AR045203A1 - Formas de dosificacion de inhibidores de la proteina de transferencia de colesteril ester e inhibidores de la hmg-coa reductosa - Google Patents
Formas de dosificacion de inhibidores de la proteina de transferencia de colesteril ester e inhibidores de la hmg-coa reductosaInfo
- Publication number
- AR045203A1 AR045203A1 ARP040102760A ARP040102760A AR045203A1 AR 045203 A1 AR045203 A1 AR 045203A1 AR P040102760 A ARP040102760 A AR P040102760A AR P040102760 A ARP040102760 A AR P040102760A AR 045203 A1 AR045203 A1 AR 045203A1
- Authority
- AR
- Argentina
- Prior art keywords
- inhibitors
- coa
- cholesteril
- protein
- ester
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Una forma de dosificación que comprende un inhibidor de la proteína de transferencia de colesteril éster como por ejemplo torcetrapib, entre otras, en una forma de solubilidad mejorada y un inhibidor de la HMG-CoA reductasa, donde la forma de dosificación proporciona la liberación inmediata del inhibidor de la HMG-CoA reductasa como por ejemplo atorvastatín, entre otros, y la liberación controlada del inhibidor de la proteína de transferencia de colesteril éster.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49240703P | 2003-08-04 | 2003-08-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR045203A1 true AR045203A1 (es) | 2005-10-19 |
Family
ID=34115617
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040102760A AR045203A1 (es) | 2003-08-04 | 2004-08-03 | Formas de dosificacion de inhibidores de la proteina de transferencia de colesteril ester e inhibidores de la hmg-coa reductosa |
Country Status (16)
Country | Link |
---|---|
US (1) | US20050038007A1 (es) |
EP (1) | EP1653926A1 (es) |
JP (1) | JP2007501217A (es) |
KR (1) | KR20060033033A (es) |
CN (2) | CN1863511A (es) |
AR (1) | AR045203A1 (es) |
AU (1) | AU2004261058A1 (es) |
BR (1) | BRPI0413363A (es) |
CA (1) | CA2534371A1 (es) |
IL (1) | IL172875A0 (es) |
MX (1) | MXPA06001506A (es) |
NO (1) | NO20061072L (es) |
RU (1) | RU2006102981A (es) |
TW (1) | TW200517145A (es) |
WO (1) | WO2005011634A1 (es) |
ZA (2) | ZA200600179B (es) |
Families Citing this family (59)
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TWI393560B (zh) * | 2003-05-02 | 2013-04-21 | Japan Tobacco Inc | 包含s-〔2(〔〔1-(2-乙基丁基)環己基〕羰基〕胺基)苯基〕2-甲基丙烷硫酯及hmg輔酶a還原酶抑制劑之組合 |
WO2005041869A2 (en) * | 2003-10-24 | 2005-05-12 | Josef Rettenmaier & Soehne Gmbh & Co., Kg | Process for co-spray drying agents with dry silicified mcc |
US8604055B2 (en) | 2004-12-31 | 2013-12-10 | Dr. Reddy's Laboratories Ltd. | Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors |
CA2605214C (en) | 2004-12-31 | 2016-07-12 | Reddy Us Therapeutics, Inc. | Benzylamine derivatives as cetp inhibitors |
US20080145427A1 (en) * | 2005-02-03 | 2008-06-19 | Alfred Berchielli | Dosage Forms Providing Controlled and Immediate Release of Cholesteryl Ester Transfer Protein Inhibitors and Immediate Release of Hmg-Coa Reductase Inhibitors |
US7737155B2 (en) | 2005-05-17 | 2010-06-15 | Schering Corporation | Nitrogen-containing heterocyclic compounds and methods of use thereof |
CN1331476C (zh) * | 2005-07-05 | 2007-08-15 | 凌沛学 | 一种辅酶a舌下含片及其制备方法 |
WO2007067593A2 (en) * | 2005-12-05 | 2007-06-14 | Merck & Co., Inc. | Self-emulsifyng formulations of cetp inhibitors |
KR100742571B1 (ko) * | 2006-03-02 | 2007-07-25 | 충남대학교산학협력단 | 초임계유체 공정을 이용한 무정형 아토르바스타틴 칼슘염및 그 제조방법 |
EP2007346A1 (en) * | 2006-05-08 | 2008-12-31 | McNeil-PPC, Inc. | Osmotic dosage form |
WO2008065502A1 (en) * | 2006-11-29 | 2008-06-05 | Pfizer Products Inc. | Pharmaceutical compositions based on a) nanoparticles comprising enteric polymers and b) casein |
KR100885029B1 (ko) * | 2007-02-07 | 2009-02-23 | 지엘팜텍 주식회사 | 경구투여용 서방성 삼중정제 |
WO2008115529A1 (en) * | 2007-03-20 | 2008-09-25 | Reliant Pharmaceuticals, Inc. | Compositions comprising omega-3 fatty acids and cetp inhibitors |
WO2008135855A2 (en) * | 2007-05-03 | 2008-11-13 | Pfizer Products Inc. | Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and a nonionizable polymer |
US20100215747A1 (en) * | 2007-07-13 | 2010-08-26 | Corey Jay Bloom | Nanoparticles comprising ionizable, poorly water soluble cellulosic polymers |
TW201016761A (en) * | 2008-10-30 | 2010-05-01 | Univ Nat Taiwan | Microporous film and preparation and use thereof |
EP2379562A1 (en) | 2008-12-16 | 2011-10-26 | Schering Corporation | Bicyclic pyranone derivatives as nicotinic acid receptor agonists |
EP2379547A1 (en) | 2008-12-16 | 2011-10-26 | Schering Corporation | Pyridopyrimidine derivatives and methods of use thereof |
MX2011013080A (es) | 2009-06-16 | 2012-01-20 | Pfizer | Formas de dosis de apixaban. |
US20130029970A1 (en) | 2009-07-10 | 2013-01-31 | Ironwood Pharmaceuticals, Inc | CB Receptor Agonists |
EP2473515A4 (en) | 2009-09-04 | 2013-11-27 | Univ Toledo | METHODS OF MAKING OPTICALLY PURE BETA-LACTONES FROM ALDEHYDES AND COMPOSITIONS OBTAINED THEREFROM |
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BR112012033341B1 (pt) | 2010-06-30 | 2022-08-23 | Cyclerion Therapeutics, Inc | Estimulantes de sgc |
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US9308190B2 (en) | 2011-06-06 | 2016-04-12 | Warsaw Orthopedic, Inc. | Methods and compositions to enhance bone growth comprising a statin |
EP2744803A2 (en) | 2011-08-18 | 2014-06-25 | Dr. Reddy's Laboratories Ltd. | Substituted heterocyclic amine compounds as cholestryl ester-transfer protein (cetp) inhibitors |
JP6140168B2 (ja) | 2011-09-27 | 2017-05-31 | ドクター レディズ ラボラトリーズ リミテッド | アテローム性動脈硬化症の処置のために有用なコレステリルエステル転送タンパク質(cetp)インヒビターとしての5−ベンジルアミノメチル−6−アミノピラゾロ[3,4−b]ピリジン誘導体 |
EP2797915B1 (en) | 2011-12-27 | 2016-07-13 | Ironwood Pharmaceuticals, Inc. | 2-benzyl-3-(oxazole/thiazole)-5-(pyrimidin-2-yl)-1(H)-pyrazole derivatives as stimulators of the soluble guanylate cyclase (sGC) for the treatment of e.g. hypertension or heart failure |
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KR101986683B1 (ko) * | 2012-12-13 | 2019-06-10 | 한미약품 주식회사 | 테트라졸 유도체를 활성 성분으로 포함하는 용해도가 개선된 고체 분산체 |
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US10300059B2 (en) * | 2014-08-28 | 2019-05-28 | Dezima Pharma B.V. | Pharmaceutical composition and therapeutic combination comprising a cholesteryl ester transfer protein inhibitor and HMG CoA reductase inhibitors |
US20170291889A1 (en) | 2014-09-17 | 2017-10-12 | Ironwood Pharmaceuticals, Inc. | Pyrazole derivatives as sgc stimulators |
US10844064B2 (en) | 2014-09-17 | 2020-11-24 | Cyclerion Therapeutics, Inc. | sGC stimulators |
WO2016044445A2 (en) | 2014-09-17 | 2016-03-24 | Ironwood Pharmaceuticals, Inc. | sGC STIMULATORS |
JP7050759B2 (ja) | 2016-09-02 | 2022-04-08 | サイクレリオン・セラピューティクス,インコーポレーテッド | 縮合二環式sgc刺激剤 |
US11690828B2 (en) | 2016-11-08 | 2023-07-04 | Cyclerion Therapeutics, Inc. | Treatment of CNS diseases with sGC stimulators |
EP3538520A2 (en) | 2016-11-08 | 2019-09-18 | Cyclerion Therapeutics, Inc. | Sgc stimulators |
CN107019927A (zh) * | 2017-04-18 | 2017-08-08 | 成都绿林科技有限公司 | 用于药品快速干燥的干燥机 |
CN109663373A (zh) * | 2018-12-26 | 2019-04-23 | 无锡市林洲干燥设备有限公司 | 甲维盐闭式循环喷雾干燥系统 |
CN110773079B (zh) * | 2019-11-18 | 2022-03-01 | 江苏博迁新材料股份有限公司 | 一种超声喷雾法制备超细粉球的方法 |
CN115724771A (zh) * | 2021-08-30 | 2023-03-03 | 中国科学院过程工程研究所 | 一种用于制备n,n’-二苯基脲的装置系统及制备n,n’-二苯基脲的工艺 |
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JP2004534822A (ja) * | 2001-06-22 | 2004-11-18 | ファイザー・プロダクツ・インク | 低溶解度および/または酸感受性の薬剤と中和された酸性ポリマーとを含む医薬組成物 |
ATE444060T1 (de) * | 2001-06-22 | 2009-10-15 | Pfizer Prod Inc | Pharmazeutische zusammensetzungen enthaltend dispersionen aus arzneistoffen und neutralen polymeren |
-
2004
- 2004-07-21 MX MXPA06001506A patent/MXPA06001506A/es unknown
- 2004-07-21 BR BRPI0413363-3A patent/BRPI0413363A/pt not_active IP Right Cessation
- 2004-07-21 CN CNA2004800290032A patent/CN1863511A/zh active Pending
- 2004-07-21 KR KR1020067002353A patent/KR20060033033A/ko not_active Application Discontinuation
- 2004-07-21 AU AU2004261058A patent/AU2004261058A1/en not_active Abandoned
- 2004-07-21 RU RU2006102981/15A patent/RU2006102981A/ru not_active Application Discontinuation
- 2004-07-21 EP EP04744109A patent/EP1653926A1/en not_active Withdrawn
- 2004-07-21 CA CA002534371A patent/CA2534371A1/en not_active Abandoned
- 2004-07-21 WO PCT/IB2004/002457 patent/WO2005011634A1/en active Application Filing
- 2004-07-21 JP JP2006522426A patent/JP2007501217A/ja active Pending
- 2004-07-27 CN CNA2004800218379A patent/CN1870978A/zh active Pending
- 2004-07-30 US US10/903,433 patent/US20050038007A1/en not_active Abandoned
- 2004-08-03 TW TW093123237A patent/TW200517145A/zh unknown
- 2004-08-03 AR ARP040102760A patent/AR045203A1/es not_active Application Discontinuation
-
2005
- 2005-12-28 IL IL172875A patent/IL172875A0/en unknown
-
2006
- 2006-01-06 ZA ZA200600179A patent/ZA200600179B/en unknown
- 2006-01-30 ZA ZA200600853A patent/ZA200600853B/en unknown
- 2006-03-06 NO NO20061072A patent/NO20061072L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
RU2006102981A (ru) | 2007-09-20 |
CA2534371A1 (en) | 2005-02-10 |
CN1863511A (zh) | 2006-11-15 |
TW200517145A (en) | 2005-06-01 |
JP2007501217A (ja) | 2007-01-25 |
MXPA06001506A (es) | 2006-05-15 |
NO20061072L (no) | 2006-05-04 |
US20050038007A1 (en) | 2005-02-17 |
ZA200600179B (en) | 2007-02-28 |
IL172875A0 (en) | 2006-06-11 |
AU2004261058A1 (en) | 2005-02-10 |
WO2005011634A1 (en) | 2005-02-10 |
ZA200600853B (en) | 2007-04-25 |
KR20060033033A (ko) | 2006-04-18 |
EP1653926A1 (en) | 2006-05-10 |
BRPI0413363A (pt) | 2006-10-10 |
CN1870978A (zh) | 2006-11-29 |
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