CN1870978A - 用于形成药物和聚合物的固体无定形分散体的喷雾干燥方法 - Google Patents
用于形成药物和聚合物的固体无定形分散体的喷雾干燥方法 Download PDFInfo
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Abstract
Description
堆积性能 | 植 |
堆积比容(cc/g) | 4.1 |
敲击比容(cc/g) | 2.6 |
Hausner比例 | 1.58 |
平均粒径(μm) | 50 |
D10、D50、D90(μm) | 16.4,45.8,90.1 |
跨距(D90-D10)/D50 | 1.6 |
残留丙酮 | 4.5% |
*10vol%颗粒具有直径小于D10;50vol%颗粒具有直径小于D50、90vol%颗粒具有直径小于D90 |
实施例 | 干燥气体流速(g/min) | 液体加料速率(g/min) | 喷嘴压力(Psi) | 入口温度(℃) | 出口温度(℃) | 冷凝器出口温度(℃) | 丙酮分压(mmHg) |
1 | 1280 | 280 | 550 | 132 | 37 | -18 | 25.0 |
2 | 1277 | 280 | 550 | 133 | 39 | -9.4 | 41.8 |
3 | 1260 | 280 | 550 | 130 | 38 | -1.2 | 65.8 |
4 | 1270 | 280 | 550 | 134 | 39 | 8.9 | 110.3 |
堆积性能 | 实施例1 | 实施例2 | 实施例3 | 实施例4 |
堆积比容(cc/g) | 4.1 | 4.0 | 3.9 | 3.8 |
敲击比容(cc/g) | 2.6 | 2.6 | 2.4 | 2.4 |
Hausner比例 | 1.58 | 1.54 | 1.63 | 1.58 |
平均粒径(μm) | 50 | 49.2 | 45.7 | 46.2 |
D10,D50,D90(μm) | 16.4,45.8,90.1 | 16.3,44.9,88.9 | 14.6,41.6,83 | 15.6,42.2,83.1 |
跨距(D90-D10)/D50 | 1.6 | 1.6 | 1.6 | 1.6 |
残留丙酮 | 4.5% | 3.4% | 3.1% | 4.8% |
实施例 | 干燥气体流速(m/hr) | 液体加料速率(kg/hr) | 喷嘴压力(Psi) | 入口温度(℃) | 出口温度(℃) | 冷凝器出口温度(℃) | 丙酮分压(mmHg) |
5 | 530 | 70 | 700 | 115 | 40 | -20 | 22.0 |
6 | 560 | 70 | 700 | 102 | 40 | 0 | 70.1 |
堆积性能 | 实施例5 | 实施例6 |
堆积比容(cc/g) | 4.2 | 3.9 |
敲击比容(cc/g) | 2.5 | 2.3 |
Hausner比例 | 1.68 | 1.70 |
平均粒径(μm) | 74 | 77 |
D10,D50,D90(μm) | 26,67,134 | 23,64,131 |
跨距(D90-D10)/D50 | 1.60 | 1.68 |
残留丙酮 | 5.4% | 3.5% |
Claims (15)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49240703P | 2003-08-04 | 2003-08-04 | |
US60/492,407 | 2003-08-04 | ||
US60/568,989 | 2004-05-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN1870978A true CN1870978A (zh) | 2006-11-29 |
Family
ID=34115617
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA2004800290032A Pending CN1863511A (zh) | 2003-08-04 | 2004-07-21 | 提供控制释放的胆固醇酯转移蛋白抑制剂以及立即释放的HMG-CoA还原酶抑制剂的剂型 |
CNA2004800218379A Pending CN1870978A (zh) | 2003-08-04 | 2004-07-27 | 用于形成药物和聚合物的固体无定形分散体的喷雾干燥方法 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA2004800290032A Pending CN1863511A (zh) | 2003-08-04 | 2004-07-21 | 提供控制释放的胆固醇酯转移蛋白抑制剂以及立即释放的HMG-CoA还原酶抑制剂的剂型 |
Country Status (16)
Country | Link |
---|---|
US (1) | US20050038007A1 (zh) |
EP (1) | EP1653926A1 (zh) |
JP (1) | JP2007501217A (zh) |
KR (1) | KR20060033033A (zh) |
CN (2) | CN1863511A (zh) |
AR (1) | AR045203A1 (zh) |
AU (1) | AU2004261058A1 (zh) |
BR (1) | BRPI0413363A (zh) |
CA (1) | CA2534371A1 (zh) |
IL (1) | IL172875A0 (zh) |
MX (1) | MXPA06001506A (zh) |
NO (1) | NO20061072L (zh) |
RU (1) | RU2006102981A (zh) |
TW (1) | TW200517145A (zh) |
WO (1) | WO2005011634A1 (zh) |
ZA (2) | ZA200600179B (zh) |
Cited By (6)
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CN103037946A (zh) * | 2010-07-29 | 2013-04-10 | 田边工业株式会社 | 减压喷雾干燥方法及减压喷雾干燥装置 |
CN105007899A (zh) * | 2012-12-20 | 2015-10-28 | 卡希夫制药有限责任公司 | 用于提高生物利用度的口腔崩解片制剂 |
CN107019927A (zh) * | 2017-04-18 | 2017-08-08 | 成都绿林科技有限公司 | 用于药品快速干燥的干燥机 |
CN109663373A (zh) * | 2018-12-26 | 2019-04-23 | 无锡市林洲干燥设备有限公司 | 甲维盐闭式循环喷雾干燥系统 |
CN110773079A (zh) * | 2019-11-18 | 2020-02-11 | 江苏博迁新材料股份有限公司 | 一种超声喷雾法制备超细粉球的方法 |
CN115724771A (zh) * | 2021-08-30 | 2023-03-03 | 中国科学院过程工程研究所 | 一种用于制备n,n’-二苯基脲的装置系统及制备n,n’-二苯基脲的工艺 |
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- 2004-07-21 CN CNA2004800290032A patent/CN1863511A/zh active Pending
- 2004-07-21 WO PCT/IB2004/002457 patent/WO2005011634A1/en active Application Filing
- 2004-07-21 MX MXPA06001506A patent/MXPA06001506A/es unknown
- 2004-07-21 AU AU2004261058A patent/AU2004261058A1/en not_active Abandoned
- 2004-07-21 RU RU2006102981/15A patent/RU2006102981A/ru not_active Application Discontinuation
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- 2004-07-21 EP EP04744109A patent/EP1653926A1/en not_active Withdrawn
- 2004-07-21 JP JP2006522426A patent/JP2007501217A/ja active Pending
- 2004-07-27 CN CNA2004800218379A patent/CN1870978A/zh active Pending
- 2004-07-30 US US10/903,433 patent/US20050038007A1/en not_active Abandoned
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2006
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Cited By (7)
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CN103037946A (zh) * | 2010-07-29 | 2013-04-10 | 田边工业株式会社 | 减压喷雾干燥方法及减压喷雾干燥装置 |
CN103037946B (zh) * | 2010-07-29 | 2015-07-22 | 田边工业株式会社 | 减压喷雾干燥方法及减压喷雾干燥装置 |
CN105007899A (zh) * | 2012-12-20 | 2015-10-28 | 卡希夫制药有限责任公司 | 用于提高生物利用度的口腔崩解片制剂 |
CN107019927A (zh) * | 2017-04-18 | 2017-08-08 | 成都绿林科技有限公司 | 用于药品快速干燥的干燥机 |
CN109663373A (zh) * | 2018-12-26 | 2019-04-23 | 无锡市林洲干燥设备有限公司 | 甲维盐闭式循环喷雾干燥系统 |
CN110773079A (zh) * | 2019-11-18 | 2020-02-11 | 江苏博迁新材料股份有限公司 | 一种超声喷雾法制备超细粉球的方法 |
CN115724771A (zh) * | 2021-08-30 | 2023-03-03 | 中国科学院过程工程研究所 | 一种用于制备n,n’-二苯基脲的装置系统及制备n,n’-二苯基脲的工艺 |
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NO20061072L (no) | 2006-05-04 |
ZA200600853B (en) | 2007-04-25 |
IL172875A0 (en) | 2006-06-11 |
TW200517145A (en) | 2005-06-01 |
KR20060033033A (ko) | 2006-04-18 |
AU2004261058A1 (en) | 2005-02-10 |
CA2534371A1 (en) | 2005-02-10 |
JP2007501217A (ja) | 2007-01-25 |
RU2006102981A (ru) | 2007-09-20 |
BRPI0413363A (pt) | 2006-10-10 |
ZA200600179B (en) | 2007-02-28 |
EP1653926A1 (en) | 2006-05-10 |
AR045203A1 (es) | 2005-10-19 |
CN1863511A (zh) | 2006-11-15 |
MXPA06001506A (es) | 2006-05-15 |
US20050038007A1 (en) | 2005-02-17 |
WO2005011634A1 (en) | 2005-02-10 |
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