CN101274079A - Dogskin plaster and technique of preparing the same - Google Patents
Dogskin plaster and technique of preparing the same Download PDFInfo
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- CN101274079A CN101274079A CNA2008100473851A CN200810047385A CN101274079A CN 101274079 A CN101274079 A CN 101274079A CN A2008100473851 A CNA2008100473851 A CN A2008100473851A CN 200810047385 A CN200810047385 A CN 200810047385A CN 101274079 A CN101274079 A CN 101274079A
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Abstract
The invention provides a dog-skin plaster and a preparation technique thereof. The dog-skin plaster is made from a substrate and raw herbal materials of black-plaster dog-skin plasters. The mass ratio of the raw herbal materials is the same as the mass ratio in the prescription of the black-plaster dog-skin plaster. A processed radix aconiti replaces an unprocessed radix aconiti, and a processed kusnezoff monkshood root replaces an unprocessed kusnezoff monkshood root, wherein no lead is contained. The preparation uses an ethanol extracting technology and a volatile-oil extracting technique to replace the extracting technology of frying vegetable oil in the original preparation, which can completely extract drug ingredients, without such disadvantages as drug ingredients being easily destroyed by high temperature and air pollution which are generated by the extracting technique of frying vegetable in the original preparation; the new substrate replaces the original black-plaster substrate, which has the advantages of larger drug quantity, easy putting up and off, good compatibility, release property and skin penetration property, without toxic lead content. The unprocessed radix aconiti and the unprocessed kusnezoff monkshood root in the original prescription are replaced respectively by the processed radix aconiti and the processed kusnezoff monkshood root, thus ensuring the effectiveness and safety of the preparation and eliminating the skin sensitization caused by the original dog-skin plaster.
Description
Technical field
The present invention relates to a kind of novel Chinese medicine for outer use dog skin plaster and preparation technology thereof.The dog skin plaster is the novel formulation of former black plaster preparation dog skin plaster being carried out the secondary development Research Institute, Radix Aconiti, Radix Aconiti Kusnezoffii substitute with Radix Aconiti Preparata and Radix Aconiti Kusnezoffii Preparata in the former prescription, substitute the fried extraction process of vegetable oil of former preparation with ethanol extraction technology and volatile oil extraction process
Background technology
Dog skin plaster is a kind of traditional black plaster preparation, is recorded in nineteen ninety-five version, version in 2000, version in 2005 " in one one of the Chinese pharmacopoeia." dog skin plaster " has the effect that relieving rheumatism and cold, invigorating blood circulation and stopping pains.Be used for the treatment of wind-cold damp pathogen, the numb limbs and tense tendons that qi depression to blood stasis causes, lumbago and skelalgia, the contracture of muscle arteries and veins, lumbar sprain and QI divergeny, wrist abdomen cold type of pain, menalgia cold-damp leukorrhagia gathers mass in the abdomen.
The dog skin plaster prescription contains 29 flavor Chinese medicines: Radix Aconiti 80 grams, Radix Aconiti Kusnezoffii 40 grams, Rhizoma Et Radix Notopterygii 20 grams, Radix Angelicae Pubescentis 20 grams, Caulis Sinomenii 30 grams, Cortex Periplocae 30 grams, Radix Saposhnikoviae 30 grams, Radix Clematidis 30 grams, Rhizoma Atractylodis 20 grams, Fructus Cnidii 20 grams, Herba Ephedrae 30 grams, Rhizoma Alpiniae Officinarum 9 grams, Fructus Foeniculi 20 grams, Cortex Cinnamomi 10 grams, Radix Angelicae Sinensis 20 grams, Radix Paeoniae Rubra 30 grams, Fructus Chaenomelis 30 grams, Lignum Sappan 30 grams, Radix Et Rhizoma Rhei 30 grams, Pine Nodular Branch 30 grams, Radix Dipsaci 40 grams, Rhizoma Chuanxiong 30 grams, the Radix Angelicae Dahuricae 30 grams, Olibanum 34 grams, Myrrha 34 grams, Borneolum Syntheticum 17 grams, Camphora 34 grams, Flos Caryophylli 17 grams, Cortex Cinnamomi 11 grams.
The tradition method for making is: above 29 flavor medicines, and Olibanum, Myrrha, Flos Caryophylli, Cortex Cinnamomi pulverize separately powdered with Camphora, borneol powder facing-up, sieve mixing; All the other Radix Aconiti etc. 23 flavor medicines, give as one thinks fit cataclasm, fried withered with edible vegetable oil 3495 grams with placing in the pot, remove slag, filter, refining is to dripping into pearl.Other gets Plumbum preparatium 1040～1140 grams, adds in the oil, stirs evenly, and receives cream, and cream is soaked in the water.Get cream,, add above-mentioned powder, stir evenly, share on animal skin or cloth, promptly with the slow fire fusing.
Dog skin plaster had once been brought into play important function for disease and the misery of removing broad masses of the people." one one of Chinese pharmacopoeia is recorded, and some shortcomings that black plaster dosage form self exists have seriously limited the production and the use of dog skin plaster though dog skin plaster was by version in 2005.As: 1, be added with the Plumbum preparatium in the substrate, the Plumbum preparatium is contained the virulent lead element of human body, in use can go in the body by dermal osmosis; 2, in the black plaster preparation process, medical material vegetable oil high temperature extraction is tempered, and oily temperature reaches 320 ℃, and many effective ingredient decompose destruction easily; 3, the polarity of vegetable oil is very little, and middle pharmaceutically active ingredient that many polarity are bigger such as alkaloids, various glycoside, polysaccharide or the like are difficult to be dissolved in the vegetable oil, and owing to these reasons, dog skin plaster is differentiated without any thin layer and the standard of assay so far; Use as medicinal powder is added in the substrate of tempering, effective ingredient discharges very slow from crude drug cell, and skin absorbs is also corresponding to slow down, and it is also slow that it begins to produce curative effect; 4, vegetable oil easily produces anaphylaxis tempering the small molecule aldehyde chemical compound that produces in the process for a long time to skin.5, black plaster produces a large amount of harmful gass in process of production, the severe contamination air.These weak points have limited the use of dog skin plaster to a great extent, and " dog skin plaster " is that its name is arranged on the market now, do not have its goods.
In addition, monarch drug Radix Aconiti in the dog skin plaster prescription, Radix Aconiti Kusnezoffii is poisonous medical material, it may be an important obstacle that is difficult to cross that dog skin plaster is carried out secondary development research, be forced to because of the toxicity of medicine possibly in research process, this situation happens occasionally in the research of Chinese medicine medicine for external use.
Summary of the invention
The purpose of this invention is to provide a kind of new medicine external plaster preparation dog skin plaster, this dog skin plaster is the novel formulation of former black plaster preparation dog skin plaster being carried out the secondary development Research Institute, changes extraction solvent, extraction process, substrate composition and the preparations shaping technology of former dog skin plaster.The extraction ingredient is complete, does not have the fried extraction process Chinese medicine of former preparation composition easily to be destroyed by high temperature, produces the air-polluting disadvantage; Substitute former black plaster dosage form with novel plaster dosage form, content of dispersion is big, and unleaded element is easily taken off easy subsides, and compatible good, release property and percutaneous permeability are good, do not have former dog skin plaster to contain poisonous lead element and sensitization of skin; And the dog skin plaster is formulated thin layer differentiate and content measuring standard, guarantee that the effectiveness and the safety of preparation provides primary condition.
According to the foregoing invention purpose, the present invention substitutes the fried extraction process of vegetable oil of former preparation with ethanol extraction technology and volatile oil extraction process.It is complete that this technology is extracted ingredient, do not have the fried extraction process Chinese medicine of former preparation composition easily to be destroyed by high temperature, produces the air-polluting disadvantage, to guarantee as far as possible fully to extract the effective ingredient in the prescription medical material;
The present invention adopts modern pharmaceutic adjuvant, and without the Plumbum preparatium, preparation is different from the substrate dosage form of black plaster dog skin plaster fully;
The present invention substitutes monarch drug Radix Aconiti, Radix Aconiti Kusnezoffii in the former dog skin plaster with Radix Aconiti Preparata and Radix Aconiti Kusnezoffii Preparata, guarantees the effectiveness and the safety of preparation.
The present invention adopts thin layer chromatography, ultraviolet spectrophotometry, high performance liquid chromatograph and gas chromatography, and effective ingredient in the preparation has been carried out discriminating and assay.
A kind of Chinese medicine external dog skin plaster of the present invention, raw medicinal material by substrate and black plaster dog skin plaster is made, it is characterized in that, identical in raw medicinal material mass ratio and the black plaster dog skin plaster side, replace Radix Aconiti, Radix Aconiti Kusnezoffii Preparata to replace Radix Aconiti Kusnezoffii with Radix Aconiti Preparata, do not contain the Plumbum preparatium, do not adopt the fried raw medicinal material extract of vegetable oil, the ethanol percolate extraction liquid (1) of raw medicinal material Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Caulis Sinomenii, Cortex Periplocae, Radix Clematidis, Herba Ephedrae, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Fructus Chaenomelis, Radix Et Rhizoma Rhei, Radix Dipsaci, Rhizoma Chuanxiong and the Radix Angelicae Dahuricae 13 flavor medical materials in the side of containing; Rhizoma Et Radix Notopterygii in the raw medicinal material, Radix Angelicae Pubescentis, Radix Saposhnikoviae, Cortex Cinnamomi, Rhizoma Atractylodis, Fructus Cnidii, Rhizoma Alpiniae Officinarum, Fructus Foeniculi, Lignum Sappan, Pine Nodular Branch, Olibanum, Myrrha and Cortex Cinnamomi 13 flavor medical materials add the volatile oil (2) of water distillation and extraction; Flos Caryophylli adds the volatile oil (3) of water distillation and extraction; The filtrate of last aqueous extract and the precipitate with ethanol filtrate (4) of the filtrate merging that medicinal residues water is carried behind the above-mentioned 14 flavor medical material distillating extracting oils, (4) merge the concentrated thick paste (5) that obtains with (1); Camphora Borneolum Syntheticum facing-up fine powder (6);
The drug extract that above-mentioned volatile oil (2)+volatile oil (3)+thick paste (5)+Camphora Borneolum Syntheticum facing-up fine powder (6) is formed accounts for 10～40% of dog skin plaster quality, and surplus is substrate.
The substrate of Chinese medicine external dog skin plaster of the present invention is made by following raw material, paraffin, monoglyceride, glycerol, swelling gelatin, sodium polyacrylate/glycerite or degree of neutralization 70% sodium polyacrylate liquid or polyacrylic resin, sodium lauryl sulfate, vaseline, lanoline.Its constituent mass proportioning is:
Paraffin: 5～40%;
Monoglyceride: 5～20%
Glycerol 1～10%;
Swelling gelatin 2～20%;
Sodium polyacrylate/glycerite 5～15%, or the sodium polyacrylate liquid 5～20% of degree of neutralization 70%, or polyacrylic resin 5～15%;
Sodium lauryl sulfate 0.5～2%;
Vaseline 0～10%;
Lanoline 0～5%;
Described swelling gelatin and sodium polyacrylate/glycerite or polyacrylic resin are mixing in 1: 2～2: 1 by mass ratio, and 50～60 ℃ of heating in water bath dissolve and mix homogeneously, are cooled to gel;
Wherein, swelling gelatin preparation method: calculate by mass, take by weighing 1 part in solid gelatin and be dissolved in 2～5 parts of glycerites, leave standstill more than 12 hours, make abundant swelling;
Sodium polyacrylate glycerite compound method: calculate by mass, take by weighing solid polypropylene acid sodium and be dissolved in 100～400 parts of glycerites for 1 part, soak molten more than 24 hours;
Glycerite compound method: calculate by mass, with 40～80 parts of glycerol and 20～60 parts of mix homogeneously of water.
Extraction process of the present invention is to carry out ethanol percolate extraction respectively according to the character of prescription Chinese crude drug, and the way of distillation is extracted volatile oil, and water extract-alcohol precipitation is ground processing into powder:
In the Chinese medicine external dog skin plaster of the present invention: the ethanol percolate extraction liquid (1) of described Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Caulis Sinomenii, Cortex Periplocae, Radix Clematidis, Herba Ephedrae, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Fructus Chaenomelis, Radix Et Rhizoma Rhei, Radix Dipsaci, Rhizoma Chuanxiong and the Radix Angelicae Dahuricae 13 flavor medical materials, for described 13 flavor pulverizing medicinal materials are become coarse powder, with the percolate of 50～80% ethanol percolate extraction gained.
In the Chinese medicine external dog skin plaster of the present invention: described Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Radix Saposhnikoviae, Cortex Cinnamomi, Rhizoma Atractylodis, Fructus Cnidii, Rhizoma Alpiniae Officinarum, Fructus Foeniculi, Lignum Sappan, Pine Nodular Branch, Olibanum, Myrrha and Cortex Cinnamomi 13 flavor medical materials are soaked the volatile oil (2) of back distillation extraction, for described 13 flavor powder medical materials are broken into coarse powder, soak the back and extract the volatile oil (light oil) (3) that obtains with the way of distillation.
In the Chinese medicine external dog skin plaster of the present invention: described Flos Caryophylli is soaked the volatile oil of back distillation extraction, for Flos Caryophylli powder is broken into coarse powder, soaks the volatile oil (heavy oil) that extract with the way of distillation back.
In the Chinese medicine external dog skin plaster of the present invention: described precipitate with ethanol filtrate (4), be with Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Radix Saposhnikoviae, Cortex Cinnamomi, Rhizoma Atractylodis, Fructus Cnidii, Rhizoma Alpiniae Officinarum, Fructus Foeniculi, Lignum Sappan, Pine Nodular Branch, Olibanum, Myrrha and Cortex Cinnamomi 13 flavor medical materials are soaked, last aqueous extract behind the distillating extracting oil, and Flos Caryophylli is soaked, last aqueous extract behind the distillating extracting oil, filters, and medicinal residues add water and decoct once again, filter, merge filtrate twice, concentrate, add the ethanol accent and contain the filtrate that alcohol amount 50%～70% is carried out the precipitate with ethanol after-filtration.
In the Chinese medicine external dog skin plaster of the present invention: described Camphora Borneolum Syntheticum facing-up fine powder: be with Camphora, Borneolum Syntheticum by the grinding that matches of the mass ratio of two medical materials in the black plaster dog skin plaster, sieve the fine drug powder that obtains.
The preparation technology of Chinese medicine external dog skin plaster of the present invention is as follows:
Calculate by mass, taking by weighing thick paste places in the container for (5) 40～80 parts, 4～8 parts of glycerol addings, 1～2 part of sodium lauryl sulfate, be heated to and dissolve, mix homogeneously, add 40～80 parts in paraffin again, 24～40 parts of monoglycerides are heated to fusing, continue heat sterilization 10 minutes, stop heating or reduce temperature, be stirred to and be even ointment shape, add swelling gelatin and sodium polyacrylate/glycerite or polyacrylic resin solution, by mass ratio is 16～30 parts of the gelinites that mixed in 1: 2～2: 1, the heating make dissolve and with the thick paste mix homogeneously, add prescription ratio volatile oil (2) (3) again, Camphora Borneolum Syntheticum facing-up fine powder (6), continue to stir into the uniform ointment of color and luster, ointment is made the patch preparation by the plaster preparation method; Perhaps,
Calculate by mass, take by weighing thick paste and place in the container 15 parts of glycerol addings for (5) 20 parts, 1 part of sodium lauryl sulfate, 10 parts of degree of neutralization 70% sodium polyacrylate are heated to and dissolve, mix homogeneously, add 15 parts in paraffin again, 20 parts of monoglycerides, 8 parts in vaseline, 2 parts of lanolines, be heated to fusing, continue heat sterilization 10 minutes, stop heating or reduce temperature, stir, add 5 parts in swelling gelatin, stir, add prescription ratio volatile oil (2) (3) again, Camphora Borneolum Syntheticum facing-up fine powder (6), continue to stir into the uniform ointment of color and luster, ointment is made the patch preparation by the plaster preparation method.
The forming method of novel external dog skin plaster of the present invention is as follows:
Ointment is evenly coated on the backing, on the ointment face, covered layer protecting film or antiadhesion barrier paraffin paper or polyethylene film, pack then; Perhaps,
Back lining materials is placed on the press mold machine, ointment is coated on the backing, on ointment, place paraffin paper, composite polyethylene film, polypropylene screen or polyethylene film adherent layer, with the press mold machine back lining materials, ointment and adherent layer paraffin paper, composite polyethylene film, polypropylene screen or polyethylene film are pressed into the uniform ointment diaphragm of thickness, the ointment diaphragm is respectively antiadhesion barrier, ointment and backing from top to bottom, the ointment diaphragm is according to dosage cut into equal-sized finished product, pack then;
Described backing is composite polyethylene film, polyethylene film, polypropylene screen, compound nonwoven cloth or cloth.
Ethanol % described in the present invention contains ethanol milliliter number in 100 milliliters of ethanol waters.
The present invention adopts thin layer chromatography that Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Radix Et Rhizoma Rhei, Rhizoma Atractylodis, Caulis Sinomenii, Herba Ephedrae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Olibanum in the dog skin plaster have been carried out the thin layer discriminating, has formulated standard.Adopt acid-base titrations that total alkaloid content in the dog skin plaster is measured, formulated content measuring standard; Adopt the HPLC method that ephedrine hydrochloride content in the dog skin plaster is measured, formulated content measuring standard.
Dog skin plaster of the present invention is compared with dog skin plaster, has following advantage:
1) use ethanol extraction technology, the volatile oil extraction process, aqueous extraction-alcohol precipitation technology substitutes fried, the oil refining process of vegetable oil of former preparation, and the ingredient of extraction is complete, does not have former formulation oils extraction process Chinese medicine composition easily by the destructive situation of high temperature.Adopt thin layer chromatography that raw medicinal materials such as Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Radix Et Rhizoma Rhei in the dog skin plaster have been formulated the thin layer judging standard.Adopt acid-base titrations that total alkaloids in the dog skin plaster has been formulated content measuring standard; Adopt the HPLC method that ephedrine hydrochloride in the dog skin plaster has been formulated content measuring standard.Changing former dog skin plaster does not have the situation of any thin layer discriminating and content measuring standard.
2) drug loading is big, can suitably increase the extractum amount in substrate according to the medication area.
3) the dog skin plaster has the property pasted preferably, tears antiadhesion barrier during use off, and ointment is close on the skin, and ointment has good adhibit quality to skin, is convenient to effective ingredient and discharges, permeates, and easily take off easy subsides, does not have any pain when taking off.
4) the similar traditional black plaster dosage form of dog skin plaster profile, but do not contain lead element (the black plaster preparation contains harmful lead element because of having added Plumbum preparatium).
5) dog skin plaster stroma component and skin have the good compatibility, therefore do not have the sensitization of skin of " dog skin plaster ".
6) dog skin plaster water content is low, and good stability can hold its shape at 50 ℃, does not melt.
7) the dog skin plaster has better release property and percutaneous permeability than dog skin plaster.
8) the dog skin plaster uses back easily washing, not ixoderm skin.
9) Radix Aconiti, Radix Aconiti Kusnezoffii in the former prescription are substituted with Radix Aconiti Preparata and Radix Aconiti Kusnezoffii Preparata, guaranteed the effectiveness and the safety of dog skin plaster preparation.
The specific embodiment
The preparation of embodiment 1 dog skin plaster preparation
Preparation technology is divided into the lower part:
1, the raw material of dog skin plaster stroma composition and quality proportioning are:
Paraffin: 5～40%;
Monoglyceride: 5～20%
Glycerol 1～10%;
Swelling gelatin (solid/glycerol: water) 2～20%;
Sodium polyacrylate solution (solid/glycerol: water) 5～15%, or sodium polyacrylate liquid (degree of neutralization 70%) 5～20%, or polyacrylic resin 5～15%;
Sodium lauryl sulfate 0.5～2%;
Vaseline 0～10%;
Lanoline 0～5%;
Gelatin swelling method: calculate by mass, take by weighing solid gelatin 20 grams, add in the glycerite of glycerol 35 grams and water 15 grams, swelling is more than 12 hours.
Sodium polyacrylate solution is prepared: calculate by mass, take by weighing sodium polyacrylate 1 gram, soak molten more than 24 hours in adding glycerol 70 grams and the water 30 gram glycerites.
Glycerite preparation: calculate glycerol 40～80 grams and water 20～60 gram mix homogeneously by mass.
Calculating by mass, with swelling gelatin and sodium polyacrylate/glycerite or polyacrylic resin, is mixing in 1: 2～2: 1 by mass ratio, and 50～60 ℃ of heating in water bath make molten and mix homogeneously, are cooled to gel.
2, the preparation of dog skin plaster ointment:
Character according to the prescription Chinese crude drug is carried out ethanol percolate extraction respectively, and the way of distillation is extracted volatile oil, and water extract-alcohol precipitation is ground processing into powder:
1), ethanol percolate extraction: Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Caulis Sinomenii, Cortex Periplocae, Radix Clematidis, Herba Ephedrae, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Fructus Chaenomelis, Radix Et Rhizoma Rhei, Radix Dipsaci, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae 13 flavor pulverizing medicinal materials become coarse powder in will writing out a prescription, use 55% ethanol percolate extraction, get percolate 1.;
2), the way of distillation is extracted volatile oil (light oil): Rhizoma Et Radix Notopterygii in will writing out a prescription, Radix Angelicae Pubescentis, Radix Saposhnikoviae, Cortex Cinnamomi, Rhizoma Atractylodis, Fructus Cnidii, Rhizoma Alpiniae Officinarum, Fructus Foeniculi, Lignum Sappan, Pine Nodular Branch, Olibanum, Myrrha, Cortex Cinnamomi 13 flavor pulverizing medicinal materials become coarse powder, soak the back and extract volatile oil with the way of distillation, get volatile oil 2.;
The way of distillation is extracted volatile oil (heavy oil): Flos Caryophylli powder is broken into coarse powder, soaks the back and extract volatile oil with the way of distillation, get volatile oil 3.;
3), water extract-alcohol precipitation: last aqueous extract filtered after the above way of distillation extracted volatile oil, and medicinal residues add water and before boil once, filter, and merge the water extract twice, was concentrated in right amount, added ethanol and transferred and contain alcohol amount 60% and carry out precipitate with ethanol, filter, filtrate 4.;
4. 1. percolate merged with filtrate, and 5. concentrating under reduced pressure gets thick paste.
4), with Camphora, Borneolum Syntheticum facing-up, sieve, fine drug powder 6..
5): calculate by mass, take by weighing thick paste 5. 40 parts put in the container, 4 parts of glycerol addings, 1 part of sodium lauryl sulfate, be heated to and dissolve, mix homogeneously adds 40 parts in paraffin again, 24 parts of monoglycerides, be heated to fusing, continue heat sterilization 10 minutes, stop heating or reduce temperature, be stirred to and be even ointment shape, add swelling gelatin and sodium polyacrylate/glycerite (perhaps the gel that mixes of polyacrylic resin solution is 16 parts, heat make molten and with the ointment mix homogeneously, add prescription ratio volatile oil more 2. 3., 6. Camphora Borneolum Syntheticum facing-up fine powder continues to stir into the uniform ointment of color and luster; Perhaps,
Calculate by mass, take by weighing thick paste 5. 20 parts put in the container 15 parts of glycerol addings, 1 part of sodium lauryl sulfate, 10 parts of degree of neutralization 70% sodium polyacrylate, be heated to and dissolve, mix homogeneously adds 15 parts in paraffin again, 20 parts of monoglycerides, 8 parts in vaseline, 2 parts of lanolines are heated to fusing, continue heat sterilization 10 minutes, stop heating or reduce temperature, stir, add 5 parts in swelling gelatin, stir, add prescription ratio volatile oil more 2. 3., 6. Camphora Borneolum Syntheticum facing-up fine powder continues to stir into the uniform ointment of color and luster.
3, dog skin plaster molding preparation:
Method 1: ointment is evenly coated on the composite polyethylene film backing, on the ointment face, covered layer protecting film or antiadhesion barrier paraffin paper or polyethylene film, pack then.
Method 2: composite polyethylene film back lining materials is placed on the press mold machine, ointment is coated on the composite polyethylene film backing, on ointment, place the polyethylene film adherent layer, with the press mold machine back lining materials, ointment and polyethylene film are pressed into the uniform ointment diaphragm of thickness, the ointment diaphragm is respectively antiadhesion barrier, ointment and backing from top to bottom, the ointment diaphragm is according to dosage cut into equal-sized finished product, pack then..
Claims (11)
1, a kind of Chinese medicine external dog skin plaster, raw medicinal material by substrate and black plaster dog skin plaster is made, it is characterized in that, identical in raw medicinal material mass ratio and the black plaster dog skin plaster side, replace Radix Aconiti, Radix Aconiti Kusnezoffii Preparata to replace Radix Aconiti Kusnezoffii with Radix Aconiti Preparata, do not contain the Plumbum preparatium, do not adopt the fried raw medicinal material extract of vegetable oil, the ethanol percolate extraction liquid (1) of raw medicinal material Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Caulis Sinomenii, Cortex Periplocae, Radix Clematidis, Herba Ephedrae, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Fructus Chaenomelis, Radix Et Rhizoma Rhei, Radix Dipsaci, Rhizoma Chuanxiong and the Radix Angelicae Dahuricae 13 flavor medical materials in the side of containing; Rhizoma Et Radix Notopterygii in the raw medicinal material, Radix Angelicae Pubescentis, Radix Saposhnikoviae, Cortex Cinnamomi, Rhizoma Atractylodis, Fructus Cnidii, Rhizoma Alpiniae Officinarum, Fructus Foeniculi, Lignum Sappan, Pine Nodular Branch, Olibanum, Myrrha and Cortex Cinnamomi 13 flavor medical materials add the volatile oil (2) of water distillation and extraction; Flos Caryophylli adds the volatile oil (3) of water distillation and extraction; The filtrate of last aqueous extract and the precipitate with ethanol filtrate (4) of the filtrate merging that medicinal residues water is carried behind the above-mentioned 14 flavor medical material distillating extracting oils, (4) merge the concentrated thick paste (5) that obtains with (1); Camphora Borneolum Syntheticum facing-up fine powder (6);
The drug extract that above-mentioned volatile oil (2)+volatile oil (3)+thick paste (5)+Camphora Borneolum Syntheticum facing-up fine powder (6) is formed accounts for 10～40% of dog skin plaster quality, and surplus is substrate.
2, Chinese medicine external dog skin plaster according to claim 1, it is characterized in that described substrate is made by following raw material: the sodium polyacrylate liquid of paraffin, monoglyceride, glycerol, swelling gelatin, sodium polyacrylate/glycerite or degree of neutralization 70% or polyacrylic resin, sodium lauryl sulfate, vaseline and lanoline.Its constituent mass proportioning is:
Paraffin: 5～40%;
Monoglyceride: 5～20%
Glycerol 1～10%;
Swelling gelatin 2～20%;
Sodium polyacrylate/glycerite 5～15%, or the sodium polyacrylate liquid 5～20% of degree of neutralization 70%, or polyacrylic resin 5～15%;
Sodium lauryl sulfate 0.5～2%;
Vaseline 0～10%;
Lanoline 0～5%;
Described swelling gelatin and sodium polyacrylate/glycerite or polyacrylic resin are mixing in 1: 2～2: 1 by mass ratio, and 50～60 ℃ of heating in water bath dissolve and mix homogeneously, are cooled to gel;
Wherein, swelling gelatin preparation method: calculate by mass, take by weighing 1 part in solid gelatin and be dissolved in 2～5 parts of glycerites, leave standstill more than 12 hours;
Sodium polyacrylate glycerite compound method: calculate by mass, take by weighing solid polypropylene acid sodium and be dissolved in 100～400 parts of glycerites for 1 part.Soak molten more than 24 hours;
Glycerite compound method: calculate by mass, with 40～80 parts of glycerol and 20～60 parts of mix homogeneously of water.
3, Chinese medicine external dog skin plaster according to claim 1, it is characterized in that: the ethanol percolate extraction liquid of described Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Caulis Sinomenii, Cortex Periplocae, Radix Clematidis, Herba Ephedrae, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Fructus Chaenomelis, Radix Et Rhizoma Rhei, Radix Dipsaci, Rhizoma Chuanxiong and the Radix Angelicae Dahuricae 13 flavor medical materials, for described 13 flavor pulverizing medicinal materials are become coarse powder, with the percolate of 50～80% ethanol percolate extraction gained.
4, Chinese medicine external dog skin plaster according to claim 1 is characterized in that: described Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Radix Saposhnikoviae, Cortex Cinnamomi, Rhizoma Atractylodis, Fructus Cnidii, Rhizoma Alpiniae Officinarum, Fructus Foeniculi, Lignum Sappan, Pine Nodular Branch, Olibanum, Myrrha and Cortex Cinnamomi 13 flavor medical materials add the volatile oil of water distillation and extraction, for described 13 flavor pulverizing medicinal materials are become coarse powder, soak the back and extract the volatile oil that obtains with the way of distillation.
5, Chinese medicine external dog skin plaster according to claim 1, it is characterized in that: described Flos Caryophylli adds the volatile oil of water distillation and extraction, for Flos Caryophylli powder is broken into coarse powder, soaks the volatile oil that extract with the way of distillation back.
6, Chinese medicine external dog skin plaster according to claim 1, it is characterized in that: described precipitate with ethanol filtrate (4) is with Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Radix Saposhnikoviae, Cortex Cinnamomi, Rhizoma Atractylodis, Fructus Cnidii, Rhizoma Alpiniae Officinarum, Fructus Foeniculi, Lignum Sappan, Pine Nodular Branch, Olibanum, Myrrha and Cortex Cinnamomi 13 flavor medical materials are soaked, last aqueous extract behind the distillating extracting oil, and Flos Caryophylli is soaked, last aqueous extract behind the distillating extracting oil, filter, medicinal residues add water and decoct once again, filter, and merge filtrate twice, concentrate, add ethanol and be transferred to and contain the filtrate that alcohol amount 50%～70% is carried out the precipitate with ethanol after-filtration.
7, Chinese medicine external dog skin plaster according to claim 1 is characterized in that: described Camphora Borneolum Syntheticum facing-up fine powder: be with Camphora and Borneolum Syntheticum by the grinding that matches of the mass ratio of two medical materials in the black plaster dog skin plaster, sieve the fine drug powder that obtains.
8, the preparation technology of the described Chinese medicine external of claim 1 dog skin plaster is characterized in that:
Calculate by mass, taking by weighing thick paste places in the container for (5) 40～80 parts, 4～8 parts of glycerol addings, 1～2 part of sodium lauryl sulfate, be heated to and dissolve, mix homogeneously, add 40～80 parts in paraffin again, 24～40 parts of monoglycerides are heated to fusing, continue heat sterilization 10 minutes, stop heating or reduce temperature, be stirred to and be even ointment shape, add swelling gelatin and sodium polyacrylate/glycerite or polyacrylic resin solution, by mass ratio is 16～30 parts of the gels that mixed in 1: 2～2: 1, the heating make dissolve and with the thick paste mix homogeneously, add prescription ratio volatile oil (2) (3) again, Camphora Borneolum Syntheticum facing-up fine powder (6), continue to stir into the uniform ointment of color and luster, ointment is made dog skin plaster preparation by the plaster preparation method.
9, the preparation technology of the described Chinese medicine external of claim 1 dog skin plaster is characterized in that:
Calculate by mass, take by weighing thick paste and place in the container 15 parts of glycerol addings for (5) 20 parts, 1 part of sodium lauryl sulfate, 10 parts of the sodium polyacrylate of degree of neutralization 70% are heated to and dissolve, mix homogeneously, add 15 parts in paraffin again, 20 parts of monoglycerides, 8 parts in vaseline, 2 parts of lanolines, be heated to fusing, continue heat sterilization 10 minutes, stop heating or reduce temperature, stir, add 5 parts in swelling gelatin, stir, add prescription ratio volatile oil (2) (3) again, Camphora Borneolum Syntheticum facing-up fine powder (6), continue to stir into the uniform ointment of color and luster, ointment is made dog skin plaster preparation by the plaster preparation method.
10, according to Claim 8 or the preparation method of 9 described Chinese medicine external dog skin plaster, it is characterized in that:
Ointment is evenly coated on the backing, covered layer protecting film or antiadhesion barrier paraffin paper or polyethylene film on the ointment face, pack then, described backing is composite polyethylene film, polyethylene film, polypropylene screen, compound nonwoven cloth or cloth.
11, according to Claim 8 or the preparation method of 9 described Chinese medicine external dog skin plaster, it is characterized in that: back lining materials is placed on the press mold machine, ointment is coated on the backing, on ointment, place paraffin paper, the composite polyethylene film, polypropylene screen or polyethylene film adherent layer, with the press mold machine with back lining materials, ointment and adherent layer paraffin paper, the composite polyethylene film, polypropylene screen or polyethylene film are pressed into the uniform ointment diaphragm of thickness, the ointment diaphragm is respectively antiadhesion barrier from top to bottom, ointment and backing, the ointment diaphragm is according to dosage cut into equal-sized finished product, pack then, described backing is the composite polyethylene film, polyethylene film, polypropylene screen, compound nonwoven cloth or cloth.
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2008100473851A CN101274079A (en) | 2008-04-18 | 2008-04-18 | Dogskin plaster and technique of preparing the same |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2008100473851A CN101274079A (en) | 2008-04-18 | 2008-04-18 | Dogskin plaster and technique of preparing the same |
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| CN101274079A true CN101274079A (en) | 2008-10-01 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102920742A (en) * | 2012-12-03 | 2013-02-13 | 富锦市孝铭科技发展有限公司 | Black plaster and preparation method thereof |
| CN105056099A (en) * | 2015-05-18 | 2015-11-18 | 黄秋 | Formula and production method of ointment for treating lumbago and lumbar vertebrae hyperosteogeny |
| CN107982465A (en) * | 2017-12-22 | 2018-05-04 | 谢清华 | Warming and activating meridian swelling and pain relieving emplastrum and preparation method |
| CN109908112A (en) * | 2019-04-19 | 2019-06-21 | 内蒙古科尔沁药业有限公司 | A kind of rubber paste emplastrum of not allergy and preparation method thereof |
| CN110478492A (en) * | 2019-09-12 | 2019-11-22 | 黑龙江中医药大学 | A kind of black plaster Matrix formulation procedure |
-
2008
- 2008-04-18 CN CNA2008100473851A patent/CN101274079A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102920742A (en) * | 2012-12-03 | 2013-02-13 | 富锦市孝铭科技发展有限公司 | Black plaster and preparation method thereof |
| CN102920742B (en) * | 2012-12-03 | 2015-04-29 | 富锦市孝铭科技发展有限公司 | Black plaster and preparation method thereof |
| CN105056099A (en) * | 2015-05-18 | 2015-11-18 | 黄秋 | Formula and production method of ointment for treating lumbago and lumbar vertebrae hyperosteogeny |
| CN107982465A (en) * | 2017-12-22 | 2018-05-04 | 谢清华 | Warming and activating meridian swelling and pain relieving emplastrum and preparation method |
| CN109908112A (en) * | 2019-04-19 | 2019-06-21 | 内蒙古科尔沁药业有限公司 | A kind of rubber paste emplastrum of not allergy and preparation method thereof |
| CN110478492A (en) * | 2019-09-12 | 2019-11-22 | 黑龙江中医药大学 | A kind of black plaster Matrix formulation procedure |
| CN110478492B (en) * | 2019-09-12 | 2023-06-06 | 黑龙江中医药大学 | Preparation method of black plaster matrix |
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