CN108310190A - A kind of Chinese medicine preparation and preparation method thereof for treating slow arrhythmia - Google Patents

A kind of Chinese medicine preparation and preparation method thereof for treating slow arrhythmia Download PDF

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CN108310190A
CN108310190A CN201810204455.3A CN201810204455A CN108310190A CN 108310190 A CN108310190 A CN 108310190A CN 201810204455 A CN201810204455 A CN 201810204455A CN 108310190 A CN108310190 A CN 108310190A
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radix
chinese medicine
medicine preparation
preparation
arrhythmia
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闫昕
刘玉洁
孙辰莹
贾永森
江春花
王清贤
李海凤
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North China University of Science and Technology
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North China University of Science and Technology
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Abstract

The present invention relates to a kind of preparation methods of Chinese medicine preparation that treating slow arrhythmia, belong to angiocardiopathy technical field of traditional Chinese medicine preparation.Technical solution is：The weight percent of each traditional Chinese medicinal components is：Cassia twig 4 6%, honey-fried licorice root 4 6%, raw Radix Astragali 15 20%, radix bupleuri 3 5%, campanulaceae 3 5%, cimicifugae foetidae 3 5%, rhizoma anemarrhenae 4 6%, Radix Codonopsis 10 15%, Radix Angelicae Sinensis 4 6%, Radix Paeoniae Alba 4 6%, meat 4 6%, Fructus Corni 5 10%, Radix Salviae Miltiorrhizae 15 20%.Full side's warming yang and benefiting qi, the multiple arteries and veins of promoting blood circulation, can effectively treat the symptoms such as slow arrhythmia heart-yang deficiency patient palpitaition, dizziness.The present invention carries out innovation reform to traditional Shengxian Tang and branch glycyrrhiza decoction, new vitality is assigned, for treating slow arrhythmia, classical prescription shares, scientific formulation, medicine source is wide, of low cost, convenient to take, with obvious effects, embodies the road of " innovation is inherited, modernization ".

Description

A kind of Chinese medicine preparation and preparation method thereof for treating slow arrhythmia
Technical field
The present invention relates to a kind of Chinese medicine preparations and preparation method thereof for treating slow arrhythmia, and it is cardiovascular to belong to treatment Disease technical field of traditional Chinese medicine preparation.
Background technology
Slow arrhythmia（Brady arrhythmia, BA）It is due to abnormality of cardiac automaticity or excitement conduction barrier Hinder caused illness, includes mainly sinus bradycardia, sick sinus syndrome, atrioventricular block etc., with ventricular rate It is characterized less than 60 beats/min, Adams-Stokes syndromes, heart source can even occurs with hemodynamic responses, severe patient Property sudden death.Current antiarrhythmic drug is clinically answered mainly for tachyarrhythmia because curative for effect extensively With.For the BA with clinical symptoms, various guides suggest row cardiac pacing therapy, but there are valences for placement artificial cardiac pacemaker A series of problems, such as lattice are expensive, popularity rate is low, late result is bad, limits clinical application.So domestic often preferred certain Drug is attempted, such as cholinergic recepter blocking agent（Such as atropine）, Beta-3 adrenergic receptor excitant（Such as salbutamol, Te Buta Woods）, isoprel etc., however such drug effect duration is shorter, and is easily recurred after being discontinued, and adverse reaction is larger, It mostly applies, should not take for a long time in first aid.Traditional Chinese medicine has into based on organic conception and diagnosis and treatment, clinical treatment BA Zhuos Effect, and side effect is less, highlights advantage.
Invention content
It is an object of the present invention to provide a kind of Chinese medicine preparation and preparation method thereof for treating slow arrhythmia, curative effect is bright Really, medicine source it is wide, it is of low cost, production and it is convenient to take, solve background technology present in the above problem.
The technical scheme is that：
A kind of Chinese medicine preparation for treating slow arrhythmia by cassia twig, honey-fried licorice root, raw Radix Astragali, radix bupleuri, campanulaceae, cimicifugae foetidae, is known Mother, Radix Codonopsis, Radix Angelicae Sinensis, Radix Paeoniae Alba, meat, Fructus Corni and Radix Salviae Miltiorrhizae composition, the weight percent of each traditional Chinese medicinal components are：Cassia twig 4-6%, toast Radix Glycyrrhizae 4-6%, raw Radix Astragali 15-20%, radix bupleuri 3-5%, campanulaceae 3-5%, cimicifugae foetidae 3-5%, rhizoma anemarrhenae 4-6%, Radix Codonopsis 10-15%, Radix Angelicae Sinensis 4- 6%, Radix Paeoniae Alba 4-6%, meat 4-6%, Fructus Corni 5-10%, Radix Salviae Miltiorrhizae 15-20%.
A kind of Chinese medicine preparation preparation method for treating slow arrhythmia, including following processing step：
Select Ramulus cinnamomi, honey-fried licorice root, raw Radix Astragali, radix bupleuri, campanulaceae, cimicifugae foetidae, rhizoma anemarrhenae, Radix Codonopsis, Radix Angelicae Sinensis, Radix Paeoniae Alba, meat, Fructus Corni And Radix Salviae Miltiorrhizae, it cleans, breaks into powder；It prepares and decocts according to weight percent, the weight percent of each traditional Chinese medicinal components is：Cassia twig 4- 6%, honey-fried licorice root 4-6%, raw Radix Astragali 15-20%, radix bupleuri 3-5%, campanulaceae 3-5%, cimicifugae foetidae 3-5%, rhizoma anemarrhenae 4-6%, Radix Codonopsis 10-15%, when Return 4-6%, Radix Paeoniae Alba 4-6%, meat 4-6%, Fructus Corni 5-10%, Radix Salviae Miltiorrhizae 15-20%；It adds water to cook, filters, the dregs of a decoction are added water pan-fried It boils, filter, water-bath is condensed into paste, dry, granulation, and the Chinese medicine preparation for the treatment of slow arrhythmia is made after packaging.
Electuary, capsule, tablet, oral can also be made in a kind of Chinese medicine preparation that treating slow arrhythmia as needed Liquid etc..
More specific processing step：Impurity is filtered using gauze, adds 5 times of water of volume ratio to decoct 1 hour, is filtered with gauze, The dregs of a decoction are added again 3 times of water of volume ratio decoct 30 minutes, merging filtrate is condensed into paste in water-bath, puts glass plate, in 80 DEG C of ovens It is dry；Dry-press process, 60 mesh of powder granularity, is made granule.
The Chinese medicine preparation for treating slow arrhythmia is used for clinical treatment BA, and closing branch glycyrrhiza decoction by Shengxian Tang adds taste to create It newly forms, Ramuli Cinnamomi and Glycyrrhizae Decoction comes from Zhang Zhongjing《The Treatise on Fevrile Diseases》, warming heart yang with cassia twig helps yang transforming qi in side；Honey-fried licorice root bowl spares QI invigorating, Papillary play the work(for activating yang, throbbing with fear according to one's conscience, surely jointly；Shengxian Tang is derived from《Records of Tradition Chinese and Western Medicine in Combination》, Radix Astragali is monarch Medicine, tonifying Qi and lifting yang, which is lifted, to fall into, the cool profit enriching yin of rhizoma anemarrhenae, overheats impairment of yin to prevent Radix Astragali, radix bupleuri, cimicifugae foetidae, campanulaceae liter carry yang-energy, and all medicines close With, the work(for rising and carrying air is played altogether, it is also in the treatment of angiocardiopathy to have application more；Again plus Radix Codonopsis, Radix Angelicae Sinensis, Radix Paeoniae Alba, meat, mountain Cornus is cloudy with benefiting qi and nourishing blood benefit, means " treating YANG within YIN ", and Radix Salviae Miltiorrhizae blood circulation and channel invigorating, all medicines share is added to play warming yang and benefiting qi, promoting blood circulation altogether again The effect of arteries and veins.
Cassia twig has effects that expelling pathogenic factors from muscles by diaphoresis, yang-tonic tongmai.Active ingredient cinnaldehydrum in cassia twig can effectively inhibit blood small Plate assembles and the formation of thrombus；Can also exciting transient receptor potential A1, and induce flow of calcium ions, enhance myocardial contractive power, Play the role of cardiac stimulant, expand blood vessel.
Honey-fried licorice root is that Radix Glycyrrhizae is processed with honey, is strengthened the spleen and stomach, multiple arteries and veins QI invigorating.The energy such as the glycyrrhiza total flavonoid in honey-fried licorice root Enough inhibit the drug-induced arrhythmia cordis such as aconitine, chloroform；Caused by myocardial ischemia-reperfusion injury, low magnesium, low potassium etc. Arrhythmia cordis also has remarkable effect.
Radix Astragali, sweet in flavor, slightly warm in nature have invigorating qi for strengthening superficies, yang invigorating and other effects.Modern pharmacological studies have shown that Radix Astragali has It is mainly Astragaloside IV to have cardiac effect, active ingredient, not only shows positive inotropic action, and energy to rat left ventricle Contraction and the diastolic function of rat are improved, while myocardial oxygen consumption does not increase.Total saponin, general flavone and first glucoside in Radix Astragali is equal There are inhibiting effect, wherein total saposins that can make cardiac muscle the Na+-K+-ATP enzymatic activitys in ischemical reperfusion injury rat heart muscle tissue The content of cAMP increases, and plays positive inotropic action.In addition, the astragalus polyose in Radix Astragali has stronger oxidation resistance, and Increase with the raising of concentration, especially more preferably to the Scavenging activity of the hydroxyl radical free radical for the most serious that is detrimental to health.
Radix bupleuri, cimicifugae foetidae liter carry yang-energy.Radix bupleuri, bitter, cold nature, soothing the liver inducing diaphoresis rise and lift yang-energy；Cimicifugae foetidae, cold nature, taste It is sweet, pungent, it is delivered with heat-clearing, rises the effect for lifting yang-energy.Clinical application is found, when treating bradycardia, adding can be with radix bupleuri It is obviously shortened the time for the treatment of.
Campanulaceae has eliminating the phlegm facilitaing lung, the carbuncle that disappears apocenosis and other effects.The study found that the U937 human monocytics in leukaemia cell Cell and the adhesion of Human umbilical vein endothelial cells can be inhibited by Platycodin D, the vascular adhesion factor and intercellular adhesion Expression because of mRNA is lowered, and then plays the role of antiatherosclerosis.
Rhizoma anemarrhenae moisturizes enriching yin, purging intense heat heat-clearing.Polyphenol components in rhizoma anemarrhenae can play the work of the protection to blood vessel endothelium With anemarrhena total saponin can make eNOS（NOS）Expression enhance and so that the release of Endothelin one is reduced, in turn It plays and protects cerebral ischemia re-pouring injured effect.
Radix Codonopsis, beneficial lung invigorating the spleen, tonifying middle-Jiao and Qi.Radix Codonopsis has the function of stronger cardiac stimulant and improvement myocardial ischemia, mainly Because it can be such that heart discharge increases, and make the convergent force enhancing of cardiac muscle.Especially the items of refilling process center function are referred to It is marked with and the indices of haemodynamics such as mean arterial pressure, heart rate and Flow of carotid artery has without the extensive of degree It is multiple, and effectively reduce the incidence of arrhythmia cordis.
Radix Salviae Miltiorrhizae has removing blood stasis and promoting blood circulation, tranquilizing and blood nourishing, relieving restlessness that clears away heart-fire and other effects, the effective ingredient tanshinone IIA pair in Radix Salviae Miltiorrhizae Cardiovascular and cerebrovascular has preferable protective effect, can improve atherosclerosis, and the inner membrance thickened is made to significantly reduce, and inhibits vascular smooth The migration of myocyte and proliferation, while also having the function of antithrombotic, anti-freezing, -1 β of serum interleukin, TNF-α and platelet count Amount is inhibited by different degrees of, and curative effect has similarity with aspirin；And there is antiarrhythmic effect, increase Cardiac electrical stability.
Radix Angelicae Sinensis, blood circulation promoting and enriching, analgesic menstruation regulating.Radix Angelicae Sinensis polysaccharide is the main component of Radix Angelicae Sinensis hematopoietic activities, can make NK and CTL Killing activity improves, and increases the immune function of body.Radix Angelicae Sinensis can also fight different degrees of Experimental Arrhythmia, and mechanism can Can with make delayed conduction, effective refractory period extends, eliminations of turning back, plateau extension, and it is related that ectopic rhythm point is suppressed etc..
Radix Paeoniae Alba, analgesic soothing the liver, menstruation regulating blood nourishing, total glucoside, which has, to resist myocardial ischemia, and protects the effect of cardiac muscle.Radix Paeoniae Alba water carries Object can make the prolonged survival period of the myocardial ischemia mouse caused by isoprel, and cardiac muscle nutritional blood flow is made to increase Add.
Longan polysaccharide contained by meat can enhance body's immunity, hence it is evident that improve respectively by T lymphocytes and bone-marrow-derived lymphocyte The cellular immunity and humoral immunity of mediation, and then the phagocytic activity of macrophage is made to enhance.
Active ingredient iridoid glycosides in dogwood fruit have anticoagulant effect, can inhibit platelet aggregation, fight The effect of protection cardiac muscle is played in the formation of thrombus.In addition, Fructus Corni can also play the role of antiarrhythmic, can make by the rhizome of Chinese monkshood The incubation period of arrhythmia cordis for the rat that alkali induces is obviously prolonged, and makes incidence that the rat room caused by calcium chloride quivers, dead Die rate significant decrease.
Full side's warming yang and benefiting qi, the multiple arteries and veins of promoting blood circulation, can effectively treat the symptoms such as BA heart-yang deficiency patients palpitaition, dizziness.Based on Chinese medicine organic conception and diagnosis and treatment, it is shorter to make up western medicine BA acting durations, is easily recurred after drug withdrawal, adverse reaction compared with A series of problems, such as big to wait short slabs, and placement artificial cardiac pacemaker is expensive, popularity rate is low, late result is bad.
The positive effect of the present invention is：Innovation reform is carried out to traditional Shengxian Tang and branch glycyrrhiza decoction, assigns new vitality, For treating slow arrhythmia, classical prescription shares, scientific formulation, and medicine source is wide, of low cost, convenient to take, with obvious effects, system It is standby simple for process, it can be applicable, embody the road of " innovation is inherited, modernization ".
Description of the drawings
Fig. 1 is influence of the present invention to experimental rat heart rate；
Fig. 2 is influence of the present invention to experimental rat heart-yang chronic diseases marked by deficiency of vital energy shape；
Fig. 3 is the present invention on the morphologic influence of experimental rat myocardial histopathology；
Fig. 4 is influence of the present invention to cAMP, cGMP content in each group rat blood serum；
Fig. 5 is the influence that the present invention improves clinical BA Heart Rates and symptom.
Specific implementation mode
The invention will be further described by the following examples.
A kind of Chinese medicine preparation for treating slow arrhythmia, by cassia twig, honey-fried licorice root, raw Radix Astragali, radix bupleuri, campanulaceae, cimicifugae foetidae, Rhizoma anemarrhenae, Radix Codonopsis, Radix Angelicae Sinensis, Radix Paeoniae Alba, meat, Fructus Corni and Radix Salviae Miltiorrhizae composition, the weight percent of each traditional Chinese medicinal components are：Cassia twig 4-6%, Honey-fried licorice root 4-6%, raw Radix Astragali 15-20%, radix bupleuri 3-5%, campanulaceae 3-5%, cimicifugae foetidae 3-5%, rhizoma anemarrhenae 4-6%, Radix Codonopsis 10-15%, Radix Angelicae Sinensis 4- 6%, Radix Paeoniae Alba 4-6%, meat 4-6%, Fructus Corni 5-10%, Radix Salviae Miltiorrhizae 15-20%.Preparation method：The above-mentioned prepared slices of Chinese crude drugs are cleaned, and powder is broken into End；It according to percentage of weight formula, adds water to cook, filters, the dregs of a decoction are added water into decoction, filtering, water-bath is condensed into paste, does It is dry, it pelletizes, electuary is made after packaging.
The various of specific embodiment want weight percentages of components see the table below：
The present invention obtains good therapeutic effect by zoopery and clinical research, and research report is as follows：
One, zoopery
1. material
1.1 SPF grades of experimental animal health male SD rats 70, weight are 200 ± 20 grams, are purchased from North China Polytechnics animal Experimental center, credit number are sCXK (army) 2014-0001.
1.2 experimental drug
Treat the Chinese medicine preparation of slow arrhythmia：It is prepared by the method that present patent application limits；
Heart treasure pill：Guangdong Tai'antang Pharmaceutical Co., Ltd. produces；
Propranolol hydrochloride tablets：Jiangsu Yabang Aipusen Pharmaceutical Co., Ltd. produces.
1.3 major experimental instruments and reagent
1.3.1 laboratory apparatus
BL-420F biological functional systems Chengdu TME Technology Co., Ltd.
Eppendorf companies of centrifuge Germany
BMJ-1B biological tissue embedding machines Tianli Aeronautics Electromechanical Co., Tianjin
Leica companies of slicer Germany
Microplate reader Tecan companies
1.3.2 reagent
Chloraldurate Tianjin great Mao chemical reagent factories
DAB colour reagent boxes Beijing Bioisystech Co., Ltd of Zhong Shan Golden Bridge
CAMP, cGMP kit Jiangsu bio tech ltd Mei Biao
2. experimental method
2.1 groupings, modeling and administration
The raising of 60 rat adaptability is randomly divided into 5 groups after a week, i.e., normal group, model group, control group（Heart treasure pill）, treatment High and low dose group, every group 12.In addition to normal group, remaining each group rats underwent thyroid gland enucleation replicates syndrome of deficiency of heart yang model.The heart After yang deficiency syndrome rat modeling success, the daily morning, every group was given Propranolol 15mg/kg, and afternoon, control group was given in addition to normal group Give heart treasure pill, each treatment group gives corresponding dosage rule and rises a heart health water decoction, normal group, model group give isometric physiological saline, Continuous 7d.
2.2 Indexs measure
2.2.1 the measurement of heart rate：BL-420F biological functional systems detection heart rate is primary before modeling and materials, and records.
2.2.2 heart-yang void sign scores
2.2.3 haematoxylin Yihong（HE）Dyeing
2.2.4 enzyme linked immunosorbent assay detects rat blood serum cAMP, cGMP content
3. result
The variation of 3.1 each group rat heart rates is compared
Before modeling, it is not significantly different between each group rat heart rate（P ＞ 0.05）；After modeling, compared with normal group, model group is big Mouse changes in heart rate no significant difference（P ＞ 0.05）；Model group rat heart rate is remarkably decreased after medication（P ＜ 0.05）；With model group The Chinese medicine preparation high and low dose group rat heart rate no significant difference of slow arrhythmia is treated in comparison before medication（P ＞ 0.05）；The Chinese medicine preparation high and low dose group rat heart rate that slow arrhythmia is treated after medication is obviously improved（P ＜ 0.05）.
The scoring of 3.2 each group rat heart-yang void signs is compared
Compared with normal group, model group rats fur color Huang is dark and gloomy, withered unglazed, and apathetic, love flocks together, and crimps hogback state Heavier, slow in reacting, activity, situation of fighting significantly reduce, and build slight of stature, body weight increase is slow, and stool is dilute, and crissum loose stools is viscous It, tactile tail is cool apparent, and model group rats heart-yang void degree significantly increases（P<0.05）；Compared with model group, Retarder theory is treated The Chinese medicine preparation high and low dose group rat heart-yang void degree of arrhythmia cordis is substantially reduced（P<0.05）.
The pathological change of 3.3 each group rat heart muscle tissues
The linear proper alignment of normal rats cardiac muscle fibre, cardiac muscle cell's even dyeing, form is complete, the external membrane of heart and inner membrance Morphologic features are normal.Model group rats cardiac muscle fibre is disorganized, is in undaform, it is seen that cardiac muscle fibre defect is broken, born of the same parents Karyopycnosis, cytoplasm dyeing are uneven, it is seen that are denaturalized, the cardiac muscle cell of swelling.Treat the Chinese medicine preparation of slow arrhythmia High and low dose group and heart treasured group have different degrees of improvement（See Fig. 1-5）
The variation of 3.4 each group rat cAMP, cGMP contents and cAMP/cGMP ratios
Compared with normal group, cAMP contents reduce in model group rats serum（P<0.05）, the raising of cGM/P contents（P<0.05）, CAMP/cGMP is reduced（P<0.01）；Compared with model group, the Chinese medicine preparation high and low dose group for treating slow arrhythmia is big CAMP contents increase in mouse serum（P<0.05）, the reduction of cGMP contents（P<0.05）, cAMP/cGMP raisings（P<0.01）.
4. conclusion
The Chinese medicine preparation for the treatment of slow arrhythmia can be such that the heart rate of heart-yang deficiency slow arrhythmia rat significantly carries Height improves myocardium markers, and cAMP contents in serum is made to increase, and cGMP contents reduce, and the ratio of cAMP and cGMP increase, in turn Elevated heart rate is played, the arrhythmia cordis caused by Propranolol is fought, improves the effect that the heart-yang chronic diseases marked by deficiency of vital energy are waited.
Two, clinical research
The patient that clinic is diagnosed as slow arrhythmia by 60 is randomly divided into treatment group and each 30 of control group, treatment group Give the Chinese medicine preparation treatment for the treatment of slow arrhythmia, control group gives the treatment of heart treasure pill, after total co-continuous treatment 6 weeks, The clinical efficacy, heart rate and disease integration of two groups of patients are compared.As a result：The effective percentage for the treatment of group is 86.67%, control Group is 60.00%, and treatment group is apparently higher than control group, and difference is statistically significant（P<0.05）；Observe pretherapy and post-treatment two groups of patients Holter situation compares display for 24 hours, and two groups of patients are improved, and treatment group becomes apparent compared with control group improvement, and two Group treatment results compare, and difference is statistically significant（P<0.05）；Each disease integration for the treatment of group is significantly lower than control group, and difference has Statistical significance（P<0.05）.
1. two groups of anti-slow arrhythmia curative effect comparative observation group total effective rates are 86.67%, control group total effective rate It is 60.00%, two groups of total effective rates have statistical significance (χ 2=4.176, P<0.05).
It is significantly improved 2. two groups of Chinese medicine syndrome integrals compare before patient's palpitaition, shortness of breath, uncomfortable in chest, weak, dizziness are relatively treated, Two groups of Chinese medicine syndrome integrals are substantially reduced before relatively treating（P<0.05）, treatment group compared with control group reduction become apparent（P< 0.05）, difference is statistically significant.
3. the more pretherapy and post-treatment patient's HR min of two groups of Heart Rates, average heart rate increase.It is examined twice through t Heart rate is statistically significant（P<0.05）.
Conclusion：The Chinese medicine preparation for the treatment of slow arrhythmia is conducive to the quickening of slow arrhythmia Heart Rate, can be apparent Mitigate the clinical symptoms of patient, it is significant in efficacy.

Claims (3)

1. a kind of Chinese medicine preparation for treating slow arrhythmia, it is characterised in that：By cassia twig, honey-fried licorice root, raw Radix Astragali, radix bupleuri, Campanulaceae, cimicifugae foetidae, rhizoma anemarrhenae, Radix Codonopsis, Radix Angelicae Sinensis, Radix Paeoniae Alba, meat, Fructus Corni and Radix Salviae Miltiorrhizae composition, the weight percent of each traditional Chinese medicinal components are： By cassia twig 5-10%, honey-fried licorice root 5-10%, raw Radix Astragali 15-25%, radix bupleuri 4-8%, campanulaceae 4-8%, cimicifugae foetidae 4-8%, rhizoma anemarrhenae 5-10%, party Join 15-25%, Radix Angelicae Sinensis 5-10%, Radix Paeoniae Alba 5-10%, meat 5-10%, Fructus Corni 5-10%, Radix Salviae Miltiorrhizae 15-25%.
2. a kind of preparation method of Chinese medicine preparation that treating slow arrhythmia, feature includes following processing step：Selection Ramulus cinnamomi, honey-fried licorice root, raw Radix Astragali, radix bupleuri, campanulaceae, cimicifugae foetidae, rhizoma anemarrhenae, Radix Codonopsis, Radix Angelicae Sinensis, Radix Paeoniae Alba, meat, Fructus Corni and Radix Salviae Miltiorrhizae, It cleans, breaks into powder；According to the weight percent of each traditional Chinese medicinal components：Cassia twig 5-10%, honey-fried licorice root 5-10%, raw Radix Astragali 15-25%, Radix bupleuri 4-8%, campanulaceae 4-8%, cimicifugae foetidae 4-8%, rhizoma anemarrhenae 5-10%, Radix Codonopsis 15-25%, Radix Angelicae Sinensis 5-10%, Radix Paeoniae Alba 5-10%, meat 5- 10%, Fructus Corni 5-10%, Radix Salviae Miltiorrhizae 15-25%, add water to cook, and filtering, water-bath is condensed into paste, dry, and it is slow that treatment is made in granulation The Chinese medicine preparation of chronic arrhythmia cordis.
3. a kind of preparation method of Chinese medicine preparation for treating slow arrhythmia according to claim 2, feature exist In more specific processing step：Impurity is filtered using gauze, adds 5 times of water of volume ratio to decoct 1 hour, is filtered with gauze, by the dregs of a decoction Again plus 3 times of water of volume ratio decoct 30 minutes, merging filtrate, and paste is condensed into water-bath, put glass plate, are dried in 80 DEG C of ovens； Dry-press process, 60 mesh of powder granularity, is made granule.
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* Cited by examiner, † Cited by third party
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CN109828070A (en) * 2019-03-15 2019-05-31 合肥创新医药技术有限公司 A kind of measuring method of Chinese medicine Shengxian Tang finger-print

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