CN1857535A - Medicine for treating cerebral infraction and its preparing method - Google Patents
Medicine for treating cerebral infraction and its preparing method Download PDFInfo
- Publication number
- CN1857535A CN1857535A CNA2006100387486A CN200610038748A CN1857535A CN 1857535 A CN1857535 A CN 1857535A CN A2006100387486 A CNA2006100387486 A CN A2006100387486A CN 200610038748 A CN200610038748 A CN 200610038748A CN 1857535 A CN1857535 A CN 1857535A
- Authority
- CN
- China
- Prior art keywords
- medicine
- rhizoma
- cerebral infarction
- volatile oil
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention provides medicine for treating cerebral infarction and its preparation process, and the medicine has high curative effect and no toxic side effect. Technologically, the medicine for treating cerebral infarction is prepared with astragalus root, grassleaved sweetflag, Chuanxiong rhizome, earthworm, corydalis tuber, oriental water plantain and spatholobus stem in certain weight proportion. Animal test proves its clinical application safety and low toxicity. The clinical application shows that the medicine has high curative effect on cerebral infarction, coronary heart disease, angina, myocardial infarction, etc.
Description
Technical field: the present invention relates to a kind of Chinese medicine and preparation method thereof, particularly a kind of medicine for the treatment of cerebral infarction and preparation method thereof.
Background technology: cerebral infarction belongs to traditional Chinese medical science apoplexy category, has another name called apoplexy.Because of the primary disease onset hurried, card is seen multiterminal, change rapidly, feature similarity with the change of wind having the nature of shifting number, so with the apoplexy name it, its cause of disease is patient deficiency of qi and blood and conscience kidney three dirty imbalance of YIN and YANG usually, is worried angry or inducement such as exopathogen invasion and attack in addition, so that QI-blood circulation is obstructed, and skin muscle arteries and veins loses in moistening and supports or hold expectorant under the arm and hold fire under the arm; Hoodwink clearly deficiency and excess folder negative and positive such as key and critical syndrome such as do not maintain mutually." danxi's experiential therapy " cloud: " the big rate master's blood deficiency of apoplexy has expectorant, controls expectorant for earlier, and inferior nourishing and enriching blood, or deficiency and excess are held fire under the arm with wet, must divide deficiency of vital energy blood deficiency again.Hemiplegia, big rate excessive phlegm belongs to dead blood stasis blood on a left side, and belonging to expectorant on the right side has heat, and the deficiency of vital energy." the clinical apoplex involving the channels and collaterals that is divided into, middle internal organs two big classes.The cerebral infarction patient belongs to apoplex involving the channels and collaterals one class more.The apoplex involving the channels and collaterals medicine typing often is divided into collaterals being void and defenceless, blood-vessel obstructive, and during ailment said due to cold or exposure is gone into and the hepatic and renal YIN deficiency, wind-yang and up-boring etc.Its symptom is that hemiplegia is unable, facial hemiparalysis, and slurred speech, hypomnesis, uncomfortable in chest, cardiopalmus, shortness of breath and fatigue etc.At present, still lack effective Drug therapy at above disease clinically.
Summary of the invention: technical problem to be solved by this invention is: provide a kind of curative effect better, and safely, the medicine of the treatment cerebral infarction that has no side effect and preparation method thereof.Its technical scheme is:
A kind of medicine for the treatment of cerebral infarction is characterized in that it is the medicament of being made by the raw material of following weight parts: Radix Astragali 20-30, Rhizoma Acori Graminei 10-20, Rhizoma Chuanxiong 10-20, Pheretima 10-20, Rhizoma Corydalis 10-20, Rhizoma Alismatis 20-30 and Caulis Spatholobi 20-30.
Radix Astragali sweet in the mouth, little wet is gone into spleen, lung meridian in the side, has key spleen QI invigorating function, and is effective to the card of the deficiency of vital energys such as numb limbs and tense tendons, hemiplegia, spontaneous sweating due to deficiency of QI.
Rhizoma Chuanxiong suffering, temperature are returned liver, gallbladder, pericardium channel, have the effect of blood-activating and qi-promoting, wind-expelling pain-stopping.
Rhizoma Acori Graminei acrid in the mouth, hardship, temperature, GUIXIN, stomach warp have the effect of the eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.
Pheretima salty in the mouth, cold is returned liver, spleen, urinary bladder channel, has the effect of endogenous wind stopping pain relieving, collateral dredging diuresis.
Caulis Spatholobi property bitter but sweet flavor, temperature are returned liver, urinary bladder channel, have the effect of circulation of qi promoting QI invigorating, relaxing muscles and tendons and activating QI and blood in the collateral.
Rhizoma Corydalis acrid in the mouth, hardship, temperature are returned liver, spleen channel, have invigorate blood circulation, the effect of circulation of qi promoting, pain relieving.
Its preparation method is:
1) Rhizoma Chuanxiong, Rhizoma Acori Graminei are added water or aquiferous ethanol and soak after 2 hours, volatile oil is collected in distillation; Volatile oil cold preservation after filtering is standby;
2) after the medicinal residues that extracted Rhizoma Chuanxiong, the Rhizoma Acori Graminei of volatile oil are together soaked 1 hour with the Radix Astragali, Pheretima, Rhizoma Corydalis, Rhizoma Alismatis, Caulis Spatholobi again, decoct each 1 hour 3 times; Merge decoction liquor, concentrate, put coldly, add ethanol, stir, precipitation, the leaching supernatant discards precipitation;
3) after filtrate decompression concentrates and reclaims ethanol, cool off, add pure water and stir evenly, cold preservation, centrifugal, discard precipitation, add above-mentioned steps 1) the middle volatile oil that obtains that extracts, and stir evenly, adjust pH value to 5.0-7.0, get extracts active ingredients liquid.
The production method of oral liquid medicine is:
Above-mentioned extracts active ingredients liquid is added cyclamate, stir evenly, add distilled water, stir evenly, measuring its density is 1.0-1.2, and pH value is 5.0-7.0, fine straining, and embedding, in sterilization in 105 ℃, 30 minutes, both.
Medicament of the present invention can also be the dosage form of administering modes such as suitable oral, the rectally made according to the conventional method on the pharmaceutics, intramuscular injection.As: said dosage form on any pharmaceuticss such as tablet, capsule, unguentum, patch, injection.
Oral liquid of the present invention (commodity stilbene vault brain plug by name is logical) medicament, show through acute toxicity test: do not have a dead mouse after giving the mouse stomach administration, the hair color of mice, activity, feed, defecation etc. are all normal, and weight increase is obvious.Its maximum dosage-feeding is 140g crude drug/kg, calculates by kg body weight, is equivalent to clinical Coming-of-Age Day consumption 37.5g crude drug (224 times of 0.625g crude drug/kg), pressing body surface area calculates, be equivalent to 28 times of 4.875g crude drug/kg, illustrate that this medicament toxicity is low, clinical practice is safer.
Diagnostic criteria through 52 examples are determined according to Chinese Medical Association in 1986 cerebrovascular academic conference is for the second time also carried out clinical treatment observation, wherein male 47 examples, women 5 examples through the Cerebral Infarction Patients that head CT scanning turns out to be the internal carotid artery system; Age 45-76 year, 60.64 ± 8.22 years old mean age; Burst patient 24 examples are sent out patient's 28 examples gradually; The course of disease 40.24 ± 21.4d.Every day three times, each 10ml (containing crude drug 3g/ml) are oral on an empty stomach, and 14 days is a course of treatment.According to the efficacy assessment standard that Chinese Medical Association's cerebrovascular academic conference for the second time in 1986 is determined, 10 examples of wherein fully recovering account for 19.23%; Marked improvement 17 examples account for 32.69%; Progressive 18 examples account for 34.62%; No change 7 examples account for 13.46%; Total effective rate is 86.54%.Illustrate that this medicament is unable to the hemiplegia due to treatment cerebral infarction, coronary heart disease, angina pectoris, the myocardial infarction etc., facial hemiparalysis, slurred speech, hypomnesis, uncomfortable in chest, cardiopalmus, the curative effect of diseases such as shortness of breath and fatigue is better.
The specific embodiment:
Embodiment 1.Get Rhizoma Chuanxiong 10kg, Rhizoma Acori Graminei 10kg, soak 2 hours after, distillation is 4 hours under 50 ℃ of temperature, pressure-0.8Kpa condition, collects volatile oil; Volatile oil cold preservation after filtering is standby; Extracted volatile oil Rhizoma Chuanxiong, Rhizoma Acori Graminei medicinal residues again with Radix Astragali 20kg, Pheretima 10kg, Rhizoma Corydalis 10kg after Rhizoma Alismatis 30kg and Caulis Spatholobi 20kg together soak 1 hour, decocts each 1 hour 3 times; Merge decoction liquor, concentrate, put coldly, add ethanol, adjust it and contain the alcohol amount about 50%, stir, precipitation, the leaching supernatant discards precipitation; After filtrate decompression concentrated and reclaims ethanol, cooling added pure water and stirs evenly, and cold preservation is centrifugal, discards precipitation, adds the volatile oil of above-mentioned Rhizoma Chuanxiong that has extracted and Rhizoma Acori Graminei, stirred evenly, and adjusted pH value to 5.0-7.0, got extracts active ingredients liquid.Extracts active ingredients liquid adds cyclamate, stirs evenly, and adds distilled water to full dose, stirs evenly, and measuring its density is 1.0-1.2, and pH value is 5.0-7.0, fine straining, and embedding in sterilization in 105 ℃, 30 minutes, gets oral liquid medicine.
Embodiment 2.Get Rhizoma Chuanxiong 15kg, Rhizoma Acori Graminei 15kg, soak 2 hours after, distillation is 4 hours under 50 ℃ of temperature, pressure-0.8Kpa condition, collects volatile oil; Volatile oil cold preservation after filtering is standby; Extracted volatile oil Rhizoma Chuanxiong, Rhizoma Acori Graminei medicinal residues again with Radix Astragali 25kg, Pheretima 15kg, Rhizoma Corydalis 15kg after Rhizoma Alismatis 25kg and Caulis Spatholobi 25kg together soak 1 hour, decocts each 1 hour 3 times; Merge decoction liquor, concentrate, put coldly, add ethanol, adjust it and contain the alcohol amount about 50%, stir, precipitation, the leaching supernatant discards precipitation; After filtrate decompression concentrated and reclaims ethanol, cooling added pure water and stirs evenly, and cold preservation is centrifugal, discards precipitation, adds the volatile oil of above-mentioned Rhizoma Chuanxiong that has extracted and Rhizoma Acori Graminei, stirred evenly, and adjusted pH value to 5.0-7.0, got extracts active ingredients liquid.Extracts active ingredients liquid adds cyclamate, stirs evenly, and adds distilled water to full dose, stirs evenly, and measuring its density is 1.0-1.2, and pH value is 5.0-7.0, fine straining, and embedding in sterilization in 105 ℃, 30 minutes, gets oral liquid medicine.
Embodiment 3.Get Rhizoma Chuanxiong 20kg, Rhizoma Acori Graminei 20kg, soak 2 hours after, distillation is 4 hours under 50 ℃ of temperature, pressure-0.8Kpa condition, collects volatile oil; Volatile oil cold preservation after filtering is standby; Extracted volatile oil Rhizoma Chuanxiong, Rhizoma Acori Graminei medicinal residues again with Radix Astragali 30kg, Pheretima 20kg, Rhizoma Corydalis 20kg after Rhizoma Alismatis 20kg and Caulis Spatholobi 30kg together soak 1 hour, decocts each 1 hour 3 times; Merge decoction liquor, concentrate, put coldly, add ethanol, adjust it and contain the alcohol amount about 50%, stir, precipitation, the leaching supernatant discards precipitation; After filtrate decompression concentrated and reclaims ethanol, cooling added pure water and stirs evenly, and cold preservation is centrifugal, discards precipitation, adds the volatile oil of above-mentioned Rhizoma Chuanxiong that has extracted and Rhizoma Acori Graminei, stirred evenly, and adjusted pH value to 5.0-7.0, got extracts active ingredients liquid.Extracts active ingredients liquid adds cyclamate, stirs evenly, and adds distilled water to full dose, stirs evenly, and measuring its density is 1.0-1.2, and pH value is 5.0-7.0, fine straining, and embedding in sterilization in 105 ℃, 30 minutes, gets oral liquid medicine.
Claims (4)
1, a kind of medicine for the treatment of cerebral infarction is characterized in that it is the medicament of being made by the raw material of following weight parts: Radix Astragali 20-30, Rhizoma Acori Graminei 10-20, Rhizoma Chuanxiong 10-20, Pheretima 10-20, Rhizoma Corydalis 10-20, Rhizoma Alismatis 20-30 and Caulis Spatholobi 20-30.
2, a kind of medicine for the treatment of cerebral infarction according to claim 1 is characterized in that described medicament is a said dosage form on any pharmaceutics.
3, a kind of medicine for the treatment of cerebral infarction according to claim 2 is characterized in that described medicament is an oral liquid.
4, a kind of preparation method of medicine of treatment cerebral infarction as claimed in claim 1 is characterized in that the step of its extracts active ingredients is:
1) Rhizoma Chuanxiong, Rhizoma Acori Graminei are added water or aquiferous ethanol and soak after 2 hours, volatile oil is collected in distillation; Volatile oil cold preservation after filtering is standby;
2) after the medicinal residues that extracted Rhizoma Chuanxiong, the Rhizoma Acori Graminei of volatile oil are together soaked 1 hour with the Radix Astragali, Pheretima, Rhizoma Corydalis, Rhizoma Alismatis, Caulis Spatholobi again, decoct each 1 hour 3 times; Merge decoction liquor, concentrate, put coldly, add ethanol, stir, precipitation, the leaching supernatant discards precipitation;
3) after filtrate decompression concentrate to reclaim ethanol, cooling added pure water and stirs evenly, and cold preservation is centrifugal, discards precipitation, added above-mentioned steps 1) in extract the volatile oil that obtains, stir evenly, adjust pH value and get extracts active ingredients liquid to 5.0-7.0.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100387486A CN100415262C (en) | 2006-03-06 | 2006-03-06 | Medicine for treating cerebral infraction and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100387486A CN100415262C (en) | 2006-03-06 | 2006-03-06 | Medicine for treating cerebral infraction and its preparing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1857535A true CN1857535A (en) | 2006-11-08 |
| CN100415262C CN100415262C (en) | 2008-09-03 |
Family
ID=37296523
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006100387486A Expired - Fee Related CN100415262C (en) | 2006-03-06 | 2006-03-06 | Medicine for treating cerebral infraction and its preparing method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100415262C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105617274A (en) * | 2016-02-22 | 2016-06-01 | 林警辉 | Composition with effects of regulating qi and activating blood circulation and preparation method thereof |
| CN115813972A (en) * | 2022-09-23 | 2023-03-21 | 梅小平 | Zhuang medicine compound medicine for treating ischemic stroke in acute stage and preparation method thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1056296C (en) * | 1996-12-26 | 2000-09-13 | 郭贵江 | Capsule for apoplexy |
| CN1260988A (en) * | 1999-01-15 | 2000-07-26 | 王文安 | Chinese-medicinal pill for treating apoplexy and hemiplegia |
| CN1124153C (en) * | 2001-08-31 | 2003-10-15 | 石家庄以岭药业股份有限公司 | Medicinal composition for restoring cardiac collaterals and its application |
| CN1209142C (en) * | 2003-01-07 | 2005-07-06 | 张廷河 | Rongshuan jiannaokang thrombolytic |
| CN1298346C (en) * | 2003-04-18 | 2007-02-07 | 侯增光 | Dynamic medicine for channels and collaterals and blood vessel |
-
2006
- 2006-03-06 CN CNB2006100387486A patent/CN100415262C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105617274A (en) * | 2016-02-22 | 2016-06-01 | 林警辉 | Composition with effects of regulating qi and activating blood circulation and preparation method thereof |
| CN115813972A (en) * | 2022-09-23 | 2023-03-21 | 梅小平 | Zhuang medicine compound medicine for treating ischemic stroke in acute stage and preparation method thereof |
| CN115813972B (en) * | 2022-09-23 | 2023-09-12 | 梅小平 | Zhuang medicine compound medicine for treating acute stage of ischemic stroke and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100415262C (en) | 2008-09-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102078520B (en) | Chinese medicinal preparation for treating nervous headache and preparation method thereof | |
| CN102283999B (en) | Traditional Chinese medicine preparation for treating insomnia | |
| CN102895349A (en) | Traditional Chinese medicine tea for treating hypertension, hyperlipidemia and hyperglycemia | |
| CN1943769A (en) | An external pharmaceutical for treatment of arrhythmia, coronary heart disease and angina pectoris | |
| CN102512552B (en) | Traditional Chinese medicine composition for treating exogenous fever | |
| CN104083438A (en) | Balsam pear-containing traditional Chinese medicinal preparation for alleviating hypertension, and preparation method thereof | |
| CN100415262C (en) | Medicine for treating cerebral infraction and its preparing method | |
| CN105687788A (en) | Pharmaceutical composition capable of softening blood vessels and application thereof | |
| CN103920058A (en) | Traditional Chinese medicine preparation for treating headache and preparation method thereof | |
| CN104306636A (en) | Ginseng root-desert cistanche kidney warming and kidney nourishing compound preparation | |
| CN115252753A (en) | Traditional Chinese medicine composition for treating insomnia and application thereof | |
| CN103463467A (en) | Miao medicinal liquor with nourishing kidney yin effects | |
| CN103041228A (en) | Traditional Chinese medicine composite for treating myasthenia gravis | |
| CN105796749B (en) | A kind of traditional Chinese medicine composition for relieving asthenopia | |
| CN104857370A (en) | Traditional Chinese medicine composition for treating breast cancer | |
| CN114504635B (en) | Chinese patent medicine for treating apoplexy sequela | |
| CN116211974B (en) | Traditional Chinese medicine composition for improving microcirculation of human body | |
| CN115919964B (en) | Pharmaceutical composition for treating cutaneous pruritus of hemodialysis patient and preparation method thereof | |
| CN102949663A (en) | Traditional Chinese medicinal composite for treating vegetative nerve functional disturbance | |
| CN103028094A (en) | Chinese patent medicine for treating coronary heart disease | |
| CN101607007B (en) | Traditional Chinese medicine preparation for treating cerebral circulation insufficiency | |
| CN108210596B (en) | Traditional Chinese medicine for reducing blood pressure and method for preparing plaster for reducing blood pressure by using traditional Chinese medicine | |
| CN104940279A (en) | Application of Chinese herbal composition to preparation of medicine for treating myocardial infarction | |
| CN104840551A (en) | Hypertension relieving mulberry leaf Chinese medicine preparation and preparing method | |
| CN104491316A (en) | Traditional Chinese medicine preparation for treating middle-warmer energy insufficiency type prostate hyperplasia |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20080903 Termination date: 20100306 |