CN104306636A - Ginseng root-desert cistanche kidney warming and kidney nourishing compound preparation - Google Patents
Ginseng root-desert cistanche kidney warming and kidney nourishing compound preparation Download PDFInfo
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Abstract
The invention discloses a ginseng root-desert cistanche kidney warming and kidney nourishing compound preparation and belongs to a formula and a preparation method of a Chinese patent medicine. The ginseng root-desert cistanche kidney warming and kidney nourishing compound preparation is prepared from American ginseng, cistanche, prepared rehmannia root, Chinese wolfberry, root of bidentate achyranthes, herba epimedii, cornua cervi pantotrichum, rhizoma cibotii, Chinese yam, cinnamon, monkshood, moutan bark and rhizoma alismatis. The ginseng root-desert cistanche kidney warming and kidney nourishing compound preparation has the effects of warming the kidney and nourishing the kidney, wherein American ginseng and cistanche are monarch drugs and have the effects of tonifying kidney yang, benefiting essence and blood; the prepared rehmannia root, Chinese wolfberry and root of bidentate achyranthes are ministerial drugs and have the effects of nourishing kidney yin, relieving waist and knee pain and assisting the monarch drugs to tonify the kidney; herba epimedii, cornua cervi pantotrichum, rhizoma cibotii, Chinese yam, cinnamon and monkshood are adjuvant drugs and have the effects of tonifying fire and helping yang, guiding fire to origin, eliminating cold to stop pain and warming meridians; and moutan bark and rhizoma alismatis are conductant drugs and have the effects of restoring yang and rescuing a patient from collapse, tonifying fire and helping yang, eliminating cold to stop pain as well as clearing damp and promoting diuresis. The ginseng root-desert cistanche kidney warming and kidney nourishing compound preparation has the effects of obviously improving insufficiency of kidney-yang, depletion of essence and blood, impotence and infertility, soreness and weakness of waist and knees, inability of muscles and bones and cold hands and feet.
Description
Technical field
The present invention relates to a Radix Panacis Quinquefolii Herba Cistanches the kidney warming and support kidney compound preparation, belong to formula and the preparation method of Chinese patent medicine.Be mainly used in insufficiency of kidney-YANG, blood and essence asthenia, sexual impotence is infertile, soreness of the waist and knees, and muscles and bones is unable, and the people of the ice-cold sign of brothers, improve significantly effect.
Background technology
In theory of Chinese medical science, kidney is very special internal organs.Ancient medicine is thought: the sexual intercourse of father and mother two essence, XianCheng's plumule, then just grow for " kidney ", possess in father and mother congenital essence (moderns' said " gene " can be interpreted as approx) namely Tibetan in kidney, therefore have the saying of " kidney be row sky ".Perhaps derive from five-elements theory and go out that (kidney belongs to water, the main winter, capable and quiet under water; Winter then stings Tibetan), or opened in it because of, ancient doctor thinks that kidney officials seal the functional characteristics of Tibetan.This be in particular in by " essence " (comprise first essence, also acquired essence is comprised) close being fixed in " kidney " and be " kidney essense ", this kind of important substance of maintaining life is made to be unlikely meaningless consume or loss, its growth promoting effects can be played, grow and the function of reproduction, therefore have saying of " kidney controlling essence storage, the smart main growth of being hidden, growth and reproduction ".Envelope is hidden and is also shown that kidney can assist the breathing of lung, and making it too not shallow has, and the gas of suction can be included in kidney, and this is called " kidney governing inspiration ".In addition, consistent with Contemporary Cognition, theory of Chinese medical science is emphasized " the main urine of kidney ", and little is by body fluid in the rising body of yang-energy in kidney, stays clearly, leaches turbid, and it is stored in bladder temporarily, periodically excreted.Add the dirty defeated cloth that also take part in body fluid in body such as spleen lung, but these dirty functions such as lung spleen depend on the promotion of yang-energy in kidney, therefore in theory of Chinese medical science, kidney regulates and decides the balance of body fluid metabolism in body, and have saying of " the main water of kidney ".
Except above-mentioned functions, theory of Chinese medical science is thought " waist is house of kidney ", and the position of kidney is waist, and the chronic trauma of waist, pain are normal relevant with kidney.Kidney is positioned at the five internal organs extreme lower position, and genitals is normal also relevant with kidney with the pathological changes of anus, and some symptom of ankle knee joint etc. also reflects the state of kidney.In addition, the essence that the bone, marrow, spinal cord, hair, tooth etc. of whole body are all hidden with kidney is closely related, because the generation marrow of refining being in kidney to be hidden, marrow is poured in bone cavity to supplement nutrition bone; Supplement nutrition and moist spinal cord; And on to note in brain be brains; To supplement nutrition hair; Tooth being the surplus of the bone; Tooth is also closely bound up with kidney essense.Moreover ear and kidney have numerous exceptionally closely to contact, and then have saying of " kidney opening at ear ".
The traditional Chinese medical science thinks insufficiency of kidney-YANG: aching pain in waist and back, seminal emission sexual impotence, polyuria or can't help, pale complexion, aversion to cold and cold limbs, watery diarrhea with indigested food or Diarrhoea, and pale tongue is fat indentation, and tongue is white, deep-slow pulse.
The present invention is for insufficiency of kidney-YANG, and blood and essence asthenia, sexual impotence is infertile, soreness of the waist and knees, and muscles and bones is unable, and brothers are ice-cold to improve significantly.
Summary of the invention
The object of this invention is to provide a Radix Panacis Quinquefolii Herba Cistanches the kidney warming and support kidney compound preparation, for insufficiency of kidney-YANG, blood and essence asthenia, sexual impotence is infertile, soreness of the waist and knees, and muscles and bones is unable, and brothers are ice-cold to improve significantly.
The present invention realizes with following technical scheme: a Radix Panacis Quinquefolii Herba Cistanches the kidney warming supports kidney compound preparation, it is characterized in that: be made up of the raw material of following weight parts:
Radix Panacis Quinquefolii 8-12 part, Herba Cistanches 8-12 part, Radix Rehmanniae Preparata 8-12 part, Fructus Lycii 8-12 part,
Radix Achyranthis Bidentatae 8-12 part, Herba Epimedii 8-12 part, Cornu Cervi Pantotrichum 3-5 part, Rhizoma Cibotii 3-5 part,
Rhizoma Dioscoreae 8-12 part, Cortex Cinnamomi 5-7 part, Radix Aconiti Lateralis Preparata 3-5 part, Cortex Moutan 5-7 part,
Rhizoma Alismatis 5-7 part.
Above-mentioned Radix Panacis Quinquefolii Herba Cistanches the kidney warming supports the preparation method of kidney compound preparation,
A () takes raw material by prescription: Herba Cistanches, Radix Rehmanniae Preparata, Radix Achyranthis Bidentatae, Herba Epimedii, Rhizoma Cibotii, Radix Aconiti Lateralis Preparata, Cortex Moutan and Rhizoma Alismatis;
B the alcohol solvent that above-mentioned ingredients merging volumetric concentration is not less than 75% is soaked 30 minutes by (), then carry out boiling reflux and extract 2-3 time; The consumption of 3 solvents and alcohol solvent are respectively 10,8,8 with the ratio of medical material volume; Time timing from boiling of boiling reflux, each backflow 1 hour;
C () merges said extracted liquid, use vacuum rotary evaporator concentrating under reduced pressure, recycling design ethanol, being concentrated to density is 1.20-1.25g/ml, obtains paste;
D (), according to recipe quantity, takes Radix Panacis Quinquefolii, Fructus Lycii, Cornu Cervi Pantotrichum, Rhizoma Dioscoreae and Cortex Cinnamomi, dry, pulverize, cross 100 mesh sieve, for subsequent use;
E () is by the paste of step (c) and step (d) fine medicinal material powder, and adjuvant comprise sucrose, dextrin, microcrystalline Cellulose and 80% ethanol, 16 mesh sieve pelletizes, carry out drying, last granulate in Constant Temp. Oven; For subsequent use;
F (), according to the requirement of dosage form, adds magnesium stearate and is prepared into tablet, capsule, granule.
The present invention can also adopt pharmaceutics of Chinese drugs common process to make capsule; Pharmaceutics of Chinese drugs common process is adopted to make tablet, powder or granule, oral liquid
Fang Xie:
Radix Panacis Quinquefolii GUIXIN, lung, kidney channel.Boosting qi and nourishing yin, clearing away heat and promoting production of body fluid.Lose for deficiency of vital energy the moon, deficiency-heat is tired of tired, and cough with asthma expectorant blood, interior-heat is quenched one's thirst, dryness of the mouth and throat.Herba Cistanches returns kidney, large intestine channel.Kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.For insufficiency of kidney-YANG, blood and essence asthenia, sexual impotence is infertile, soreness of the waist and knees, and muscles and bones is unable, dryness of the intestine constipation.Herba Cistanches is also desert Radix Ginseng, cures mainly insufficiency of kidney-YANG, temperature compensation essence and blood, protects the liver and moisturize, and has very important dietetic therapy effect and effect.Radix Rehmanniae Preparata returns liver, kidney channel.Enrich blood YIN nourishing, beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, dizzy.Fructus Lycii returns liver, kidney channel.Nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, impotence and seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.Fructus Lycii sweet in the mouth, property is put down, and returns Liver and kidney warp, can nourishing kidney yin, and " Fructus Lycii is highly seasoned and pure, is good at nourishing YIN, has sun in the moon, therefore can QI invigorating, so YIN nourishing and unlikely the moon declines, supporing yangly can make Yang Wang.Radix Achyranthis Bidentatae is bitter, sweet, sour, flat.Return liver, kidney channel.Eliminating blood stasis and inducing menstruation, invigorating the liver and kidney, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome, conducting blood to flow downwards.For amenorrhea, dysmenorrhea, soreness of waist and knee joint, muscles and bones is unable, stranguria, edema, headache, dizzy, toothache, and aphtha is spitted blood, epistaxis.Its acrid-sweet flavor of Herba Epimedii, its temperature, returns liver, kidney channel.It is warm in nature and not dry, mends and not high, supporing yang and not impairment of YIN, is the key medicine of flat kidney-replenishing.Cornu Cervi Pantotrichum returns kidney, Liver Channel.Invigorating kidney-YANG, benefiting essence-blood, bone and muscle strengthening.For insufficiency of kidney-YANG, blood and essence asthenia, sexual impotence spermatorrhea.Rhizoma Cibotii is bitter, sweet, temperature.Return liver, kidney channel.Wind-damp dispelling, invigorating the liver and kidney, strong waist knee joint.For rheumatic arthralgia, soreness of the waist and knees, weakness of the lower extremities.Rhizoma Dioscoreae returns spleen, lung, kidney channel.Spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.Cortex Cinnamomi returns kidney, spleen, the heart, Liver Channel.Mend fire supporing yang, guiding fire to origin, dispersing cold for relieving pain, promoting the flow of QI-blood by warming the meridian.For sexual impotence cold womb, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, upward floating of YANG in deficiency condition, the symptoms such as dizzy conjunctival congestion.Radix Aconiti Lateralis Preparata GUIXIN, kidney, spleen channel.Recuperating depleted YANG and rescuing the patient from collapse, mends fire supporing yang, dispersing cold for relieving pain.For YANG-depletion collapse, kidney yang deficiency, sexual impotence cold womb, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor, arthralgia due to cold-dampnes.Invigorating spleen and reinforcing stomach, trains first nourishing kidney, and cure mainly asthenia damage, human body is become thin, soreness of waist and knee, the dark tinnitus of order, poor appetite.Cortex Moutan GUIXIN, kidney, spleen channel.Recuperating depleted YANG and rescuing the patient from collapse, mends fire supporing yang, dispersing cold for relieving pain.For YANG-depletion collapse, cold extremities faint pulse, deficiency of heart-YANG, obstruction of qi in the chest and cardialgia, deficiency and coldness is vomited and diarrhoea, coldness and pain in the epigastrium, kidney yang deficiency, sexual impotence cold womb, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor, arthralgia due to cold-dampnes.Clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.Nutrient blood is entered, maculae caused by violent heat pathogen etc. for heat.Rhizoma Alismatis returns kidney, urinary bladder channel.Promoting diuresis to eliminate damp pathogen, expels the heat-evil, and changes turbid blood fat reducing.For dysuria, edema distension, oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria, hyperlipemia.
Radix Panacis Quinquefolii, Herba Cistanches have the effect of kidney-replenishing, benefiting essence-blood and bone and muscle strengthening, and above two tastes are monarch.Radix Rehmanniae Preparata, Fructus Lycii, Radix Achyranthis Bidentatae nourishing kidney yin, and to soreness of waist and knee joint, there is mitigation, help monarch's the kidney invigorating, with it for minister.Herba Epimedii, Cornu Cervi Pantotrichum, Rhizoma Cibotii, Rhizoma Dioscoreae, Cortex Cinnamomi, Radix Aconiti Lateralis Preparata are mended fiery supporing yang, guiding fire to origin, dispersing cold for relieving pain, promoting the flow of QI-blood by warming the meridian, with it for assistant.More than Cortex Moutan, Rhizoma Alismatis two taste recuperating depleted YANG and rescuing the patient from collapse, mend fire supporing yang, dispersing cold for relieving pain, promoting diuresis to eliminate damp pathogen, with it for making.This prescription is for insufficiency of kidney-YANG, and blood and essence asthenia, sexual impotence is infertile, soreness of the waist and knees, and muscles and bones is unable, and brothers are ice-cold to improve significantly.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described;
Embodiment 1
Prescription:
Radix Panacis Quinquefolii 200g, Herba Cistanches 200g, Radix Rehmanniae Preparata 200g, Fructus Lycii 200g, Radix Achyranthis Bidentatae 200g, Herba Epimedii 200g, Cornu Cervi Pantotrichum 80g, Rhizoma Cibotii 80g, Rhizoma Dioscoreae 200g, Cortex Cinnamomi 120g, Radix Aconiti Lateralis Preparata 80g, Cortex Moutan 120g, Rhizoma Alismatis 120g.
Preparation method
According to recipe quantity, by Herba Cistanches, Radix Rehmanniae Preparata, Radix Achyranthis Bidentatae, Herba Epimedii, Rhizoma Cibotii, Radix Aconiti Lateralis Preparata, Cortex Moutan and the Rhizoma Alismatis ingredients alcohol solvent with 75% (V/V), soak 30 minutes, then boil, timing 1 hour from boiling; So extract 3 times altogether; The solvent load of 3 times is respectively 10 of medical material volume, 8,8 times; Merge above-mentioned 3 extracting solution;
According to recipe quantity, by Radix Panacis Quinquefolii, Fructus Lycii, Cornu Cervi Pantotrichum, Rhizoma Dioscoreae and Cortex Cinnamomi, dry, pulverize, cross 100 mesh sieve and obtain fine medicinal material powder, for subsequent use.
By the extracting solution vacuum rotary evaporator concentrating under reduced pressure after merging, recycling design ethanol, being concentrated to density is 1.25g/ml, to the paste and above-mentioned fine medicinal material powder that obtain and the ethanol of adjuvant (sucrose, dextrin, microcrystalline Cellulose etc.) and (V/V) 80% be concentrated, 16 mesh sieve pelletizes, carry out drying in Constant Temp. Oven, last granulate, is effective ingredient, for subsequent use.
According to the requirement of dosage form, the magnesium stearate adding recipe quantity is prepared into tablet.
Embodiment 2
Prescription:
Radix Panacis Quinquefolii 200g, Herba Cistanches 200g, Radix Rehmanniae Preparata 200g, Fructus Lycii 200g, Radix Achyranthis Bidentatae 200g, Herba Epimedii 200g, Cornu Cervi Pantotrichum 80g, Rhizoma Cibotii 80g, Rhizoma Dioscoreae 200g, Cortex Cinnamomi 120g, Radix Aconiti Lateralis Preparata 80g, Cortex Moutan 120g, Rhizoma Alismatis 120g.
Preparation method
According to recipe quantity, by Herba Cistanches, Radix Rehmanniae Preparata, Radix Achyranthis Bidentatae, Herba Epimedii, Rhizoma Cibotii, Radix Aconiti Lateralis Preparata, Cortex Moutan and the Rhizoma Alismatis ingredients alcohol solvent with 75% (V/V), soak 30 minutes, then boil, timing 1 hour from boiling; So extract 2 times altogether; The solvent load of 2 times is respectively 10 of medical material volume, 8 times; Merge above-mentioned 2 extracting solution;
According to recipe quantity, by Radix Panacis Quinquefolii, Fructus Lycii, Cornu Cervi Pantotrichum, Rhizoma Dioscoreae and Cortex Cinnamomi, dry, pulverize, cross 100 mesh sieve and obtain fine medicinal material powder, for subsequent use.
By the extracting solution vacuum rotary evaporator concentrating under reduced pressure after merging, recycling design ethanol, being concentrated to density is 1.20g/ml, to the paste and above-mentioned fine medicinal material powder that obtain and the ethanol of adjuvant (sucrose, dextrin, microcrystalline Cellulose etc.) and (V/V) 80% be concentrated, 16 mesh sieve pelletizes, carry out drying in Constant Temp. Oven, last granulate, is effective ingredient, for subsequent use.
According to the requirement of dosage form, fill is prepared into capsule.
Efficacy analysis
Therapeutic effect
Treatment group 98 example, effective 78 examples (79.6%), effective 53 examples (54.1%), invalid 7 examples (7.1%).Total effective rate is 133.7%.Matched group 85 example, effective 58 examples (68.2%), effective 32 examples (37.6%), invalid 16 examples (18.8%).Total effective rate is 105.8%.Two groups of total effective rates compare, significant difference.
Typical case:
(1) certain female: 44 years old, diabetics, soreness of the waist and knees, weak asthenia, hypomnesis, dizzy, aversion to cold and cold limbs, green around the gills, hectic fever, polyuria etc.Take 5-8g every day, oral.After taking 6 months, somatosensory is relatively light, and the phenomenon such as soreness of the waist and knees, weak asthenia, dizzy, aversion to cold and cold limbs, green around the gills, flushed cheeks, hectic fever, polyuria makes moderate progress.Taking now, effect is better always.
(2) certain man, 43 years old, operating pressure is large, often with headache, sleep bad, slight Hypertension, soreness of the waist and knees, weak asthenia, hypomnesis, dizzy, aversion to cold and cold limbs, polyuria etc. have taken the capsule prepared according to the party, after 2 months, sleep, soreness of the waist and knees, weak asthenia, dizzy, aversion to cold and cold limbs, polyuria situation improvement.Taking now, successful always.
(3) certain female: 68 years old, often feels dizzy, forgetful, spiritlessness and weakness, lassitude, vigor is low, fatiguability, fear of cold are afraid of cold, coolness of extremities, health are sent out heavy, soreness of waist and knee joint, back cold type of pain, muscles and bones wither soft etc.Taken the capsule prepared according to the party, after 3 months, energetic, sleep quality, spiritlessness and weakness, soreness of waist and knee joint, back cold type of pain, fear of cold is afraid of cold, coolness of extremities is alleviated.Taking now, effect is fine always.
Claims (6)
1. a Radix Panacis Quinquefolii Herba Cistanches the kidney warming supports kidney compound preparation, it is characterized in that: be made up of the raw material of following weight parts:
Radix Panacis Quinquefolii 8-12 part, Herba Cistanches 8-12 part, Radix Rehmanniae Preparata 8-12 part, Fructus Lycii 8-12 part,
Radix Achyranthis Bidentatae 8-12 part, Herba Epimedii 8-12 part, Cornu Cervi Pantotrichum 3-5 part, Rhizoma Cibotii 3-5 part,
Rhizoma Dioscoreae 8-12 part, Cortex Cinnamomi 5-7 part, Radix Aconiti Lateralis Preparata 3-5 part, Cortex Moutan 5-7 part,
Rhizoma Alismatis 5-7 part.
2. Radix Panacis Quinquefolii Herba Cistanches the kidney warming according to claim 1 supports a preparation method for kidney compound preparation, it is characterized in that:
A () takes raw material by prescription: Herba Cistanches, Radix Rehmanniae Preparata, Radix Achyranthis Bidentatae, Herba Epimedii, Rhizoma Cibotii, Radix Aconiti Lateralis Preparata, Cortex Moutan and Rhizoma Alismatis;
B the alcohol solvent that above-mentioned ingredients merging volumetric concentration is not less than 75% is soaked 30 minutes by (), then carry out boiling reflux and extract 2-3 time; The consumption of 3 solvents and alcohol solvent are respectively 10,8,8 with the ratio of medical material volume; Time timing from boiling of boiling reflux, each backflow 1 hour;
C () merges said extracted liquid, use vacuum rotary evaporator concentrating under reduced pressure, recycling design ethanol, being concentrated to density is 1.20-1.25g/ml, obtains paste;
D (), according to recipe quantity, takes Radix Panacis Quinquefolii, Fructus Lycii, Cornu Cervi Pantotrichum, Rhizoma Dioscoreae and Cortex Cinnamomi, dry, pulverize, cross 100 mesh sieve, for subsequent use;
E () is by the paste of step (c) and step (d) fine medicinal material powder, and adjuvant comprise sucrose, dextrin, microcrystalline Cellulose and 80% ethanol, 16 mesh sieve pelletizes, carry out drying, last granulate in Constant Temp. Oven; For subsequent use;
F (), according to the requirement of dosage form, is prepared into tablet, capsule, granule.
3. Radix Panacis Quinquefolii Herba Cistanches the kidney warming as claimed in claim 1 supports kidney compound preparation, it is characterized in that: adopt pharmaceutics of Chinese drugs common process to make capsule.
4. Radix Panacis Quinquefolii Herba Cistanches the kidney warming as claimed in claim 1 supports kidney compound preparation, it is characterized in that adopting pharmaceutics of Chinese drugs common process to make tablet.
5. Radix Panacis Quinquefolii Herba Cistanches the kidney warming as claimed in claim 1 supports kidney compound preparation, it is characterized in that adopting pharmaceutics of Chinese drugs common process to make powder or granule.
6. Radix Panacis Quinquefolii Herba Cistanches the kidney warming as claimed in claim 1 supports kidney compound preparation, it is characterized in that adopting pharmaceutics of Chinese drugs common process to make oral liquid.
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Cited By (3)
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| CN108785482A (en) * | 2017-05-05 | 2018-11-13 | 洛阳士雄聚元医疗集团股份有限公司 | It is a kind of to treat the relatively infertile Chinese medicine of women |
| CN108936598A (en) * | 2018-05-22 | 2018-12-07 | 河南中立生物科技有限公司 | A kind of five-element support kidney and decompose congee and preparation method thereof |
| CN110856732A (en) * | 2018-08-06 | 2020-03-03 | 严育斌 | Capsule for treating impotence |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101628071A (en) * | 2009-08-25 | 2010-01-20 | 红桃开集团股份有限公司 | Medicament composition for strengthening kidney and tonifying Yang |
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| CN101628071A (en) * | 2009-08-25 | 2010-01-20 | 红桃开集团股份有限公司 | Medicament composition for strengthening kidney and tonifying Yang |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108785482A (en) * | 2017-05-05 | 2018-11-13 | 洛阳士雄聚元医疗集团股份有限公司 | It is a kind of to treat the relatively infertile Chinese medicine of women |
| CN108936598A (en) * | 2018-05-22 | 2018-12-07 | 河南中立生物科技有限公司 | A kind of five-element support kidney and decompose congee and preparation method thereof |
| CN110856732A (en) * | 2018-08-06 | 2020-03-03 | 严育斌 | Capsule for treating impotence |
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