CN110917307A

CN110917307A - External-use water aqua for treating verruca plantaris and preparation method thereof

Info

Publication number: CN110917307A
Application number: CN201911361356.7A
Authority: CN
Inventors: 万俊梅; 吴丝雨; 郭立伟; 徐继芳; 彭爱华
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-12-26
Filing date: 2019-12-26
Publication date: 2020-03-27

Abstract

The invention relates to the field of traditional Chinese medicines, and discloses an external-use liquid for treating plantar wart, which comprises an A lotion prepared from pure traditional Chinese medicines and a B external-use smearing liquid applied to an affected part, wherein the A lotion comprises the following raw material medicines: lithospermum, raw coix seeds, isatis roots, radix sophorae flavescentis, golden cypress, folium isatidis, safflower, rhizoma cyperi, equisetum hiemale, fructus cnidii, cocklebur fruits and radix angelicae; the B external application smearing water agent is a pentafluorouracil solution with the solubility of 5-10%. The lotion A is prepared from pure traditional Chinese medicines, has scientific and reasonable formula, simple preparation and no toxic or side effect, can effectively treat the plantar wart by being matched with the external smearing water aqua B, has no skin tissue damage in the treatment process, does not influence the daily life of a patient, and has quick recovery, no residue and no relapse.

Description

External-use water aqua for treating verruca plantaris and preparation method thereof

Technical Field

The invention relates to the field of traditional Chinese medicines, in particular to an external water aqua for treating verruca plantaris and a preparation method thereof.

Background

Warts are caused by Human Papillomavirus (HPV) infection, with an incidence of 13.1% accounting for 50% of the total HPV infection. Plantar wart occurs on the sole of the foot, and pain or extrusion pain can be caused at special parts, so that pain and inconvenience are brought to patients, and the influence is large. In the field of warts and warts in traditional Chinese medicine, the warts are considered to be formed by long-term friction on soles, insufficient endowment, insufficient striae, pathogenic wind attacking skin, or exuberant liver fire, stagnation of qi and blood, and vein dispergation, or due to liver blood deficiency, exogenesis of muscle and qi, and stagnation of qi and blood. Trauma and friction can be the cause of the disease, and hyperhidrosis in the foot is also related to the occurrence of plantar wart.

Plantar warts are more difficult to treat than common warts, and the methods for treating plantar warts are numerous. The whole body has long course of treatment, the curative effect is difficult to be determined, and the adverse reaction of the medicine is large. Common treatment methods are:

1. local physical therapy such as cryotherapy, fulgery, laser therapy or surgical resection, among others, wherein: the cryotherapy has adverse reactions such as pain, edema, blister or blood blister, subcutaneous emphysema, systemic reaction, hemorrhage, secondary infection, depigmentation, pigmentation, chronic ulcer, scar formation, nerve injury, etc.; the electric cautery therapy, the laser therapy or the surgical excision have large trauma to the injured part, the local repair time is long, the inconvenience is brought to the life of the patient, the secondary infection is easy, the patient with the scar constitution is forbidden to use, the treatment is not thorough, the recurrence is easy, permanent scars or recurrence can be caused, and the use is not suitable; the pelma skin has large elasticity and much movement, and the scar tissue has no elasticity, so that the drawing pain which cannot be treated can be caused during movement, and the long-term pain is brought to the patient;

2. chemical corrosive drugs such as phtalamine, tretinoin, 0.7% cantharidin and the like can also be used, but the drugs are not easy to absorb due to verruca plantaris surface keratosis, and the curative effect is poor;

3. topical bleomycin is also used for treatment of plantar warts and the like.

The above treatment methods mostly have local tissue damage, and the intact skin and mucosa are natural barriers for virus defense, and lactic acid in skin sweat, fat in sebum and lysozyme in mucosa secretion have the functions of preventing virus invasion and killing virus. It is critical that treatment of plantar warts maintain normal tissue intact and avoid damage to surrounding tissues.

Disclosure of Invention

The technical problem to be solved by the invention is as follows: aiming at the defects of treating the plantar wart in the prior art, the external water aqua for treating the plantar wart and the preparation method thereof are provided, the external water aqua can keep the integrity of normal tissues and avoid damaging surrounding tissues, and has good treatment effect.

In order to solve the technical problems, the technical scheme provided by the invention is as follows:

an external-use water aqua for treating verruca plantaris comprises a lotion A prepared from pure traditional Chinese medicines, wherein the lotion A comprises the following raw material medicines:

lithospermum, raw coix seeds, isatis roots, lightyellow sophora roots, golden cypress, indigowoad leaves, safflower, nutgrass galingale rhizome, common scouring rush herbs, common cnidium fruits, cocklebur fruits and dahurian angelica roots.

Further, the externally applied liquid preparation B is applied to an affected part and is a pentafluorouracil solution with the solubility of 5% -10%.

Further, the B external application water aqua is a 5% solubility pentafluorouracil solution.

Further, the dosage of the raw materials of the lotion A is as follows:

20-50 parts of lithospermum, 30-70 parts of raw coix seeds, 30-70 parts of isatis roots, 10-30 parts of sophora flavescens, 10-30 parts of golden cypress, 30-70 parts of folium isatidis, 6-20 parts of safflower carthamus, 20-50 parts of rhizoma cyperi, 30-70 parts of equisetum hiemale, 15-40 parts of fructus cnidii, 15-40 parts of cocklebur fruits and 12-30 parts of angelica dahurica.

Further, the dosage of the raw materials of the lotion A is as follows:

40 parts of lithospermum, 60 parts of raw coix seeds, 60 parts of isatis roots, 20 parts of sophora flavescens, 20 parts of golden cypress, 60 parts of folium isatidis, 12 parts of safflower, 40 parts of rhizoma cyperi, 60 parts of equisetum hiemale, 30 parts of fructus cnidii, 30 parts of cocklebur fruits and 24 parts of angelica dahurica.

The invention also provides a preparation method of the external water aqua for treating plantar wart, which comprises the following steps:

1) decocting: putting the raw materials into a special medicinal bag for decoction, soaking in clear water for 30 minutes, putting into a traditional Chinese medicine decocting machine, adding 1000ml of clear water, and decocting at 110 deg.C for 1 hr;

2) subpackaging: taking out the medicine bag after the decoction is finished, and subpackaging and plastic-sealing the decocted liquid medicine in the traditional Chinese medicine decocting machine according to 200 ml/bag.

The pharmacology of each raw material medicine of the invention is as follows:

lithospermum: [ PROPERTIES AND FLAVOUR ] bitter and cold in taste. [ GUIJING ] returning to the heart, enveloping and regulating the liver meridian. Expect blood, promoting blood circulation, clearing away heat and toxic materials. It can be used for treating warm heat macula, damp-heat jaundice, purpura, emesis, epistaxis, hematuria, stranguria with turbid urine, constipation due to heat accumulation, burn, eczema, erysipelas, and carbuncle.

Raw coix seeds: [ PROPERTIES AND FLAVOUR ] sweet, bland and slightly cold. [ GUIJING ] can enter spleen, lung and kidney meridians. [ FUNCTIONS AND INDICATIONS ] can remove dampness, invigorate spleen, relax muscles and tendons, relieve arthralgia, clear heat and relieve distension. Can be used for treating edema, loempe, dribbling urination, diarrhea, leukorrhagia, rheumatalgia, spasm of tendons and vessels, pulmonary abscess, intestinal abscess, and verruca plana.

Radix isatidis: [ PROPERTIES AND FLAVOUR ] bitter and cold in taste. [ GUIJING ] enters liver and stomach meridians. [ FUNCTIONS AND INDICATIONS ] can clear away heat and toxic materials, cool blood and relieve sore throat. Can be used for treating toxic heat, speckle, hyperpyrexia, headache, epidemic headache, throat ulcer, erysipelas, itching cheek, pharyngitis, and sore.

Flavescent sophora root: [ PROPERTIES AND FLAVOUR ] bitter in taste and cold in nature. [ GUIJING ] GUIJING is responsible for the heart, liver, stomach, large intestine and bladder meridians. [ FUNCTIONS AND INDICATIONS ] can clear away heat, eliminate dampness, kill parasites and induce diuresis. Can be used for treating dysentery with heat, hematochezia, jaundice, anuria, leucorrhea with red and white discharge, pudendal swelling, pudendal pruritus, eczema, skin pruritus, scabies, tinea, leprosy, and trichomonas vaginitis.

Phellodendron bark: [ PROPERTIES AND FLAVOUR ] bitter in taste and cold in nature. [ GUIJING ] enters kidney and bladder meridians. [ FUNCTIONS AND INDICATIONS ] has effects of clearing heat, eliminating dampness, purging pathogenic fire, removing dampness, removing toxic substance, and treating sore. Can be used for treating damp-heat dysentery, jaundice, dark urine, leukorrhagia, pudendal pruritus, pyretic stranguria, pain, tinea pedis, asthenia, bone-steaming, overstrain, night sweat, spermatorrhea, pyocutaneous disease, toxic swelling, eczema, sore, and cortex Phellodendri. Can be used for treating hyperactivity of fire due to yin deficiency, night sweat and steaming bone.

Folium isatidis: [ PROPERTIES AND FLAVOUR ] bitter and cold in taste. [ GUIJING ] enters liver, heart, stomach and spleen meridians. [ FUNCTIONS AND INDICATIONS ] can clear away heat and toxic materials, cool blood and remove ecchymoses. Can be used for treating fever, polydipsia, unconsciousness, macula, hematemesis, epistaxis, jaundice, dysentery, etc.

Safflower: [ PROPERTIES AND FLAVOUR ] pungent and warm. [ GUIJING ] returning to the heart and liver meridians. [ FUNCTIONS AND INDICATIONS ] can promote blood circulation, dredge meridians, dispel blood stasis, and relieve pain. It can be used for treating amenorrhea due to blood stasis, thoracic obstruction, cardiodynia, abdominal mass, and arthralgia.

Rhizoma cyperi: [ PROPERTIES AND WESTERPHIS ] is pungent, slightly bitter, slightly sweet and mild. [ GUIJING ] enters liver, spleen and triple energizer meridians. [ FUNCTIONS AND INDICATIONS ] can soothe the liver, relieve depression, regulate qi, relieve epigastric distention, regulate menstruation and relieve pain. Can be used for treating stagnation of qi due to depression of the liver, distending pain in chest and hypochondrium, hernia pain, breast pain, stagnation of qi in spleen and stomach, abdominal distention, fullness and pain, menoxenia, amenorrhea, and dysmenorrhea.

B, horsetail: [ PROPERTIES AND FLAVOUR ] is sweet, bitter and neutral. [ GUIJING ] enters lung, liver and gallbladder meridians. [ FUNCTIONS AND INDICATIONS ] can dispel wind, dispel heat, relieve muscles and remove nebula. It is indicated for nebula, lacrimation in the wind, intestinal wind, bloody flux, liver failure, malaria, laryngalgia, carbuncle and swelling.

Fructus cnidii: [ PROPERTIES AND WESTERN PROPERTIES ] is pungent, bitter and warm; has little toxicity. [ GUIJING ] enters kidney meridian. [ FUNCTIONS AND INDICATIONS ] can warm kidney, strengthen yang, eliminate dampness, dispel wind, and kill parasites. Can be used for treating sexual impotence, cold womb, leukorrhagia due to cold-dampness, lumbago due to damp arthralgia, vulval eczema, pudendal pruritus, and trichomonas vaginitis.

Fructus xanthil: [ PROPERTIES AND WESTERN PROPERTIES ] with bitter, sweet, pungent and warm properties; and (5) small toxicity. [ GUIJING ] enters lung and liver meridians. [ FUNCTIONS AND INDICATIONS ] can dispel pathogenic wind and cold; clearing nasal orifices; dispelling wind-damp; relieving itching. Nasosinusitis; headache due to wind-cold evil; rheumatic arthralgia; rubella; eczema; scabies and tinea.

Radix angelicae: [ PROPERTIES AND WESTERN ] is warm in nature, pungent in flavor, fragrant in smell and slightly bitter. [ GUIJING ] enters lung, spleen and stomach meridians. [ FUNCTIONS AND INDICATIONS ] can dispel wind-damp, promote blood circulation, expel pus, promote granulation, and alleviate pain. Can be used for treating headache, toothache, nasosinusitis, hemorrhoid, leucorrhea with red and white discharge, carbuncle, cellulitis, pyocutaneous disease, and skin pruritus.

While the main ingredient of the topical liniment B, namely, pentafluorouracil (5-FU), inhibits DNA synthesis by inhibiting thymidylate synthase. The action of this enzyme may transfer one carbon unit of formyltetrahydrofolate to deoxyuridine-phosphate to synthesize thymidine monophosphate. Pentafluorouracil also has a certain inhibitory effect on RNA synthesis, and can destroy the replication and synthesis of tumor cells. The same principle can be used to stop the hyperproliferation of epithelial cells to form a keratinized state for the treatment of plantar warts.

The lithospermum and the safflower of the lotion A have the functions of promoting blood circulation by removing blood stasis, detoxifying and promoting eruption; radix Isatidis, folium Isatidis, and cortex Phellodendri can clear away heat and toxic materials; the sophora flavescens and the coix seeds remove dampness and toxin; the nutgrass galingale rhizome, the common scouring rush herb, the common cnidium fruit and the siberian cocklebur fruit regulate qi and relieve depression, and dispel wind and heat; the angelica dahurica granulation promoting and pain relieving effects are achieved by combining various medicines, have the effects of clearing heat and removing toxicity, promoting blood circulation to remove blood stasis, removing dampness and promoting granulation and pain relieving, promote wart dissipation and have obvious effect by matching with the B external application water aqua-pentafluorouracil solution.

In addition, in recent research reports, warm water foot bath is also shown to promote the migration, migration and maturation of Langerhans Cells (LC) at the virus infection part and the apoptosis of keratinocyte cells, soften the stratum corneum, promote the direct contact of liquid medicine and the affected part and promote the rapid absorption of the medicine.

The practical method of the invention comprises the following steps: after feet are cleaned, adding about 2000ml of warm water into a bag of lotion A, uniformly mixing and soaking feet for 20-30 minutes, wiping the mixture dry, and then wiping the mixture on the affected part with external application water aqua B once a day; a treatment course is 30-45 days.

Compared with the prior art, the invention has the advantages that:

the lotion A is prepared from pure traditional Chinese medicines, has scientific and reasonable formula, simple preparation and no toxic or side effect, can effectively treat plantar wart by being matched with an external smearing water aqua B, has no skin tissue damage in the treatment process, does not influence the daily life of a patient, and has the advantages of quick recovery, no residue and no relapse.

Detailed Description

The present invention is described in detail below for the purpose of better understanding technical solutions of the present invention by those skilled in the art, and the description of the present invention is only exemplary and explanatory and should not be construed as limiting the scope of the present invention in any way.

The invention provides an external water aqua for treating verruca plantaris, which comprises lotion A prepared from pure traditional Chinese medicines, and comprises the following raw material medicines:

The raw materials are used in the following weight portions:

The external application liquid for treating plantar wart also comprises an external application liquid B applied to an affected part, wherein the external application liquid B is a pentafluorouracil solution with the solubility of 5-10%, and preferably 5%.

The present invention will be described in further detail with reference to the following examples:

example 1

Taking 20g of lithospermum, 30g of raw coix seeds, 30g of isatis roots, 10g of sophora flavescens, 10g of phellodendron barks, 30g of folium isatidis, 6g of safflower, 20g of rhizoma cyperi, 30g of equisetum hiemale, 15g of fructus cnidii, 15g of cocklebur fruits and 12g of angelica dahurica, mixing, putting into a special medicine bag for decoction, soaking in clear water for 30 minutes, putting into a traditional Chinese medicine decocting machine, adding 1000ml of clear water, decocting at the temperature of 110 ℃ for 1 hour to obtain an A lotion with the crude drug concentration of about 0.3g/ml, and subpackaging according to 200 ml/bag.

Wherein the concentration of crude drug is (the dosage of crude drug (g) -the dry weight of residue (g))/the volume of liquid medicine (ml).

Example 2

Mixing 30g of lithospermum, 45g of raw coix seeds, 45g of isatis roots, 15g of sophora flavescens, 15g of phellodendron barks, 45g of folium isatidis, 9g of safflower, 30g of rhizoma cyperi, 55g of equisetum hiemale, 25g of fructus cnidii, 20g of cocklebur fruits and 16g of angelica dahurica, and preparing the lotion A with the crude drug concentration of about 0.37g/ml according to the preparation method of the embodiment 1.

Example 3

Mixing 40g of lithospermum, 60g of raw coix seeds, 60g of isatis roots, 20g of sophora flavescens, 20g of phellodendron barks, 60g of folium isatidis, 12g of safflower, 40g of rhizoma cyperi, 60g of equisetum hiemale, 30g of fructus cnidii, 30g of cocklebur fruits and 24g of angelica dahurica, and preparing the lotion A with the crude drug concentration of about 0.45g/ml according to the preparation method of the embodiment 1.

Example 4

Taking 50g of lithospermum, 70g of raw coix seeds, 70g of isatis roots, 30g of sophora flavescens, 30g of phellodendron barks, 70g of folium isatidis, 20g of safflower, 50g of rhizoma cyperi, 70g of equisetum hiemale, 40g of fructus cnidii, 40g of cocklebur fruits and 30g of angelica dahurica, mixing, and obtaining the lotion A with crude drug concentration of about 0.6g/ml according to the preparation method of the embodiment 1.

It should be noted that, the traditional Chinese medicine decocting machine adopted in the above embodiment has an automatic water replenishing function, and performs automatic water replenishing according to the liquid level change in the monitoring decocting process, so as to ensure that the volume of the liquid medicine in the traditional Chinese medicine decocting machine is constant, and the automatic water replenishing belongs to the conventional prior art, for example: liquid level monitoring is carried out by adopting a liquid level sensor, and water is supplemented into the traditional Chinese medicine decocting machine by adopting a PLC (programmable logic controller) controlled pump.

Respectively using the lotion A prepared in the examples 1-4 to wash and soak the affected parts of a plurality of patients with plantar warts, adding about 2000ml of warm water into one bag of the lotion A, uniformly mixing and soaking feet for 20-30 minutes, controlling the temperature of the warm water at 40-45 ℃, wiping the mixture dry, and then smearing the affected parts with 5% of a pentafluorouracil solution once a day; a treatment course is 30-45 days.

Comparing the therapeutic effects of the specific applications of examples 1 to 4, the actual therapeutic effect of example 1 is generally better than that of example 1, the actual therapeutic effect of example 2 is better than that of example 1, the actual therapeutic effects of examples 3 and 4 are the best, and the doses of the raw materials of example 4 are higher than those of examples 3 and 4, but the effects are equivalent to those of example 3, and in conclusion, example 3 is the best example.

It should be noted that, because the external side effect of the traditional Chinese medicine is small, mainly depends on skin absorption, theoretically, the larger the dosage of each Chinese herbal medicine component contained in the lotion A is, the better the treatment effect is, but the chemical components contained in the traditional Chinese medicine are very complex, not only contain various effective components, but also have ineffective components and also contain toxic components, and because the absorption and recovery capability of the affected part is limited, each Chinese herbal medicine component is too much and also can cause unnecessary waste, and by combining the comparison of the above embodiments 1 to 4, through repeated clinical tests, the optimal dosage ratio of each raw material medicine can be obtained as follows:

The dosage of the pentafluorouracil in the externally applied liniment is approximate to the toxic dosage, skin tissues also have the effect of absorbing the medicine into blood, the externally applied recommended solubility dosage is 5-10 percent usually, the treatment effect is not obvious when the concentration is too low, the side effect is large when the concentration is too high, the pentafluorouracil can be properly adjusted according to the actual condition of a patient in practical application, and the concentration of the pentafluorouracil solution is preferably 5 percent through repeated clinical tests, so that the treatment effect is optimal.

26 patients with plantar wart are clinically observed by the external-use water aqua, and the clinical report is as follows:

1. general data

The 26 patients who participated in the statistics were all from the outpatient clinic of this hospital, 12 men and 14 women. The age is 17-57 years, the average age is 32.2 years, the course of disease is 30 days-6 years, and the average age is 7 months.

2. Diagnostic criteria

Case observation: the skin damage is 2-9 cm, yellow or grey-brown papules are polluted at a single sole part or multiple parts of the soles of the toes, the surface is rough and ultra, black spots are formed in the center, the fusion is increased, the texture is hard, and the relevant standards of clinical dermatology are met.

3. Method of treatment

3.1 prescription:

and (A) lotion: 40g of lithospermum, 60g of raw coix seeds, 60g of isatis roots, 20g of sophora flavescens, 20g of golden cypress, 60g of folium isatidis, 12g of safflower, 40g of rhizoma cyperi, 60g of equisetum hiemale, 30g of fructus cnidii, 30g of cocklebur fruits and 24g of angelica roots.

B, external application smearing preparation: 5% strength pentafluorouracil solution.

3.2 the preparation method comprises the following steps: mixing the above raw materials, decocting with water (common Chinese medicinal preparation available in pharmacy), and packaging in 200 ml/bag.

3.3 methods of use: 1 bag each time, 1 time each time, and 20-30 minutes each time, wherein the water temperature is 50 ℃, 5% of pentafluorouracil solution is smeared on an affected part after wiping dry, and 30-45 days is a treatment course.

4. Therapeutic effects

4.1 treatment criteria:

the wart body completely falls off, and the patient without relapse is healed in the follow-up period;

more than 70% of warts fall off, and the effect is obvious when the volume is obviously reduced;

more than 30% of warts fall off, and the warts are effective when the volume is reduced;

the wart is not effective when less than 30% of the wart falls off and the volume is not obviously reduced.

4.2 results

The disease is cured by 23 cases (88.5 percent), improved by 3 cases (11.5 percent) and not cured by 0 case (0 percent). The total effective rate is 100 percent according to the cure plus improvement.

5. Typical cases

Case one:

wu, a certain woman, 22 years old, Shayangxian county, guan.

Diagnosis and treatment time: 2016, 7, 23 months.

The medical history: the plantar region and the inner side of the thumb of the right foot of the patient are scattered in a plurality of warts, and the warts on the plantar region are fused and about 11 cm.

And (3) clinical diagnosis: plantar warts.

The treatment method comprises the following steps: 5% of pentafluorouracil is singly used for scrubbing the affected part in 2016 (7 months and 23 days) until 8 months and 27 days, the effect is not good after one month of treatment, and the skin damage area is not obviously reduced. The treatment started on day 8/28: after the feet are cleaned, a bag of lotion is added with about 2000ml of warm water, the mixture is uniformly mixed and used for soaking the feet for 20-30 minutes, and after the mixture is wiped dry, 5% of pentafluorouracil is used for scrubbing the affected part once a day. One wart of about 1cm is left in the sole after 10 months and 3 days, the skin lesion is completely cured after 10 months and 15 days, and the skin lesion is completely recovered. After one year, no recurrence occurs after follow-up.

Case two:

guo in a certain age, male, age 42, administration of Shayangxian county.

Diagnosis and treatment time: 6 and 25 months in 2017.

The medical history: the left foot thumb of the patient is scattered in 3 warts, and the number of the warts is about 0.2-1.5 CM.

The treatment method comprises the following steps: the traditional Chinese medicine is soaked and washed for 15 days, once a day, and the skin damage disappears and the normal state is recovered after 15 days. After one year, no recurrence occurs after follow-up.

The foregoing is a more detailed description of the invention in connection with specific preferred embodiments and it is not intended that the invention be limited to these specific details. For those skilled in the art to which the invention pertains, several simple deductions or substitutions can be made without departing from the spirit of the invention, and all shall be considered as belonging to the protection scope of the invention.

Claims

1. An external water aqua for treating plantar wart is characterized in that: the lotion A is prepared from pure traditional Chinese medicines and comprises the following raw material medicines:

2. The topical aqueous formulation for treating plantar warts as claimed in claim 1, wherein: the externally applied liquid B is a pentafluorouracil solution with the solubility of 5-10%.

3. The topical aqueous formulation for treating plantar warts as claimed in claim 2, wherein: the B external application water aqua is a pentafluorouracil solution with the solubility of 5%.

4. The topical aqueous formulation for treating plantar warts as claimed in claim 1, wherein: the lotion A comprises the following raw material medicaments in dosage:

5. The topical aqueous formulation for treating plantar warts according to claim 4, wherein: the lotion A comprises the following raw material medicaments in dosage:

6. The preparation method of the external water aqua for treating plantar wart as claimed in claims 1-5, comprising the following steps: