CN103340987B - Pharmaceutical composition for abatement of fever - Google Patents
Pharmaceutical composition for abatement of fever Download PDFInfo
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- CN103340987B CN103340987B CN201310322918.3A CN201310322918A CN103340987B CN 103340987 B CN103340987 B CN 103340987B CN 201310322918 A CN201310322918 A CN 201310322918A CN 103340987 B CN103340987 B CN 103340987B
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Abstract
The invention discloses a pharmaceutical composition for abatement of a fever. The pharmaceutical composition is prepared from the following raw materials: the effective components: peucedanum praeruptorum, dried virgin soil, radix puerariae, radix angelicae citriodorae, pennisetum, soil asarum, radix scrophulariae and liquorice. The pharmaceutical composition has effect for most people with fever, can be used exclusively or jointly with modern febrifuge, and has special effect for non-infectious patients with fever, the reason of which cannot be found out.
Description
Technical field
The invention belongs to Chinese medicine is the pharmaceutical composition of preparation of raw material, the Chinese medicine composition of particularly bringing down a fever.
Background technology
According to medical statistics, in the Disease needing clinical treatment, what have heating paresthesia accounts for about 85%.For the disease taking heating as main clinical manifestation, modern medicine is divided into infectious disease and noninfectious disease.For infectious disease, modern medicine is generally make great efforts to find out or carry out judgement pathogenic microorganism through comprehensive analysis, applies antibiotics targetedly, in the hope of killing pathogenic microorganism.But find out pathogenic microorganism not a duck soup, very high to equipment, technical requirement, at funds, also of a high price in the time.Modern medicine is usually difficult to find out exact cause for noninfectious fever.Therefore, in clinical treatment practice, often running into heating last for days, the several months does not move back, and even delaying the several years can not find out its reason person.Antipyretic analgesic is applied to this kind of patient, can temporarily remove or alleviate patient because of the misery caused of generating heat, but cure the symptoms, not the disease.Clinical conventional antibiotic neither be all effective to all fever patients in conjunction with the scheme of hormone therapy, also will bear the risk of bacterial drug resistance and hormone side effect.
The traditional Chinese medical science differs widely because of its theoretical system and modern medical theory, to the disease with heating being main manifestations clinically, treats by theory of Chinese medical science is dialectical, does not need to find out to be which kind of virus, which kind of bacteriological infection, still can obtain good efficacy.Inventor is according to oneself experience in this respect, earlier application 00121310.5 and 200910262865.4 two antipyretic patent, they show distinctive effect in clinical practice, but along with the test of time, original technology or showed limitation in indication, or because the numerous and jumbled curative effect of component is not good enough, have much room for improvement.
Summary of the invention
The present invention is according to me up-to-date research and experience accumulation, and to the improvement of the applicant's formerly two patent (patent application) prescriptions, it is extensively effective to fever patient, and easily make, easy to use, without obvious toxic-side effects.
Pharmaceutical composition of the present invention pharmacodynamic raw materials used is expressed as by its weight portion: Radix Peucedani 5 ~ 20 parts, Radix Rehmanniae 10 ~ 30 parts, Radix Puerariae 4 ~ 12 parts, the Radix Angelicae Dahuricae 3 ~ 10 parts, Herba Violae diffusae 9 ~ 15 parts, TUXIXIN 1 ~ 5 part, Radix Scrophulariae 9 ~ 15 parts, 2 ~ 10 parts, Radix Glycyrrhizae.
The preferred weight proportioning of pharmaceutical composition of the present invention pharmacodynamic raw materials used is, Radix Peucedani 11 ~ 13 parts, Radix Rehmanniae 19 ~ 21 parts, Radix Puerariae 7 ~ 9 parts, the Radix Angelicae Dahuricae 5 ~ 7 parts, Herba Violae diffusae 12 ~ 14 parts, TUXIXIN 2.5 ~ 3.5 parts, Radix Scrophulariae 12 ~ 14 parts, Radix Glycyrrhizae 5 ~ 7.
The optimum weight proportioning of pharmaceutical composition of the present invention pharmacodynamic raw materials used is, Radix Peucedani 12 parts, Radix Rehmanniae 20 parts, Radix Puerariae 8 parts, the Radix Angelicae Dahuricae 6 parts, Herba Violae diffusae 13 parts, TUXIXIN 3 parts, Radix Scrophulariae 13 parts, 6 parts, Radix Glycyrrhizae.
Above formulation ratio is the general side of pharmaceutical composition of the present invention for bringing down a fever.Also be divided into polytype to fever diseases by Chinese medical discrimination, medication should be distinguished to some extent.For adapting to each Heat Syndrome of TCM typing, medicine composition of the present invention and consumption proportion can also do following multiple optimization.
Optimization side one, the basis of above basic recipe increases Herba Androsaces umbellatae 15 ~ 30 parts, is adapted to have sore throat obviously, coughs heavier, belongs to respiratory tract infection type fever patient.
Optimization side two, the basis of above basic recipe increases the Radix Astragali 15 ~ 20 parts; Radix Angelicae Sinensis 6 ~ 15 parts, is adapted to belong to qi-deficiency type fever patient by Chinese medical discrimination.
Optimization side three, the basis of above basic recipe increases Cortex Cinnamomi 2 ~ 3 parts, is adapted to belong to deficiency of spleen-YANG type fever patient by Chinese medical discrimination.
Optimize Fang Si, the basis of optimization side three increases Radix Aconiti Lateralis Preparata 3 ~ 9 parts again, is adapted to belong to general deficiency of yang type fever patient by Chinese medical discrimination.
The present invention relates to 13 kinds of raw material of Chinese medicine medicines to be defined as follows:
Radix Peucedani: be the root of samphire Peucedanum praeruptorum DUNN, its effect is wind and heat dispersing, sending down the abnormal ascending QI blood stasis dispelling.
Radix Rehmanniae: another name Radix Rehmanniae, the Radix Rehmanniae, for the dry rhizome of Radix Rehmanniae is celebrated in scrophulariaceae rehmannia glutinosa plant or bosom, its effect is clearing away heat and nourishing YIN, and removing heat from blood is moisturized.
Radix Puerariae: another name Radix puerariae, Pachyrhizua angulatus, be the root of leguminous plant Pueraria lobota, its effect is expelling pathogenic factors from muscles for reducing heat, promoting the production of body fluid to quench thirst, rash, antidiarrheal.
The Radix Angelicae Dahuricae: have another name called that Radix Angelicae Dahuricae (Radix Heraclei Scabridi), nine steps are fragrant, fragrant chicken feet, be the root of the samphire Radix Angelicae Dahuricae or Radix angelicae dahuricae, its effect is expelling pathogenic wind from the body surface, wet dissipation pain relieving, detumescence and apocenosis.
Herba Violae diffusae: call white Viola grypoceras A. Gray, seven-star lotus, be the herb of Violaceae plant PUTAOJIN, its effect is expelling wind and clearing away heat, subduing swelling and detoxicating.
TUXIXIN: another name Herba Asari, southern Herba Asari, for aristolochiaceae plant Herba Asari Forbesii or its belong to root or the herb of various plants together, its effect for dispeling the wind, cold expelling, pain relieving.
Radix Scrophulariae: another name Radix Scrophulariae, be the root of goatweed Radix Scrophulariae or Radix Scrophulariae, its effect is heat clearing away YIN nourishing, eliminating fire and detoxication.
Radix Glycyrrhizae: the root welding technology of glycyrrhizic legume, its effect is spleen reinforcing stomach function regulating, relieving spasm to stop pain, expelling phlegm for arresting cough, removing toxic substances, coordinating the actions of various ingredients in a prescription.
Herba Androsaces umbellatae: another name TianXing grass, Caulis et folium pavettae hongkongensis, be the herb of Ofthe Primulaceae Herba Androsaces Umbellatae (Herba Androsaces Coccineae), its effect is heat-clearing and toxic substances removing.
The Radix Astragali: the root of the leguminous plant Radix Astragali or astragalus mongholicus Bge, its effect is invigorating the spleen and replenishing QI, consolidating superficial resistance, diuretic, holder skin ulcer granulation promoting.
Radix Angelicae Sinensis: be the root of umbelliferae angelica, its effect, for enriching blood, is invigorated blood circulation, regulating menstruation, intestine moistening.
Radix Aconiti Lateralis Preparata: Radix Aconiti Lateralis Preparata is the side root of cohosh Aconitum carmichjaelii Debx., and Radix Aconiti Lateralis Preparata is Radix Aconiti Lateralis Preparata processed product, its effect is that recuperating depleted YANG mends fire, warming middle-JIAO to relieve pain, dispelling cold and removing dampness.
Cortex Cinnamomi: call beautiful osmanthus, Cortex Cinnamomi, Cortex Cinnamomi, be the bark of canella Cortex Cinnamomi, its effect is kidney-replenishing, warming the spleen and stomach, removing accumulated cold, promoting blood circulation.
In formula of the present invention, Herba Violae diffusae, Radix Puerariae are monarch drug, and Radix Peucedani, the Radix Angelicae Dahuricae are ministerial drug, and Radix Rehmanniae, TUXIXIN, Radix Scrophulariae are adjuvant drug; Radix Glycyrrhizae is for making medicine, and combined effect, assembles toxin, and by the table in inner, then by table, then to the table in table, i.e. sweat gland, pore, by transmembrane transport, is diffused into external disappearance, reaches the object that heat moves back calm pulse.
Process for preparing medicine: pharmaceutical composition of the present invention can be made into the dosage forms such as capsule, granular pattern electuary, oral liquid by usual way.
Drug use method: different dosage form drug dose is converted into crude drug equivalent for adult 1.2-2.0 gram every day, and point 2-6 time oral.Capsule wherein can fill No. 0 capsule, one containing 0.1 gram, be grown up each oral 0.3-0.5 gram, 3-4 time on the one.For adult's influenza, symptom is heavier, and body temperature is person more than 39 DEG C, can strengthen drug dose, oral 0.5 gram at every turn, 3-6 time on the one, treats that heat is moved back, continues to take 1-2 days.Pharmaceutical composition of the present invention is suitable for being used alone, and also can merge with modern medicine antipyretic and be used for infective fever, improve therapeutic effect, Shorten the Treatment Process.
Pharmaceutical composition of the present invention uses natural Chinese medicine preparation, and pharmacodynamic raw materials kind used is few, and medical material syntagmatic is simple, is extensively suitable for the disease with heating being main manifestations clinically, and curative effect is reliable, has no side effect, safe ready.Can not heating cause be found out for application modern medicine means and be diagnosed as the non-infectious patient of " unknown heating ", " fever of unknown ", especially for several years several months a few days heating protracted course of disease person, more aobvious unique curative effect.Compared with commonly using antipyretic with modern medicine, because not containing calm antiallergic agent, so do not produce dizzy drowsy after taking medicine; Because not containing hormone, so do not destroy immunity of organisms.
Detailed description of the invention
By the following examples pharmaceutical composition of the present invention and formulation method are described in further detail.
embodiment 1-6by the basic side preparation raw materials used component of pharmaceutical composition of the present invention and consumption
Raw material variety | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 |
Radix Peucedani | 12 | 11 | 13 | 5 | 20 | 12 |
Radix Rehmanniae | 20 | 19 | 21 | 30 | 10 | 20 |
Radix Puerariae | 8 | 7 | 9 | 4 | 12 | 7 |
The Radix Angelicae Dahuricae | 6 | 5 | 7 | 10 | 3 | 5 |
Herba Violae diffusae | 13 | 12 | 14 | 9 | 15 | 14 |
TUXIXIN | 3 | 2.5 | 3.5 | 5 | 1 | 3.5 |
Radix Scrophulariae | 13 | 12 | 14 | 9 | 15 | 13 |
Radix Glycyrrhizae | 6 | 5 | 7 | 10 | 2 | 6 |
embodiment 7-10by optimization side's preparation raw materials used component of pharmaceutical composition of the present invention and consumption
Raw material variety | Embodiment 7 | Embodiment 8 | Embodiment 9 | Embodiment 10 |
Radix Peucedani | 12 | 12 | 12 | 12 |
Radix Rehmanniae | 20 | 20 | 20 | 20 |
Radix Puerariae | 8 | 8 | 8 | 8 |
The Radix Angelicae Dahuricae | 6 | 6 | 6 | 6 |
Herba Violae diffusae | 13 | 13 | 13 | 13 |
TUXIXIN | 3 | 3 | 3 | 3 |
Radix Scrophulariae | 13 | 13 | 13 | 13 |
Radix Glycyrrhizae | 6 | 6 | 6 | 6 |
Herba Androsaces umbellatae | 22 | |||
The Radix Astragali | 18 | |||
Radix Angelicae Sinensis | 10 | |||
Cortex Cinnamomi | 3 | 2 | ||
Radix Aconiti Lateralis Preparata | 6 |
Preparation method: above each embodiment, all can be prepared into the dosage forms such as tablet, capsule, oral liquid, granular pattern electuary by usual way.
the routine observation of curative effect of experimental example 1 Drug therapy of the present invention FUO 122
For verifying the curative effect of medicine of the present invention, inventor adopts control methods, has carried out clinical experiment observation, be reported as follows large sample case.
one. physical data
(1) case selection
Observe Fever of unclear origin 122 example altogether, be divided into two groups at random, apply Drug therapy of the present invention for one group, be called " experimental group "; Another group compares, and based on antipyretic analgesic acetaminophen, with the use of antimicrobial drug Erythromycin and norfloxacin, is called " Western medicine group ".All patients all check UP through clinicist, and make blood, urine, feces routine inspection, assisted to carry out fluoroscopy of chest, do the ultrasound diagnosis of liver,spleen,kidney, biliary tract, bladder, make tuberculin test by higher level hospital, and some patients has made blood, urine antibacterial culturing.Check through above, observed patient all fails to clarify a diagnosis because making with regard to febrile disease, the tentative diagnosis that some patients makes " suspected of viral infection ".
This report relates to experimental group 79 example, Western medicine group 43 example.Two groups of patients without marked difference, therefore have comparability widely in sex, age, on ordinary days health etc.
(2) the degree of heat and the persistent period
According to the most high fever occurred every day before each patient's medication, its degree of heat to be divided into slightly, moderate, severe three class.Be slight lower than 38 DEG C, 38---39 DEG C are moderate, and more than 39 DEG C is severe.The degree of heat of two group of 122 routine patient is as shown in table 1.
Light and heavy degree distribution held by table 1
Slightly (lower than 38 DEG C) | Moderate (38---39 DEG C) | Severe (more than 39 DEG C) | Add up to | |
Experimental group | 10 examples | 39 examples | 30 examples | 79 examples |
Western medicine group | 5 examples | 14 examples | 24 examples | 43 examples |
Add up to | 15 examples | 53 examples | 54 examples | 122 examples |
(3) course of disease:122 routine patient's heating continuing times are as shown in table 2.
Table 2 heating continuing time distributes
Within 15 days | 16-30 days | 31-60 days | More than 61 days | Add up to | |
Experimental group | 43 examples | 21 examples | 8 examples | 7 | 79 examples |
Western medicine group | 18 examples | 12 examples | 8 examples | 5 | 43 examples |
Add up to | 61 examples | 33 examples | 16 examples | 12 | 122 examples |
two. administrated method:
Experimental group: choose crude drug by the formulation ratio of embodiment 1, all pulverize, cross 80-100 mesh sieves, by each drug powder mix homogeneously, with No. 0 capsule fill, one containing 0.1 gram, be grown up each oral 0.3-0.5 gram, 3-4 time on the one, body temperature be tending towards decline time medication both uninterruptedly also do not stop, until body temperature recover normally to reach 3 days completely after drug withdrawal.
Western medicine group: with the use of following three kinds of medicines:
1. oral paracetamol, each 0.3g, every day 3 times 7 days is a course for the treatment of.Fever time is still had to start the next course for the treatment of every 3 days.
2. amoxicillin, reaches 4 courses for the treatment of in the treatment of use acetaminophen, increases and use, each 0.5g, every day 3 times when heating is not still disappeared, be used in conjunction for 4-8 weeks.
3. norfloxacin, reaches Gao Re to body temperature or fever time increases use more than 12 weeks persons, each 300mg, every day 3 times.
Auxiliary treatment: two groups of patients all note abundant rest, and alignment degree above heating person emphasize to lie up.All patients all note strengthening nutrition, add if desired with high-energy, homovitamin, high protein diet.
three. therapeutic outcome
(1) curative effect judging standard
According to the change synthetic determination curative effect of the gentle clinical symptoms of patient's medication forebody-afterbody.Curative effect is divided into following 4 grades:
Recovery from illness: resolution of fever after medication, subjective symptoms disappears completely, again FUO does not occur in after drug withdrawal 1 month.
Effective: resolution of fever after medication, symptom substantially disappears or is clearly better, but after drug withdrawal, the heating of continuous more than 2 days occurs in 1 month again, is controlled after medication again; Or after drug withdrawal, only there is the unware low grade fever of patient, do not affect work and life.
Take a turn for the better: after medication, body temperature decreases, but does not reach normal level, and symptom alleviates to some extent.
Invalid: after medication body temperature and subjective symptoms unchanged, even increase the weight of to some extent.
(2) efficacy analysis
Two groups of therapeutic outcomes are shown in Table 3.
Table 3 drug study group of the present invention and Western medicine group comparitive study
* total effective rate (%)=(recovery from illness number of cases+effective number of cases+improvement number of cases)/total number of cases × 100%
Table 3 shows, on cure rate and obvious effective rate two indices, experimental group is higher than Western medicine group, and the two has statistically marked difference; On improvement rate, Western medicine group is better than experimental group, and in inefficiency, Western medicine group is also higher than experimental group, but through statistical procedures, two groups of there was no significant differences on this two indices; Total effective rate, the experimental group applying medicine of the present invention exceeds Western medicine group 10.15%.
four. experiment conclusion
Medicine of the present invention has the strong lung of spleen invigorating, the merit that Xuan Qingwen is loose.For temporarily not ascertaining the reason, even several months, " fever of unknown " of several years or " unknown heating " case application medicine of the present invention are mainly impose treatment and have good result particularly to delay a few days.For having made the disease of clarifying a diagnosis by modern medical theory, while the corresponding Modern medical therapy means of application, apply medicine of the present invention make auxiliary treatment, can therapeutic effect be improved, accelerate disease recovery from illness.
Claims (7)
1. the pharmaceutical composition for bringing down a fever, it is characterized in that, pharmacodynamic raw materials used comprises following kind, and its consumption proportion is expressed as with weight portion: Radix Peucedani 5 ~ 20 parts, Radix Rehmanniae 10 ~ 30 parts, Radix Puerariae 4 ~ 12 parts, the Radix Angelicae Dahuricae 3 ~ 10 parts, Herba Violae diffusae 9 ~ 15 parts, TUXIXIN 1 ~ 5 part, Radix Scrophulariae 9 ~ 15 parts, 2 ~ 10 parts, Radix Glycyrrhizae.
2. pharmaceutical composition according to claim 1, it is characterized in that, the weight proportion of pharmacodynamic raw materials used is: Radix Peucedani 11 ~ 13 parts, Radix Rehmanniae 19 ~ 21 parts, Radix Puerariae 7 ~ 9 parts, the Radix Angelicae Dahuricae 5 ~ 7 parts, Herba Violae diffusae 12 ~ 14 parts, TUXIXIN 2.5 ~ 3.5 parts, Radix Scrophulariae 12 ~ 14 parts, 5 ~ 7 parts, Radix Glycyrrhizae.
3. pharmaceutical composition according to claim 1, is characterized in that, the weight proportion of pharmacodynamic raw materials used is: Radix Peucedani 12 parts, Radix Rehmanniae 20 parts, Radix Puerariae 8 parts, the Radix Angelicae Dahuricae 6 parts, Herba Violae diffusae 13 parts, TUXIXIN 3 parts, Radix Scrophulariae 13 parts, 6 parts, Radix Glycyrrhizae.
4. pharmaceutical composition according to claim 1, is characterized in that, pharmacodynamic raw materials used also comprises following kind, and its consumption proportion is expressed as with weight portion: Herba Androsaces umbellatae 15 ~ 30 parts.
5. pharmaceutical composition according to claim 1, is characterized in that, pharmacodynamic raw materials used also comprises following kind, and its consumption proportion is expressed as with weight portion: the Radix Astragali 15 ~ 20 parts; Radix Angelicae Sinensis 6 ~ 15 parts.
6. pharmaceutical composition according to claim 1, is characterized in that, pharmacodynamic raw materials used also comprises following kind, and its consumption proportion is expressed as with weight portion: Cortex Cinnamomi 2 ~ 3 parts.
7. pharmaceutical composition according to claim 6, is characterized in that, pharmacodynamic raw materials used also comprises following kind, and its consumption proportion is expressed as with weight portion: Radix Aconiti Lateralis Preparata 3 ~ 9 parts.
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Citations (1)
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CN101313936A (en) * | 2007-06-01 | 2008-12-03 | 北京亚东生物制药有限公司 | Medicament composition for dispelling wind and relieving pain, preparation method and quality control method thereof |
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CN101313936A (en) * | 2007-06-01 | 2008-12-03 | 北京亚东生物制药有限公司 | Medicament composition for dispelling wind and relieving pain, preparation method and quality control method thereof |
Non-Patent Citations (2)
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中医药治疗发热的近况(综述);孙波;《中国城乡企业卫生》;20020630(第03期);41-44 * |
略论中医退热十五法;柯新桥;《中国中医急症》;20071215;第16卷(第12期);1494-1496 * |
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