after mixing it with water, and three times on the one, each 5.

Embodiment 4: clinical observation:

(I) object and method:

A) object: this group case is in January, 2002---the Patients with Cerebral Infarction that be in hospital at Heze city of Shandong province Dan County central hospital Neurology Department in October, 2010, all check through brain CT, MRI and make a definite diagnosis, be divided at random treatment group and matched group, (a) treatment group 357 examples, man's 216 examples, age 41-76 year, average 69 ± 11.2 years old; Woman's 141 examples, age 47-81 year, average 67 ± 9.6 years old, course of disease 12-48 hour, average 11 ± 7.1 hours, there were hypertension history 31 examples Clinical Nerve Function Deficiency scoring (NDS) (19.8 ± 9.4 minutes), type 2 diabetes mellitus 27 examples, history of cerebrovascular 11 examples; (b) matched group 367 examples, male 241 examples, age 38-71 year, average 59 ± 11.8 years old; Woman's 126 examples, age 44-79 year, average 61 ± 12.4 years old, NDS 18.1 ± 7.7 minutes has hypertension history 29 examples, type 2 diabetes mellitus 30 examples, hyperlipemia 25 examples, two groups of patient genders, age, NDS divides and is the comparison of past medical history, difference not statistically significant, and Cerebral hemorrhage equally, myocardial infarction, autoimmune disease, tumor, viral infection, pneumonia, severe cardiac pulmonary insufficiency and serious hepatic and renal function injure person.

B) method:

1. Therapeutic Method: two groups of patients all improve cerebral circulation when being admitted to hospital, antiplatelet, fat-reducing medicament, dehydrant reaches suits the medicine to the illness, rehabilitation, treatment group adds on the basis of above conventional therapy with 5 of the made capsules of the present invention, every day three times, be in hospital average 16.5 days 14-28 days, two groups of patients all take Bayaspirin 0.1g once a day after leaving hospital, nimodipine 30mg every day three times, Chi Ting 20mg is cut down once a day in the Lip river, and the hypertension person gives antihypertensive drugs makes controlling of blood pressure in normal range, treatment group adds 5 of the made capsules of the present invention, every day three times on this basis.

2. observation of curative effect and evaluation criteria, two groups of patients are before treatment and on the treatment point rear 1 month, 3 months, 6 months, 9 months, 12 months, 18 months, 24 months unified time, carry out NDS evaluation and Barthel index (BI) evaluation with " apoplexy Clinical Nerve Function Deficiency standards of grading " that the 4th the cerebrovascular academic conference in the whole nation passed through, and in each time period two groups of recurrent cases are carried out respectively the Statistical Comparison analysis, cerebral hemorrhage, myocardial infarction and other serious disease person of generation arranged in the observation process, namely naturally withdraw from.

(II) statistical method: carry out statistical analysis with the Spss12.0 statistical software, measurement data is with mean ± standard deviation (X ± S) expression, the mean of two samples relatively with the t check, relatively test with X2 by enumeration data or group data, and there is statistical significance P＜0.05 for difference.

(III) result:

A) comparison of two groups of each time point NDS scorings for the treatment of front and back sees Table 1:

Table 1: the comparison of each time point NDS scoring before and after treatment group and the treatment of matched group case (X ± S)

Group

Before the treatment

January after the treatment

March after the treatment

June after the treatment

JIUYUE after the treatment

December after the treatment

Treated rear 18 months

Treated rear 24 months

Treatment group

19.8±9.3

8.2±7.6

8.24±7.2

8.16±7.0

7.90±7.1

7.92±7.0

7.14±6.6

6.47±6.1

Matched group

18.1±7.7

6.7±7.6

14.65±7.4

13.79±7.2

13.52±7.3

13.49±7.1

12.41±6.8

11.20±6.2

Shown that by table 1 each time point NDS scoring for the treatment of group is starkly lower than matched group, statistics has significant difference, and there were significant differences for comparative statistics before each group and the treatment, p＜0.05;

B) comparison of two groups of each time point BI scorings for the treatment of front and back sees Table 2:

The comparison of each time point BI scoring before and after table 2 treatment group and the treatment of control group (X ± S)

Table 2 shows that each time point BI index all is increased significantly before and after treatment group and the treatment of control group, and there were significant differences for statistics, and treatment group is apparently higher than matched group, and there were significant differences for statistics, p＜0.05;

C) comparison of two groups of interior association with recurrence of cerebral infarction situations of each time period of case sees Table 3:

Table 3: association with recurrence of cerebral infarction situation in each time period for the treatment of group and matched group

Table 3 shows that treatment group recurs 20 examples (5.60%), and matched group recurs 37 examples (10.08%), and two groups relatively have statistics there were significant differences, p＜0.05, and () be every group of routine number of each time period association with recurrence of cerebral infarction.Treatment group generation cerebral hemorrhage 4 examples, acute myocardial infarction 1 example, matched group generation cerebral hemorrhage 6 examples, acute myocardial infarction 3 examples, diabetic ketoacidosis 1 example and withdrawing from.

From above every results suggest, no matter treatment group all obviously is better than matched group in NDS and BI scoring and the relapse rate of each time period, the total relapse rate for the treatment of group also is starkly lower than matched group, illustrate that the made capsule of the present invention has obvious therapeutic effect really to aspects such as the treatment of ischemic cerebrovascular and prevention of recurrence, this also provides preferably a kind of method for the measure that the clinician treats ischemic cerebrovascular and secondary prevention, and does not have obvious toxic and side effects.

(IV) therapeutic effect:

Systematic observation and Long-term by two groups of cases, show that the made capsule of the present invention has obvious therapeutical effect to ischemic cerebrovascular, and can reduce the relapse rate of ischemic cerebrovascular, treatment group is put the scoring of epineural functional impairment degree and the scoring of activity of daily living all obviously is better than matched group in each observing time, 2 years total relapse rates 5.60% for the treatment of group, 2 years total relapse rates 10.08% of matched group, treatment group is starkly lower than matched group, have significant difference, demonstrate the made capsule of the present invention to treatment and the preventive effect of ischemic cerebrovascular.

Take the made capsule neurological functional recovery of the present invention and obviously be better than matched group, improved patient's quality of life, can obviously reduce the relapse rate of ischemic cerebrovascular, result of the present invention shows that each time point function of nervous system scoring for the treatment of group obviously is better than matched group, the relapse rate of ischemic cerebrovascular also is starkly lower than matched group in each time point, illustrate that the made capsule of the present invention all obviously is better than matched group to therapeutical effect and the aspects such as neurological rehabilitation at a specified future date and relapse rate of ischemic cerebrovascular acute stage, clinical effectiveness obviously and definite.

The made capsule of the present invention adheres to taking for a long time, can improve patient's cerebral blood circulation, reduces blood viscosity, and the multiple actions such as antiplatelet aggregation can reduce the relapse rate of ischemic cerebrovascular, have preferably clinical value.

Claims (2)

1. Chinese medicinal capsule for the treatment of ischemic cerebrovascular, it is characterized by: its active component is comprised of the raw material of following parts by weight:

Ramulus Mori 25-35 part, Radix Cyathulae 15-25 part, Fructus Liquidambaris 15-25 part

Herba Lycopodii 10-20 part, Caulis Spatholobi 10-20 part, Rhizoma Chuanxiong 10-20 part

Radix Salviae Miltiorrhizae 10-20 part, Flos Carthami 5-15 part, Scorpio 5-15 part

Fructus Chaenomelis 10-20 part, Rhizoma Pinelliae 15-25 part, Fructus Trichosanthis 10-15 part

Radix Glycyrrhizae 4-8 part.

2. the Chinese medicinal capsule for the treatment of ischemic cerebrovascular according to claim 1, it is characterized by: its active component is comprised of the raw material of following parts by weight:

30 parts of Ramulus Moris, 20 parts of Radix Cyathulaes, 20 parts of Fructus Liquidambaris

15 parts of Herba Lycopodiis, 15 parts of Caulis Spatholobis, 15 parts of Rhizoma Chuanxiongs

15 parts of Radix Salviae Miltiorrhizaes, 10 parts on Flos Carthami, 10 parts of Scorpios

15 parts of Fructus Chaenomeliss, 20 parts of Rhizoma Pinelliae, 12 parts of Fructus Trichosanthiss

6 parts of Radix Glycyrrhizae.