CN1891219A - 含有瑞舒伐他汀或匹伐他汀和b族维生素的药物组合物 - Google Patents
含有瑞舒伐他汀或匹伐他汀和b族维生素的药物组合物 Download PDFInfo
- Publication number
- CN1891219A CN1891219A CNA2005100808851A CN200510080885A CN1891219A CN 1891219 A CN1891219 A CN 1891219A CN A2005100808851 A CNA2005100808851 A CN A2005100808851A CN 200510080885 A CN200510080885 A CN 200510080885A CN 1891219 A CN1891219 A CN 1891219A
- Authority
- CN
- China
- Prior art keywords
- group
- vitamin
- folic acid
- pharmaceutical composition
- pitavastatin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Abstract
Description
组别 | 剂量(mg/kg) | 主动脉壁斑块面积%均值 | ET(pg/ml) | NO(μmol/L) |
正常对照模型组叶酸组瑞舒伐他汀瑞舒伐他汀+叶酸瑞舒伐他汀+叶酸 | --0.522+0.042+0.5 | 015.2±4.113.9±3.711.6±3.3*8.3±3.1**▲7.9±2.2**▲▲ | 214.3±52.9372.1±76.2325.6±51.0308.4±57.4*256.5±55.6**▲249.1±40.8**▲ | 101.3±38.045.8±12.865.7±20.1**63.5±21.3**82.9±15.5**▲83.8±13.6**▲ |
组别 | 剂量(mg/kg) | 主动脉壁斑块面积%均值 | ET(pg/ml) | NO(μmol/L) |
正常对照模型组叶酸匹伐他汀钙匹伐他汀钙+叶酸匹伐他汀钙+叶酸 | --0.50.20.2+0.040.2+0.5 | 020.4±7.317.4±5.314.4±3.5*12.0±2.6**11.2±2.6**▲ | 156.0±25.3348.2±44.2306.3±52.4293.4±42.7*256.4±36.0**▲247.2±42.4**▲ | 86.2±17.437.8±13.753.0±15.2*57.5±21.9*64.2±26.4**▲62.1±19.3**▲ |
组别 | 剂量(mg/kg) | 主动脉壁斑块面积%均值 | ET(pg/ml) | NO(μmol/L) |
正常对照模型组叶酸瑞舒伐他汀+叶酸匹伐他汀钙+叶酸洛伐他汀+叶酸辛伐他汀+叶酸阿伐他汀+叶酸 | --0.252+0.250.2+0.252+0.251+0.251+0.25 | 020.2±5.517.8±3.110.8±3.1**▲9.9±4.0**▲14.6±4.9**13.7±4.2**13.9±3.7** | 204.4±54.3362.1±63.9307.9±70.4239.5±54.9**▲245.0±42.6**▲302.9±56.1**294.9±33.4**280.9±46.8** | 96.6±21.041.2±15.654.6±15.683.8±14.0**▲82.4±12.3**▲67.1±16.4**65.2±18.2**63.5±15.0** |
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Date of cancellation: 20160705 Granted publication date: 20090624 Pledgee: China Everbright Bank, Limited by Share Ltd, Shenzhen, Bagualing branch Pledgor: Beijing Aosa Medicine Research Centre Co., Ltd. Registration number: 2013990000309 |
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PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
PM01 | Change of the registration of the contract for pledge of patent right |
Change date: 20160705 Registration number: 2013990000309 Pledgee after: China Everbright Bank, Limited by Share Ltd, Shenzhen, Bagualing branch Pledgee before: China Everbright Bank Shenzhen Bagualing branch |
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Address after: 100176 Beijing economic and Technological Development Zone, West Beijing Road, No. 18, block C, room 216 Patentee after: Beijing Aosa Medicine Research Centre Co., Ltd. Address before: 100176 No. 18 West South Road, Beijing economic and Technological Development Zone, C512 Patentee before: Beijing Aosa Medicine Research Centre Co., Ltd. |
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Effective date of registration: 20211229 Address after: 518057 the 1st and 2nd floors of Building 2, phase III of biological incubator, No.16, Gaoxin Zhongyi Road, central high tech Zone, Nanshan District, Shenzhen City, Guangdong Province; the east side of the 1st floor and the 2nd and 3rd floors of building 3 Patentee after: SHENZHEN AUSA PHARMACEUTICAL Co.,Ltd. Address before: 100176 room 216, block C, 18 West Ring Road, Beijing economic and Technological Development Zone, Beijing. Patentee before: Beijng Aosa Medical Research Center, Inc. |
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TR01 | Transfer of patent right |