CN109260345A - A kind of callus promoting blood circulation composition and its preparation and preparation method - Google Patents
A kind of callus promoting blood circulation composition and its preparation and preparation method Download PDFInfo
- Publication number
- CN109260345A CN109260345A CN201811366734.6A CN201811366734A CN109260345A CN 109260345 A CN109260345 A CN 109260345A CN 201811366734 A CN201811366734 A CN 201811366734A CN 109260345 A CN109260345 A CN 109260345A
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- Prior art keywords
- callus
- composition
- blood circulation
- blood
- weight
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abstract
The present invention provides a kind of callus promoting blood circulation composition and its preparation and preparation method, the composition is mainly made of catechu, cordate houttuynia, Chinese gall, Asian puccoon, Chloranthus glaber, Dysosma versipellis, dragon's blood, purslane, aloe and borneol, the callus composition and its preparation are suitable for various limbs joint swelling pains, aseptic inflammation, traumatic ulcer, furuncle swelling toxin, the diseases such as scald；It is mainly used for treating various rheumatic arthritis, hydrops articuli, the swollen pain of wound is generated heat, and I -- the diseases such as II degree of burn and scald and diabetes.
Description
Technical field
The invention belongs to Chinese herbal product field, in particular to a kind of callus promoting blood circulation composition and its preparation and preparation method.
Background technique
Traumatic injury is a kind of common sudden unexpected somatic damage, and pain feels bad the shape also with swelling and hemostasis
Condition occurs.Arthritis belongs to the common disease frequently-occurring disease for seriously endangering health of people, and clinical manifestation is size arthroncus, pain
Bitterly, it deforms, or even loses self care ability.
Diabetes are a kind of serious complication of diabetes, are that diabetic is disabled or even lethal major reason
One of, it not only causes suffering to patient, and it is made to add huge financial burden.According to incompletely statistics, diabetic foot
Ulcer accounts for 20% or so.
Currently available technology does not disclose a kind of for treating traumatic injury, arthritis and the drug of diabetes.
Summary of the invention
In order to solve the above technical problem, the present invention provides a kind of callus promoting blood circulation composition and its preparation and preparation methods.
Specific technical solution of the present invention is as follows:
The present invention provides a kind of callus promoting blood circulation composition, and the composition is mainly formed by the constituents extraction of following parts by weight:
Catechu 10-15 cordate houttuynia 10-15 Chinese gall 5-8
Asian puccoon 10-30 Chloranthus glaber 10-20 Dysosma versipellis 5-12
Dragon's blood 5-10 purslane 7-15 aloe 5-20
Borneol 3-10.
Further to improve, composition is prepared via a method which to obtain:
1) catechu, cordate houttuynia, Chinese gall, Asian puccoon, Chloranthus glaber, Dysosma versipellis, purslane and aloe are weighed according to parts by weight, so
The extracting solution of 100-300 parts by weight is added afterwards, ultrasonic extraction 3 times, combined extract, filtering obtains crude extract, every time ultrasound temperature
Degree is 45-50 DEG C, ultrasonic time 10-15min；
2) crude extract for obtaining step 1) is centrifuged, and obtains clarified solution, and clarified solution is extracted with ethyl acetate 2 times, is associated with
Machine phase, anhydrous sodium sulfate dry, filter, filtrate concentration, dry, and mixture is made；
3) dragon's blood and borneol and grinding are crossed into 120 meshes, is uniformly mixed with mixture, callus promoting blood circulation composition is made.
Further to improve, which is made of glycine betaine, citric acid and glycine that weight part ratio is 2:1:2.5
The mixture of eutectic solvent and water, the weight percent of eutectic solvent are 15-20%.
Another aspect of the present invention provides a kind of callus blood-activating cream, wants including the right that weight part ratio is 70-155:180-250
The promoting blood circulation composition of callus described in asking 1 and auxiliary material.
Further to improve, the auxiliary material includes each ingredient of following parts by weight:
Beeswax 30-50 vaseline 150-200.
Further to improve, the auxiliary material includes each ingredient of following parts by weight:
Sodium laurate 35-55 Propiram 20-35 octyldodecanol 100-120
Sorbefacient 25-40.
Further to improve, the sorbefacient includes each ingredient of following parts by weight:
Karaya Gum 15-25 hard palmitamide 7.5-10
Octodecyl betaine 2.5-5.
It is further to improve, the parts by weight of each ingredient of callus blood-activating cream are as follows:
Callus promoting blood circulation composition:
12 cordate houttuynia of catechu, 12 Chinese gall 7
21 Chloranthus glaber of Asian puccoon, 15 Dysosma versipellis 9
8 purslane of dragon's blood, 12 aloe 12
Borneol 7
Auxiliary material:
45 Propiram of sodium laurate, 30 octyldodecanol 115
18.5 hard palmitamide 8 of Karaya Gum
Octodecyl betaine 3.2.
Another aspect of the present invention provides a kind of preparation method of callus blood-activating cream, which includes the following steps:
S1: preparation callus promoting blood circulation composition；
S2: callus promoting blood circulation composition is placed in heating in pot, and sodium laurate, Propiram and octyldodecanol dissolution is added,
Then sorbefacient is added, stirs evenly, but at cream to get.
Callus promoting blood circulation composition and callus blood-activating cream provided by the invention are in preparation treatment of arthritis, pain, swelling, bruise
Application in damage, furuncle swelling toxin, scald or diabetes drug.
Beneficial effects of the present invention: the present invention provides a kind of callus promoting blood circulation composition and its preparation and preparation method, should be more
Hurt composition and its preparation is suitable for various limbs joint swelling pains, aseptic inflammation, traumatic ulcer, furuncle swelling toxin, water
The diseases such as burning hot wound；Be mainly used for treating various rheumatic arthritis, hydrops articuli, the swollen pain fever of wound, I -- II degree burn and scald with
The diseases such as diabetes.
Specific embodiment
A kind of callus of embodiment 1 promoting blood circulation composition
Callus promoting blood circulation composition comprises the following components in parts by weight:
A kind of callus of embodiment 2 promoting blood circulation composition
Callus promoting blood circulation composition comprises the following components in parts by weight:
The callus composition is prepared via a method which to obtain:
1) catechu, cordate houttuynia, Chinese gall, Asian puccoon, Chloranthus glaber, Dysosma versipellis, purslane and aloe are weighed according to parts by weight, so
The extracting solution of 200 parts by weight is added afterwards, ultrasonic extraction 3 times, combined extract, filtering obtains crude extract, each ultrasonic temperature is
45 DEG C, ultrasonic time 15min；The extracting solution is made of glycine betaine, citric acid and the glycine that weight part ratio is 2:1:2.5
Eutectic solvent and water mixture, the weight percent of eutectic solvent is 15%；
2) crude extract for obtaining step 1) is centrifuged, and obtains clarified solution, and clarified solution is extracted with ethyl acetate 2 times, is associated with
Machine phase, anhydrous sodium sulfate dry, filter, filtrate concentration, dry, and mixture is made；
3) dragon's blood and borneol and grinding are crossed into 120 meshes, is uniformly mixed with mixture, callus promoting blood circulation composition is made.
A kind of callus of embodiment 3 promoting blood circulation composition
Callus promoting blood circulation composition comprises the following components in parts by weight:
The callus composition is prepared via a method which to obtain:
1) catechu, cordate houttuynia, Chinese gall, Asian puccoon, Chloranthus glaber, Dysosma versipellis, purslane and aloe are weighed according to parts by weight, so
The extracting solution of 300 parts by weight is added afterwards, ultrasonic extraction 3 times, combined extract, filtering obtains crude extract, each ultrasonic temperature is
50 DEG C, ultrasonic time 10min；The extracting solution is made of glycine betaine, citric acid and the glycine that weight part ratio is 2:1:2.5
Eutectic solvent and water mixture, the weight percent of eutectic solvent is 20%；
2) crude extract for obtaining step 1) is centrifuged, and obtains clarified solution, and clarified solution is extracted with ethyl acetate 2 times, is associated with
Machine phase, anhydrous sodium sulfate dry, filter, filtrate concentration, dry, and mixture is made；
3) dragon's blood and borneol and grinding are crossed into 120 meshes, is uniformly mixed with mixture, callus promoting blood circulation composition is made.
A kind of callus blood-activating cream of embodiment 4
The callus blood-activating cream comprises the following components in parts by weight:
The callus promoting blood circulation composition 100 of embodiment 1
Beeswax 40
Vaseline 170
The callus blood-activating cream the preparation method comprises the following steps:
1) by catechu, Chinese gall, Chloranthus glaber, Dysosma versipellis, dragon's blood, cordate houttuynia, purslane, aloe, Asian puccoon first uses vegetable oil
It impregnates 2 weeks, is then heated to boiling, with decocting with slow fire 30 minutes, so that drug is become sallow to spend, cooled filtrate is spare；
2) by dragon's blood, it is spare that borneol ground 120 meshes；
3) filtered fluid is set and is heated in pot, beeswax 30g is added, then dragon's blood is added in vaseline 200g dissolution at low temperature
Borneol powder, be cooled to after mixing cream to get.
A kind of callus blood-activating cream of embodiment 5
The callus blood-activating cream comprises the following components in parts by weight:
The callus blood-activating cream the preparation method comprises the following steps:
S1: according to the method preparation callus promoting blood circulation composition of embodiment 2；
S2: callus promoting blood circulation composition is placed in heating in pot, and sodium laurate, Propiram and octyldodecanol dissolution is added,
Then sorbefacient is added, stirs evenly, but at cream to get.
A kind of callus of embodiment 6 promoting blood circulation composition
The callus blood-activating cream comprises the following components in parts by weight:
The callus blood-activating cream the preparation method comprises the following steps:
S1: according to the method preparation callus promoting blood circulation composition of embodiment 3；
S2: callus promoting blood circulation composition is placed in heating in pot, and sodium laurate, Propiram and octyldodecanol dissolution is added,
Then sorbefacient is added, stirs evenly, but at cream to get.
A kind of callus of embodiment 7 promoting blood circulation composition
The callus blood-activating cream comprises the following components in parts by weight:
The callus blood-activating cream the preparation method comprises the following steps:
S1: preparation callus composition:
1) catechu, cordate houttuynia, Chinese gall, Asian puccoon, Chloranthus glaber, Dysosma versipellis, purslane and aloe are weighed according to parts by weight, so
The extracting solution of 300 parts by weight is added afterwards, ultrasonic extraction 3 times, combined extract, filtering obtains crude extract, each ultrasonic temperature is
50 DEG C, ultrasonic time 10min；The extracting solution is made of glycine betaine, citric acid and the glycine that weight part ratio is 2:1:2.5
Eutectic solvent and water mixture, the weight percent of eutectic solvent is 17%；
2) crude extract for obtaining step 1) is centrifuged, and obtains clarified solution, and clarified solution is extracted with ethyl acetate 2 times, is associated with
Machine phase, anhydrous sodium sulfate dry, filter, filtrate concentration, dry, and mixture is made；
3) dragon's blood and borneol and grinding are crossed into 120 meshes, is uniformly mixed with mixture, callus promoting blood circulation composition is made；
S2: callus promoting blood circulation composition is placed in heating in pot, and sodium laurate, Propiram and octyldodecanol dissolution is added,
Then sorbefacient is added, stirs evenly, but at cream to get.
A kind of callus of reference examples 1 promoting blood circulation composition
Callus promoting blood circulation composition comprises the following components in parts by weight:
A kind of callus of reference examples 2 promoting blood circulation composition
Callus promoting blood circulation composition comprises the following components in parts by weight:
A kind of callus of reference examples 3 promoting blood circulation composition
Callus promoting blood circulation composition comprises the following components in parts by weight:
A kind of callus of reference examples 4 promoting blood circulation composition
Callus promoting blood circulation composition comprises the following components in parts by weight:
The composition the preparation method comprises the following steps:
1) catechu, cordate houttuynia, Chinese gall, Asian puccoon, Chloranthus glaber, Dysosma versipellis, purslane and aloe are weighed according to parts by weight, so
The water of 300 parts by weight is added afterwards, ultrasonic extraction 3 times, combined extract, filtering obtains crude extract, and each ultrasonic temperature is 50
DEG C, ultrasonic time 10min；
2) crude extract that step 1) obtains is extracted with ethyl acetate 2 times, merges organic phase, anhydrous sodium sulfate is dry, mistake
Filter, filtrate concentration is dry, and mixture is made；
3) dragon's blood and borneol and grinding are crossed into 120 meshes, is uniformly mixed with mixture, callus promoting blood circulation composition is made.
A kind of callus blood-activating cream of reference examples 5
The callus blood-activating cream comprises the following components in parts by weight:
The preparation method of callus blood-activating cream is the same as embodiment 5.
A kind of callus blood-activating cream of embodiment 6
The callus blood-activating cream comprises the following components in parts by weight:
The preparation method of callus blood-activating cream is the same as embodiment 5.
A kind of callus blood-activating cream of reference examples 7
The callus blood-activating cream comprises the following components in parts by weight:
The preparation method of callus blood-activating cream is the same as embodiment 5.
1 swelling of experimental example experiment
SD rat is taken, the volume of right hind foot of rat plantar is surveyed with solvent method, then to right hind foot of rat plantar subcutaneous injection 10%
Fresh albumen 0.05mL/ only, so that rat causes scorching, will cause scorching rat to be randomly divided into 6 groups, and test 1-2 group, compare 1-4 group, and every group
It 5, is administered as follows:
It tests 1 group: smearing the callus blood-activating cream of embodiment 4；
It tests 2 groups: smearing the callus blood-activating cream of embodiment 5；
It compares 1 group: smearing the paste that control 1 callus promoting blood circulation composition is formed (auxiliary material is same as Example 4)；
It compares 2 groups: smearing the paste that control 2 callus promoting blood circulation composition is formed (auxiliary material is same as Example 4)；
It compares 3 groups: smearing the paste that control 3 callus promoting blood circulation composition is formed (auxiliary material is same as Example 4)；
It compares 4 groups: smearing the paste that control 4 callus promoting blood circulation composition is formed (auxiliary material is same as Example 4)；
After 6h is administered to group rat, the volume of right hind foot of rat plantar is measured, with vola pedis volume ratio before administration compared with calculating is swollen
Expansibility, test result are shown in Table.
Experimental result of the 1 callus blood-activating cream of table to rat paw edema
The foot swelling of rat can be significantly reduced in composition provided by the invention as can be seen from the table, has extraordinary
Antiphlogistic effects.
Test 2 writhing methods measurement callus blood-activating cream analgesic activities
Rheumatic arthritis mouse is constructed using II Collagen Type VI, then successful female mice 40 of selection modeling, is divided into 8
Group, every group of mouse are administered as follows: blank control group (physiological saline is given in stomach-filling), positive controls (give by stomach-filling
Indomethacin), the administration 1-2 group callus blood-activating cream of embodiment 4 and 5 (joint part smearing), (joint part applies control 1-4 group
Smear the paste (auxiliary material is same as Example 4) that control 1-4 callus promoting blood circulation composition is formed), every group 5.After administration, number 20min
The writhing number of interior mouse.Mouse web portion and hind leg are extended because of stimulation is once defined as a writhing response.Experimental result is logical
Cross the reflection of inhibition percentage.
Percentage=(physiological saline group be averaged the several administration groups of writhing be averaged writhing number)/physiological saline group is inhibited averagely to turn round
Body number × 100%, the results are shown in Table 2.
2 callus blood-activating cream writhing assay result of table
By above-mentioned test result it is found that callus blood-activating cream provided by the present invention is extraordinary to the pain caused by arthritis
Inhibiting effect.
3 callus blood-activating cream Performance of experimental example
The performance of the callus blood-activating cream of each embodiment and reference examples is evaluated, investigation project includes moisture retention and guarantees the quality
Phase the results are shown in Table 3.
3 callus blood-activating cream Performance result of table
After saving specified time, packaging is opened, according to its surface property and its shelf-life of use limits.
Callus blood-activating cream provided by the invention has good shelf-life and moisture retention as can be seen from the table.
The mucocutaneous absorption test of experimental example 4
Experimental method: taking Adult male rats, puts to death, and removing is mucocutaneous, is placed in spare in physiological saline, use
Franz diffusion cell, effective infiltrating area are 0.5cm2, reception medium is physiological saline, and acceptance pool volume is 5mL.
By 4 pieces of treated rat skin mucous membrane is uniformly divided into homalographic, it is divided into test 1-2 group, control 1-2 group, examination
Test mucocutaneous piece of the 1-2 group callus blood-activating cream that the embodiment of the present invention 4 and 5 is respectively coated, mucocutaneous piece of control 1-2 group
The callus blood-activating cream of reference examples 6-7 is respectively coated；Every piece of skin coats 0.1g callus blood-activating cream；The skin chunk of coating is placed in
Penetrating absorption is carried out in 37 DEG C, 500r/min in supply pool, removes whole acceptable solutions respectively at 0.5,1,2,4,6,8,10,12h
Except (while supplementing same amount of normal saline), 8000r/min is centrifuged 10min, takes supernatant, calculates excretion using trypan blue staining
The number of body, unit of account area accumulate transdermal penetration amount Qn, with QnIt maps to time t, and linear to the straight line portion in curve
It returns, gained straight slope, that is, steady-state permeation rate Js (μ/cm2H), 4 be the results are shown in Table.
4 Transdermal Absorption test result of table
As can be seen from the table, Karaya Gum, hard palmitamide and octadecyl is added in callus promoting blood circulation composition
Dimethyl betaine is remarkably improved callus blood-activating cream percutaneous permeability.
Claims (10)
- The composition 1. a kind of callus is invigorated blood circulation, which is characterized in that the composition is mainly formed by the constituents extraction of following parts by weight:
- The composition 2. callus as described in claim 1 is invigorated blood circulation, which is characterized in that the composition is to be prepared via a method which It obtains:1) catechu, cordate houttuynia, Chinese gall, Asian puccoon, Chloranthus glaber, Dysosma versipellis, purslane and aloe are weighed according to parts by weight, then plus Enter the extracting solution of 100-300 parts by weight, ultrasonic extraction 3 times, combined extract, filtering obtains crude extract, each ultrasonic temperature is 45-50 DEG C, ultrasonic time 10-15min；2) crude extract for obtaining step 1) is centrifuged, and obtains clarified solution, and clarified solution is extracted with ethyl acetate 2 times, merges organic phase, Anhydrous sodium sulfate dries, filters, filtrate concentration, dry, and mixture is made；3) dragon's blood and borneol and grinding are crossed into 120 meshes, is uniformly mixed with mixture, callus promoting blood circulation composition is made.
- The composition 3. callus as claimed in claim 2 is invigorated blood circulation, which is characterized in that the extracting solution is 2:1 by weight part ratio: 2.5 glycine betaine, the eutectic solvent of citric acid and glycine composition and the mixture of water, the weight percent of eutectic solvent For 15-20%.
- 4. a kind of callus blood-activating cream, the callus promoting blood circulation group described in claim 1 for being 70-155:180-250 including weight part ratio Close object and auxiliary material.
- 5. callus blood-activating cream as claimed in claim 4, which is characterized in that the auxiliary material includes each ingredient of following parts by weight:Beeswax 30-50 vaseline 150-200.
- 6. callus blood-activating cream as claimed in claim 4, which is characterized in that the auxiliary material includes each ingredient of following parts by weight:Sodium laurate 35-55 Propiram 20-35 octyldodecanol 100-120Sorbefacient 25-40.
- 7. callus blood-activating cream as claimed in claim 6, which is characterized in that the sorbefacient includes each of following parts by weight Ingredient:Karaya Gum 15-25 hard palmitamide 7.5-10Octodecyl betaine 2.5-5.
- 8. callus blood-activating cream as claimed in claim 6, which is characterized in that the parts by weight of each ingredient of callus blood-activating cream are as follows:Callus promoting blood circulation composition:Auxiliary material:45 Propiram of sodium laurate, 30 octyldodecanol 11518.5 hard palmitamide 8 of Karaya GumOctodecyl betaine 3.2.
- 9. a kind of preparation method of callus blood-activating cream as claimed in claim 6, which is characterized in that the preparation method includes as follows Step:S1: preparation callus promoting blood circulation composition；S2: callus promoting blood circulation composition is placed in heating in pot, sodium laurate, Propiram and octyldodecanol dissolution is added, then Be added sorbefacient, stir evenly, but at cream to get.
- The callus blood-activating cream described in composition and claim 4-8 10. a kind of described in any item callus of claim 1-3 are invigorated blood circulation Application in preparation treatment of arthritis, pain, swelling, traumatic injury, furuncle swelling toxin, scald or diabetes drug.
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Application publication date: 20190125 |