CN101468076A - Chinese medicine gel for treating arthritis and preparation method thereof - Google Patents
Chinese medicine gel for treating arthritis and preparation method thereof Download PDFInfo
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- CN101468076A CN101468076A CNA2007100946367A CN200710094636A CN101468076A CN 101468076 A CN101468076 A CN 101468076A CN A2007100946367 A CNA2007100946367 A CN A2007100946367A CN 200710094636 A CN200710094636 A CN 200710094636A CN 101468076 A CN101468076 A CN 101468076A
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- radix aconiti
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Abstract
The invention relates to a traditional Chinese medicine gel for treating arthritis and preparation method thereof, belonging to medical field. The gel is composed of raw sihcuan axonite root extract and pharmaceutical adjuvant by the following weight ratio: raw sihcuan axonite root extract 1.5%, camphor 0.1%, musk 0.04%, high molecular matrix material 0.1-5%, humectant 5-15%, preservatives 0-0.5%, solvent 50-80%.
Description
Technical field
The invention belongs to medical technical field, specifically Chinese medicine gel of a kind of treatment of arthritis and preparation method thereof.
Background technology
Arthritis is clinical common with multiple difficult and complicated illness, belongs to motherland's medical science arthromyodynia category.The epidemiology special investigation shows, incidence rate that should disease in China's mid-aged population is up to 70%, and wherein cervical vertebra, lumbar vertebra and kneed sickness rate are the highest, and the three amounts to and accounts for more than 90% of osteoarthrosis, along with China steps into aging society gradually, this problem is more outstanding.
The method of existing treatment of arthritis, doctor trained in Western medicine often adopt oral nonsteroidal antipyretic analgesic or operative therapys such as " tractions ".The oral drugs side effect is many; The operative treatment cycle is long, expense is high, misery is big, and easily recurrence.Chinese medicine is unique advantage aspect treatment of arthritis, extract oral, external application, fumigation and wash method, acupuncture, processs and treats and the small needle knife therapy all has positive effect.But oral preparation of Chinese traditional medicinal contains hypertoxic medicines such as Radix Aconiti, Rhizoma Arisaematis, Semen Strychni more, and dosage is difficult to grasp, and sees that from the biopharmaceutics angle being difficult in diseased region reaches effective blood drug concentration, has influenced the performance of curative effect of medication.
Chinese medicine " inner disease outer treat " is theoretical with a long history, a large amount of good recipes, proved recipe have been accumulated, but external treatment with Chinese medicine medicine ubiquity dosage form falls behind, dosage is big, use shortcomings such as inconvenience, therefore utilize modern preparation technique exploitation evident in efficacy lasting, Chinese medicine for outer use easy to use becomes an important topic of the modernization of Chinese medicine.
Summary of the invention
For solving above-mentioned technical deficiency, one of technical problem to be solved by this invention provides Chinese medicine gel of a kind of treatment of arthritis and preparation method thereof.
Technical scheme of the present invention is that a kind of Chinese medicine gel of treatment of arthritis is prepared from by Radix Aconiti extract and pharmaceutic adjuvant, it is characterized in that:
The Radix Aconiti extract is prepared from the following method: the Radix Aconiti material is ground into coarse powder, adopts 70% acidic ethanol pH=3 percolation to extract, collects 8 times and measure percolates, with the percolate decompression recycling ethanol, water is concentrated into relative density 1.05～1.07, and 60 ℃ of heat are surveyed, filter, filtrate is used ammonia adjust pH 9～10, chloroform extraction 5 times, to the inanimate object alkali reaction, combining extraction liquid reclaims chloroform, gets clear paste, 60 ℃ of drying under reduced pressure promptly get the Radix Aconiti extract.
The Chinese medicine gel of above-mentioned a kind of treatment of arthritis, the part by weight that it is characterized in that Radix Aconiti extract and pharmaceutic adjuvant is: Radix Aconiti extract 1.5%, Camphora 0.1%, Moschus 0.04%, polymer-based material 0.1-5%, wetting agent 5-15%, antiseptic 0-0.5%, solvent 50-80%.
Described polymer-based material refers at least a in carbopol, propylene glycol, triethanolamine, hypromellose, azone, propylene glycol, ethyl hydroxybenzoate, polyvinylpyrrolidone, the benzalkonium bromide; Wetting agent refers to glycerol.
Two of technical problem to be solved by this invention provides the preparation method of the Chinese medicine gel of this treatment of arthritis.
The preparation method of the Chinese medicine gel of above-mentioned treatment of arthritis is characterized in that, polymer-based material is added water-soluble expanding, Radix Aconiti extract, Camphora are with 70% dissolve with ethanol, and the artificial Moschus adds wetting agent, antiseptic with ether dissolution, solubilizer stirs to ormal weight, gel.
Solvent adopts water or distilled water; The antiseptic material adopts at least a, can be disodiumedetate.
Advantage of the present invention: compared with prior art, the present invention makes gel with the Chinese medicine compound recipe, by percutaneous drug delivery, not only can avoid the GI irritation of oral administration, reduce systemic blood concentration, reduce toxic and side effects, and prolonged action time, reduce administration number of times, improved the compliance of patient's medication, and preparation technology of the present invention is simple, and is easy to use, for the clinical treatment of osteoarthritis provides a kind of new medicine.
The specific embodiment
Embodiment 1
The Radix Aconiti material is ground into coarse powder, adopts 70% acidic ethanol pH=3 percolation to extract, collects 8 times and measure percolates, with the percolate decompression recycling ethanol, water is concentrated into relative density 1.05～1.07, and 60 ℃ of heat are surveyed, filter, filtrate is used ammonia adjust pH 9～10, chloroform extraction 5 times, to the inanimate object alkali reaction, combining extraction liquid reclaims chloroform, gets clear paste, 60 ℃ of drying under reduced pressure promptly get the Radix Aconiti extract.
Carbopol 940 1g are added water-soluble expanding, add Radix Aconiti extract 1.5g; Camphora 0.1g is with 70% dissolve with ethanol, and artificial Moschus 0.04g adds after with ether dissolution; Add propylene glycol 10ml, triethanolamine 1.5g, glycerol 5ml, disodiumedetate 0.05g again, adding distil water stirs to 100g, gel.
Embodiment 2
The Radix Aconiti material is ground into coarse powder, adopts 70% acidic ethanol pH=3 percolation to extract, collects 8 times and measure percolates, with the percolate decompression recycling ethanol, water is concentrated into relative density 1.05～1.07, and 60 ℃ of heat are surveyed, filter, filtrate is used ammonia adjust pH 9～10, chloroform extraction 5 times, to the inanimate object alkali reaction, combining extraction liquid reclaims chloroform, gets clear paste, 60 ℃ of drying under reduced pressure promptly get the Radix Aconiti extract.
Hypromellose 1.5g added 50 times the abundant swelling of distilled water, add Radix Aconiti extract, Flos Daturae extract 1.5g, Camphora 0.1g, Moschus 0.04g, glycerol 1.5g, azone 5ml, propylene glycol 15ml, ethyl hydroxybenzoate 0.1g, adding distil water stirs to 100g, gel.
Embodiment 3
The Radix Aconiti material is ground into coarse powder, adopts 70% acidic ethanol pH=3 percolation to extract, collects 8 times and measure percolates, with the percolate decompression recycling ethanol, water is concentrated into relative density 1.05～1.07, and 60 ℃ of heat are surveyed, filter, filtrate is used ammonia adjust pH 9～10, chloroform extraction 5 times, to the inanimate object alkali reaction, combining extraction liquid reclaims chloroform, gets clear paste, 60 ℃ of drying under reduced pressure promptly get the Radix Aconiti extract.
Polyvinylpyrrolidone 0.04g added 50 times the abundant swelling of distilled water, add Radix Aconiti extract 1.5g, Camphora 0.1g, Moschus 0.04g, glycerol 12ml, benzalkonium bromide 0.05g respectively by said ratio, adding distil water stirs to 100g, gel.
Claims (4)
1. the Chinese medicine gel of a treatment of arthritis, be prepared from by Radix Aconiti extract and pharmaceutic adjuvant, it is characterized in that: the Radix Aconiti extract is prepared from the following method: the Radix Aconiti material is ground into coarse powder, adopt 70% acidic ethanol pH=3 percolation to extract, collect 8 times of amount percolates, with the percolate decompression recycling ethanol, water is concentrated into relative density 1.05～1.07,60 ℃ of heat are surveyed, filter, filtrate is used ammonia adjust pH 9～10, chloroform extraction 5 times, to the inanimate object alkali reaction, combining extraction liquid reclaims chloroform, gets clear paste, 60 ℃ of drying under reduced pressure promptly get the Radix Aconiti extract.
2. the Chinese medicine gel of a kind of treatment of arthritis according to claim 1, the part by weight that it is characterized in that Radix Aconiti extract and pharmaceutic adjuvant is: Radix Aconiti extract 1.5%, Camphora 0.1%, Moschus 0.04%, polymer-based material 0.1-5%, wetting agent 5-15%, antiseptic 0-0.5%, solvent 50-80%.
3. the Chinese medicine gel of a kind of treatment of arthritis according to claim 2, it is characterized in that described polymer-based material refers at least a in carbopol, propylene glycol, triethanolamine, hypromellose, azone, propylene glycol, ethyl hydroxybenzoate, polyvinylpyrrolidone, the benzalkonium bromide; Wetting agent refers to glycerol.
4. the preparation method of the Chinese medicine gel of a treatment of arthritis, it is characterized in that, polymer-based material is added water-soluble expanding, Radix Aconiti extract, Camphora are with 70% dissolve with ethanol, the artificial Moschus adds wetting agent, antiseptic with ether dissolution, and solubilizer is to ormal weight, stir, gel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100946367A CN101468076A (en) | 2007-12-26 | 2007-12-26 | Chinese medicine gel for treating arthritis and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100946367A CN101468076A (en) | 2007-12-26 | 2007-12-26 | Chinese medicine gel for treating arthritis and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101468076A true CN101468076A (en) | 2009-07-01 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007100946367A Pending CN101468076A (en) | 2007-12-26 | 2007-12-26 | Chinese medicine gel for treating arthritis and preparation method thereof |
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| CN (1) | CN101468076A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973679A (en) * | 2012-12-21 | 2013-03-20 | 四川省中医药科学院 | Preparation method of total alkaloids extract in aconitum medical material or processed products of aconitum plants |
| CN105997848A (en) * | 2016-07-02 | 2016-10-12 | 青海民族大学 | Tangut anisodus radix and musk gel and preparation method thereof |
| CN108273002A (en) * | 2018-03-01 | 2018-07-13 | 区门秀 | A kind of transdermal ointment for treating osteoarthritis |
-
2007
- 2007-12-26 CN CNA2007100946367A patent/CN101468076A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973679A (en) * | 2012-12-21 | 2013-03-20 | 四川省中医药科学院 | Preparation method of total alkaloids extract in aconitum medical material or processed products of aconitum plants |
| CN105997848A (en) * | 2016-07-02 | 2016-10-12 | 青海民族大学 | Tangut anisodus radix and musk gel and preparation method thereof |
| CN108273002A (en) * | 2018-03-01 | 2018-07-13 | 区门秀 | A kind of transdermal ointment for treating osteoarthritis |
| CN108273002B (en) * | 2018-03-01 | 2021-07-20 | 区门秀 | Transdermal ointment for treating osteoarthritis |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20090701 |