CN101766698A - capsule for treating rhinitis - Google Patents
capsule for treating rhinitis Download PDFInfo
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- CN101766698A CN101766698A CN200810240617A CN200810240617A CN101766698A CN 101766698 A CN101766698 A CN 101766698A CN 200810240617 A CN200810240617 A CN 200810240617A CN 200810240617 A CN200810240617 A CN 200810240617A CN 101766698 A CN101766698 A CN 101766698A
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Abstract
The invention discloses a capsule for treating rhinitis, belonging to the traditional Chinese medicine pharmaceuticals; flower bud of lily magnolia, angelica, ligusticum wallichii, forsythia, baikal skullcap root, corydalis tuber, schisandra chinensis, radix saposhnikoviae, rhizome, asarum and liquorice are used as raw material, the raw materials are prepared into capsules by the conventional preparation process according to different characteristics of each traditional Chinese medicine; the capsule has the functions of relieve rheumatic pains and releasing lungs, clearing away heat and toxic material and relieving stuffiness and relieving pain and is used for syndrome of acute and chronic rhinitis wind-heat retention in lung, such as nasal obstruction, rhinorrhoea and headache and the like and treating both principle and secondary aspects of disease, the curative effect is exact; after pharmacological tests, the capsule is proved to have obvious inhibiting effect on mouse abdominal cavity capillary permeability increasing caused by acetic acid, granuloma hyperplasia induced by implantation of cotton pellets and five disease germs such as B type hemolytic streptococcus, the result shows that the capsule has anti-inflammatory, bacterial inhibition and controlling inflammatory secretion.
Description
Technical field
The invention belongs to field of traditional Chinese medicine pharmacy, be specifically related to a kind of capsule that is used for the treatment of rhinitis.
Background technology
Rhinitis is that a kind of because intrinsic factor Abwehrkraft des Koepers reduces, the disease due to the stimulation of extrinsic factor atmospheric pollution, and clinical manifestation is that intermittence, alternate nasal obstruction, headache, nasal discharge increase, sneeze has small amount bleeding etc. sometimes.It is a kind of common disease, easily raises difficult questions and controls.Its sickness rate height, the course of disease time is long, if malpractice or delay treatment, meeting grievous injury human body throat organ, pulmonary, heart and generation nasopharyngeal carcinoma etc.The rhinitis disease is listed in one of difficult medical problem, in case ill, not only bring misery, and bring huge stress to the household to patient.
At present, the method for treatment rhinitis has: operative treatment, local injection treatment, laser therapy, western medicine and treatment by Chinese herbs etc.Adopt operative treatment, local injection treatment and laser therapy, make the suffered wound of patient big, misery is many, the medical expense height, and general patient is beyond affordability; Western medicine, towards blood agent, glucocorticoid hormones nasal drop, spray etc., these medicines take stopgap measures often as alkali, can not solve its root problem, and can cause nose, throat's drying, stimulation, the nasal cavity capillary fragility causes that nasal cavity is often hemorrhage, even medicamentous rhinitis occurs.And treat the Chinese patent medicine and the various decoction of rhinitis at present, be symptomatic treatment, treatment time is long, and dose is big, though rhinitis is had certain curative effect, but just reach the alleviation disease, and not radical cure, so rhinitis is easy to recurrence, and side effect is bigger, the intestines and stomach to patient causes stimulation easily, damages patient's the intestines and stomach mucosa, causes the generation of other disease of patient.
Summary of the invention
The invention provides a kind of capsule that is used for the treatment of rhinitis, purpose is to provide a kind of double effecting a permanent cure of taking stopgap measures, the Chinese medicine that giving consideration to both the incidental and fundamental and side effect are little, and the preparation method of preparation of the present invention is provided.
The present invention is achieved by the following technical solutions:
A kind of capsule that is used for the treatment of rhinitis, it is that raw material is made by following parts by weight of Chinese traditional medicine material:
15～60 parts of 25～70 parts of Rhizoma Chuanxiongs of 40～90 parts of Radix Angelicae Sinensis of Flos Magnoliae
20～50 parts of 25～60 parts of Rhizoma Corydalis of 40～75 parts of Radix Scutellariaes of Fructus Forsythiae
50～95 parts of 50～100 parts of Rhizoma Cimicifugaes of 30～70 parts of Radix Saposhnikoviaes of Fructus Schisandrae Chinensis
20～55 parts in 20～60 portions of Radix Glycyrrhizaes of Herba Asari
And the weight portion proportioning of described each Chinese crude drug raw material is:
40 parts of 50 parts of Rhizoma Chuanxiongs of 65 parts of Radix Angelicae Sinensis of Flos Magnoliae
35 parts of 45 parts of Rhizoma Corydalis of 60 parts of Radix Scutellariaes of Fructus Forsythiae
70 parts of 75 parts of Rhizoma Cimicifugaes of 50 parts of Radix Saposhnikoviaes of Fructus Schisandrae Chinensis
35 parts in 40 portions of Radix Glycyrrhizaes of Herba Asari
Its preparation method is:
(1) raw material powder is broken into coarse powder, and is standby;
(2) get Flos Magnoliae, Rhizoma Chuanxiong coarse powder, mix, water vapour distillation volatile oil is collected volatile oil to the greatest extent, and the aqueous solution after the distillation filters, filtrate for later use;
(3) get Radix Angelicae Sinensis, Radix Scutellariae, Rhizoma Corydalis, each coarse powder of Herba Asari, add 40～80% ethanol extractions 2～5 times, each 1～2 hour, merge extractive liquid, (medicinal residues are standby) filters filtrate recycling ethanol, and being condensed into 50～70 ℃ of heat, to survey relative densities be 1.12～1.16 clear paste, standby;
(4) get all the other five tastes coarse powder such as Fructus Forsythiae, Fructus Schisandrae Chinensis, mix, decoct with water 2～4 times with (3) alcohol extraction medicinal residues, each 1～3 hour, collecting decoction filtered, the filtrate of filtrate and (2) merges, and being condensed into 60～80 ℃ of heat, to survey relative densities be 1.10～1.16 clear paste, standby;
The two clear paste mix homogeneously that (5) will make are dried to dried cream, pulverize, and add an amount of pharmaceutics adjuvant, granulate, and spray into volatile oil, mixing, and airtight a few hours, encapsulated, make capsule, promptly.
Function of the present invention cures mainly and is: the lung qi dispersing that dispels the wind, heat-clearing and toxic substances removing, understand things pain-stopping, and be used for the acute or chronic rhinitis wind heat and accumulate the lung card, disease is seen nasal obstruction, watery nasal discharge, headache etc.
For beneficial effect of the present invention better is described, simultaneously in order to estimate the capsular pharmacological action of the present invention, we have carried out following experimental study:
Principal agent side: Flos Magnoliae 65g, Radix Angelicae Sinensis 50g, Rhizoma Chuanxiong 40g, Fructus Forsythiae 60g, Radix Scutellariae 45g, Rhizoma Corydalis 35g, Fructus Schisandrae Chinensis 50g, Radix Saposhnikoviae 75g, Rhizoma Cimicifugae 70g, Herba Asari 40g, Radix Glycyrrhizae 35g makes capsule according to preparation method of the present invention.
1 test material
1.1 reagent: capsule of the present invention, TONGXIAO BIYAN PIAN.
1.2 animal: SPF level KM mice, male and female are not limit, 18～22g.
1.3 strain: beta hemolytic streptococcus (32210), staphylococcus aureus (26003), Pseudomonas aeruginosa (10104), shigella dysenteriae (51252), colon bacillus (44155).
2 test methods and result
2.1 influence to the mouse peritoneal capillary permeability
Get the KM mice, press the gastric infusion of dosage shown in the table 1, matched group gavages with the volume normal saline, tail vein injection 0.5%Evans blue 0.2ml behind the administration 30min, lumbar injection 0.2ml 0.7%HAc divides the flushing abdominal cavity 2 times with the 10ml normal saline simultaneously, collect washing liquid, the NaOH 0.1ml that adds 0.1mol/L, centrifugal behind the placement 20min, measure trap in ultraviolet spectrophotometer 590nm place.The results are shown in Table 1.
Table 1 capsule of the present invention to H+ cause that the mouse peritoneal capillary permeability increases influence the result (x ± s, n=10)
Annotate: through t check, * P＜0.05, * * P＜0.01
The result shows, two dosage groups of capsule of the present invention and positive control TONGXIAO BIYAN PIAN group all can very remarkable inhibition H+ due to the abdominal cavity capillary permeability increase, and effect is better than positive control TONGXIAO BIYAN PIAN group.
2.2 influence to the mice granuloma induced by implantation of cotton pellets
Get the KM mice, press the gastric infusion of dosage shown in the table 2 respectively, the medicinal oxidation cortisone of positive control, 0.5h etherization after the administration, strange portion imbeds aseptic cotton balls (cotton balls soaks with the gentamycin of 1800 μ g/ml concentration) later 1 time/d of gastric infusion, the 7d continuously of 1 10mg about every Mus.1h puts to death animal after the last administration, gets the granuloma induced by implantation of cotton pellets tissue, puts 60 ℃ of dry 3h, 2 granuloma induced by implantation of cotton pellets tissues about every Mus is merged weigh, and organize a statistical.The results are shown in Table 2.
Table 2 capsule of the present invention to the mice granuloma induced by implantation of cotton pellets influence the result (x ± s, n=10)
Annotate: through t check, * P＜0.05, * * P＜0.01
The result shows that two dosage groups of capsule of the present invention all have the granuloma induced by implantation of cotton pellets hamartoplasia effect that very suppresses significantly, and effect is better than the TONGXIAO BIYAN PIAN group.
2.3 vitro antibacterial activity
Routine operation: adopt two times of method dilution medicines, the plate punch method is surveyed medicine inhibition zone (aperture is 5mm, and antibacterial circle diameter is mm).The results are shown in Table 3.
Table 3 capsule vitro antibacterial activity of the present invention result
The result shows that capsule body of the present invention is outer all to have obvious bacteriostasis to staphylococcus aureus, beta hemolytic streptococcus, Pseudomonas aeruginosa, shigella dysenteriae and colon bacillus, and is wherein comparatively responsive to dysentery bacterium, group B streptococcus.
3 conclusions
Experimental result: (1) capsule of the present invention can significantly suppress mouse peritoneal capillary permeability and mice granuloma induced by implantation of cotton pellets, shows the hypertrophy that this medicine can reduce oozing out of secretions and prevent and treat the inflammation tissue; (2) in-vitro antibacterial test shows: capsule of the present invention has obvious inhibitory action to beta hemolytic streptococcus etc.The result shows that capsule of the present invention has antiinflammatory, antibacterial, inhibition rheuminess effect.
The specific embodiment of form is described in further detail foregoing of the present invention by the following examples.Following example is based on the above-mentioned subject area of the present invention, but is not limited to following example.
The specific embodiment
Embodiment:
Adopt each prescription of following proportioning:
Side (1):
Flos Magnoliae 65g Radix Angelicae Sinensis 50g Rhizoma Chuanxiong 40g
Fructus Forsythiae 60g Radix Scutellariae 45g Rhizoma Corydalis 35g
Fructus Schisandrae Chinensis 50g Radix Saposhnikoviae 75g Rhizoma Cimicifugae 70g
Herba Asari 40g Radix Glycyrrhizae 35g
Side (2):
Flos Magnoliae 40g Radix Angelicae Sinensis 35g Rhizoma Chuanxiong 20g
Fructus Forsythiae 40g Radix Scutellariae 25g Rhizoma Corydalis 40g
Fructus Schisandrae Chinensis 50g Radix Saposhnikoviae 50g Rhizoma Cimicifugae 60g
Herba Asari 30g Radix Glycyrrhizae 20g
Side (3):
Flos Magnoliae 90g Radix Angelicae Sinensis 60g Rhizoma Chuanxiong 50g
Fructus Forsythiae 70g Radix Scutellariae 55g Rhizoma Corydalis 50g
Fructus Schisandrae Chinensis 70g Radix Saposhnikoviae 100g Rhizoma Cimicifugae 90g
Herba Asari 60g Radix Glycyrrhizae 50g
All adopt following preparation method to make:
(1) raw material powder is broken into coarse powder, and is standby;
(2) get Flos Magnoliae, Rhizoma Chuanxiong coarse powder, mix, water vapour distillation volatile oil is collected volatile oil to the greatest extent, and the aqueous solution after the distillation filters, filtrate for later use;
(3) get Radix Angelicae Sinensis, Radix Scutellariae, Rhizoma Corydalis, each coarse powder of Herba Asari, add 60% ethanol extraction 3 times, each 1 hour, merge extractive liquid, (medicinal residues are standby) filtered, filtrate recycling ethanol, and being condensed into 60 ℃ of heat, to survey relative densities be 1.14 clear paste, standby;
(4) get all the other five tastes coarse powder such as Fructus Forsythiae, Fructus Schisandrae Chinensis, mix with (3) alcohol extraction medicinal residues, decoct with water 3 times, each 2 hours, collecting decoction filtered, and filtrate merges with the filtrate of (2), and being condensed into 70 ℃ of heat, to survey relative densities be 1.14 clear paste, standby;
The two clear paste mix homogeneously that (5) will make are dried to dried cream, pulverize, and add adjuvant, granulate, and spray into volatile oil, mixing, and airtight 2 hours, encapsulated, promptly.
Claims (4)
1. capsule that is used for the treatment of rhinitis is characterized in that it is that raw material is made by following parts by weight of Chinese traditional medicine material:
15～60 parts of 25～70 parts of Rhizoma Chuanxiongs of 40～90 parts of Radix Angelicae Sinensis of Flos Magnoliae
20～50 parts of 25～60 parts of Rhizoma Corydalis of 40～75 parts of Radix Scutellariaes of Fructus Forsythiae
50～95 parts of 50～100 parts of Rhizoma Cimicifugaes of 30～70 parts of Radix Saposhnikoviaes of Fructus Schisandrae Chinensis
20～55 parts in 20～60 portions of Radix Glycyrrhizaes of Herba Asari.
2. a kind of capsule that is used for the treatment of rhinitis according to claim 1, wherein the weight portion proportioning of each Chinese crude drug raw material is:
40 parts of 50 parts of Rhizoma Chuanxiongs of 65 parts of Radix Angelicae Sinensis of Flos Magnoliae
35 parts of 45 parts of Rhizoma Corydalis of 60 parts of Radix Scutellariaes of Fructus Forsythiae
70 parts of 75 parts of Rhizoma Cimicifugaes of 50 parts of Radix Saposhnikoviaes of Fructus Schisandrae Chinensis
35 parts in 40 portions of Radix Glycyrrhizaes of Herba Asari.
3. according to each described a kind of capsule that is used for the treatment of rhinitis of claim 1-2, its preparation method is:
(1) raw material powder is broken into coarse powder, and is standby;
(2) get Flos Magnoliae, Rhizoma Chuanxiong coarse powder, mix, water vapour distillation volatile oil is collected volatile oil to the greatest extent, and the aqueous solution after the distillation filters, filtrate for later use;
(3) get Radix Angelicae Sinensis, Radix Scutellariae, Rhizoma Corydalis, each coarse powder of Herba Asari, add 40～80% ethanol extractions 2～5 times, each 1～2 hour, merge extractive liquid, (medicinal residues are standby) filters filtrate recycling ethanol, and being condensed into 50～70 ℃ of heat, to survey relative densities be 1.12～1.16 clear paste, standby;
(4) get all the other five tastes coarse powder such as Fructus Forsythiae, Fructus Schisandrae Chinensis, mix, decoct with water 2～4 times with (3) alcohol extraction medicinal residues, each 1～3 hour, collecting decoction filtered, the filtrate of filtrate and (2) merges, and being condensed into 60～80 ℃ of heat, to survey relative densities be 1.10～1.16 clear paste, standby;
The two clear paste mix homogeneously that (5) will make are dried to dried cream, pulverize, and add an amount of pharmaceutics adjuvant, granulate, and spray into volatile oil, mixing, and airtight a few hours, encapsulated, make capsule, promptly.
4. according to each described a kind of capsule that is used for the treatment of rhinitis of claim 1-2, its function cures mainly and is: have the function of the lung qi dispersing that dispels the wind, heat-clearing and toxic substances removing, understand things pain-stopping, be used for the acute or chronic rhinitis wind heat and accumulate the lung card, disease is seen nasal obstruction, watery nasal discharge, headache etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810240617A CN101766698A (en) | 2008-12-26 | 2008-12-26 | capsule for treating rhinitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810240617A CN101766698A (en) | 2008-12-26 | 2008-12-26 | capsule for treating rhinitis |
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| Publication Number | Publication Date |
|---|---|
| CN101766698A true CN101766698A (en) | 2010-07-07 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN200810240617A Pending CN101766698A (en) | 2008-12-26 | 2008-12-26 | capsule for treating rhinitis |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103055155A (en) * | 2012-12-26 | 2013-04-24 | 柳州市中医院 | Traditional Chinese medicine for treating nasopharyngeal carcinoma and preparation method thereof |
| CN106509892A (en) * | 2016-10-28 | 2017-03-22 | 芜湖市诺康生物科技有限公司 | Health product for alleviating human body fatigue and preparation method thereof |
-
2008
- 2008-12-26 CN CN200810240617A patent/CN101766698A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103055155A (en) * | 2012-12-26 | 2013-04-24 | 柳州市中医院 | Traditional Chinese medicine for treating nasopharyngeal carcinoma and preparation method thereof |
| CN106509892A (en) * | 2016-10-28 | 2017-03-22 | 芜湖市诺康生物科技有限公司 | Health product for alleviating human body fatigue and preparation method thereof |
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Open date: 20100707 |