CN100534482C - Soft capsule for treating vascular headaehe - Google Patents
Soft capsule for treating vascular headaehe Download PDFInfo
- Publication number
- CN100534482C CN100534482C CNB2004100141256A CN200410014125A CN100534482C CN 100534482 C CN100534482 C CN 100534482C CN B2004100141256 A CNB2004100141256 A CN B2004100141256A CN 200410014125 A CN200410014125 A CN 200410014125A CN 100534482 C CN100534482 C CN 100534482C
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- soft capsule
- vegetable oil
- rhizoma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000007901 soft capsule Substances 0.000 title claims abstract description 11
- 230000002792 vascular Effects 0.000 title 1
- 239000003814 drug Substances 0.000 claims abstract description 13
- 208000001407 Vascular Headaches Diseases 0.000 claims abstract description 8
- 210000000582 semen Anatomy 0.000 claims description 10
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 9
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 8
- 239000008158 vegetable oil Substances 0.000 claims description 8
- 229940079593 drug Drugs 0.000 claims description 4
- 241000202807 Glycyrrhiza Species 0.000 claims description 3
- 241000545442 Radix Species 0.000 claims description 3
- 235000006463 Brassica alba Nutrition 0.000 claims description 2
- 241000220262 Sinapis alba Species 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 4
- 241000202726 Bupleurum Species 0.000 abstract 1
- 235000018142 Hedysarum alpinum var americanum Nutrition 0.000 abstract 1
- 240000006461 Hedysarum alpinum var. americanum Species 0.000 abstract 1
- 244000236658 Paeonia lactiflora Species 0.000 abstract 1
- 235000008598 Paeonia lactiflora Nutrition 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 27
- 206010019233 Headaches Diseases 0.000 description 10
- 231100000869 headache Toxicity 0.000 description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
- 239000000843 powder Substances 0.000 description 9
- 230000000694 effects Effects 0.000 description 7
- 239000000284 extract Substances 0.000 description 7
- 208000019695 Migraine disease Diseases 0.000 description 6
- 206010027599 migraine Diseases 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 238000005325 percolation Methods 0.000 description 6
- 239000000341 volatile oil Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 239000002775 capsule Substances 0.000 description 5
- 206010043269 Tension headache Diseases 0.000 description 4
- 208000008548 Tension-Type Headache Diseases 0.000 description 4
- FINHMKGKINIASC-UHFFFAOYSA-N Tetramethylpyrazine Chemical compound CC1=NC(C)=C(C)N=C1C FINHMKGKINIASC-UHFFFAOYSA-N 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 230000003203 everyday effect Effects 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 108010010803 Gelatin Proteins 0.000 description 3
- 235000010489 acacia gum Nutrition 0.000 description 3
- 239000001785 acacia senegal l. willd gum Substances 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 239000008273 gelatin Substances 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 235000011852 gelatine desserts Nutrition 0.000 description 3
- 230000002650 habitual effect Effects 0.000 description 3
- 230000002175 menstrual effect Effects 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 239000006188 syrup Substances 0.000 description 3
- 235000020357 syrup Nutrition 0.000 description 3
- PKRPFNXROFUNDE-LLVKDONJSA-N Byakangelicin Chemical compound O1C(=O)C=CC2=C1C(OC[C@@H](O)C(C)(C)O)=C1OC=CC1=C2OC PKRPFNXROFUNDE-LLVKDONJSA-N 0.000 description 2
- 206010064012 Central pain syndrome Diseases 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 239000003605 opacifier Substances 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 229930024421 Adenine Natural products 0.000 description 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 229960000643 adenine Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- PKRPFNXROFUNDE-UHFFFAOYSA-N biac-angelicin Natural products O1C(=O)C=CC2=C1C(OCC(O)C(C)(C)O)=C1OC=CC1=C2OC PKRPFNXROFUNDE-UHFFFAOYSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 description 1
- 229940114124 ferulic acid Drugs 0.000 description 1
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 description 1
- 235000001785 ferulic acid Nutrition 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 230000003821 menstrual periods Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000012372 quality testing Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
A Chinese medicine in the form of soft capsule for treating vascular headache is prepared from 8 Chinese-medicinal materials including Chuan-xiong rhizome, bupleurum root, white peony root, liquorice root, etc. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to the Chinese medicinal capsule agent of a kind of treatment vascular headache (particularly migraine, gynecologic menstrual headache, tension headache), particularly a kind of soft capsule.
Background technology
Vascular headache, particularly migraine, gynecologic menstrual headache, tension headache just obtained diagnosis before more than 3000 years, as untimely treatment, 80% can forming the habit property migraine, and forms the familial hereditary headache, causes very big harm for work and life.The migrainous medicine of treatment mostly is Western medicine at present, and side effect is big, is not suitable for long-term and preferred the use; It is more that Chinese medicine preparation contains the medicine of Rhizoma Gastrodiae composition at present, and most of experts think Rhizoma Gastrodiae treatment headache also the expert to think that Rhizoma Gastrodiae is not suitable for the treatment headache.The hemialgia electuary that with the Rhizoma Chuanxiong is principal agent has been used for many years determined curative effect clinically.But control hemialgia electuary dose big (each 20 grams, every day 3 times), mouthfeel poor (particularly the Rhizoma Chuanxiong taste is big) has influenced patient's use greatly.
Summary of the invention
The objective of the invention is to overcome the shortcoming that prior art exists, the soft capsule of a kind of vascular headache that is used for the treatment of, particularly migraine, gynecologic menstrual headache, tension headache is provided.
Purpose of the present invention is achieved through the following technical solutions:
Prescription:
Rhizoma Chuanxiong: 20 parts of-10 parts of Radix Bupleuri: 2 parts of-4 parts of Radixs Angelicae Dahuricae: 1 part-2 parts
Semen Sinapis Albae: 6 portions of-12 portions of Radix Paeoniae Albas: 10 portions of-5 portions of Rhizoma Cyperis: 4 parts-8 parts
Semen Pruni: 2 portions of-4 portions of Radix Glycyrrhizaes: 2 parts-4 parts, vegetable oil is an amount of
Above-mentioned formula optimization is:
4 parts of 1 portion of Rhizoma Cyperis of 2 parts of Radixs Angelicae Dahuricae of 20 parts of Radix Bupleuri of Rhizoma Chuanxiong
2 parts in 6 portions of Radix Glycyrrhizaes of 2 parts of Semen Sinapis Albaes of 10 parts of Semen Prunis of the Radix Paeoniae Alba
Preparation method is:
1, with Rhizoma Chuanxiong, the Radix Angelicae Dahuricae distillating extracting oil of described weight portion; Rhizoma Cyperi, Radix Bupleuri, Semen Pruni are ground into coarse powder, according to the percolation under fluid extract and the extractum item, use ethanol percolation, behind the recovery ethanol, are evaporated to thick paste (proportion is 1.1-1.35); The Radix Paeoniae Alba, Radix Glycyrrhizae, Semen Sinapis Albae decoct with water twice, each two hours.Collecting decoction is concentrated in right amount, adds ethanol and reaches 75% to containing the alcohol amount, precipitates 48 hours, reclaims ethanol, is evaporated to thick paste (proportion is 1.1-1.35), and two kinds of thick pastes merge, and drying under reduced pressure is ground into fine powder.
2, fine powder adds an amount of vegetable oil and above-mentioned volatile oil, mixing.
3, preparation capsule shells, the material mixture ratio of capsule shells
Gelatin: arabic gum: glycerol: syrup: distilled water is 1.0: 0.25: 0.75: 0.15: 1.5, or 10: 1: 10.4: 16.1, or 13.6: 2.6: 6.8: 5.9: 2.27, or 2.75: 0.5: 1.25: 1.35: also need add an amount of pigment and opacifier TiO in right amount
2
The soft capsule 0.25 gram/grain-0.45 gram/grain that is prepared into.
By above-mentioned technology, from Rhizoma Chuanxiong, extract volatile oil and contain ligustrazine, ferulic acid, adenine, gland glycoside composition, from the Radix Angelicae Dahuricae, extract in the volatile oil and contain the byak-angelicin composition.
Beneficial effect is: the soft capsule of novel form provided by the invention treatment vascular headache, that its advantage is is rapid-action, dose is little, take with easy to carry, mouthfeel good, can carry out the quality testing of qualitative, quantitative, good stability.
The present invention is because of with the Rhizoma Chuanxiong in the compound recipe, the Radix Angelicae Dahuricae utilizes science and advanced extracting method, extract active drug volatile oil respectively, the ligustrazine that extracts in the Rhizoma Chuanxiong etc. has the wind of searching, removing blood stasis with potent drugs, the analgesic effect, and also have the Rhizoma Cyperi resolving depression of regulating the flow of vital energy in the side, Semen Sinapis Albae clearing away phlegm eliminating stagnation, the Radix Bupleuri reconciling superficies and interior, through sick institute, increased the analgesic effect, in order to prevent that above-mentioned all medicines from all being that hot diffusing attacking scurried the healthy energy of hurting sb.'s feelings, so add the Radix Paeoniae Alba again, the soft and moist convergence of Semen Pruni is to help it, and Radix Glycyrrhizae is delayed it, so having, perfect square complements each other, improve curative effect, can complement each other again, transfer its inclined to one side victory, bring out the best in each other.
The specific embodiment
Further set forth the preparation method of medicine of the present invention by the following examples.
Embodiment 1
Prescription: Rhizoma Chuanxiong 3000g Radix Bupleuri 300g Radix Angelicae Dahuricae 150g Rhizoma Cyperi 600g
Radix Paeoniae Alba 1500g Semen Pruni 300g Semen Sinapis Albae 900g
Radix Glycyrrhizae 300g
Method for making:
Get Rhizoma Chuanxiong, Radix Angelicae Dahuricae distillating extracting oil, the aqueous solution after distillation device is in addition collected; Rhizoma Cyperi, Radix Bupleuri, Semen Pruni are ground into coarse powder, according to the percolation under fluid extract and the extractum item, use ethanol percolation, behind the recovery ethanol, are evaporated to thick paste 293 grams (proportion is about 1.30); The Radix Paeoniae Alba, Radix Glycyrrhizae, Semen Sinapis Albae decoct with water twice, each two hours.Collecting decoction and above-mentioned aqueous solution are concentrated in right amount, add ethanol and reach 75% to containing the alcohol amount, precipitate 48 hours, reclaim ethanol, are evaporated to thick paste 706 grams (proportion is about 1.30), two kinds of thick pastes merging, and drying under reduced pressure is ground into fine powder.
Fine powder is added vegetable oil and above-mentioned volatile oil, and mixing is made 900 of soft capsules (0.45 gram/grain is taken 3 at every turn, takes every day 3 times).
Annotate: the material mixture ratio of capsule shells
Gelatin: arabic gum: glycerol: syrup: distilled water is 1.0: 0.25: 0.75: 0.15: 1.5, add pigment, opacifier TiO again
2
Embodiment 2
Prescription: Rhizoma Chuanxiong 3000g Radix Bupleuri 300g Radix Angelicae Dahuricae 150g Rhizoma Cyperi 600g
Radix Paeoniae Alba 1500g Semen Pruni 300g Semen Sinapis Albae 900g
Radix Glycyrrhizae 300g
Method for making:
Get Rhizoma Chuanxiong, Radix Angelicae Dahuricae distillating extracting oil; Rhizoma Cyperi, Radix Bupleuri, Semen Pruni are ground into coarse powder, according to fluid extract and extractum item percolation down, use ethanol percolation, behind the recovery ethanol, are evaporated to thick paste 293 and restrain (this heavy be about 1.30); The Radix Paeoniae Alba, Radix Glycyrrhizae, Semen Sinapis Albae decoct with water twice, each two hours.Collecting decoction is concentrated in right amount, adds ethanol and reaches 75% to containing the alcohol amount, precipitates 48 hours, reclaims ethanol, is evaporated to thick paste 347 grams (proportion is about 1.30), two kinds of thick pastes merging, and drying under reduced pressure is ground into fine powder.
Fine powder is added vegetable oil and above-mentioned volatile oil, mixing, (0.35 gram/grain is taken 3 at every turn, takes every day 3 times to make 900 of soft capsules.
Annotate: the material mixture ratio of capsule shells
Gelatin: arabic gum: glycerol: syrup: distilled water is 13.6: 2.6: 6.8: 5.9: 2.27
The test example
Below be clinical observation on the therapeutic effect by testing example, further set forth effective effect of medicine of the present invention:
1, physical data: clinical hospital: Affiliated Hospital of Nanjing Medical University department of Chinese medicine case is selected:
A, migraineur: the family history patient is arranged: 200, wherein the women is 120,80 of male, and the course of disease is more than 3 years;
B, habitual migraineur: 300, wherein the women is 200,100 of male, and the course of disease is more than 2 years;
C, female menstrual period headache patient: 100, the course of disease is unfixing;
D, tension headache patient: 200, the course of disease is unfixing.
2, efficacy assessment standard:
Produce effects: take the average onset in 30-50 minute in back, reach the pain relieving purpose, do not recur by taking 1-3 month course of treatment the long-term migraine within 5 years or habitual headache patient cured in the 1-2 of back;
Effectively: take the average onset in 30-50 minute in back, reach part pain relieving purpose, improve by the migraine and the habitual headache patient that take 1-3 month course of treatment within 2 years, but not necessarily do not recur;
Invalid: invalid after taking, take 3 days without any the effect that improves the headache degree.
3, instructions of taking: every day 3 times, each 3 (0.35 gram/grain)
4, clinical treatment result:
Produce effects: 500 examples are effective: 220 examples are invalid: 80 examples
Total effective rate: 90%
Claims (2)
1, a kind of soft capsule for the treatment of vascular headache, it is made by following bulk drugs and vegetable oil;
Rhizoma Chuanxiong: 20-10 part Radix Bupleuri: 2-4 part Radix Angelicae Dahuricae: 1-2 part
Semen Sinapis Albae: 6-12 part Radix Paeoniae Alba: 10-5 part Rhizoma Cyperi: 4-8 part
Semen Pruni: 2-4 part Radix Glycyrrhizae: 2-4 part vegetable oil is an amount of.
2, the soft capsule of treatment vascular headache according to claim 1 is characterized in that being made by following raw medicaments in portion by weight and vegetable oil:
4 parts of 1 portion of Rhizoma Cyperis of 2 parts of Radixs Angelicae Dahuricae of 20 parts of Radix Bupleuri of Rhizoma Chuanxiong
2 parts in 6 portions of Radix Glycyrrhizaes of 2 parts of Semen Sinapis Albaes of 10 parts of Semen Prunis of the Radix Paeoniae Alba
Vegetable oil is an amount of.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100141256A CN100534482C (en) | 2004-02-21 | 2004-02-21 | Soft capsule for treating vascular headaehe |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100141256A CN100534482C (en) | 2004-02-21 | 2004-02-21 | Soft capsule for treating vascular headaehe |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1657065A CN1657065A (en) | 2005-08-24 |
| CN100534482C true CN100534482C (en) | 2009-09-02 |
Family
ID=35006895
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100141256A Expired - Lifetime CN100534482C (en) | 2004-02-21 | 2004-02-21 | Soft capsule for treating vascular headaehe |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100534482C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104189351A (en) * | 2014-09-29 | 2014-12-10 | 洛阳御平国生物科技有限公司 | Traditional Chinese medicine for treating migraine |
| CN110559379A (en) * | 2019-09-27 | 2019-12-13 | 湖北神农汉方生物科技有限公司 | Preparation method of pure traditional Chinese medicine powder decoction granules |
-
2004
- 2004-02-21 CN CNB2004100141256A patent/CN100534482C/en not_active Expired - Lifetime
Non-Patent Citations (2)
| Title |
|---|
| 中华人民共和国卫生部 药品标准 中药成方制剂. 中华人民共和国卫生部药典委员会 编，137. 1998 |
| 中华人民共和国卫生部 药品标准 中药成方制剂. 中华人民共和国卫生部药典委员会 编，137. 1998 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1657065A (en) | 2005-08-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102764339A (en) | Maca composition for improving sexual dysfunction and preparation method and application thereof | |
| CN102397372A (en) | Medicinal composition and pharmaceutical preparation and application thereof to treating irritable bowel syndrome | |
| CN102362950A (en) | Traditional Chinese medicine for treating leucoderma | |
| CN103405582A (en) | Traditional Chinese medicine composition for improving joint gall of rheumatoid arthritis | |
| CN101347605B (en) | Chinese medicinal composition for treating gout and preparation method and application thereof | |
| CN101904985B (en) | Medicament for treating skin itch and preparation method thereof | |
| CN100534482C (en) | Soft capsule for treating vascular headaehe | |
| CN104857366A (en) | Preoperative intervention medicine composition for neurosurgery and application thereof | |
| CN101987135A (en) | Medicine for treating tetanus and preparation method thereof | |
| CN105343847A (en) | Traditional Chinese medicine composition for treating eczema containing folium artemisiae argyi and preparing method thereof | |
| CN104352994A (en) | Pharmaceutical preparation for sexual dysfunction | |
| CN1321677C (en) | Chinese herbal medicine for curing hyperthyroidism | |
| CN110237119A (en) | A kind of pharmaceutical composition that treating mucous membrane of mouth class disease and preparation method and purposes | |
| CN115770279B (en) | Traditional Chinese medicine composition for treating chronic lower limb vein diseases, decoction and preparation thereof | |
| CN103520684A (en) | Traditional Chinese medicine compound for reducing blood sugar | |
| CN115814020B (en) | Traditional Chinese medicine composition for treating ventricular arrhythmia and application thereof | |
| CN114053379B (en) | Traditional Chinese medicine composition for reducing uric acid and relieving gout as well as preparation method and application thereof | |
| CN102018849A (en) | Traditional Chinese medicine composition for preventing irregular menstruation and preparation method thereof | |
| CN101468124A (en) | Chinese medicinal composition for preventing and treating menoxenia and method for preparing the same | |
| CN101879227B (en) | Chinese medicinal composition for treating protrusion of lumbar intervertebral disci and preparation method thereof | |
| CN101766698A (en) | capsule for treating rhinitis | |
| CN107184860B (en) | Traditional Chinese medicine composition for treating eczema and preparation method and application thereof | |
| CN101912501B (en) | Medicament for treating ormarthritis and preparation method thereof | |
| CN105213852A (en) | A kind of Chinese patent medicine and preparation method for the treatment of facial acne | |
| CN102018758A (en) | Traditional Chinese medicinal composition for preventing and treating abnormal menstruation and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: JIANGSU EHAI PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: ZHANG YANJUN Effective date: 20120502 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 221000 XUZHOU, JIANGSU PROVINCE TO: 221004 XUZHOU, JIANGSU PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20120502 Address after: 221004 No. 18 Yang Shan Road, Xuzhou Economic Development Zone, Xuzhou, Jiangsu Patentee after: JIANGSU YI SEA PHARMACEUTICAl Co.,Ltd. Address before: 221000, Jiangsu, Xuzhou province Lantau Peak Kang residence area B7 building 403 room, Zhang Weifang closed Patentee before: Zhang Yanjun |
|
| CX01 | Expiry of patent term |
Granted publication date: 20090902 |
|
| CX01 | Expiry of patent term |