CN1895641A - Medicinal preparation with blood-activating, anti-inflammatory and analgesic functions and its making method - Google Patents
Medicinal preparation with blood-activating, anti-inflammatory and analgesic functions and its making method Download PDFInfo
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- CN1895641A CN1895641A CN 200610200584 CN200610200584A CN1895641A CN 1895641 A CN1895641 A CN 1895641A CN 200610200584 CN200610200584 CN 200610200584 CN 200610200584 A CN200610200584 A CN 200610200584A CN 1895641 A CN1895641 A CN 1895641A
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Abstract
A medicine for promoting blood circulation, reliveing inflammation and treating pain is prepared from ibuprofen, nitrone, alcohol and 18 Chinese-medicinal materials including cinnamon bark, Chuan-xiong rhizome, myrrh, safflower, etc. Its preparing process is also disclosed.
Description
Technical field: the present invention relates to a kind ofly invigorate blood circulation, antiinflammatory, analgesic pharmaceutical preparation and preparation method thereof, belong to the pharmaceutical technology field.
Background technology: arthromyodynia is in clinical genus commonly encountered diseases, frequently-occurring disease.Numbness promptly hinders closes obstructed meaning, and after human body flesh table, meridians suffered exopathogen invasion and attack, the wind-cold damp pathogen visitor was in meridians, muscle arteries and veins, joint, and the cold-evil is caused a disease and made coagulation of QI-blood, can not be unimpeded, thereby cause that limbs, joint, muscle etc. locate pain.Cause the generation of primary disease, endogenous cause of ill is an insufficiency of vital energy and blood, the Wei Bugu of battalion, and exopathogenic factor and weather conditions, living environment are relevant, and wind and cold three heresies that wet are taken advantage of a weak point.The Therapeutic Principle is: enriches blood and invigorates blood circulation, and dispelling wind and removing obstruction in the collateral, the cold expelling dampness removing is set upright pain relieving.Existing black plaster all adds Plumbum preparatium or Hydrocerussitum (Ceruse), has certain toxic and side effects.In addition, black plaster is to be got by vegetable oil high temperature frying preparation, and the part effective ingredient is destroyed under hot conditions, and curative effect is subjected to a certain degree influencing, and therapeutic effect is not obvious.
Summary of the invention:
The objective of the invention is to: provide a kind of and invigorate blood circulation, antiinflammatory, analgesic pharmaceutical preparation and preparation method thereof, the present invention is directed to the deficiencies in the prior art, the preparation that is provided adopts the former powder of Chinese medicine, without high-temperature process, guaranteed that fully Effective Components of Chinese Herb is not subjected to pyritous destruction, and utilize transdermal drag delivery, make that effective ingredient is easier to play a role by the through affected part of skin, thereby play quick-acting, effect efficiently.
The present invention constitutes like this: it is with Radix Angelicae Pubescentis 250～350g, Cortex Acanthopancis 250～350g, Radix Clematidis 50～150g, Herba Taxilli 150～250g, Cortex Cinnamomi 200～300g, Fructus Evodiae 50～150g, Rhizoma Curcumae Longae 150～250g, Rhizoma Chuanxiong 150～250g, Olibanum 50～150g, Myrrha 50～150g, Flos Carthami 5～15g, Rhizoma Et Radix Notopterygii 50～150g, Ramulus Cinnamomi 250～350g, the Radix Aucklandiae 250～350g, Radix Notoginseng 30～70g, Camphora 2～8g, Mentholum 2～8g, Borneolum Syntheticum 0.5～1.5g, ibuprofen 25～35g and suitable adjuvant are made.
Say that accurately it is the patch made from Radix Angelicae Pubescentis 300g, Cortex Acanthopancis 300g, Radix Clematidis 100g, Herba Taxilli 200g, Cortex Cinnamomi 250g, Fructus Evodiae 100g, Rhizoma Curcumae Longae 200g, Rhizoma Chuanxiong 200g, Olibanum 100g, Myrrha 100g, Flos Carthami 10g, Rhizoma Et Radix Notopterygii 100g, Ramulus Cinnamomi 300g, Radix Aucklandiae 300g, Radix Notoginseng 50g, Camphora 5g, Mentholum 5g, Borneolum Syntheticum 1g, ibuprofen 30g and azone 15g, ethanol 3000ml.
The present invention invigorates blood circulation, the preparation method of antiinflammatory, analgesic pharmaceutical preparation is: get Cortex Cinnamomi 50g, Flos Carthami 10g, soaked 24 hours, filter with 80% ethanol 2900ml, and standby after the medicinal residues drying and crushing; Radix Angelicae Pubescentis, Cortex Acanthopancis, Radix Clematidis, Herba Taxilli, Fructus Evodiae, Rhizoma Curcumae Longae, Rhizoma Chuanxiong, Olibanum, Myrrha, Rhizoma Et Radix Notopterygii, Ramulus Cinnamomi, the Radix Aucklandiae, Radix Notoginseng and remaining Cortex Cinnamomi, Flos Carthami powder are broken into fine powder, mix with standby medicated powder, according to dosage be sub-packed in the bag, place on the plaster carrier, the lid lining promptly gets the patch medicinal powder package; In above-mentioned ethanol filtrate, camphorate, Mentholum, Borneolum Syntheticum, ibuprofen, azone, stir and make dissolving, supply 3000ml with ethanol, fill according to dosage, packing promptly gets patch medicinal liquid bag.
Arthromyodynia is common clinical, frequently-occurring disease.Its basic pathogenesis is: endogenous cause of ill is an insufficiency of vital energy and blood, the Wei Bugu of battalion, and exopathogenic factor and weather conditions, living environment are relevant, and wind and cold three heresies that wet are taken advantage of a weak point.The Therapeutic Principle is: enriches blood and invigorates blood circulation, and dispelling wind and removing obstruction in the collateral, the cold expelling dampness removing is set upright pain relieving.
" Radix Angelicae Pubescentis " is bitter, hot in the side, temperature, and expelling wind and dampness, dispersing cold for relieving pain, easing joint movement is the monarch drug in the side; Cortex Acanthopancis, Radix Clematidis, Herba Taxilli, expelling wind and removing dampness, promoting blood circulation to remove obstruction in the collateral, bone and muscle strengthening is the ministerial drug in the side; Cortex Cinnamomi, Fructus Evodiae, Rhizoma Curcumae Longae, Rhizoma Chuanxiong, Olibanum, Myrrha, Flos Carthami, promoting the flow of QI-blood by warming the meridian, blood-activating and qi-promoting, dispersing cold for relieving pain, adjuvant drug for it; Rhizoma Et Radix Notopterygii, Ramulus Cinnamomi, the Radix Aucklandiae, Radix Notoginseng, the cold expelling that induces sweat is during promoting the flow of QI-blood by warming the meridian, circulation of qi promoting are transferred, the analgesic therapy of invigorating blood circulation, messenger drug for it; More than all medicines, cooperative compensating amounts to expelling wind and removing dampness, promoting blood circulation to remove obstruction in the collateral is set upright the effect of pain relieving.Be used for diseases such as all pains of waist, lower limb, wing, the back of the body, muscles and bones, joint, cold sensation in the bone that rheumatic arthralgia, articular sprain and cold-damp cause and numb limbs and tense tendons.Ibuprofen in the side is clinical common analgesics, on the basis of traditional Chinese medical science conditioning, gives quickly alleviating pain, and Camphora, Mentholum, Borneolum Syntheticum, azone have osmosis, make effective ingredient infiltrate skin rapidly.Be used for the treatment of anemofrigid-damp arthralgia, myalgia, arthralgia, diseases such as traumatic injury.
Compared with prior art, preparation of the present invention can be invigorated blood circulation effectively, antiinflammatory, analgesia, is applicable to diseases such as pain such as waist that rheumatic arthralgia, articular sprain and cold-damp cause, lower limb, wing, the back of the body, muscles and bones, joint, cold sensation in the bone and numb limbs and tense tendons, has no side effect.Be cutaneous permeable agent and with the azone, make release rapid, and form the medicated layer of high concentration, but the through lesions position performance of rapid osmotic is invigorated blood circulation, antiinflammatory, analgesic effect at illing skin with dissolve with ethanol Camphora, Mentholum, Borneolum Syntheticum, ibuprofen; Steady quality,, nonirritant nontoxic to illing skin, safe and reliable, have no drug resistance; Volume is little, and is in light weight, pollution clothes not, and it is very convenient to portably use.
In order to ensure the effect of preparation of the present invention, the applicant has carried out following experimental study:
One, Study on Preparation
1. Chinese crude drug of the present invention extracts, characteristics according to the contained effective ingredient of used each Chinese crude drug, adopt the filtering extraction process of soak with ethanol, soak with ethanol extraction method such as the volatile oil in Cortex Cinnamomi, the Flos Carthami, cinnamic acid, cinnamic aldehyde, Carthamus yellow, used Chinese crude drug effective ingredient can fully be extracted, and Camphora, Mentholum, Borneolum Syntheticum, ibuprofen directly are dissolved in the ethanol.The applicant has determined the best technological parameters such as extracting concentration range and soak time that soaks of ethanol by test.
The screening of concentration of alcohol
| Concentration of alcohol | 30-40% | 50-60% | 65-95% |
| Solute effect | Medicine dissolution is incomplete, and more precipitation is arranged in the solution. | Medicine dissolves fully substantially, and small amount of precipitate is arranged in the solution. | Medicine dissolution is complete, and precipitation is not seen in dissolving. |
By observing the dissolubility of medicine, concentration of alcohol is at 65-95%, and medicine dissolution is complete.So determine that concentration of alcohol is 65-95%, the best is 80%.
Utilize the TLC analytical technology, determine best soak time, experimental result shows that soak time is about 24 hours, and TLC chromatograph spot colors no change was advisable so determine soak time in 24 hours.
2. the present invention adopts Chinese medicine preparation, and as special carrier, azone is made cutaneous permeable agent with Chinese medicinal powder, and in use the active component of other medicines is constantly come out by dissolve with ethanol, affected part in the skin that goes directly under the effect of cutaneous permeable agent; Formula proportion and processing parameter have been determined by experiment; In development and trial-manufacturing process, make analgesic effect more obvious with ibuprofen.The patch surface of making is complete bright and clean, and dosage is accurate, and is no mouldy, denaturalization phenomenon.Adopt this preparation technology, prove, adapt to industrialized great production, produce stable, quality controllable through pilot production.
Two, preliminarily stabilised investigation
According to the pilot-scale preparation process condition, prepared three batches of preparations of the present invention, to investigate according to the index of intending quality standard certainly and method, study on the stability is the result show, preparation is steady quality under the room temperature natural conditions.
Three, pharmacological toxicology research
The acute toxicity test of rabbit skin single administration, rabbit administration subacute toxicity test, the test of rat administration skin irritation, multiple dosing is to the irritation test of damaged skin, the guinea pig skin hypersensitive test, and the result all shows: when patch of the present invention adopts percutaneous drug delivery approach, used dosage, the used course of treatment, toxicity is little, non-stimulated, no erythema, safety range is big.
Rabbit intact skin long term toxicity test: continuous 7 days percutaneous drug deliveries of patch high dose of the present invention (be equivalent to clinical Coming-of-Age Day consumption 100 times), middle dosage (be equivalent to clinical Coming-of-Age Day consumption 95 times), low dosage (be equivalent to clinical Coming-of-Age Day consumption 50 times), the general situation of animal, local skin do not have erythema, no edema; Drug withdrawal is also no abnormality seen of above-mentioned observation after 7 days.
Rabbit damaged skin long term toxicity test: local scratch is caused at the unhairing position, slight oozing of blood occurs, identical with intact skin then medication administration, and the skin irritation reaction does not appear in animal.Administration group one side skin and substrate liquid one side skin compare, difference that there are no significant.Long-term toxicity test for animals shows that erythema and edema reaction all do not appear in the clinical employing percutaneous drug delivery of patch of the present invention approach, used dosage, skin, and safety range is big.In view of the above result of the test as can be seen said preparation do not have the toxicology meaning, thereby provide the drug safety foundation for clinical verification.
Four, pharmacodynamic study
1, analgesic test: clinical analgesic test, acute soft tissue contusion.Result of the test: obvious analgesic activity is all arranged.
2, antiinflammatory test: clinical articular sprain, hinder the back sharp ache, local swelling, ecchymosis, the joint movement function that occurs in various degree is obstructed.Result of the test: patch of the present invention has the obvious suppression effect.
3, the experiment of invigorating blood circulation: the result shows that patch of the present invention can reduce blood stasis viscosity hematocrit and electrophoresis index, and promoting blood circulation to remove blood stasis has good improvement effect to the Blood stasis hemorheology.
Conclusion: patch of the present invention has antiinflammatory, analgesia and function of promoting blood circulation to disperse blood clots.Thereby for the function of determining said preparation, cure mainly and the clinical application scope, provide experimental basis.
In a word, by the main result of study to preparation of the present invention, this preparation is safe in utilization, and determined curative effect is quality controllable, and each production link carries out in strict accordance with operation SOP, thereby has reached controlled, even, the stable purpose of process.
The specific embodiment:
Embodiments of the invention: get Cortex Cinnamomi 50g, Flos Carthami 10g, soaked 24 hours, filter with 80% ethanol 2900ml, standby after the medicinal residues drying and crushing; Radix Angelicae Pubescentis 300g, Cortex Acanthopancis 300g, Radix Clematidis 100g, Herba Taxilli 200g, Fructus Evodiae 100g, Rhizoma Curcumae Longae 200g, Rhizoma Chuanxiong 200g, Olibanum 100g, Myrrha 100g, Rhizoma Et Radix Notopterygii 100g, Ramulus Cinnamomi 300g, Radix Aucklandiae 300g, Radix Notoginseng 50g and Cortex Cinnamomi 200g are ground into fine powder, mix with standby medicated powder, according to dosage be sub-packed in the bag, place on the plaster carrier, the lid lining promptly gets the patch medicinal powder package; Camphorate in above-mentioned ethanol filtrate 5g, Mentholum 5g, Borneolum Syntheticum 1g, ibuprofen 30g, azone 15g stir and make dissolving, supply 3000ml with ethanol, fill according to dosage, and packing promptly gets patch medicinal liquid bag.This patch can be made into following three kinds of specifications: (1) length and width 9cm * 12cm, thickness are 0.6cm, and every subsides medicated powder weight is not less than 2.3g; (2) length and width 9cm * 9cm, thickness are 0.6cm, and every subsides medicated powder weight is not less than 1.6g; (3) length and width 7.5cm * 7.5cm, thickness are 0.6cm, and every subsides medicated powder weight is not less than 1.3g.Using method: open the medicinal liquid bag, medicinal liquid is poured on the medicinal powder package, after medicinal liquid is penetrated in the medicinal powder package, is affixed on the affected part and gets final product.
The present invention also can make ointment, gel, membrane or liniment according to common process.
Claims (3)
- One kind invigorate blood circulation, antiinflammatory, analgesic pharmaceutical preparation, it is characterized in that: it with Radix Angelicae Pubescentis 250～350g, Cortex Acanthopancis 250～350g, Radix Clematidis 50～150g, Herba Taxilli 150～250g, Cortex Cinnamomi 200～300g, Fructus Evodiae 50～150g, Rhizoma Curcumae Longae 150～250g, Rhizoma Chuanxiong 150～250g, Olibanum 50～150g, Myrrha 50～150g, Flos Carthami 5～15g, Rhizoma Et Radix Notopterygii 50～150g, Ramulus Cinnamomi 250～350g, the Radix Aucklandiae 250～350g, Radix Notoginseng 30～70g, Camphora 2～8g, Mentholum 2～8g, Borneolum Syntheticum 0.5～1.5g, ibuprofen 25～35g and suitably adjuvant make.
- According to claim 1 describedly invigorate blood circulation, antiinflammatory, analgesic pharmaceutical preparation, it is characterized in that: it is the patch made from Radix Angelicae Pubescentis 300g, Cortex Acanthopancis 300g, Radix Clematidis 100g, Herba Taxilli 200g, Cortex Cinnamomi 250g, Fructus Evodiae 100g, Rhizoma Curcumae Longae 200g, Rhizoma Chuanxiong 200g, Olibanum 100g, Myrrha 100g, Flos Carthami 10g, Rhizoma Et Radix Notopterygii 100g, Ramulus Cinnamomi 300g, Radix Aucklandiae 300g, Radix Notoginseng 50g, Camphora 5g, Mentholum 5g, Borneolum Syntheticum 1g, ibuprofen 30g and azone 15g, ethanol 3000ml.
- 3. invigorate blood circulation as claimed in claim 1 or 2, the preparation method of antiinflammatory, analgesic pharmaceutical preparation, it is characterized in that: get Cortex Cinnamomi 50g, Flos Carthami 10g, soaked 24 hours, filter with 80% ethanol 2900ml, standby after the medicinal residues drying and crushing; Radix Angelicae Pubescentis, Cortex Acanthopancis, Radix Clematidis, Herba Taxilli, Fructus Evodiae, Rhizoma Curcumae Longae, Rhizoma Chuanxiong, Olibanum, Myrrha, Rhizoma Et Radix Notopterygii, Ramulus Cinnamomi, the Radix Aucklandiae, Radix Notoginseng and remaining Cortex Cinnamomi, Flos Carthami powder are broken into fine powder, mix with standby medicated powder, according to dosage be sub-packed in the bag, place on the plaster carrier, the lid lining promptly gets the patch medicinal powder package; In above-mentioned ethanol filtrate, camphorate, Mentholum, Borneolum Syntheticum, ibuprofen, azone, stir and make dissolving, supply 3000ml with ethanol, fill according to dosage, packing promptly gets patch medicinal liquid bag.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610200584 CN1895641A (en) | 2006-06-20 | 2006-06-20 | Medicinal preparation with blood-activating, anti-inflammatory and analgesic functions and its making method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610200584 CN1895641A (en) | 2006-06-20 | 2006-06-20 | Medicinal preparation with blood-activating, anti-inflammatory and analgesic functions and its making method |
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| CN1895641A true CN1895641A (en) | 2007-01-17 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104825567A (en) * | 2015-04-16 | 2015-08-12 | 李殿国 | Compound ibuprofen medical patch and preparation method thereof |
| CN105148246A (en) * | 2015-10-23 | 2015-12-16 | 郑州奇经健康科技有限公司 | Traditional Chinese medicine composition, preparing method thereof and application of traditional Chinese medicine composition to collateral-activating and bone-curing medicine preparing |
| CN105902730A (en) * | 2016-04-22 | 2016-08-31 | 谢兴文 | Cold-dispelling cinnamon-and-cassia twig-containing traditional Chinese medicinal composition |
| CN106955340A (en) * | 2017-02-28 | 2017-07-18 | 金虹旭 | A kind of Chinese and Western medicine magnetic therapy plaster |
-
2006
- 2006-06-20 CN CN 200610200584 patent/CN1895641A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104825567A (en) * | 2015-04-16 | 2015-08-12 | 李殿国 | Compound ibuprofen medical patch and preparation method thereof |
| CN104825567B (en) * | 2015-04-16 | 2018-02-09 | 山东大学第二医院 | A kind of compound iuprofen drug paste and preparation method |
| CN105148246A (en) * | 2015-10-23 | 2015-12-16 | 郑州奇经健康科技有限公司 | Traditional Chinese medicine composition, preparing method thereof and application of traditional Chinese medicine composition to collateral-activating and bone-curing medicine preparing |
| CN105902730A (en) * | 2016-04-22 | 2016-08-31 | 谢兴文 | Cold-dispelling cinnamon-and-cassia twig-containing traditional Chinese medicinal composition |
| CN106955340A (en) * | 2017-02-28 | 2017-07-18 | 金虹旭 | A kind of Chinese and Western medicine magnetic therapy plaster |
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