CN103028094A - Chinese patent medicine for treating coronary heart disease - Google Patents

Abstract

The invention belongs to the technical field of traditional Chinese medicines and relates to a Chinese patent medicine for treating coronary heart disease. The Chinese patent medicine is prepared from 1000 parts of ginseng, 20-30 parts of saffron, 500 parts of pseudo-ginseng, 50-100 parts of rhizoma corydalis, 50-100 parts of radix curcumae and 50-100 parts of Szechuan lovage rhizome. The medicine provided by the invention is obtained through the combination of clinic experience accumulated for many years and repeated experiments, so that the medicine has unique therapeutic effect on chest congestion, breath shortness, weakness and pain caused by coronary heart disease and angina. A comprehensive therapeutic effect is acquired through the joint action of various Chinese herbal medicines so as to rapidly permeate the active ingredients of the medicines into focuses. The Chinese patent medicine has the therapeutic effects of soothing the liver, dredging stagnation, replenishing qi, nourishing blood, activating blood circulation, removing stasis, promoting qi circulation, relieving pain, clearing away heart fire, soothing the nerve, expanding blood vessels, increasing coronary blood flow, improving heart vitality, exciting a central nerve system, lowering blood pressure and cholesterol and softening the vessels. The formula of the Chinese patent medicine is proper and strict, and coronary heart disease caused by various reasons can be quickly treated by the Chinese patent medicine disclosed by the invention. Besides, the Chinese patent medicine also has the advantages of fast effect, short therapeutic course, high efficiency and low fees.

Description

A kind of Chinese patent medicine for the treatment of coronary heart disease

Technical field

The present invention relates to a kind of Chinese medicine, particularly a kind of Chinese patent medicine for the treatment of coronary heart disease.

Background technology

Coronary heart disease belongs to the traditional Chinese medical science " thoracic obstruction " category, and with feeling of oppression and pain in the chest, shortness of breath and fatigue is clinical main manifestations, and modern medicine is referred to as cardiovascular disease.Cardiovascular disease is the cause of death of No. 1 in the world.Heart of Europe investigation in 2006 shows that Europe has 40,000 people to die from the cardiovascular diseases every year.The incidence rate of the sudden cardiac death that U.S.'s coronary heart disease is relevant is in 30～400,000/year.

Since the eighties in 20th century, the factors such as compared with developed countries, the rapid growth of China's economy and living standards of the people improve, diet structure is unreasonable, crowd's physical exertion minimizing, body weight risings, serum cholesterol rising, hypertension, smoking rate in male are risen, rhythm of life quickening, social mentality's pressure increase the weight of cause China's cardiovascular diseases's M ﹠ M to be year by year ascendant trend.Statistical data confirms in addition, and the inland of China had 51.5 ten thousand people to die from this disease in 2000, and the whole nation was 1,860,000 person-times in hospital because of coronary heart disease in 2004.The statistics indication of World Health Organization's " Global disease burden ", till the year two thousand twenty, the annual number because of cardiovascular disease death of China might reach 4,000,000.How to allow increasing patient obtain more effective treatment, reduce its mortality rate, this has become the common problems of concern of international medical community.

As seen, primary disease is the commonly encountered diseases of serious threat human health, frequently-occurring disease.Along with advancing of disease, myocardial infarction, heart failure can appear, and it is the major reason that disables.There is no the genesis of effective method control coronary heart disease both at home and abroad.

Summary of the invention

The objective of the invention is to overcome the prior art deficiency and provide that a kind of instant effect, expense are low, the Chinese patent medicine of the treatment coronary heart disease of determined curative effect.

For realizing purpose of the present invention, existing according to following technical scheme.This medicine is to be made by the raw material of following weight portion proportioning: plant the Chinese patent medicine for the treatment of coronary heart disease, it is characterized in that it is to be made by the raw material of following weight portion proportioning: 1000 parts of Radix Ginsengs, 20-30 parts of Stigma Crocis, 500 parts of Radix Notoginseng, 50-100 parts of Rhizoma Corydalis, 50-100 parts of Radix Curcumaes, 50-100 parts of Rhizoma Chuanxiongs.

Preparation method of the present invention is:

(1), take by weighing above-mentioned each component medicine by prescription, for subsequent use;

(2), with pulverizer the above-mentioned medicine that takes by weighing was pulverized 150 orders, mixing, drying is filled 0.3 capsule, and be get final product.

The present invention thinks that according to the dialectical theory of the traditional Chinese medical science spleen is source of generating QI and blood, and the vigorous then QI and blood of temper source is sufficient, and the irritability bar reaches then the sufficient and perfusion heart arteries and veins of QI and blood with flourish heart.If eating cold and uncooked food excessively, the delicious food of being addicted to drink, or the melancholy excessively impairment of the spleen of feelings will causes the temper virtual loss, QI and bloodization is given birth to not enoughly first, heart arteries and veins is lost fill; Second the deficiency of vital energy is short of power, and overfatigue makes heart arteries and veins stasis blocking in addition, causes eventually syndrome of blood stasis due to qi deficiency.Stagnation of heart-blood, heart arteries and veins is not smooth, then causes the sensation of oppression over the chest with shortness of breath angina pectoris; The deficiency of vital energy is lost and to be filled, and the disease such as the tired power of dedicate one's life to then is so the pathogenesis of blood stasis due to qi deficiency is common in the morbidity of coronary heart disease.The disease of effecting a permanent cure is many from depressed liver-energy dispersing and QI regulating, invigorating the spleen for dissipating phlegm, and clearing away heart-fire for tranquillization is started with and is obtained good effect.

The side separates:

Radix Ginseng, strongly invigorating primordial QI, multiple arteries and veins takes off invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, the Fructus Alpiniae Oxyphyllae of calming the nerves admittedly.Modern pharmacological research shows that Radix Ginseng has widely pharmacological action to cardiovascular system.Zoopery proof Radix Ginseng is significantly increased cardiac muscle to the tolerance of anoxia, and cardiac output is increased, and myocardial contraction strengthens, decreased heart rate.The ginsenoside can promote phosphoric acid synthetic, and it is active to improve lipoprotein lipase, be hydrolyzed in the blood vessel of acceleration fat and Chylomicron, thus the metabolism of quickening lipid.Radix Ginseng can promote cholesterol to drain from excrement, promotes the conversion of blood cholesterol, and blood cholesterol is reduced.Old friend's ginseng has certain preventive and therapeutic effect to common Senile disease such as hypertension, atherosclerosis, coronary heart disease.

Stigma Croci, warm in nature, acrid in the mouth, promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.Pharmacological research demonstration Stigma Croci can stop thrombosis to further develop and progressively alleviate thrombosis, the effect of cholesterol reducing.Can improve preferably the microcirculation disturbance of cardiac muscle and cerebral tissue, play the effect for the treatment of coronary heart disease.

Radix Notoginseng, stop blooding, invigorate blood circulation, analgesic therapy.Cure mainly to fall and pounce on congestive edema, thoracic obstruction angor.Radix Notoginseng contains abundant Radix Notoginseng total arasaponins, Radix Notoginseng total arasaponins is blood vessel dilating directly, reduce peripheral vascular resistance, suppress vasomotor center, the more important thing is that Radix Notoginseng total arasaponins can improve Coronary microcirculation, therefore Radix Notoginseng total arasaponins at blood vessel dilating, lower coronary resistance, increase coronary flow, tighten and improve Coronary microcirculation, in the having additional nutrients property myocardial flow, can strengthen myocardial contraction, strengthen blood vessel elasticity, reduce arterial pressure, slightly subtract heart rate, thereby obviously reduce the oxygen consumption of cardiac muscle, be used for the treatment of coronary heart disease.

Rhizoma Corydalis, promoting blood circulation to remove blood stasis is arranged, the function of promoting the circulation of QI pain relieving is used for pain of each qi depression to blood stasis of whole body, and uncomfortable in chest, angina pectoris that coronary heart disease is caused have good therapeutical effect.Studies confirm that, separablely in the Rhizoma Corydalis go out 15 kinds of alkaloids, wherein Corydaline, second element, ugly element, the last of the ten Heavenly stems, element all had analgesic activity, and is especially remarkable with analgesia, the sedation of tetrahydropalmatine.It is a kind of Tetrahydropalmatine, with berberine be the molecular structure of same type.With barbiturate synergism is arranged, can resist again the central excitation effect of amfetamine and caffeine.Tetrahydropalmatine also has the effect of anti-5-HT.Rhizoma Corydalis second element also can make thyroid weight increase.Dehydrogenation Rhizoma Corydalis first element can increase coronary flow and Nutritional myocardium blood flow, prevents myocardial ischemia.

Radix Curcumae, return liver, the heart, lung meridian.Have promoting blood circulation and stopping pain, fragrance reaches thoroughly, dispersing the stagnated live-QI to relieve the stagnation of QI, promoting QI circulation for relieving depression, the removing heat from blood that clears away heart-fire, promoting the function of the gallbladder to alleviate jaundice effect.Can be used for the treatment of chest and abdomen swelling and pain, breast side of body epigastric pain, twinge.

Rhizoma Chuanxiong,Acrid in the mouth, warm in nature.Return liver, gallbladder, pericardium channel, hot loose temperature is logical, the function blood circulation promoting and blood stasis dispelling, and effect extensively is applicable to the disease of various stagnation of blood stasis." book on Chinese herbal medicine is just ": Rhizoma Chuanxiong, its property is kind loose, walks again Liver Channel, and the blood medicine in the gas is also.Dispersing wind and cold is arranged, control headache, removing blood stasis with potent drugs holds, and promoting blood circulation is separated stagnation of QI, and by pain, the evacuation of pus detumescence is stimulated the menstrual flow clinical treatment for pain in chest and hypochondrium by blood.

Medicine of the present invention is in conjunction with for many years summary of clinical experience, get through repeatedly testing, thus this medicine to coronary heart diseases and angina pectoris cause uncomfortable in chest, breathe hard, weak, pain has unique curative effect, it adopts multiple Chinese herbal medicine synergy, comprehensive measure makes the active ingredient rapid permeability focus of medicine.Play dispersing the stagnated live-QI to relieve the stagnation of QI, benefiting qi and nourishing blood, blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, clearing away heart-fire for tranquillization, blood vessel dilating, increase coronary flow, improve heart vigor, stimulating central nervous system system, reduce blood pressure and the curative effect of cholesterol, vessel softening, its prescription compatibility is proper, rigorous, the Chinese medicine of the application of the invention can be cured the coronary heart disease that a variety of causes causes fast, and the advantage that instant effect, short treating period, efficient are high, expense is little.

The specific embodiment:

Take by weighing raw material in following ratio:

1000 parts of Radix Ginsengs, 20-30 parts of Stigma Crocis, 500 parts of Radix Notoginseng, 50-100 parts of Rhizoma Corydalis, 50-100 parts of Radix Curcumaes, 50-100 parts of Rhizoma Chuanxiongs.

Preparation method of the present invention is:

(1), take by weighing above-mentioned each component medicine by prescription, for subsequent use;

(2), with pulverizer the above-mentioned medicine that takes by weighing was pulverized 150 orders, mixing, drying is filled 0.3 capsule, and be get final product.

Drug administration method of the present invention is: every day 3 times, early, middle and late after meal each once, each 3-5, warm water delivery service.

Be the effect that shows that the present invention treats, the inventor is by having carried out clinical observation to clinical 200 cases of Henan College Of Traditional Chinese Medicine one attached institute.

Data and method conclusion

1 physical data

200 examples 1.1 case history is originated, male's 108 examples wherein, women's 92 examples, 40～70 years old age, average 57.6 years old.Course of disease two weeks to 10 year, average 7.8 years.

1.2 case is selected

1.2.1 " diagnosis of unstable angina pectoris and the treatment " that diagnostic criteria Western medicine diagnose standard adopts angiocardiology branch of Chinese Medical Association to work out.Tcm diagnosis standard reference " guideline of clinical investigations of the traditional Chinese medical science Drugs in Therapy thoracic obstruction (angina pectoris) ", tcm syndrome differentiation and typing belongs to because of blood stasis due to qi deficiency.Classical symptom: uncomfortable in chest, chest pain, breathe hard, weak.

1.2.2 inclusive criteria: 1. meet the diagnostic criteria of (getting rid of the infarction angina pectoris, ariant angina) of doctor trained in Western medicine unstable angina pectoris; 2. meet the disease of tcm diagnostic criteria; 3. Electrocardioscopy has obvious myocardial ischemia evidence.

1.2.3 exclusion standard: do not meet Western medicine diagnose standard and differential diagnosis in tcm standard person; When being diagnosed as the coronary heart disease heart infarction and other heart diseases person; Gestation or women breast-feeding their children.Those who are allergic to this drug; Be associated with the serious primary disease person such as cardiovascular, lung, liver, kidney and hemopoietic system, the psychotic; All inclusive criterias that do not meet, not in accordance with regulations medication can't be judged that curative effect or data are not congruent to affect the treatment and safety judgement person.

2 Therapeutic Method

Matched group sorbitrate 10mg, 3 times/d is oral, metoprolol 12.5mg, 2 times/d is oral, aspirin 100mg, 1 time/d is oral, 23 times/d of TONGXINLUO JIAONANG.Treatment group adds medicine of the present invention on the Western medicine basis, each 5, every day 3 times, takes altogether for 6 weeks.Two groups of cases angina pectoris attacks during observing treatment is difficult to spontaneous remission person and gives the buccal nitroglycerin.

3 observation indexs

3.1 curative effect determinate standard

3.1.1 recovery from illness: transference cure, nitroglycerin is stopped using, and it is normal that the electrocardiogram ST-T changes recovers; 3.1.2 produce effects: symptom obviously alleviates, and nitroglycerin obviously reduces use, and the electrocardiogram ST-T changes obviously improves; 3.1.3 effectively: sx↓, nitroglycerin reduces use, and the electrocardiogram ST-T changes improves; 3.1.4 invalid: symptom is without obvious improvement, and nitroglycerin is without minimizing, and the electrocardiogram ST-T changes is without improvement.

3.2 health giving quality observation index

3.2.1 chest pain, uncomfortable in chest, 3.2.2 shortness of breath and fatigue, 3.2.3, the number of times of angina pectoris attacks, persistent period and nitroglycerin consumption, the Electrocardiographic change of 3.2.4.

4 results

4.1 clinical efficacy after the treatment: see Table 1

Clinical efficacy (%) after table 1 treatment

The example number	Recovery from illness	Produce effects	Effectively	Invalid	Total effective rate %
						200	50	68	80	2	98

4.2 cardinal symptom changes before and after the treatment: see Table 2

4.3 untoward reaction without.

Claims (2)

1. a Chinese patent medicine for the treatment of coronary heart disease is characterized in that it is to be made by the raw material of following weight portion proportioning: 1000 parts of Radix Ginsengs, 20-30 parts of Stigma Crocis, 500 parts of Radix Notoginseng, 50-100 parts of Rhizoma Corydalis, 50-100 parts of Radix Curcumaes, 50-100 parts of Rhizoma Chuanxiongs.

2. a kind of preparation method for the treatment of the Chinese patent medicine of coronary heart disease according to claim 1 is characterized in that:

(1), take by weighing above-mentioned each component medicine by prescription, for subsequent use;

(2), with pulverizer the above-mentioned medicine that takes by weighing was pulverized 150 orders, mixing, drying is filled 0.3 capsule, and be get final product.